Wilsons disease is a rare inherited disorder which is characterized by impaired copper excretion which leads to excessive deposition of copper in many tissues and organs like brain, liver, and eye. This is also characterized by Kaiser-Fleischer ring, low serum ceruloplasmin levels and elevated urinary copper excretion [1]. A 26year male patient came to the neurology department with chief complaints of involuntary tremors of both hands and difficulty in walking in the last one month associated with swaying to one side in the last 20 days. On examination the patient is having Kaiser-Fleisher ring positive and upon further investigation Magnetic resonance imaging brain was performed which revealed the features in favor of Wilson’s disease. And for this condition the patient is treated with chelating agents and benzodiazepines.

Dr venkata rama rao nallani

Purpose: The study aims to explore all possible morphological features of calcium oxalate monohydrate and calcium oxalate dihydrate crystals and their habits in case of inhibition. Methods: The study was carried out on a glass slide to observe the growth and inhibition of calcium oxalate monohydrate (COM) crystals by using infusions (5-20%) of Macrotyloma uniflorum (Lam.) Verdc, Phaseolus lunatus Linn. and Phaseolus vulgaris Linn. The reagents of the double diffusion gel technique were used for this purpose. Results: Calcium oxalate crystals are divided into three types: calcium oxalate monohydrate, dihydrate, and trihydrate. These types are further divided into sub-types based on their morphology. In the case of calcium oxalate monohydrate (COM), these crystals are donuts, dumbbells, needles, platy, prismatic, rosette, round edges and X-shaped. Calcium oxalate dihydrate (COD) is the elongated large rods and tetragonal bipyramidal forms. In the present study, dendritic or arborescent (tree-like platy crystals) were observed for the first time as part of a COM growth. Long chain loose agglomerates and compact aggregated crystals are the typical pattern of calcium oxalate crystals. All tested infusions caused growth inhibition of calcium oxalate crystals. Smaller nucleation zones and defective shapes of the grown crystals are declared different growth inhibition patterns. Conclusion: This study gives extensive information about morphology, aggregation and growth inhibition of calcium oxalate crystals.

Dr. salman ahmed

Host plant resistance is an important tool for minimizing the losses in pigeonpea due to spotted pod borer, Maruca vitrata, which is the most threatening hidden pest of pigeonpea crop. Experiment was carried out to study the morphological and chemical traits in pigeonpea associated with expression of resistance to M. vitrata and their incidence in different sowing dates. The incidence of M. vitrata varied significantly among different sowing dates. Crop sown on D2 (1st week of July) resulted in maximum pod infestation by M. vitrata (13.1%). Minimum pod infestation (2.3%) and (2.9%) was recorded in D4 (3rd week of July) and D1 (3rd week of June) sown crop, respectively. Among different varieties, AL-201 registered lowest pod infestation (4.3%) as compared to Pusa-992 (7.9%). The non-glandular (type A), and glandular (type B) pod trichome density of top, middle and lower canopy of the plant and the pod wall thickness was responsible for the resistance to M. vitrata. Whereas, non-glandular (type C) pod trichomes, pod length, seed width and number of seeds per pod were associated with the susceptibility to spotted pod borer. Expression of resistance to M. vitrata pod infestation was associated with low amounts of crude protein and total soluble sugar and higher amount of fat content, phenol content and tannin content of seed as well as pod wall

Dr. babu lal jat

Gender financing is a typical issue now a days , women face so many challanges in obtaining financial support from bank . Practical social order,low confidence of Bankers on women ,bankers neglecting attitude in some cases discourage the women to come up with entrepreneurial idea or venture creation and thus women are legging behind men in business field .To integrate women in the mainstream development process ,the equality as well as equity is important to restrict gender discrimination .

Md. abdur rahman choudhury

The human body has been theorized in many ways, including the entire notion of the woman as a human creation. It is generally agreed that this concept refers to our perceptions, thoughts, and feelings about our bodies, which influence our behaviour about our bodies. The article examines numerous authors whose individual genealogies meet on the common ground of identity theory and women's lives and is supported by a theoretical framework based on conceptions of identity, body-image and self-image in women and feminist discourse. This paper probes into the concepts of identity in women through the literary canvas of Dr. Bhabendra Nath Saikia and demonstrates the effects of body image and self-image on the development of identity. Of course, an extensive discussion of the short stories of Dr. Saikia is beyond the scope of this paper. The aim of this paper is to analyse the concepts through the two short stories short titled "Dhura Xaap" (ঢ োৰো সোপ 1958) and "Sringkhol" (শ ৃংখল, 1970) by Dr, Bhabendra Nath Saikia. The paper seeks to explore the concepts of self-image, identity and body image through three female characters ‘Chandrika’, ‘Janeki’ and ‘Ambika’.

Banani das

The current study was designed to explore the antiemetic effect of the methanolic extracts of Acalypha fimbriata Schumach. & Thonn., Acalypha ornata Hochst., and Acalypha wilkesiana cv. godseffiana Muell Arg., aerial parts using chick emesis model to validate their folk use in G.I. disorders. Emesis was induced by the oral administration of copper sulfate to male chicks. All the extracts (150 mg/kg orally) showed an antiemetic effect and were compared with the reference drug chlorpromazine. Among all the extracts, Acalypha ornata Hochst., leaves extract showed the highest (94.51%) and Acalypha fimbriata Schumach. & Thonn., stem extract showed the lowest (35.04%) antiemetic effect.

Dr. salman ahmed

Inflammation is said to be a healthy component of the body immune system's reaction. Inflammation is characterised by four key symptoms: pain, redness, heat or warmth and swelling. As secondary metabolites, plants may produce a wide range of phytochemical compounds, which possess anti-inflammatory characteristics. Herbal remedies are important therapies for a wide range of ailments all over the world. There are around 7 500 species of medicinal plants, including representatives from over 17 000 flowering plant species. Even when synthetic chemistry has developed out their expectations, the use of natural ingredients in the manufacture of drugs used in contemporary medicine is unparalleled. By interfering with the biology of inflammation, anti-inflammatory medications may assist to minimise tissue damaging and increase patient’s comfort. Because of the bulky figure of species reachable for study, the effective development of novel naturally taking place anti-inflammatory drugs is mostly dependent on a multidisciplinary approach to discovering new chemicals. Despite the statistic that many review papers have been produced in this field, the conventional of them simply examined the issue from an area perspective. Several non-steroidal anti-inflammatory drugs have been shown to reduce inflammation and pain by decreasing the isoform of the cyclooxygenase enzyme's digestion of arachidonic acid, hence lowering prostaglandin production. Non-steroidal anti-inflammatory drugs have a host of harmful effects. There are, however, medicinal herbs with anti-inflammatory pharmacological properties that have few or no negative effects.

Mediterranean journal of pharmacy and pharmaceutical sciences

The study examined public-private sectors’ collaboration in human resource management and curriculum development in the administration of public senior secondary schools in Rivers State. The study adopted the descriptive survey design. Two research questions and two hypotheses guided the study. The population of the study comprised 281 principals in the 281 public secondary schools in Rivers State. The proportionate stratified random sampling technique was used to draw up sample of 259 principals representing 92.2% of the population of the study (211 male principals and 70 female principals). An instrument titled: Public-Private Sectors’ Collaboration for School Administration Questionnaire (PPSCSAQ) designed in the modified 4-point Likert Scale with a reliability index of 0.87 was used for data collection. The face and content validities were ensured. Mean and standard deviation were used in answering the research question while z-test was used in testing the hypotheses at 0.05 level of significance. The finding of the study showed that to a high extent public-private sectors collaborate in human resource management and curriculum development in the administration of public senior secondary schools in Rivers State. It was recommended among others that the government should provide enabling environment and formulate favourable policies to sustain public-private sectors’ collaboration as it ensures effective human resource management in the state.

Fxintegrity publishing

Trans fatty acids (TFA) are the geometrical isomers of monounsaturated and polyunsaturated fatty acids that affect the functional and physicochemical properties of these fatty acids, which in turn affect their metabolism in humans. Since the database available for trans fatty acids in food from India is scarce, the research report generates data about trans fatty acid content in selected foods popular in north India. In this report, various food samples like cookies, chocolates, biscuits, pizza, fries, indigenous snacks like samosa, pakora and indigenous sweets like jalebi, gulab jamun, and laddoo were analyzed for the Trans Fatty Acid (TFA) content by gas chromatography. A large variation was found in trans fatty acid content among these food samples. The results also showed that only 4.5% of the samples were found to contain TFA less than 0.5% while approximately 8% of samples having more than 5% TFA (1 branded and 6 non-branded samples). Also, a large variation was found in the trans fatty acid content of branded and non-branded food samples with the mean value of TFA in branded and non-branded food groups as 1.781 and 6.125 respectively and the t-value of 0.852 between the two groups. When regulations are emphasizing on labelling the TFA content on the product, there are arrays of unlabelled products which are not governed under any regulations. Hence there is a need for strong food regulations to bring levels of trans fats in processed foods to negligible levels.

Shalini purwar

This paper explores the topic of supply chain management using case studies of companies from the automotive industry. Focus is given to the manner in which supply chain strategies in the automotive industry are designed and implemented, and how automotive companies configure their supply chains through collaboration, lean principles and agility. The paper also explores how advanced technologies, notably Big Data analytics and the Internet of Things, are utilised in the automotive industry to maintain a competitive advantage. Key findings made in the discussion are that success in supply chain management is greatly enhanced if firms seek to integrate the different components making up the supply chain. Additionally, the collaboration between entities fosters trust, which is a vital ingredient in the application of lean principles. The automotive industry shows that companies should pursue flexibility and efficiency, which are captured in the notions of agility and leanness, respectively. The paper identifies collaboration and advanced technologies as two critical sources of sustainable competitive advantages to organisations primarily in reference to supply chain management.

Mohamed sorogy

Toxicity of different insecticides was evaluated against 2nd and 3rd instar larvae of Helicoverpa armigera under laboratory conditions by leaf dipping method. The insecticides viz., thiodicarb 75WP, novaluron 10EC, spinetroam 11.7EC, indoxacarb 15.8EC, quinalphos 25EC, rynaxypyr 18.5SC, emamectin benzoate 5SG and cypermethrin 25EC were tested. Spinetoram was found most effective in managing the 2nd instar larvae of H. armigera and it was followed by novaluron 10EC and indoxacarb 15.8EC as compared to cypermethrin 25EC. Emamectin benzoate 5SG @ 1 x 10-7 to 1 x 10-9 per cent concentrations recorded 100% mortality against 2nd instar larvae and LC50 values for 3rd instar larvae was 0.00000000045%. Insecticides novaluron 10EC, spinetoram 11.7EC and cypermethrin 25EC did not show promising and consistent results against 3rd instar larvae of H. armigera at 24 hrs. The LT50 of novaluron 10EC at 0.00005% concentration was 19.861 hrs and it was 28.144 hrs at 0.000001% against 2nd instar larvae of H. armigera

Dr. babu lal jat

In the world of yoga there are ―Eight limbs path‖ which helps in different aspects like coordination of body and mind and helps to create positivity of mind and help the body healthy and fit by which the functioning of the body improves. In today‘s modern life various type of disease and deformity takes place most of the things takes place due to unbalanced food, & other. The mind is always wondering and being rebellious, never focusing on the moment. It is the mind job to think, it is relentlessly interpreting everything. That is seen, perceived and experienced and this pattern of habit goes through change to behavior and attitude. Many people who practice yoga do so to maintain their health and well-being, improve physical fitness, relieve stress, and enhance quality of life. In addition, they may be addressing specific health conditions, such as back pain, neck pain, arthritis, and anxiety. Basically yoga has been more effective than control and waitlist control conditions, although not always more effective than treatment comparison groups such as other forms of exercise. More randomized controlled studies are needed in which yoga is compared to active exercise groups. Having established the physical and mental health benefits of yoga makes it ethically questionable to assign participants to inactive control groups. Shorter sessions should be investigated for cost-effectiveness and for daily practice.

Yatendra sharma

Stability studies ensuring the maintenance of product quality, safety and efficacy throughout the shelf life are considered as pre-requisite for the acceptance and approval of any pharmaceutical product. These studies are required to be conducted in a planned way following the guideline issused by ICH, WHO and or other agencies. Importance of various methods followed for stability testing of pharmaceutical products, guideline issued for stability testing and other aspects related to stability of pharmaceutical products have been presented in a present review.

Prachi barbhaiya

The objective of this research was to investigate the effect of initial chick weight at the first day of the hatch on subsequent performance of Iraqi local chickens. 150 unsexed chicks of local chickens weighted at first day of hatch then divided to five groups (A, B, C, D, E) according to the initial weight (26.4, 31.89, 36.38, 41.09, 46.91) gm, the birds were reared in a wooden cage consist of individual compartments with dimensions (30×30×40) cm, The feed and water was available adlibitum, The birds and feed weighted weekly by sensitive balance. The result shows that initial weight had a significant effect on body weight, weight gain, feed and protein consumption, and growth rate but not significant on feed and protein conversion, where group E showed the best results, The relationship between initial body weight and productive traits were studied and the prediction equation of productive traits depending on initial weight shows highly significant

Rafea mohammedtaher khulel

The genus Caesalpinia belongs to the family Caesalpiniaceae and includes 280 species distributed in tropic and subtropical regions of the world. Historically, species of the genus Caesalpinia have been used to treat a wide range of ailments, such as malaria, ascariasis, dysentery, fever, rheumatism, and influenza. Phytochemical works led to the isolation of triterpenoids, diterpenes, flavonoids, steroids and phenolic compounds. Pharmacological studies have shown that the extracts and compounds isolated from this genus exhibited anticancer, anti-inflammatory, anti-malarial, antipyretic, anti-microbial, anti-rheumatic, antiulcer and anti-diabetic activities. Therefore, this review aims to provide a comprehensive overview of the genus Caesalpinia's ethnopharmacology, phytochemistry and pharmacology.

Dr. salman ahmed

The study of molluscan animals is called Malacology and the study of molluscan shell is called as conchology. The scaling of metabolic rates with body mass is one of the best known and most studied characteristics of aquatic animals. We studied here how body size is related to rate of oxygen consumption, ammonia excretion and O: N ratio in Freshwater Bivalve Mollusc Lamellidens marginalis species in an attempt to know how body size specific changes affect their metabolism. The freshwater bivalve molluscs with specific body size i.e. small (76-79 mm in shell-length) and large (90-94 mm in shell-length) were chosen for experimental work from Bhima River at Siddhatek on April and May during summer. The adult bivalve molluscs with small body size reported high value in rate of oxygen consumption and O: N ratio but rate of ammonia excretion was low value in small body sized bivalves compared to large ones. The results are discussed in the flush of metabolic processes in fresh-water bivalve molluscs.

Dr. pritesh ramanlal gugale

This exploratory case study employed Appreciative Inquiry Framework in answering the following questions: 1) What are the expectations set by the following to the student homosexuals; a) Self, b) Parents and c) Teachers; 2. What are the positive and negative effects of these expectations to the student homosexuals? and 3) How do these expectations affect the process of identity development of the student homosexuals?. The participants are five college students who identified themselves as homosexual. Written consent was secured to ensure that the research abides to the ethical standards. The data was triangulated through analysing the point of view of the student participants, their parents and their teachers. Results revealed that expectations set by the student homosexuals, their parent and teachers are all contributory factors that affect the identity development of student homosexuals. Moreover, it was revealed that those who have problems in their identity development experienced difficulties in their performance in school. Positive and negative effects of expectations were also noted as the participants shared their stories. With the results, it was recommended that teachers must treat all their students equally regardless of their gender preferences in life. Activities that support the holistic personalities of students must be given emphasis. The parents must support their children in whatever endeavour they take and provide them guidance to be successful in their academic pursuits. Lastly, a model of counselling procedure for student homosexuals was proposed.

Darrel ocampo

This study's objective was to determine the distribution of allele frequencies of CYP2C9 and CYP2C19 gene polymorphisms among the Papuan population, known as the second-largest ethnic group in Indonesia. According to recent research, there is a decrease in CYP2C9 and CYP2C19 produced by humans globally, including in Indonesia. These gene polymorphisms aid in the transmission of various endogenous and exogenous drugs in the human body. Material and Methods: A sum of 99 subjects, comprising 73 male and 26 female subjects aged 20-30 years, were used for this research. PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) analysis using AvaII, NsiI, and SfaNI enzymes tested for the genotypes CYP2C9 and CYP2C19 administered. The distribution of genotypes was calculated in the population (P<0.05) using the Hardy-Weinberg equilibrium. The Faculty of Medicine Gadjah Mada University's Medical and Health Research Ethics Committee (MHREC) accepted this research with written consent. The results revealed that in Papua subjects, CYP2C9*2 (rs1799853) and CYP2C19*17 (rs12248560) alleles were absent while in 17 percent of the population CYP2C9*3 (rs1057910) allele frequency was. In conclusion, CYP2C9*3 has the highest polymorphism rate in Indonesia, with the absence of CYP2C9*2 and CYP2C19*17. Therefore, genetic drift can occur within this ethnic group.

Syahrul tuba

Diabetes mellitus is a common and chronic metabolic disorder. Uncontrolled diabetes mellitus leads to body organ damage if not treated properly. Educational intervention is necessary from health-care providers such as pharmacists to prevent or reduce organ damage and complications among the diabetic patients. Several studies have demonstrated the contribution of pharmacists in achieving a better control of diabetes mellitus. Thus, this study intended to assess the knowledge and practice regarding foot care among Libyan diabetic patients in Al-Bayda city. In addition, to determine the association between knowledge and practice regarding diabetic foot care with selected demographic variables. This is a cross sectional study conducted at Diabetes Center Aljabal Al akhdar in Al-Bayda between April and August, 2022. A total of 400 participants with diabetes were enrolled and interviewed by using a self-design questionnaire for knowledge and practice of foot care after taking verbal agreement. Data was analyzed by using SPSS software version 26.0. In this study, 191 subjects were male (47.8%) and 209 subjects (52.3%) were female. On the topic of foot care, 51.8% of the participants stated they did know how to perform correct foot hygiene and 33.5% stated that drying should consist of passing a towel between their toes. Female subjects statistically had more knowledge than male subjects on the right footwear and correct way of nail cutting (p < 0.01 and p < 0.001, respectively). In relation to practice, the frequency of patients with a good practice was 126 (31.5%) and with poor practice was 274 (68.5%). Evaluating the parameters dry, moisturize and nail cutting, women showed a significant difference in relation to men, with a high significance level in the three parameters. In conclusion, the knowledge and practice of foot care in Libyan patients with diabetes were poor. So, an educational program is recommended to improve the awareness of foot care. Diabetic patients should be provided information about self-care of their feet by health care providers such as pharmacists to prevent and delay onset of foot complications and improve the quality of life.

Mediterranean journal of pharmacy and pharmaceutical sciences

On January 2021, cases affected by coronavirus epidemic are constantly increasing, Libyan Ministry of Health provides the vaccine to the people those who are most at risk. The purpose of this study was to assess and verify the adverse effects of the first dose of the AstraZeneca COVID-19 vaccine. The study conducted at the Aljmail city, west region of Libya. The study was cross-sectional study during the period of August 31st and November 5th, 2021. The method involved 133 adult Libyan participants of both gender ageing more than 18 years old. The preliminary data were 54.0% who developed post-vaccination symptoms. The participant's aged 60 years and more with chronic diseases were more likely to have adverse effects after receiving the first dose of vaccine. In conclusion, AstraZeneca vaccine was good and effective but this study indicates a need for a large and long period study to confirm the safety of the vaccine use in the adult people.

Mediterranean journal of pharmacy and pharmaceutical sciences