To the editor, Breast cancer remains one of the leading causes of cancer-related mortality worldwide, necessitating innovative and multifaceted therapeutic strategies. [1] We propose a promising combination approach that synergizes Artificial Intelligence (AI), oncolytic virotherapy, probiotic therapy, stem cell therapy, and immunotherapy to target breast cancer more effectively. more...
To the editor, Hepatitis B virus (HBV) infection remains a global public health concern, with over 296 million chronic carriers worldwide and an estimated 820,000 deaths annually due to HBV-related complications such as cirrhosis and hepatocellular carcinoma (HCC). [1] While serological markers like hepatitis B surface antigen (HBsAg) more...
To the editor, Somalia’s healthcare system, already burdened by decades of conflict and instability, continues to face immense challenges in access, equity, and governance. In this fragile setting, integrating bioethics into healthcare reform offers not only a moral compass but also a practical strategy for rebuilding trust and guiding more...
To the editor, On April 24, 2025, the World Health Organization (WHO) issued an urgent call to reinvigorate global action to end malaria, releasing updated guidelines that reflect both progress and persisting challenges in combating this deadly disease. [1] This renewed guidance arrives at a critical juncture: global malaria cases more...
To the editor, Umbilical venous catheter (UVC) is a widely used venous access device in neonates of any gestational age due to the immediate accessibility of the umbilical vein and the simplicity of the procedure of its placement. Several complications of UVC have been reported, including the thrombotic and infective more...
Congenital constriction band syndrome (CBS) is a rare condition characterized by either partial or complete circular constrictions around limbs or digits. Possible consequences include acrosyndactyly of the digits, terminal amputations, and localized swelling with digital edema distal to the constrictions. Occasionally, a constriction band may lead to injury of a more...
Pneumocephalus is a rare condition characterized by the presence of intracranial air, most commonly seen after head trauma or surgery. Although it is often asymptomatic, it can lead to serious complications such as tension pneumocephalus and seizures. This study presents a case of iatrogenic pneumocephalus and seizures that developed after more...
Fetus-in-fetu represents an extremely unusual condition where a malformed parasitized twin with an organized vertebral column is present within the body of its host, leading to a variety of symptoms due to its mass effect. Its pathogenesis and features differ from both teratoma and fetiform teratoma. Detailed radiological more...
Situs inversus totalis (SIT) is a rare birth defect marked by a complete reversal of the positions of abdominal and thoracic organs, resembling a mirrored image. This condition can raise challenges both in diagnosis and treatment procedures. Management of cholelithiasis in SIT patients presents difficulties due to the anatomical differences. more...
Breast cancer commonly metastasizes to the bones, liver, lungs, and brain. However, metastasis to endocrine glands, particularly the adrenal and pituitary glands, is rare. We report the case of a 54-year-old woman with hormone receptor–positive, HER2-negative invasive ductal carcinoma of the right breast who initially showed more...
PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis, and adenitis) is the most common periodic fever disorder in childhood, typically resolving by early adolescence. Relapse after a prolonged symptom-free interval is rare and has been reported following tonsillectomyrelated remission. We describe a 13-year-old girl with intact tonsils who more...
Background: Cardiovascular diseases (CVDs) disproportionately affect conflict zones like Yemen, where diagnostic limitations persist. This meta-analysis evaluated the global prognostic utility of the red cell distribution width (RDW) and the neutrophil-to-lymphocyte ratio (NLR) as predictors of CVD and aimed to establish region-specific thresholds for low-resource more...
Background: Perforation is the most serious surgical complication of peptic ulcer disease due to its attendant high morbidity and mortality. Hypovolemia, a consequence of gastro-duodenal perforation, is considered to be a cause of renal hypo perfusion with accompanied decreased clearance of urea and creatinine. The aim of this study more...
Background: Lichen planus (LP) is a papulosquamous cutaneous disorder that manifests as intensely itchy violaceous flat-topped polygonal papules and plaques. To compare the efficacy of topical clobetasol propionate 0.05% versus topical tacrolimus 0.1% in the treatment of LP. Methods: This prospective Comparative Study was conducted at the more...
Background: Glaucoma is a group of disorders that can lead to irreversible vision loss if untreated. It affects individuals across all ages, genders, and ethnicities, with intraocular pressure (IOP) being the only modifiable risk factor. Regional studies highlight variations in the prevalence of glaucoma subtypes, underscoring the need for population- more...
Background: Percutaneous coronary intervention (PCI) has remained one of the greatest treatment modalities of the spectrum of atherosclerotic coronary artery disease over the past few years due to its high efficacy and minimal invasiveness. The most common cause of stent failure is stenting under-expansion, which complicates PCI. Thus, it more...
Background: Previously, Ocimum sanctum (Lamiaceae), commonly known as holy basil, has been noted for its anti-ulcer properties, primarily attributed to its oil and leaf extracts. However, the anti-ulcer activity of an ethanolic extract derived from the whole plant has not been reported. This study aimed to evaluate the more...
Background: Evidence has suggested that school-based physical activity programs (SBPAPs) including structured physical education, extracurricular sports, and activity-based learningenhance memory and other cognitive functions. However, evidence on whether Indian adolescents can achieve improved cognition or increased academic performance also remains scarce. This study aimed to examine the relationship more...
Background: Hyoscine N-butylbromide (HBB; Buscopan) is commonly used in obstetric practice to accelerate labor and facilitate cervical dilation, yet variability in knowledge, attitude, and clinical usage persists among practitioners. This study assessed the knowledge, attitude, and usage patterns of HBB among medical practitioners at Abia State University Teaching Hospital ( more...
Background: Sickle cell disease (SCD) is one of the most common genetic diseases worldwide, with very high prevalence rates in sub-Saharan Africa, especially Nigeria. Given the importanceand benefits of newborn screening (NBS), it is essential to assess awareness and acceptance of NBS for SCD and the factors influencing its more...