Health Sciences articles list

Pyrazole carbaldehyes as antiinflammatory agents-synthesis and in vitro membrane stabilization method

Pyrazole is a nitrogen containing 5-membered heterocyclic compound containing 3 carbons& 2 nitrogen atoms in the adjacent position of ring structure and is chemically known as 1, 2- diazole. Pyrazole nucleus is present in many pharmaceutically important compounds and intermediates . Majority of anti-inflammatory agents currently employed have GI irritation and enhanced acidity as side effects. As part of our efforts to develop newer and effective anti-inflammatory agents , ten newer pyrazole carbaldehydes were synthesized and evaluated for their anti-inflammatory activity using Diclofenac was the standard. Out of ten compounds synthesized, all compounds exhibited comparable activity with that of the standard.Highest percentage of haemolysis was observed for Pyrazole carbaldehydes with methoxy phenyl groups as substituents. These compounds should be considered for developing as leads for newer & safer anti-inflammatory agents.

Vinod B

A comparative study of social and economic aspect of migration

India is a country of immense diversity. It is home to people of many different racial, languages, ethnic, religious, and national backgrounds. Groups of people in India differ from each other not only in physical or demographic characteristics but also in distinctive patterns of behavior and these patterns are determined by social and cultural factors like language, region, religion, and caste. Apart from behaviour, economic development, level of education and political culture of the people in various social segments differ from region to region. More you can say that economy and cultures have been enriched by the contributions of migrants from round the globe. In an increasingly globalised world, migratory movements is continuously shaping the countries all over the world. Some countries like India and Ireland, which set the example of economic development and social integration, have the positive impact of the migration by globalisation and some countries like USA, which recently witness racism, xenophobia and discrimination have the negative impact on the migrants. It does not mean India do not face fragmentation and USA do not have cohesion. USA have many stories which show successful integration process, that facilitated the lives of immigrant communities, but being a developed country it still suffers from cultural alienation. In these countries, borders are built within borders to create cultural divides that do not allow people to integrate. Recently, this problem has become more prominent due to the rise of terrorism, clash of cultures in the world, leading to the glorification of stereotypes. People are becoming less accepting towards anyone who does not belong to their region. Migration does not stop after people move from one place to another place. The main question start after that ‘now what’ they will do. That is why this topic needs to be discussed thoroughly in order to find better solutions. This paper will begin with an analysis of different approaches to Migration, discuss the target groups for integration policies, provide indicators of the current situation of migrants and proceed to an analysis of integration tools: legislation, social policies and participatory processes. It will focus not only on the impact of migration but also on social integration, mix culture like indo-western culture in a comparative basis.

Ekta Meena

A comparative study of social and economic aspect of migration

India is a country of immense diversity. It is home to people of many different racial, languages, ethnic, religious, and national backgrounds. Groups of people in India differ from each other not only in physical or demographic characteristics but also in distinctive patterns of behavior and these patterns are determined by social and cultural factors like language, region, religion, and caste. Apart from behaviour, economic development, level of education and political culture of the people in various social segments differ from region to region. More you can say that economy and cultures have been enriched by the contributions of migrants from round the globe. In an increasingly globalised world, migratory movements is continuously shaping the countries all over the world. Some countries like India and Ireland, which set the example of economic development and social integration, have the positive impact of the migration by globalisation and some countries like USA, which recently witness racism, xenophobia and discrimination have the negative impact on the migrants. It does not mean India do not face fragmentation and USA do not have cohesion. USA have many stories which show successful integration process, that facilitated the lives of immigrant communities, but being a developed country it still suffers from cultural alienation. In these countries, borders are built within borders to create cultural divides that do not allow people to integrate. Recently, this problem has become more prominent due to the rise of terrorism, clash of cultures in the world, leading to the glorification of stereotypes. People are becoming less accepting towards anyone who does not belong to their region. Migration does not stop after people move from one place to another place. The main question start after that ‘now what’ they will do. That is why this topic needs to be discussed thoroughly in order to find better solutions. This paper will begin with an analysis of different approaches to Migration, discuss the target groups for integration policies, provide indicators of the current situation of migrants and proceed to an analysis of integration tools: legislation, social policies and participatory processes. It will focus not only on the impact of migration but also on social integration, mix culture like indo-western culture in a comparative basis.

Ekta Meena

Study of temperature variation in human peripheral region during wound healing process due to plastic surgery

In this paper, investigations are made to analyze the human body temperature during wound healing process due to surgery. Wound is considered after the skin graft. Skin graft is a technique used in plastic surgery. Skin is the first line of defense between the human and environment, it is very susceptible to damage. Internal body or core temperature (Tb) is one of the clinical vital signs along with pulse and respiratory rates. Any disturbance in body temperature will drive complexities in wound healing process. These studies are important in the mechanism of establishing the limits of thermal regulation of human body during the healing process in different situations and conditions. The Finite element method is used to analyze tissues temperature for normal tissues (donor site) and abnormal tissues (tissues after surgery). Appropriate boundary conditions have been framed. Numerical results are obtained using Crank Nicolson Method.

Manisha Jain

An efficient classifier decision tree for active context source discover on mobile pervasive environment

Mobile pervasive environment interact with several devices at varying service ranges. The technical heterogeneity of pervasive environment is expected to increase the system flexibility and adaptability on modeling with context training phase. While working with context based training phase, time entity measure is considered as the significant issue. The evaluation of the services through numerous devices during training phase does not acquire an effective service monitoring on mobile pervasive environment. Mobile pervasive environment based information extraction fails to modify the patterns as activities change over time. To improve the flexibility of context training phase in mobile pervasive environment, an Active Context Source Discover Training Phase (ACSDTP) with Classifier Decision Tree Support (CDTS) mechanism is proposed in this paper. Our research work is to develop an effective modification (i.e., updation) of the pattern on training phase with real world context as per changes over time. Initially, the ACSDTP set up the available sensors in pervasive environment to work with the ever changing set of context users. The available sensors are maintained using the Active Discover process. Second, the CDTS mechanism is designed using weighted prediction for easy identification of context result on the training phase. Decision tree is operated separately using the learning techniques, where the identification is performed in a significant manner with minimal time factor. The learning process is performed to identify the inferred situations. Finally, the integration process is carried out to work with the complex association between the situations and sensor data in the mobile pervasive environment to achieve flexibility and adaptability factor. Experiment is conducted on factors such as time entity measure rate, precision ratio, and user context result determination level.

Dr H Shaheen

Metapuf: a challenge response pair generator

Physically unclonable function (PUF) is a hardware security module preferred for hardware feature based random number and secret key generation. Security of a cryptographic system relies on the quality of the challenge-response pair, it is necessary that the key generation mechanism must unpredictable and its response should constant under different operating condition. Metastable state in CMOS latch is undesirable since it response becomes unpredictable, this feature used in this work to generate a unique response. A feedback mechanism is developed which forces the latch into the metastable region; after metastable state, latch settle to high or state depends on circuit internal condition and noise which cannot be predicted. Obtained inter hamming variation for 8 PUF is 51% and average intra hamming distance is 99.76% with supply voltage variation and 96.22% with temperature variation.

Abhishek Kumar

Intersection of caste and gender based subjugation

One of the unique features of Indian society is prevalence of caste system which was originated thousands of years back to demarcate the people engaged in different occupation or jobs. Initially it was not much rigid but gradually people belonging to upper castes for their own selfish means to maintain their monopoly made this arrangement hereditary and started treating people of lower castes disgracefully. For preservation of this system, people started controlling their women to prevent inter-caste marriages and the concept of endogamy came up. This robbed away many types of freedom from women. For women belonging to lower castes, this situation is worse as they are doubly subjugated on the basis on caste as well as gender. Men belonging to their own caste treat them as secondary beings. This paper throws light on this intersection. How intersection of these two kinds of inequalities place them at the lowest position in Indian society. Dr. B.R. Ambedkar rises as their leader who all his life worked for empowerment of downtrodden section of society. He argues that education is the primary tool for evading these differences among people. He further emphasizes to adopt the concept of exogamy to break the backbone of Indian caste system and to immediately leave a religion or culture which legitimizes such system of inequality among people of the same land.

Swati sharma

Intersection of caste and gender based subjugation

One of the unique features of Indian society is prevalence of caste system which was originated thousands of years back to demarcate the people engaged in different occupation or jobs. Initially it was not much rigid but gradually people belonging to upper castes for their own selfish means to maintain their monopoly made this arrangement hereditary and started treating people of lower castes disgracefully. For preservation of this system, people started controlling their women to prevent inter-caste marriages and the concept of endogamy came up. This robbed away many types of freedom from women. For women belonging to lower castes, this situation is worse as they are doubly subjugated on the basis on caste as well as gender. Men belonging to their own caste treat them as secondary beings. This paper throws light on this intersection. How intersection of these two kinds of inequalities place them at the lowest position in Indian society. Dr. B.R. Ambedkar rises as their leader who all his life worked for empowerment of downtrodden section of society. He argues that education is the primary tool for evading these differences among people. He further emphasizes to adopt the concept of exogamy to break the backbone of Indian caste system and to immediately leave a religion or culture which legitimizes such system of inequality among people of the same land.

Swati sharma

Objective: pyrazolopyrimidines are heterocyclic molecules containing nitrogen as the main composition, and hence, they exhibit pharmacological efficacy. they are analogs of purines so that possessing wide applications in the field of medicinal chemi

Objective: Pyrazolopyrimidines are heterocyclic molecules containing nitrogen as the main composition, and hence, they exhibit pharmacological efficacy. They are analogs of purines so that possessing wide applications in the field of medicinal chemistry. The main objective of this study is to synthesize different derivatives of pyrazole-pyrimidine classes by adopting simple methodology as well as by employing green chemistry. The purpose of the synthesis of these molecules is to study the antitumor activity against Ehrlich ascites carcinoma (EAC) cell lines. Methods: After literature studies, it makes us to involve in the research of synthetic organic chemistry, especially to synthesize new compounds of pyrazolopyrimidines. We are reported solvent-free synthesis of pyrazolo [3,4-d]-pyrimidine-thiones through ethyl acetoacetate, hydrazine hydrate, thiourea, and different benzaldehydes. An ionic liquid 2-methyl-imidazolium-oxalate catalyzed the reactions under ultrasonication bath. Both conventional and ultrasonic methods were employed and comparison studies have been made. It was found that ultrasonic method completed the reaction quicker than the conventional method. All the synthesized compounds were confirmed their structures by 1 HNMR, Fourier transform infrared, 13C-NMR, and elemental analysis spectra. The compounds were tested for in vitro anticancer activity against EAC cell lines. Most compounds revealed significant anticancer activity relative to doxorubicin as a positive control with inhibitory concentration (IC50) values. Results: Ultrasonication method is a simple method under which all the reactions were completed at faster time (<7 min) compared to the convention method. Among eight molecules, 8a and 8d completed the reactions at a faster rate. We reported IC50 values of all the molecules, in which 8e and 8g were exhibited excellent potency against EAC cell lines at different concentrations .

Dr Ganesh N Yallappa

Effect of calcium of lactose free millet milk on growth and development in albino weanling rats

Background:Calcium, the very important mineralhelps in growth and development ofinfants.Calcium helps in building strong bones, teeth,proper functioning of nerves and muscle, blood clot and in activating the enzymes that convert food into energy. Infants and Children are growing new bone all the time, they need continuous supply of calcium to support the healthy growth.Milk is the only food for infants which is richest source of calcium. Some infants are sensitive to lactose in milk because they have Lactose Intolerance. The present study aimsto develop an alternate milk forlactose intolerance infants with finger millet and pearl millet.Method:Traditional methods were used to process the milletswhich help in retaining and increasing the nutritional content in millets.The millet milk was analyzed for calcium content using the ICPMS.The millet milk was supplemented for 6 weeks to albino rats in comparison with cow milk. The tibia weight and length were measured and calcium content in tibia was analyzed. Result:The calcium content of the millet milk was 80mg/100mlwhere as in cow milk it was 120mg/100ml.The mean calcium content of the tibia inalbino rats was15.35±3.50mg/dl fed with millet milkand20.40±3.74mg/dl in rats fed with cow milk.Conclusion: The developed millet milk contain good amount of calcium on par with cow’s milk, it can be used as substitute milk for lactose intolerant infants.

Kimeera Ambati

Analgesic and antiemetic activity of cleome viscosa l.

The seeds of Cleome viscosa are used in traditional systems of medicine for the treatment of many diseases in Asia. This study evaluated fixed oil from the seeds of Cleome viscosa for analgesic and antiemetic activity by using the acetic acid induced writhing test in mice (intraperitoneally) and chick emetic model (oral treatment) respectively. The results showed significant analgesic and antiemetic activities of Cleome viscosa fixed oil.

Dr. Salman Ahmed

A study to assess the effectiveness of infrared radiation therapy on pain perception and wound healing among primi postnatal women with episiotomy

Motherhood has true nobility and unique capacities. Pregnancy and childbirth are special events in women’s lives. This study aimed to assess the effectiveness of Infra-red radiation therapy on pain perception and wound healing among primi postnatal women with episiotomy in Christian mission hospital, Madurai. The study was conducted among 60 postnatal women, 30 in experimental group and 30 in control group, who were selected by using purposive sampling technique. Data collection was done as planned 6 weeks were taken for data collection procedure. The data gathered were analyzed and the interpretation was made on the study objectives. The paired‘t’ test and independent‘t’ test were used to find out the effectiveness of infrared radiation therapy. Comparison of pain perception and wound healing status values between pre-test and post-test, experimental and control group showed a significant difference at 0.05 levels. The study concluded that the infrared radiation therapy was effective in reducing episiotomy pain and wound healing. Therefore, infra-red radiation therapy should be used to augment the therapy of episiotomy. Keywords: Pain perception, Wound healing, Episiotomy, Infrared lamp

Elsi Queen

Assess the prevalence of polycystic ovarian syndrome among adolescent girls.

World Health Organization (WHO) estimation disclosed over 116 million girls (3.4%) area unit stricken by PCOS worldwide. The predisposing risk factors embrace genetic science, system, lifestyle/environment, fatness that contributes to the event of PCOS. it's calculable that between 5 to ten % of U.S. girls of childbearing age have PCOS. that is regarding five million girls, which makes the condition one among the foremost common secretion endocrine disorders among girls of generative age. A study to assess the prevalence of PCOS among adolescent women at hand-picked setting, Chennai. Objective: to assess the prevalence of PCOS among adolescent women. Methodology: A non-experimental descriptive analysis style was adopted during this study. The non-probability convenient sampling technique was accustomed choose the sample size of two hundred adolescent Girls. The assessment of the prevalence of PCOS was administrated employing a self-reported check list through a Googletype. A survey link was sent to the respondents, via email and WhatsApp& teams. knowledge was analyzed by descriptive and inferential statistics. Result: our Majority (36.5%) of the samples had gentle & moderate PCOS symptoms and twenty-sevenths had severe symptoms. relating to physical activity, the bulk (38%) of the samples had gentle physical activity, thirty-fourth had moderate physical activity and twenty-eighth had severe activity. There was a direct correlation between PCOS symptoms and Physical activity. There was a statistically vital relationship between PCOS symptoms with age, religion, academic standing, dietary habits, previous information, supply of data, the cycle of emission and BMI and there was a statistically vital relationship between physical activity with age, Religion, academic standing, monthly family financial gain, age at the time of start, previous information, supply of data, variety of family, Cycleof emission & BMI. Conclusion: PCOS among adolescents is a rising problem that wants careful assessment, timely intervention, and appropriate treatment. Diagnosis of PCOS in adolescence remains a challenge attributable to overlapping symptoms of PCOS with traditional time of life changes in adolescents. life-style modifications for weight reduction and dietary modifications and psychological content plays vital role in these young ladies for preventing long run complications. Keywords: Poly cystic ovarian syndrome (PCOS), Prevalence, PCOS symptoms, Physical activity, Adolescent Girls.

Elsi Queen

Knowledge and practice on covid-19 among general public

COVID-19 is associate communicable disease caused by severe acute respiratory syndrome coronavirus. It's currently a virulent disease unfold moving several countries globally. The aim of this study is to assess the knowledge and practices of COVID-19 among general public at the selected setting, Chennai. The main objective was to assess the knowledge and practice on COVID-19, correlate the knowledge with practice on COVID-19, and associate the knowledge and practice on COVID-19 with the demographic variables among the public. A Quantitative non-experimental analysis style was used to assess the knowledge and practice of COVID-19. Sixty individuals were chosen through the non-probability convenience sampling technique. The findings of the analysis disclosed that the majority (40%) of the samples had a high level of knowledge and 43.3% of them had a good practice, 33.3% of them had a moderate level of knowledge and 30% of them had moderate practice, whereas 26.7% of them had a low level of knowledge and 26.7% of them had poor practice on COVID 19. Keywords:- COVID-19, Knowledge, Practice, Pandemic, General Public.

Elsi Queen

Melioidosis: distinctive clinico-epidemiological characteristics in southern india

As it is increasingly being reported from India, we carried out a prospective study of patients with culture-proven melioidosis from south India, examining clinical, laboratory features, epidemiological data, risk factors, treatments, outcomes at three and six months, and factors associated with mortality.Between 2014 and 2018, 31 cases were identified. Diabetes (83.9%) and alcohol abuse (58.1%) were common risk factors. Musculoskeletal, skin and soft tissue manifestations together constituted 48.4% of presentations, while 29% had pneumonia. During the intensive phase, 74.2% received one of three recommended antibiotic regimes, but 51.6% did not receive continuation treatment. Pneumonia and lack of continuation treatment were independently associated with a high mortality of 25.8%. Hot spots for melioidosis exist in India, and there is considerable diversity of presentation, including skin, soft tissue, musculoskeletal and neurological involvement. High rates of bacteraemia are shown.

Aneesh Basheer

Sumitra Nain

Dept Of Pharmacy,banasthali Vidyapith

Dr Prerna Soni

Pandit Ravishankar Shukla University Raipur Chhattisgarh

Dhivya R

Psgr Krishnammal College For Women

Dr Vipul Sharma

Gurukul Knagri University, Haridwar

Dr Narendar Bhojak

Gcrc, P.g. Department Of Chemistry Government Dungar College (three Times Consecutively ’a’grade By Naac) Bikaner 334001

Reet Kumar Reet

Mahatma Gandhi Central University Motihari Bihar

Nsikakabasi George

Kano State Ministry Of Health

Annette Veit

Austria

Sudipta Saha

Sri Sri University

Akarue, Blessing Okiemute

College Of Education, Warri

Souren Bhattacharya

University Of Technology , Jaipur, Rajasthan