Dr. Salman Ahmed

. therapeutic potential of marine peptides in glioblastoma: mechanistic insights

• Authors Details :  
• Salman Ahmed,  
• Muhammad Mohtasheemul Hasan,  
• Michael Aschner,  
• Hamed Mirzaei,  
• Waqas Alam,  
• Syed Muhammad Mukarram Shah,  
• Haroon Khan

Journal title : Cellular Signalling

Publisher : Elsevier BV

Print ISSN : 0898-6568

Page Number : 110142

Journal volume : 87

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Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in humans. It is characterized by excessive cell growth, accelerated intrusion of normal brain tissue, and a poor prognosis. The current standard of treatment, including surgical removal, radiation therapy, and chemotherapy, is largely ineffective, with high mortality and recurrence rates. As a result, traditional approaches have evolved to include new alternative remedies, such as natural compounds. Aquatic species provide a rich supply of possible drugs. The physiological effects of marine peptides in glioblastoma are mediated by a range of pathways, including apoptosis, microtubule balance disturbances, suppression of angiogenesis, cell migration/invasion, and cell viability; autophagy and metabolic enzymes downregulation. Herein, we address the efficacy of marine peptides as putative safe therapeutic agents for glioblastoma coupled with detailed molecular mechanisms.

Article DOI & Crossmark Data

DOI : https://doi.org/10.1016/j.cellsig.2021.110142

Article Subject Details

• Pharmacognosy
• Pharmacology
• Pharmacology and toxicology
• Pharmacy

Article Keywords Details

• Angiogenesis
• Apoptosis
• Cell cycle arrest
• Marine peptides
• Metastasis
• Mitosis

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