Antiemetic activity of some aromatic plants

Authors Details :
Muhammad Mohtasheemul Hasan,
Salman Ahmed,
Ziauddin Ahmed,
Iqbal Azhar

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The current study was conducted to explore the antiemetic activity of ten aromatic medicinal plants viz., Carissa carandus L. (fruits), Chichorium intybus L (flowers), Cinnamum tamala L (leaves), Curcuma caesia Roxb (rhizomes), Lallemantia royleana Benth (leaves), Matricaria chamomila L (flowers), Piper longum L (fruits), Piper methysticum G. Forst (fruits), Piper nigrum Linn. (fruits) and Syzygium aromaticum (Linn.) Merr. & Perry (flowering buds) was studied using a chick emetic model. The ethanol extracts of these plants were administered at 150 mg/kg body weight orally. Domperidone was given at 100 mg/kg as a reference drug. All the extracts decrease in retches induced by copper sulphate pentahydrate given orally at 50 mg/kg body weight and showed comparable antiemetic activity with domperidone. Compound targeted antiemetic activity is further suggested. Aromatic plants have tendency to relief from nausea. Alpinea offinarum,Zingiber officinale, Mentha piperita, Menthaspicata and Lavandula angustifola,are aromatic plants reported to possess antiemetic activity. So, presentinvestigation was done to evaluate more aromatic plantsregarding their antiemetic activity. Results of the antiemeticactivity of the ethanol extracts of Carissa carandus,Chichorium intybus, Cinnamum tamala, Curcuma caesia,Lallemantia royleana, Matricaria chamomila, Piper longum, Piper methysticum, Piper nigrum and Syzygium aromaticum are shown in the Table. All the extracts showed antiemeticactivity comparable with domperidone. The % inhibition was recorded as Carissa carandus (68.29), Chichorium intybus (73.86), Curcuma caesia (89.97), Cinnamum tamala (70.64), Lallemantia royleana (83.61), Matricaria chamomila (59.92), Piper longum (81.65), Piper methysticum (80.03), Piper nigrum (89.48) and Syzygium aromaticum (87.81). The highest % inhibition was shown by Curcuma caesia (89.97) and the lowest by Matricaria chamomila (59.92), whereas domperidone showed 80.18 % inhibition of emesis.