Awareness about special education in hyderabad

pecial Needs Education (SNE) highly plays a crucial for all those children and adults with disabilities. In this article, I aim to research the awareness levels of SNE in various schools and communities in the city of Hyderabad, India. A qualitative approach was taken for this purpose. My research also includes a case study of a special needs child along with his family and academic background, in order to know the degree of awareness among parents.

Husna habib Husna habib

University students’ fear of success from the perspective of positive psychology

The aim of this study was to examine university students’ fear of success from the perspective of positive psychology. Two objectives were addressed: first, analyzing the relation between fear of success, optimism, self-esteem, self-efficacy, and search for meaning in life; second, exploring the variance of the fear of success, taking into account the affective dimension of the self (self-esteem) and search for meaning in life. The results confirmed that fear of success was positively related to search for meaning, and negatively to optimism, self-esteem, and self-efficacy. The variance of the fear of success was explained by the self-esteem and search for meaning in life. Implications for school psychologists were discussed.

Elena stănculescu

Leveraging iks in business and management – a roadmap for viksit bharat 2047

This paper investigates the transformative potential of Indian Knowledge Systems (IKS) in modern business and management practices, aligning with India's vision for "Viksit Bharat 2047"—a roadmap toward becoming a developed nation by 2047. Integrating ancient Indian wisdom with advanced Artificial Intelligence (AI) provides an innovative framework for enhancing decision-making, sustainability, and innovation across diverse industries. This study aims to incorporate key IKS principles such as holistic management, ethical leadership, and community-centered business models into AI-driven methodologies to create a forward-thinking approach in Indian business contexts. Using a mixed-method research design, the study combines qualitative insights from traditional Indian texts with quantitative analysis of case studies where IKS principles are applied in contemporary businesses. The findings reveal that concepts like ―Dharma‖ (ethical responsibility), ―Artha‖ (resource management), and ―Karma‖ (action-driven leadership) play a crucial role in corporate governance, social responsibility, and achieving sustainable development goals when combined with AI's analytical power. This synergy addresses current challenges, including environmental sustainability, social equity, and ethical governance. The research demonstrates that a balanced integration of AI and IKS can foster inclusive and sustainable growth, supporting India's self-reliance and competitiveness on a global scale. The paper provides a roadmap for academics, policymakers, and business leaders to leverage IKS with AI, aiming for an innovative and resilient India by 2047.

Dr tatayya bommali

Akshaya patra model: feeding knowledge hungry children

While today, he was ready to serve 1.4 million meals for schoolchildren, Mr.CC Das, Program Director, Akshaya Patra Foundation from Bangalore also faced the challenges 15-years before its establishment like any other start-up. Similar was the case of Mr.Trilok Gautam, Executive Supervisor, who was working in a remote village called Baran in Rajasthan. On his visit during the mid-day meal preparation, he was inspecting the quality of meal, where women were busy in preparing food. They were preparing bread by rolling the dough, while few were chopping vegetables with utmost hygienic care. Cleaner, safer, quality meal was to be prepared and served for 1,500 poor students. These children earlier used to go hungry from the school. On November 28th 2001, Supreme Court of India gave a verdict and directed the State Government and Union Territories to provide mid-day meal to every child in Government and Government-assisted primary schools. The Right to Food Law emerged as a fundamental right, enforced due to constitutional amendment under Article 32 of the constitution. Hence, every State Government geared up to make the mid-day meal scheme successful in their respective States. The Karnataka government also participated and named this programme as ‘Akshara Dashoha’. Government of Karnataka took the pioneering step to involve NGOs like Akshaya Patra as an important partner of the government to run this innovative mid-day meal scheme under the Public Private Partnership (PPP) Model. Presently, Indian mid-day meal scheme considered as one of the largest mid-day meal programme in the world has a target to reach out nearly 120 million children in the country.

Nitin Mali Nitin mali

Antiurolithiatic plants: multidimensional pharmacology

Urolithiasis has been a common problem for centuries and has a high recurrence. This review aims to provide comprehensive information about traditionally used antiurolithiatic plants and their scientifically proven pharmacological activities like analgesic, anti-inflammatory, antioxidant, astringent, demulcent, diuretic, litholytic, lithotriptic, antiurolithiatic, antispasmodic, ACE inhibition and Phospholipase A2 inhibition as a plausible mechanism of action. A total of 503 species, 365 genera and 119 families were cited for treating kidney stones. The most cited families are Asteraceae (41), Fabaceae (34), Lamiaceae (26), Apiaceae (21), Rosaceae (19) and Poaceae (16). The most commonly used plant parts are root and rhizome (25%), mode of preparation decoction (62%), and oral administration route in all cases. This review will provide the opportunities for the future research and development of new natural antiurolithiatic compounds.

Dr. Salman Ahmed Dr. salman ahmed

Diversity status of beneficial microorganisms in heavy metal polluted tannery effluent treatment area in dindugal, tamil nadu

Industrial waste is one of the most essential sources of contamination in the surface environment. Among different industries, tannery industry releases huge amount of pollutants into the ecosystem. Long term disposal of the tannery wastes has resulted in wide contamination of agricultural land and water sources in different parts of India. An attempt was made to study the diversity status of different microbial organisms in tannery effluent treated samples in Dindugal, Tamil Nadu. It was found that Electrical Conductivity (EC) and heavy metal contents were higher and population density of different beneficial microbes found better. Among different microbes isolated, phosphate solubilizing microbes (PSB) was found maximum which is followed by fungi and actinomycetes. The population density of non-symbiotic and symbiotic nitrogen fixers were found to be low in numbers when compared to other samples screened. Similarly, occurrence and distribution of AM fungal spores were also found low in heavy metal polluted samples as compared to the samples collected from non-polluted outside tannery effluent treatment area. Among different Arbuscular Mycorrhizal (AM) fungi, Glomus species was found to be dominant in the samples collected from outside tannery effluent treatment area as compared to tannery effluent samples.

Dr. SARANYA DEVI K Dr. saranya devi k

Public knowledge, attitudes and practices related to eye diseases in southern indian population

Background: This study was conducted to determine the level of the public knowledge, attitudes and practices related to common eye diseases in the southern Indian population. Methods: A cross sectional population-based survey used a semi structured questionnaire on awareness, knowledge, attitude and practices related to eye diseases. Stratified multistage cluster random sampling method was used with a sample size of 867 adults >16 years based on, estimated awareness of cataract 70%, assuming an expected rate of 85%, design effect of 1.5, margin of error 4% with 95% confidence interval with 25% from urban areas and 75% from rural areas. A pilot study was conducted to validate the questions used in the main study. SPSS (version 19) used for analysis. Results: A total of 782/867 (90.1%) subjects participated in the survey, with females 47.4%. Awareness of major eye diseases for cataract 81.5%, glaucoma 47.8%, refractive error 74.3%, squint 89.0%, diabetic retinopathy 65.0% and age-related macular degeneration 36.7% respectively. 41.8% subjects reported wearing glasses either for distance, near or for both. Of the 777 subjects only 294 people underwent an eye examination by an ophthalmologist in the last two years (37.8%). 57.5% subjects had knowledge of the nearest eye care facility within five kilometers of their residence. Electronic media were the major source of information on eye health. Conclusions: Though the awareness levels of common eye diseases were quite high, the knowledge of cataract (10.4%) was poor. There is a need to increase the level of awareness for eye diseases like glaucoma and age-related macular degeneration.

srinivasa reddy pallerla Srinivasa reddy pallerla

Preparation and characterization and biodistribution studies of lomustine loaded plga nanoparticles by interfacial deposition method

The incorporation of lomustine, a hydrophobic anticancer drug into PLGA nanoparticles by interfacial deposition method was optimized. Based on the optimal parameters, it was found that lomustine-PLGA nanoparticles with acceptable properties could be obtained. Optimization of formulation variables to control the size and drug entrapment efficiency of the prepared nanoparticles seems to be based on the same scientific principles as drug-loaded nanoparticles prepared by nanoprecipitation, solvent evaporation method. The process was the most important factor to control the particle size, while both the drug-polymer interaction and the partition of drug in organic and aqueous phases were the crucial factors to govern the drug entrapment efficiency. PLGA concentration at lower level (100 mg), 1:5 organic phase: aqueous ratio, 1%w/v PVA concentration, 3%w/v pluronic F68 achieved smaller particle size. Additionally, L:G ratio of PLGA 75:25, lower volume of organic solvent (1:10 organic phase: aqueous phase), higher initial drug content (10mg) enhanced the drug entrapment efficiency and maintained lomustine concentration in blood for an extended time period, elevated lomustine concentration in lungs and slowed the elimination of lomustine. The biodistribution profiles of prepared nanoparticles in albino mice showed higher plasma drug concentration for longer period of time, elevated drug concentration in lungs and slow elimination from kidney. No toxic effects of prepared nanoparticles were observed in histopathological examination of lungs and kidney. The systematic investigation reported here promises the development of PLGA nanoparticles loaded with lomustine when tested in Lung Cancer cell line L132 and toxicological/ histopathological studies in albino mice.

Archana Mehrotra Archana mehrotra

Education and practice of pharmacy in libya

In Libya, pharmacy education and practice have a similar pattern to medical education and practice. Both sectors of public and private pharmacy education and pharmacy practice still significantly unchanged for more than forty years. It is a traditional pharmacy style of education and practice with a limited change of education and practice. Now, there are more than ten public pharmacy colleges and more than five private colleges established in Libya for a population of seven millions. In addition, there are several intermediate pharmacy institutes which provide a middle degree in pharmacy practice with a very limited knowledge in pharmaceutical sciences and training. Practice of pharmacy in Libya is still a classical mode with only dispensing medicines directly in almost a nonprofessional way and an old fashion way. However, the situation is old and complicated that needs a great deal of attention from different health policymakers and authorities such as Ministry of High Education and Ministry of Health, National Pharmaceutical Union and Libyan Association for Pharmacists.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Strategic international business management - lidl plans

Will discuss how the German giant Lidl plans to take expansionary steps in a Mexican or Norwegian market to add to its success records in the European and North American markets. Lidl began modestly in 1973 with a small shop that runs three members and offers 500 products to 10,500 stores in 29 countries. Lidl has many pros, plus the disadvantages to consider when evaluating the components available in each country, both the pros and cons of this analysis will be reviewed using PESTLE, five- force models, internal value-activities, international business being able to. Accordingly, the next targeted expansion decision will be made.

Mohamed Sorogy Mohamed sorogy

Implementasi model pembelajaran take and give pada mata pelajaran ips kelas v di mi ar-rahim arjasa

This research is the result of research that describes the implementation of the Take and Give learning model in the fifth grade social studies subject at MI Ar-Rahim, Arjasa, Jember. The learning process includes 3 stages, namely the planning, implementation, and evaluation stages. This research aims to answer. Based on the background described above, the formulation of the problems in this study are: 1. How is the preparation in implementing the Take and learning model for class V social studies subjects at MI Ar-Rahim, Arjasa District, Jember Regency? 2. What is the process of implementing the Take and Give learning model for the fifth grade social studies subject at MI Ar-Rahim, Arjasa District, Jember Regency? 3. How is the evaluation in implementing the Take and Give learning model for the fifth grade social studies subject at MI Ar-Rahim, Arjasa District, Jember Regency? The research method used is descriptive qualitative with data collection techniques using observation, interviews and documentation. The data sources in this study were the Principal, Teachers and Grade V Students of Class V Social Studies at MI Ar-Rahim, and other supporting documents. The results of this study indicate: 1. The implementation of the Take and Give learning model in the preparation stage has fulfilled all preparations well. 2. The process of implementing learning in class makes the learning atmosphere fun and students become more active. 3. At the evaluation stage all students have reached the assessment criteria in 3 aspects of the assessment, namely attitudes, knowledge and skills Penelitian ini adalah hasil penelitian yang menggambarkan tentang implementasi model pembelajaran Take and Give pada mata pelajaran IPS kelas V di MI Ar-Rahim Kecamatan Arjasa Kabupaten Jember. Proses pembelajaran tersebut meliputi 3 tahap, yaitu tahap perencanaan, pelaksanaan, dan evaluasi. Adapun penelitian ini bertujuan untuk menjawab Berdasarkan latar belakang yang telah dipaparkan di atas, maka rumusan masalah dalam penelitian ini adalah: 1. Bagaimana persiapan dalam mengimplementasikan model pembelajaran Take and mata pelajaran IPS kelas V di MI Ar-Rahim Kecamatan Arjasa Kabupaten Jember? 2. Bagaimana proses dalam implementasi model pembelajaran Take and Givemata pelajaran IPS kelas V di MI Ar-Rahim Kecamatan Arjasa Kabupaten Jember? 3. Bagaimana evaluasi dalam mengimplementasikan model pembelajaran Take and Givemata pelajaran IPS kelas V di MI Ar-Rahim Kecamatan Arjasa Kabupaten Jember? Metode penelitian yang digunakan adalah kualitatif deskriptif dengan teknik pengumpulan data menggunakan observasi, wawancara dan dokumentasi. Adapun sumber data dalam penelitian ini adalah Kepala Sekolah, Guru dan Peserta didik kelas V mata pelajaran IPS kelas V di MI Ar-Rahim, dan dokumen penunjang lainnya. Hasil penelitian inimenunjukkan: 1. Implementasi model pembelajaran Take and Give pada tahap persiapan sudah memenuhi segala persiapan dengan baik. 2. Proses pelaksanaan pembelajaran dikelas membuat suasana belajar menjadi menyenangkan dan peserta didik menjadi lebih aktif. 3. Pada tahap evaluasi semua peserta didik telah mencapai kriteria penilaian dalam 3 aspek penilaian yaitu sikap, pengetahuan dan keterampilan.

EDUCARE: Journal of Primary Education Educare: journal of primary education

Effect of educational intervention on osteoporosis among tribal premenopausal women

Background:- Tribals are weaker section which holds in outstanding number of tribal population in our country. They are not having proper knowledge on osteoporosis. Osteoporosis is a significant problem in aging population especially in females, it impacts structural and social burden on health care services in tribals. Objective:- Aim of this study is to determine the knowledge regarding osteoporosis among tribal premenopausal women in tribal area of Guntur Dist. Andhra Pradesh Methods:- This study is descriptive quantitative study conducted among 177 Sugali women & 23 Chenchu women of tribal area in Guntur Dist. Andhra Pradesh from 2015 November to December 2015. A self-administered questionnaire was used to assess the knowledge on osteoporosis by conducting Pre-Tests on this group of people. After Educational Intervention was given with the help of self-instructional module and also conducted a Post Test on these same Group of people Results:- The mean age was 40 to 50 years. Majority of the participants are 177 (100%) Sugali women and 23 Chenchu women in these 177 in which n.150 (84%) women are having poor knowledge and remaining 27 (16%) women have average knowledge. In Chenchu women 20 (86%) women were having poor knowledge and remaining 3 (14%) women have average knowledge on all five aspects of questions regarding Osteoporosis, Menopause, Diet, Exercises and Preventive Methods. After Educational Intervention was given their knowledge was improved by a fraction on Osteoporosis. In the Post-Test 101 (57%) women gained average knowledge but remaining 76 (43%) women remained with poor knowledge among Sugali Women. Out of 23 (100%) women of Chenchu tribe 7 (30%) women got average knowledge and the remaining 16 (70%) women remained with poor Knowledge on Osteoporosis Conclusion:- Although majority of participants had low level of knowledge on Osteoporosis in all aspects regarding Menopause, Diet, Exercises and Preventive methods of Osteoporosis. They perceived a little knowledge on Osteoporosis in all aspects towards preventing Osteoporosis. Comparitively Sugali women are having better knowledge than Chenchu women in all aspects of Osteoporosis. Key words:- Osteoporosis, Knowledge, Effect, Pre-Menopausal, Tribal Women.

Mangeswari K Mangeswari k

Factors affecting the ecological status of industrialized cities and measures to monitor them

The development of science and technology proves once again how infinite human needs are. The concentration of the population in large cities, on the one hand, accelerates the process of urbanization and affects the level of development of the state. On the other hand, the state of the environment has a negative impact on urban ecology. From ancient times the population has been striving to create favourable conditions for themselves and such a process is still going on, especially when the negative consequences of this are clearly felt in the health of the population living in cities. Solving this problem is one of the main tasks of urboecology. The development of modern methods of geo-ecological monitoring of the ecological condition of cities, especially in areas with high industrial specialization. The development of measures to improve the health of the population in ecologically critical areas is of a great importance today. To this end, this article discusses in detail the industrialized Navoi region and its urban and ecological situation, the factors affecting it.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Implementasi reward dan punishment dalam membentuk karakter disiplin peserta didik di madrasah ibtidaiyah al-hidayah jember

Giving stimulus from educators in the form of giving appreciation and punishment will greatly affect the way of thinking and behavior of students in achieving the goals of character education that have been set. This study aims to describe the implementation of reward and punishment in shaping the character of students' discipline. This research uses a qualitative approach with the type of case study. Methods of data collection using interviews, observation and documentation. The validity of the data used source triangulation and technical triangulation. The results of this study indicate: (1) The implementation of rewards in shaping the discipline character of students is done by giving rewards in the form of praise and giving appreciation in the form of gifts. (2) The implementation of punishment in shaping the disciplinary character of students is carried out by giving gradual warnings, giving spontaneous warnings and written warning letters. (3) Evaluation of the implementation of rewards and punishments in shaping the character of students' discipline is using process evaluation, which is an assessment carried out during the learning process by observing the attitudes of students everyday when they are in the madrasa environment.. Pemberian stimulus dari pendidik berupa pemberian apresiasi dan hukuman akan sangat mempengaruhi cara berpikir dan tingkah laku peserta didik dalam mencapai tujuan pendidikan karakter yang sudah ditetapkan. Penelitian ini bertujuan untuk mendeskripsikan implementasi reward dan punishment dalam membentuk karakter disiplin peserta didik. Penelitian ini menggunakan pendekatan kualitatif dengan jenis studi kasus. Metode pengumpulan data menggunakan wawancara, observasi dan dokumentasi. Keabsahan data menggunakan triangulasi sumber dan triangulasi tehnik. Hasil penelitian ini menunjukkan: (1) Implementasi reward dalam membentuk karakter kedisiplinan peserta didik dilakukan dengan memberikan reward dalam bentuk pujian serta memberikan apresiasi dalam bentuk hadiah. (2) Implementasi punishment dalam membentuk karakter kedisiplinan peserta didik dilakukan dengan cara memberi peringatan secara bertahap, memberi teguran spontan dan surat peringatan tertulis. (3) Evaluasi implementasi reward dan punishment dalam membentuk karakter kedisiplinan peserta didik adalah menggunakan evaluasi proses, yaitu penilaian yang dilakukan di saat proses pembelajaran berlangsung dengan mengamati dari sikap peserta didik sehari-hari ketika berada di lingkungan madrasah.

EDUCARE: Journal of Primary Education Educare: journal of primary education

An assessment of the underground water collected from ogbete area enugu state, nigeria

Water contamination has become a global challenge which must be tackled. This study examined the contamination level of water in four locations at Ogbete area Enugu state. Carters street had the highest pH of 5.23 which is below the WHO standards limits for drinking water. The conductivities ranged from the highest conductivity 1445 μs/cm, which is below the WHO limits (8-10,000 μs/cm), TDS (1000 mg/l., TSS (WHO (500 mg/l). For alkalinity, the four locations were all below the (150 mg/l) standard set by World Health Organisation. Results showed that most of the physicochemical, biological and heavy metals parameters considered in this study were significantly above the permissible or allowed by WHO. It is therefore recommended that the water should be treated before use.

OKECHUKWU OBED CHUKWUEMEKA Okechukwu obed chukwuemeka

Bank liquidity risk and bank credit risk: implication on bank stability in ghana

Bank sector crisis across the globe is largely blamed on the joint effort of bank liquidity and bank credit risks. And so, the twin concepts of liquidity and credit risks have come under keen academic scrutiny, especially in investment finance. Contributing to the extant literature on these developments, secondary data were obtained from the websites of nine banks in Ghana, spanning 2008 to 2018, to determine how liquidity and credit risks separately and interactively impact bank stability in Ghana. Analysis of data was done using a panel regression through the fixed effects model after running the Hausman Test. The study confirms an inverse liquidity risk-bank stability relationship, emphasising the need to channel idle funds into interest-earning securities to consolidate bank profits. Although a further revelation suggests an insignificant negative relationship between credit risk and bank stability, it re-echoes the need to implement policy recommendations made by the Banks and Specialised Deposit-Taking Institutions’ ACT 2016 (ACT 930), section 62 of Ghana, on the threshold to lend funds to clients. The bank-size-stability relationship was positive. Increasing bank size through establishing more branches nationwide is encouraged but to a precautionary level since banks tend to suffer diseconomies of large scale operations due to unregulated expansion. There is the need to observe the Basel III provisions on maintenance of a 30-day optimum liquidity threshold of up to 100% and above. Besides, banks should tighten up their credit requirements and also ensure loan repayments history is monitored to benefit clients who are in good standing.

Juabin matey

Detection of newcastle disease antibodies amongst local chicken slaughtered in live bird markets in kaduna, nigeria

Newcastle Disease Virus (NDV) constitutes a major constraint to the poultry production system in Nigeria. This study was carried out to investigate the seroprevalence of NDV antibodies in local chickens (Gallus domesticus) slaughtered in five different live bird markets (LBMs) in Kaduna metropolis, Nigeria. Three hundred blood samples were collected and screened for antibodies against NDV using Haemagglutination Inhibition (HI). An overall seroprevalence rate of 23% (95%:CI18.5-28.0) was recorded in this study. Seroprevalence based on different LBMs revealed a higher prevalence of 28.3% (95% : Cl 18.0-40.7) in Sabo market, followed by Sokoto road market 26.7% (Cl:16.7-38.9), Kawo market 18.3% (95% Cl: 10.0-29.6), Railway market 13.3% (Cl:6.4-23.5), and the lowest prevalence was recorded in central market 11.7% (Cl:5.2-21.7). The difference in seroprevalence among the LBMs was not statistically significant (p > 0.05). Higher seroprevalence of NDV antibodies in female birds 30.5 % (Cl: 24.1-37.6) was recorded compared to male 13.9% (Cl: 8.3-21.4). The study indicated that NDV is endemic in the population. LBMs location had no significant influence on the seroprevalence of NDV in the study area. The difference in seroprevalence between sexes was statistically significant (p < 0.05). Therefore, this study demonstrated the need for a regular strategic vaccination programme against NDV in local chickens in Kaduna metropolis.

Bitrus Inuwa Bitrus inuwa

A study on work life balance of self employed women entrepreneurs in mangalore city

Increasing presence of women in economic pursuits like entrepreneurship activities is believed to be the result of development policies. This belief ignores the role of socioeconomic factors in the growth and development of women entrepreneurship. Many women entered the world of business and they have become successful entrepreneurs in various business activities. Women entrepreneurs in Dakshina Kannada district have set up business ventures in a range of industries. The study has been conducted to know the extent of problems faced in managing work and life by women entrepreneurs. Majority of the respondents started their business or service to become independent and to meet the financial needs of their family. From the study it has to be found that majority of the women find it difficult to manage their work and family and they are trying to overcome these difficulties by time management and with the help of their family members.

Thara S Shetty Thara s shetty

Dr.ismath shameem

Background: Unexplained infertility is a frustrating diagnosis both for the patient and the clinician, with a prevalence of 16%-37%. It commonly refers to a ‘diagnosis’ made when tubal, ovulatory and husband factors are ruled out. A couple is usually referred for evaluation after 1 year of unsuccessful trials of conception with unprotected intercourse in the fertile phase of the menstrual cycle. Unani formulation comprises of baikh asgand (Withania somnifera Dunal), baikh piyabansa (Barleria prionitis Linn), gule dhawa (Anogeissus latifolia) and gule nilofar (Nymphaea alba Linn) were used for the treatment of uqr, possessing the properties of muqawwi rahim, moaene hamal, moallide mani, etc. Case presentation: A married couple (22 years female partner & 26 years male partner) presented to NIUM Hospital OPD, with chief complaint of failure to conceive since 5 years. The couple report a high degree of stress related to their lack of success. Investigations were carried to check for tubal patency, ovulatory function and semen analysis. Diagnosis of unexplained infertility was made after thorough evaluation of the case. The powder of above mentioned formulation was given 6g twice a day orally with milk from 5th day of cycle for 5 days. Patient got conceived after taking treatment for two consecutive cycles. Discussion: Here we report evidence based management with Unani medicine to help combat the significant physical, psychosocial and economic toll on couples. Keywords: Unexplained infertility; Primary infertility; Uqr; Muqawwi rahim; Moaene hamal; Moallide mani; Unani medicin

Dr ismath shameem

The effects of severe hypobaric hypoxia and inhibition of hypoxia-inducible factor-1 (hif-1) on biomarkers of cardiac and skeletal muscle injury in rats

The goal of the present study was to investigate the molecular mechanisms that underlie heart andskeletal muscle damage in male Wistar rats weighing 200–250 g in response to a 3-h exposure to 180 mm Hg(5% O2) in the model of severe hypobaric hypoxia. It has been demonstrated that the level of the cardiac bio-marker troponin I in the blood plasma of rats exposed to severe hypobaric hypoxia for 3 h increased signifi-cantly compared to the control group, indicating myocardial injury. At the same time, the administration ofthe HIF-1α transcription factor inhibitor did not affect the plasma level of troponin I. In contrast, the releaseof the non-specific biomarker myoglobin into the bloodstream did not increase in response to hypoxia com-pared to the control animals. In addition, 24 h after the exposure to severe hypobaric hypoxia the serum myo-globin level was significantly lower in animals administered with the HIF-1α inhibitor topotecan than in ratsthat did not receive topotecan. Therefore, it may be assumed that the inhibition of the HIF-1α transcriptionfactor 10 min before exposure to severe hypobaric hypoxia reduces skeletal muscle damage. The mechanismsthat affect the adaptation of heart and skeletal muscles to hypoxia are discussed.

Даниил Федоров Даниил Федоров

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