Karishma
Metastatic breast carcinoma with adrenal and pituitary involvement: a case report
Journal title : Yemen Journal of Medicine
Publisher : Mansa STM Publishers
Online ISSN : 2583-4614
Page Number : 458-462
Journal volume : 04
Journal issue : 02
30 Views Case Report
Breast cancer commonly metastasizes to the bones, liver, lungs, and brain. However, metastasis to endocrine glands, particularly the adrenal and pituitary glands, is rare. We report the case of a 54-year-old woman with hormone receptor–positive, HER2-negative invasive ductal carcinoma of the right breast who initially showed a favorable response to standard therapy. Surveillance imaging in late 2022 revealed a left adrenal mass, subsequently confirmed as metastatic breast carcinoma. Following laparoscopic adrenalectomy, she developed primary adrenal insufficiency. By mid-2023, she presented with pituitary metastases, resulting in hypopituitarism, diabetes insipidus, and severe visual impairment. Despite targeted radiosurgery, her disease progressed rapidly, and she died in December 2024. This case illustrates an unusual metastatic pattern involving both the adrenal and pituitary glands and demonstrates the potential for aggressive clinical behavior even in hormone receptor–positive breast cancer. Clinicians should maintain a high index of suspicion for atypical metastatic sites to ensure timely diagnosis and optimize palliative care strategies.
Article DOI & Crossmark Data
DOI : https://doi.org/10.63475/yjm.v4i2.0108
Article Subject Details
Article Keywords Details
Article File
Full Text PDFMore Article by Karishma
The internal medicine residency program at hamad medical corporation (hmc) is accredited by the accreditation council for graduate medical education–international (acgme-i). upon c...
The city that never sleeps, a vibrant tapestry of dense neighborhoods and relentless energy, has long grappled with the pervasive challenge of air pollution. the very dynamism that...
Background: acute and chronic heart or kidney failure affect each other in cardiorenal syndromes (crs). in crs, hemodynamic and non-hemodynamic changes occur, causing acute or prog...
Dignity therapy (dt) is an evidence-based psychotherapeutic approach originally designed to alleviate emotional and existential distress in patients with terminal illnesses. while ...