Dr. Salman Ahmed
Herbal drug interaction: mechanistic details through the pharmacokinetic portfolio
Journal title : CNS & Neurological Disorders - Drug Targets
Publisher : Bentham Science Publishers Ltd.
Print ISSN : 1871-5273
Page Number : 677-686
Journal volume : 20
Journal issue : 8
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Background: Many individuals today use herbs as a drug alongside medicine and non-physician-recommended medications, as herbs are thought to be natural and safe. However, many herbs can potentially interact with other drugs, causing hazardous effects and diminished therapeutic effects of different prescriptions. Objective: It ought to be comprehended that herbal drugs contain multiple active compounds in different percentages, which can change the enzymatic frameworks, transporters, and physiological processes. Methods: Data on pharmacokinetic drug interactions with herbal products were searched using different search engines, such as Google Scholar, Scopus, and ScienceDirect. Results: This worldwide increment in herbal drug popularity has risen concerning HDIs. These PD or PK interactions are particularly significant for medications. Assessment of herbal drug interactions is complex because of inconsistency in herbal drug composition and frequently meagre information on active constituent pharmacokinetics. These restrictions are further bewildered by the differing points of view concerning herbal product regulation. Conclusion: It is concluded that a basic assessment of certain pharmacokinetic HDI is needed to settle on educated choices regarding patient safety. The expanding comprehension of HDPKI will direct more attention to potential interactions.
Article DOI & Crossmark Data
DOI : https://doi.org/10.2174/1871527319666201008151710
Article Subject Details
Article Keywords Details
- active compounds
- drug absorption
- drug interactions
- enzymatic frameworks
- pharmacokinetic mechanisms
- Herbal medicine
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