Inhibitory potential of phaseolus lunatus l. seeds to digestive enzymes

Mehreen Zaheer; Anum Kalim; Shah Ali Ul Qadar; Salman Ahmed; Muhammad Mohtasheemul Hasan

Dr. Salman Ahmed

Authors Details :
Mehreen Zaheer,
Anum Kalim,
Shah Ali Ul Qadar,
Salman Ahmed,
Muhammad Mohtasheemul Hasan

Journal title : BioSight

Publisher : University of Karachi

Print ISSN : 2710-0286

Page Number : 59-69

Journal volume : 4

Journal issue : 2

33 Views Original Article

Introduction: Study was conducted with an objective of investigating the inhibitory effect of Phaseolus lunatus seeds extract on three enzymes (α-amylase, maltase and glucoamylase) involved in diabetes. The disadvantages related to the use of synthetic drugs make it necessary to search for alternative medicines from medicinal plants. One therapeutic approach for treating postprandial hyperglycaemia is to decrease the plasma glucose level, which can be attained by lowering the starch hydrolysis by digestive enzymes such as α-amylase, maltase and glucoamylase. The use of synthetic antidiabetic agents caused gastrointestinal side effects. Methods: Hence, the research was aimed to evaluate the potential of Phaseolus lunatus seeds extract to inhibit α-amylase, maltase and glucoamylase as a possible mechanism of hypoglycemia caused by this plant with fewer side effects. Phaseolus lunatus, also known as Lima bean, is native to Tropical America and grown worldwide. Lima bean has been prescribed traditionally to treat different diseases, including diabetes. Result: The results of the present study showed that Phaseolus lunatus seeds extract has exerted both time and concentration-dependent Significant inhibitory effects on these digestive enzymes might be due to the cumulative impact of phytoconstituents in the plant extract. Conclusion: Therefore, it can be said that the part mechanisms by which Phaseolus lunatus exhibited its antidiabetic activity might be through inhibiting this digestive enzyme.