Profile Pic of Syahrul Tuba Syahrul Tuba

The frequencies of allele distribution of cyp2c9 and cyp2c19 gene polymorphisms in healthy papuan population, indonesia

  • Authors Details :  
  • Syahrul Tuba,  
  • Zullies Ikawati,  
  • Mustofa

Journal title : Chiang Mai University Journal of Natural Sciences

Publisher : Chiang Mai University

Print ISSN : 1685-1994

Journal volume : 20

Journal issue : 3

880 Views Research reports

This study's objective was to determine the distribution of allele frequencies of CYP2C9 and CYP2C19 gene polymorphisms among the Papuan population, known as the second-largest ethnic group in Indonesia. According to recent research, there is a decrease in CYP2C9 and CYP2C19 produced by humans globally, including in Indonesia. These gene polymorphisms aid in the transmission of various endogenous and exogenous drugs in the human body. Material and Methods: A sum of 99 subjects, comprising 73 male and 26 female subjects aged 20-30 years, were used for this research. PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) analysis using AvaII, NsiI, and SfaNI enzymes tested for the genotypes CYP2C9 and CYP2C19 administered. The distribution of genotypes was calculated in the population (P<0.05) using the Hardy-Weinberg equilibrium. The Faculty of Medicine Gadjah Mada University's Medical and Health Research Ethics Committee (MHREC) accepted this research with written consent. The results revealed that in Papua subjects, CYP2C9*2 (rs1799853) and CYP2C19*17 (rs12248560) alleles were absent while in 17 percent of the population CYP2C9*3 (rs1057910) allele frequency was. In conclusion, CYP2C9*3 has the highest polymorphism rate in Indonesia, with the absence of CYP2C9*2 and CYP2C19*17. Therefore, genetic drift can occur within this ethnic group.

Article DOI & Crossmark Data

DOI : https://doi.org/10.12982/CMUJNS.2021.066

Article Subject Details


Article Keywords Details



Article File

Full Text PDF





More Article by Syahrul Tuba

Potential of pharmacological and herbal for covid-19: a narrative review

The pandemic coronavirus disease 2019 (covid-19) caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2) presents an unprecedented challenge to identify effective d...

Removing the stigma and discrimination for people with hiv/aids: the main role of civil society

Hiv/aids cases in indonesia continue to increase and have spread to all provinces in indonesia. bandung is one of the cities with a high number of people living with hiv/aids in in...