Karishma
Assessment of ethanolic extract of ocimum sanctum whole plant (oswp) in ethanol-induced gastric mucosal damage in rats
Journal title : Yemen Journal of Medicine
Publisher : Mansa STM Publishers
Online ISSN : 2583-4614
Page Number : 399-404
Journal volume : 04
Journal issue : 02
17 Views Original Article
Background: Previously, Ocimum sanctum (Lamiaceae), commonly known as holy basil, has been noted for its anti-ulcer properties, primarily attributed to its oil and leaf extracts. However, the anti-ulcer activity of an ethanolic extract derived from the whole plant has not been reported. This study aimed to evaluate the antiulcer effect of the ethanolic extract of O. sanctum whole plant (OSWP) in an experimental ulcer model. Methods: The study, conducted at PCSIR Labs Complex in Karachi in August 2024, was approved by the Ethical Use of Experimental Animals Committee (IEC/OSWP-05). This study investigates the anti-ulcer activity of an ethanolic extract of OSWP in a rat model of ethanol-induced gastric mucosal damage at 200, 300, and 400 mg/kg body weight, with ranitidine (50 mg/kg) used as a positive control. Outcome measures included ulcer index (UI), percentage protection, and gastric pH. Results: The ethanolic extract of OSWP demonstrated dose-dependent gastroprotective effects. At 200, 300, and 400 mg/kg, the UIs were 9.49 ± 2.40, 4.55 ± 1.44, and 2.5 ±2.25, respectively, with corresponding protection ranging from 48.9% to 86.54% for the 200 to 400 mg/kg doses (p < 0.05). Gastric pH increased from 5.6 to 7.6. In comparison, ranitidine (50 mg/kg) resulted in a UI of 4.0 ± 0.88, 78.47% protection (p < 0.05), and a pH of 7.0. Conclusions: The study demonstrates the dose-dependent anti-ulcer activity in the ethanolic extract of OSWP, which may be further developed as a potential anti-ulcer agent. A graphical presentation of the whole experimental process is shown in Figure 1.
Article DOI & Crossmark Data
DOI : https://doi.org/10.63475/yjm.v4i2.0153
Article Subject Details
Article Keywords Details
Article File
Full Text PDFMore Article by Karishma
The internal medicine residency program at hamad medical corporation (hmc) is accredited by the accreditation council for graduate medical education–international (acgme-i). upon c...
The city that never sleeps, a vibrant tapestry of dense neighborhoods and relentless energy, has long grappled with the pervasive challenge of air pollution. the very dynamism that...
Background: acute and chronic heart or kidney failure affect each other in cardiorenal syndromes (crs). in crs, hemodynamic and non-hemodynamic changes occur, causing acute or prog...
Dignity therapy (dt) is an evidence-based psychotherapeutic approach originally designed to alleviate emotional and existential distress in patients with terminal illnesses. while ...