Nowadays, the pharmacy profession is moving toward a multidisciplinary approach. Besides the pharmacists’ role beyond dispensing and checking the safety, quality and efficacy of the delivered medications, pharmacists are currently using their clinical knowledge to serve the community through different disciplines including drug counseling, vaccination, screening, and drug therapy management

Mediterranean journal of pharmacy and pharmaceutical sciences

Standardization of crude drugs is a code of conduct and an essential need of the time. Substitution and adulteration now become a widespread practice, which makes the global crude drug market unsafe for crude drugs depending on the world population. Moreover, crude drug evaluation is not easy because numerous influential factors affect the bio-efficacy and reproducibility of therapeutic effects. The broad spectrum of standardization ensures the correct substance in the proper amount for desired therapeutic effects. It also provides all possible careful measures taken from collection and manufacturing to drug dispensing for clinical application. The authors have tried to cover precise tools for crude drug standardization in the present review.

Dr. salman ahmed

There is an upsurge in gestational diabetes mellitus with many devastating consequences for the mother and developing fetus. Insulin therapy remains a mainstay. However, insulin is expensive and comes with the pain of multiple injections. Therefore, there is a need to explore commonly administered oral hypoglycemic agents to cater for the increasing gestational diabetes mellitus-associated neurological complications. This study assesses the effects of glibenclamide, metformin and insulin on the pups’ prefrontal cortex in diabetic pregnant rats. 35 sexually matured adult female rats weighing between 120 g and 160 g were used and assigned into five groups (A to E) of seven rats each group. Diabetes was induced by streptozotocin (45 mg/kg and 35 mg/kg; ip). Hyperglycemic rats were treated with insulin (1.0 UI daily), metformin (200 mg/kg/day) and glibenclamide (0.6 mg/kg/day). Body weight and blood glucose levels were evaluated. Rats were sacrificed at 18-day gestation, the pups were harvested, and their brains were processed for tissue oxidative stress markers and various histological examinations. Glibenclamide and metformin caused a significant blood glucose reduction at 37.9% and 40.7%, respectively, compared to the insulin group (33.09%). There was no significant difference in the body-organ ratio in rats treated with metformin when compared to rats treated with insulin. Metformin and glibenclamide had a significant increase in tissue glutathione reductase and a decrease in malondialdehyde compared with insulin and diabetic control groups. The pups’ prefrontal cortex showed degenerated neuronal cells in the diabetic control animals. The diabetic rats treated with metformin and glibenclamide showed improved pyramidal neurons compared with diabetic and insulin groups. This study suggests that metformin and glibenclamide glycemic control may prevent and improve antioxidant enzymes and reverse some neurotoxic effects caused by streptozotocin-induced diabetes in rats.

Mediterranean journal of pharmacy and pharmaceutical sciences

During the 16th century, firearms played a transformative role in Indian warfare, considerably enhancing the effectiveness of the Mughal army. The introduction of muskets and artillery by Babur in 1526 revolutionized military strategies, giving the Mughals a decisive advantage in battles and sieges. The Mughal army’s structure, particularly under Akbar’s Mansabdari system, centralized control and ensured a loyal, efficient military force. This technological and organizational superiority enabled the Mughals to consolidate power over diverse regions through a combination of military might and diplomacy. By the 17th century, there was a significant change in rebellions as firearms started being used by peasants. This shift in weaponry fundamentally altered the nature of these uprisings, empowering the peasantry in new ways to resist authority. Multiethnic regional powers also recognized the importance of firearms, acquiring them from the Mughals or Europeans, and employing them effectively in battles. In the mid-18th century, the Marathas and later the Mysore Sultanate took a notable step by establishing arms factories and engaging European experts to produce advanced firearms. This marked a departure from the past, where regional powers typically relied on the Mughals or European companies for firearm procurement. This shift toward domestic arms production signaled a move toward greater self-sufficiency and the development of advanced firepower. By the 18th century, the Mughal Empire was in decline, and multiethnic regional powers and European colonial forces, equipped with advanced firearms, challenged and eventually overshadowed Mughal dominance.

Bidyut patar

This paper delves into the dynamic intersection of Artificial Intelligence (AI) and Remote Patient Monitoring (RPM), exploring how the integration of these technologies is reshaping the landscape of healthcare. By examining recent breakthroughs, practical implementations, and ethical considerations, the article elucidates the transformative potential of AI-enhanced RPM in providing personalized, proactive, and efficient healthcare solutions.

Dhruvitkumar talati

Background: This study investigated the utilization of consumer health informatics in health promotion among the staff of tertiary institutions in Rivers state. Subjects & Methods: A cross-sectional descriptive research design was used. Two research questions guided this paper. The population of this paper comprised all the 13,046 staff of tertiary institutions in Rivers state. A sample of 1226 staff was drawn using multi-stage sampling techniques. An instrument titled, “Utilization of Consumer Health Informatics in Health Promotion Questionnaire” (UCHIHPQ) was adopted for data collection. The instrument was validated and reliability yielded an index of 0.80. Mean and Standard Deviation statistics were used to answer the research questions. The statistical analysis was performed with the use of SPSS v23. Results: The result revealed among others that to a very large extent, the respondents accepted that consumer health informatics was used to improve their nutritional and physical health status. Conclusion: It was therefore concluded and recommended among others that staff of tertiary institutions in Rivers state should regularly use intelligent informatics applications to attain a healthy balance between self-reliance and seeking professional help concerning nutritional and physical health matter

Fxintegrity publishing

Introduction: Saliva is a crucial diagnostic tool to evaluate oral health. Chewing sugar-free gum is an effective method to increase salivary flow and can also be employed a medium for the administration of medicinal ingredients. Aim: To evaluate and compare the effect of chewing xylitol, herbal and probiotic chewing gums on salivary acidogenicity levels. Materials and Methods: A single centre, randomised, doubleblind, multiple arm parallel clinical trial was conducted on 60 children aged between 6-11 years. Baseline salivary pH was recorded with the pH meter and then the participants were asked to consume chocolate and salivary pH was recorded at an interval of 5, 30, and 60 minutes. Then children were randomly allocated to Group A-Xylitol chewing gum (control group, n=20), Group B-Herbal chewing gum (n=20), and Group C-Probiotic chewing gum (n=20) and instructed to chew gum according to their assigned group and salivary pH was again recorded at an interval of 5, 30, and 60 minutes. The change in salivary pH was evaluated using one-way Analysis of Variance (ANOVA) and Post-hoc Bonferroni’s test. Results: The mean age of the study population was 9.23±1.38 years. Statistically significant (p<0.001) increase in pH was recorded post consumption of probiotic, xylitol and herbal chewing gums and the mean salivary pH values recorded at 60 minutes were 7.20±0.21, 7.01±0.23 and 6.43±0.22, respectively. Conclusion: The observations of the study showed that xylitol, herbal and probiotic chewing gums reversed the fall in salivary pH, after an acidogenic challenge with probiotic being better among the three groups.

Dr. neeti tatiya

In 2016, the World Health Organization (WHO) estimated that approximately 4.2 million premature deaths world wide were attributable to exposure to particulate matter 2.5 μm (PM2.5). This study assessed the environmental burden of disease attributable to PM2.5 at the national level in Malaysia. We estimated the population-weighted exposure level (PWEL) of PM10 concentrations in Malaysia for 2000, 2008, and 2013 using aerosol optical density (AOD) data from publicly available remote sensing satellite data (MODIS Terra). The PWEL was then converted to PM2.5 using Malaysia's WHO ambient air conversion factor. We used AirQ+ 2.0 software to calculate all-cause (natural), ischemic heart disease (IHD), stroke, chronic obstructive pulmonary disease (COPD), lung cancer (LC), and acute lower respiratory infection (ALRI) excess deaths from the National Burden of Disease data for 2000, 2008 and 2013. The averagePWELs for annual PM2.5 for 2000, 2008, and 2013 were 22 μg m-3, 18 μg m-3 and 24 μg m-3, respectively. Using the WHO 2005 Air Quality Guideline cut-off point of PM2.5 of 10 μg m-3, the estimated excess deaths for 2000, 2008, and 2013 from all-cause (natural) mortality were between 5893 and 9781 (95 % CI: 3347–12,791), COPD was between 164 and 957 (95 % CI: 95–1411), lung cancer was between 109 and 307 (95 % CI: 63–437), IHD was between 3 and 163 deaths, according to age groups (95 % CI: 2–394) and stroke was between 6 and 155 deaths, ac-cording to age groups (95 % CI: 3–261). An increase in estimated health endpoints was associated with increased estimated PWEL PM2.5 for 2013 compared to 2000 and 2008. Adhering the ambient PM2.5 level to the Malaysian AirQuality Standard IT-2 would reduce the national health endpoints mortality

Mohamad iqbal mazeli

The aim of this study was to evaluate the proximate and micronutrient composition, physical, biochemical and sensory properties of the bread produced from blends of wheat, acha, uzaaku and unere composite flours. Six samples (A-F) were produced in the following ratios A= 100:0:0 (100% Wheat), B= 80% wheat flour, 10% acha, 5% uzaaku flour, 5% unere; C = 70% wheat flour, 10% acha, 10% uzaaku flour, 10% unere; D = 60% wheat flour, 15% acha, 15% uzaaku flour, 10% unere; E = 50% wheat flour, 20% acha, 15% uzaaku flour, 15% unere; F = 40% wheat flour, 20% acha, 20% uzaaku flour, 20% unere. The parameters were analyzed using standard methods. The proximate composition of the bread showed significant increase (p<0.05) in protein, fat, crude fibre, ash, and caloric (energy) value which ranged between 7.69-18.32%, 2.41-3.70%, 2.473.86%, 3.09-4.03%, and 285.25-304.06 (Kcal/kg) and a significant decrease (p<0.05) in moisture content (20.72-26.14%) and carbohydrate (49.37-58.20%), respectively. The micronutrient content showed increase in calcium, magnesium, potassium, iron, zinc, phosphorus, vitamin B1, B2, B3, A and C as the amount of substituted flour blends increases. The result of the physical properties showed decrease in the loaf weight, loaf height, loaf volume and specific volume ranged from 240.60-218.80 g, 3.33-6.66 cm, 155.00-205.00 cm3, 0.71-0.85 cm3/g, respectively. The result of the serum biochemical parameters of rats fed the composite bread samples showed significant decrease (p<0.05) in AST, ALT, ALP, Bilirubin, creatine, urea and albumin values, respectively. The sensory attributes of the bread showed significant differences (p<0.05) in colour, aroma, taste, crumb texture and general acceptability such that the values obtained ranged from 6.05-8.90, 6.008.45, 6.40-8.60, 5.85-8.30 and 6.10-8.35, respectively. The findings of the study showed that supplementation of wheat with 10% acha, 10% uzaaku and 10% unere flour blends could produce well accepted bread samples.

Okechukwu obed chukwuemeka

Background: Epilepsy and cerebral palsy (CP) are reported as the two most common indications for electroencephalogram (EEG) requests in children in Nigeria. Although several studies have examined epilepsy and EEG findings in the country, most have not documented the conditions under which EEG recordings were performed—whether during wakefulness, natural sleep, sleep deprivation, or drug-induced sleep. This study aimed to compare the effectiveness of sleep deprivation and the use of melatonin in achieving sleep EEG recordings in children with epilepsy and CP versus those with epilepsy without CP, at the Pediatric Neurology Clinic of Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria. Methods: This was a cross-sectional comparative study involving children aged 6 months to 15 years, conducted between March 2022 and February 2023. A total of 121 subjects with epilepsy associated with CP (Group 1) and 124 subjects with epilepsy not associated with CP (Group 2) were consecutively recruited. Conventional inter-ictal sleep EEG recordings were performed using an EEG machine (Model: Satellite P200-132, Toshiba Europe GmbH, DC 19V, 3.4A). Data were analyzed using SPSS version 25.0, and a p-value of <0.05 was considered statistically significant. Results: Of the subjects with epilepsy and CP (Group 1), 67 (55.4%) achieved sleep EEG recordings following sleep deprivation, while 54 (44.6%) required sleep induction with melatonin. Among subjects with epilepsy without CP, 107 (86.3%) attained sleep EEG recordings after sleep deprivation, whereas 17 (13.7%) required melatonin-induced sleep. The difference between the two groups regarding the need for melatonin to induce sleep was statistically significant (p < 0.001). Conclusions: Sleep deprivation was more effective in achieving sleep EEG recordings in children with epilepsy who did not have CP.

Karishma

Researchers have developed several authentication techniques for route predictions based on user requirements. These techniques estimate the shortest path and available resources in vehicular communication networks. In the current research, the existing authentication techniques for vehicular communication are compared and their inadequacies are identified. Then, new authentication technique based on route forecasting are presented for vehicular communication networks, with the service provider anticipating alternate routes for customers if the current routes have more network traffic congestion. By presenting the most efficient route, the suggested model allows users to maximise their time efficiency. Using A* algorithm, VCN agent seeks path with less network traffic congestion. This algorithm determines the shortest path between a source and a destination. Users are provided with several options by the service provider. User accepts the finest option that meets their needs. This method allows the service provider to deliver at least 15 routes within three seconds. This strategy is beneficial when a significant number of vehicles are stuck in traffic and consumers require network resources to utilise their time effectively.

Vartika agarwal

This paper centers around how innovations adds to enhancing interoperability between IoT gadgets, and making effectively utilization of IoT gadgets. The proposed stage innovation gives semantic-based IoT data administrations, and semantic interoperability of IoT gadgets. This administration stage can be material to a great deal of semantic IoT administrations: gathering imperceptible data in genuine condition by brilliant gadgets, giving keen life benefits by sharing, taking an interest, circulating open detecting data.

Dr h shaheen

In the research described in this paper, we used computer simulations to analyze and compare different types of game strategies in the popular board game Don't Get Angry. Following a brief introduction, we summarized a few previous research papers examining similar board games' game strategies. Next, after a review of the Don't Get Angry game's official rules, we outlined four strategies that can be applied to increase the likelihood of winning. We simulated 50,000 games in which all four players made their moves randomly and 50,000 games where each used a different strategy. We tracked how frequently each player finished first, second, third, or last during the simulations. Furthermore, we recorded how many rounds were needed to complete the game for each player, how many times the players’ pawns were kicked out and returned to their houses by other players, and the number of players’ remaining steps during every gameplay. From the analysis of the recorded data, we could conclude that significant differences exist in the chances of winning the game for the examined strategies when all players use different strategies. The results improve the specific domain knowledge for the Don't Get Angry board game. It may help create more vigorous computer opponents and encourage further study to create a tool for evaluating students' strategic thinking while playing.

Ladislav végh

In an era where technology prevails, entrepreneurs as well as marketers see the need to keep up with the fast pace of change or risk being outdated. Gone are the days when a pure-bricks business model will thrive well in current market scenario. It is practically impossible to design a marketing strategy without considering social networks. Social media had become really important gradient in today’s marketing mix in general and in promotion mix in particular. Adapting some form of marketing online through social media is a key node for all businesses, especially in an industry where trends constantly change such as fashion and handicrafts. The paper carries out empirical research to understand the effectiveness of social media as a marketing tool and an effort has been made to analyze the extent social media helps consumers in buying decision making. In addition strategies have been suggested for maximizing the effectiveness. Various statistical tests have been applied to support the research hypothesis.

Abu bashar

Konsep edutainment mencoba memadukan antara pendidikan dan hiburan, yang didalam konsep edutainment tersebut terdapat beberapa pendekatan yang lebih kita kenal sebagai SAVI (Somatik, Auditori, Visual dan Intelektual). Metode penelitian ini menggunakan jenis penelitian Library research, yaitu jenis penelitian yang dilakukan dan difokuskan pada penelaahan, pengkajian dan pembahasan literature-literatur, baik klasik maupun modern. Literature berbahsa arab, inggris, Indonesia dan sebagainya yang ada kaitannya dengan persoalan ini. Penelitian ini bersifat analisis deskriptif. Sumber data penelitian ini yaitu: Sumber primer dari pemikiran Beby De Poter. Sumber skunder meliputi: buku, artikel atau esai yang membahas konsep edutainment, dan buku yang berkenaan dengan konsep psikologi belajar anak, serta buku pendidikan karakter, terutama karakter cinta tanah air. Hasil penelitian ini menunjukkan: (1) Pembelajaran Edutainment Dalam Penanaman Karakter Cinta Tanah Air Bagi Anak Usia Dini Di Sekolah Dasar, yaitu: menumbuhkan karakter cinta tanah air, memunculkan emosi minat anak seperti rasa senang dan gembira dalam pembelajaran, guru dalam menyampaikan pembelajaran di kelas harus menunjukkan sikap kepedulian terhadap peserta didik. (2) Proses Penanaman Karakter Cinta Tanah Air Bagi Anak Usia Dini Di Sekolah Dasar, yaitu: proses pembelajaran interaksi antara siswa dan guru terbangun suasana menyenangkan, fleksibiltas guru dalam menyampaikan materi menyesuaikan dengan emosi peserta didik, hubungan keakraban dan persahabatan sebagaimana teman sendiri, dan guru memberikan kebabasan berexspresi kepada perserta didik pada saat proses pembelajaran.

Educare: journal of primary education

The valuable effects of regular exercise for promotion of health and therapy of diseases were obviously evaluated. The notion that exercise can be considered as a medication has been hypothesized. The growing problems of obesity and non-communicable diseases have placed a great burden on public health experts to promote physical literacy and physical activity among the modern day population. Physical literacy and physical activity have become the cornerstones of women’s health. Women have certain special needs that includes reproductive health. Increased physical activity and maintaining normal body image and body weight will help a woman attain physical, mental and spiritual development. With the growing number of women with obesity and the implication of obesity as one of the main risk factors for non-communicable diseases like diabetes, hypertension, stroke and osteoarthritis, a knowledge and awareness about physical activity is essential. Thus, physical activity is a fundamental aspect of the improvement of motor skills and work performance, allowing a better healthy lifestyle. Physical exercise is effective to be measured as a drug, however, more care should be considered to the dosing and individual variations between genders.

Mediterranean journal of pharmacy and pharmaceutical sciences

The purpose of this meta-methods study (i.e., involving the full[er] integration of multiple methods research approaches and mixed methods research approaches) was to examine challenges experienced by students at Stellenbosch University that hinder their ability successfully to learn online during the emergency remote teaching that began in April 2020 due to the COVID-19 pandemic. Specifically, 1,932 students completed an online questionnaire. Analyses of the open-ended responses via WordStat 8.0.29 topic modeling (i.e., crossover mixed analysis) led to the identification of seven (challenge) themes that categorised the students’ challenges. In turn, via a principal component analysis of the themes (i.e., crossover mixed analysis), these seven themes were collapsed into four dimensions (i.e., meta-themes). A latent class analysis (i.e., qualitizing) yielded seven profiles of students. Disaggregating the themes by demographic and location variables led to the identification of subgroups who are most at risk for experiencing each challenge type. Implications of these and other findings are discussed.

Dr emmanuel ojo

This study discusses credibility of both the traditional and social media from the audience perspective. Numerous definitions and conceptualisations of media credibility are either source or medium based but there are also numerous measurements made on the concept that gave rise to varied findings. An attempt was made to associate the concept of credibility with media exposure, postulating that the greater use of media would mean greater credibility. Two studies were made involving a total of 4095 respondents with 1544 questionnaires distributed in April 2019, and 2551questionnaires in January 2018 to investigate the concept of credibility and its correlate with media use. The first period was before the General Elections but the April 2019 study was made after the May General Election giving an idea how credibility could have changed under a new government. The results of this study revealed that Malaysians perceived the traditional media, including TV, radio, and newspapers, were more credible than the new media (internet, online news portals, Facebook, and Twitter). TV was perceived to have the highest credibility, while Twitter, the lowest credibility. The social media suffered low credibility due to the surrounding discussions on fake news, false information, and post-truth issues. The sources of content in the traditional media are mostly known or verified, unlike that of the new media, thus paving for the poor evaluation of credibility of the new media.

Mohammed fadel arandas

Emesis encompasses the forceful expulsion of the stomach's contents via the mouth or sometimes the nose. The adverse effects of currently available anti-emetic agents potentiate the natural product researchers to explore natural anti-emetics with fewer side effects. The presented communication reviews the anti-emetic effect of two hundred and forty-five plants belonging to seventy-eight families in different parts of the world. It also outlined the anti-emetic effect of plant extracts and isolated secondary metabolites studied through a variety of animal models of emesis. The reported anti-emetic plants in different countries and cultures and the scientific studies on extracts may help in the identification of promising single chemical compound(s) that may be used as potential leads for developing safe anti-emetic agents in future. Moreover, the reported secondary metabolites having the same effect may open the door for the search for the same secondary metabolites from other natural sources. This review will provide useful information for discovering natural anti-emetic compounds and fill the gaps in knowledge.

Dr. salman ahmed

Purpose. Our aim is to correlate the clinical condition of patients with COVID-19 infection with the 25-point CT severity score by Chang et al. (devised for assessment of ARDS in patients with SARS in 2005). Materials and Methods. Data of consecutive symptomatic patients who were suspected to have COVID-19 infection and presented to our hospital were collected from March to April 2020. All patients underwent two consecutive RT-PCR tests and had a noncontrast HRCT scan done at presentation. From the original cohort of 1062 patients, 160 patients were excluded leaving a total number of 902 patients. Results. The mean age was 44.2 ± 11.9 years (85.3% males, 14.7% females). CT severity score was found to be positively correlated with lymphopenia, increased serum CRP, d-dimer, and ferritin levels (p < 0.0001). The oxygen requirements and length of hospital stay were increasing with the increase in scan severity. Conclusion. The 25-point CT severity score correlates well with the COVID-19 clinical severity. Our data suggest that chest CT scoring system can aid in predicting COVID-19 disease outcome and significantly correlates with lab tests and oxygen requirements.

Kamal singh