Shilpa Sangle

Synthesis of biologically active compound 1,4-dihydropyridine by using an efficient and versatile silica supported mgo catalyst

• Authors Details :  
• Dipak R Tope,  
• Shilpa L. Sangle,  
• Jyoti A. Agashe ,  
• Yogita R. Shelke Ashok V. Borhade

87 Views Original Article

A simple one pot synthesis has been developed for the synthesis 1,4-dihydropyridine using an efficient and reusable silica supported MgO solid catalyst by condensation of dimedone, ethyl acetoacetate, aldehyde and ammonium acetate in methanol as a solvent at room temperature. The reactions could be carried out under mild reaction conditions with very good yield of polyhydroquinoline, up to 92%. This catalyst could be recycled very easily, which makes this methodology environmentally benign.

Article Subject Details

• Chemistry

Article Keywords Details

• 1
• 4-dihydropyridine; Multicomponent reaction; Silica supported MgO; Recyclable catalyst

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