Dr. Salman Ahmed

Apoptosis induced by luteolin in breast cancer: mechanistic and therapeutic perspectives

• Authors Details :  
• Salman Ahmed,  
• Haroon Khan,  
• Deborah Fratantonio,  
• Muhammad Mohtasheemul Hasan,  
• Samin Sharifi,  
• Nazanin Fathi,  
• Hammad Ullah,  
• Luca Rastrelli

Journal title : Phytomedicine

Publisher : Elsevier BV

Print ISSN : 0944-7113

Page Number : 152883

Journal volume : 59

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Background: Breast cancer is a commonly found malignancy worldwide in women, and effective treatment is regarded as a substantial clinical challenge even in the presence of several options. Extensive literature is available that demonstrates polyphenols, the richly introduced phytopharmaceuticals, as anticancer agents. Among these polyphenols, resveratrol, silibinin, quercetin, genistein, and curcumin are reported to have tremendous potential against breast cancer. However, till now, no comprehensive survey has been found about the anticarcinogenic properties of luteolin against breast cancer. Scope and approach: This review targeted the available literature on luteolin in the treatment of breast cancer, its effects in combination with other anticancer drugs, and possible mechanisms. Key findings and conclusion: Lutein's outstanding therapeutic potential in the treatment of breast cancer has been recorded not just as a chemopreventive and chemotherapeutic agent but also complemented by its synergistic effects with other anti-cancer therapies such as cyclophosphamide, doxorubicin, and NSAIDs such as celecoxib and possible underlying mechanisms. Ideally, this review will open new dimensions for luteolin as an effective and safe therapeutic agent in diminishing breast cancer.

Article DOI & Crossmark Data

DOI : https://doi.org/10.1016/j.phymed.2019.152883

Article Subject Details

• Breast cancer
• Breast pathology
• Clinical trials
• Oncology
• Pharmacognosy
• Pharmacology
• Pharmacology and toxicology

Article Keywords Details

• Apoptosis
• Breast cancer
• Luteolin
• Medicinal plants
• Pharmacognosy
• Pharmacology
• Phytochemistry

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