This dissertation aimed to critically investigate how UK manufacturing companies can employ 3PL services to enhance business profitability. A simple, cross-sectional sequential mixed methods research methodology was implemented with the qualitative phase being used to explain the findings of the quantitative phase, which was performed first. Data for the quantitative period were collected using an online questionnaire that was designed and administered through a Google survey (N= 416). At the same time, semi-structured interviews were performed via Zoom calls with senior executives and managers of UK manufacturing firms (N= 5). Descriptive statistics, a one-sample t-test, and stepwise regression were used for quantitative data analysis using SPSS while manual analysis of interview data was performed in Microsoft Excel. The results showed that transportation and fleet management were the services that UK manufacturing companies outsourced to the most significant extent while clearing and forward and inventory management were the services that were outsourced to the lowest degree. The reasons behind this trend included the level of risk involved in outsourcing a particular service, availability of 3PL providers offering the outsourcing service, and the cost involved. In terms of feasibility, all items were scored highly, although increased operational flexibility and significant reduction of operational costs ranked highest. Finally, the stepwise regression test revealed four statistically significant models with an overall prediction power of 20.1% on business profitability. The statistically significant predictor variables were a reduction of operational costs, increased operational flexibility, reduced fixed asset costs, and the gaining of external resources from 3PL service providers.

Mohamed sorogy

Viral hepatitis is one of the main public health concerns around the world. Even though infection management techniques have been implemented over the last few decades, eradication or significant reduction has remained a mystery. The purpose of this study is to look into the prevalence of acute infectious hepatitis in the East of Libya and how the type of virus, age, gender, clinical manifestations, and outcome are related. This is a hospital-based retrospective study. The data on the frequency and distribution of viral hepatitis based on age, gender, seasonal, clinical, and ultrasound findings, and the outcomes during a period of two years from January 2020 to December 2021 were collected and analyzed. Of the 0.39% (72 cases) of total hospital admissions (18340) under the age of 15 years old for acute infectious hepatitis patients, the most common age group was 5-12 years (79.6%). Winter accounted for 41.6% of all the cases. Females made up 65.3% of the cases. Jaundice was the most prevalent presentation (87.5%). Hepatomegaly was seen in 83.3% of the patients. Most of the cases have mild hyperbilirubinemia (5-9 mg/dL, 75.0%). Approximately 1/5th of the patients' serum glutamic-oxaloacetic transaminase (SGPT), and nearly 1/3rd of the patients' SGPT levels were in the range of 1000-2000. One patient's hepatitis C was positive, one patient's hepatitis B was positive, and 97.2% were positive for hepatitis A. 88.8% of the individuals recovered without complications, whereas 11.1% showed symptoms of hepatic failure but recovered. The present study indicates that acute hepatitis A is more prevalent, especially in the winter. Those who are females and 5-12 years of age were more affected by acute viral hepatitis in Libya.

Mediterranean journal of pharmacy and pharmaceutical sciences

The CuS@reduced graphene oxide (CuS/RGO) hybrid nanocomposite was synthesized by facile hydrothermal method and used as a photoelectrode material in photovoltaic applications. In the hydrothermal route, RGO is formed by the reduction of GO with simultaneous formation of CuS/RGO nanocomposites. The CuS/RGO nanocomposites was investigated using powder XRD, TEM, HR-TEM, Raman, XPS, DRS UV–Vis spectroscopy, Photoluminescence (PL) measurements. XRD and TEM results suggest that CuS crystalline with individual spherical like homogeneous nanoparticles sizes in the range of 45–35 nm, which is distributed throughout the RGO sheets. We further construct the flexible photoelectrodes by using CuS and RGO and studied the photovoltaic performance. Photovoltaic parameters, such as short-circuit photocurrent density, open circuit voltage, fill factor and conversion efficiency were found to be 16 mA/cm2 , 0.71 V, 70.1% and 7.81% respectively, for CuS/RGO photoelectrode. The improved photo conversion efficiency of CuS/RGO is due to enhancing the electronic injection ability and reducing the photogenerated charge recombination. These photovoltaic results indicate a simple methodology for the low cost and effortless synthesis of an alternative CuS/RGO photoelectrode in high performance photovoltaic devices.

Dr.k.k.saravanan

Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that catalyzes Ca2+-dependent protein modifications. TG2 enzyme disruption has been implicated in several different disease processes and disorders such as Huntington and Parkinson’s diseases, cancers such as breast, ovarian and pancreatic cancers. Coeliac disease (CD) is the one disease state that TG2 activity plays a crucial role. To date, a gluten-free diet is the only accepted form of therapy for CD. Because of the important role of TG2 enzyme in the initiation of CD, therefore, this study was aimed at the identification of TG2 inhibitors from natural sources, as a potential intervention in CD therapy. Competitive amine inhibitors are the most widely used TG2 inhibitors because they are commercially available, chemically stable and relatively non-toxic in living systems. The natural products chosen for this study were dietary flavonoids. Flavonoids were extracted from different food samples. The flavonoids food extracts were subjected to the TG2 activity assays to examine their effect on the enzyme activity. The assays were carried out under optimal conditions of pH, Ca2+ and with N, N-dimethylcasein (acyl-donor) or casein (acyl-acceptor) as acyl-donor substrates and biotin cadaverine (acyl-acceptor) or TVQQEL as (acyl-donor) substrates. TG activity was measured by two different microplate assays, Biotin-labeled cadaverine incorporation assay and Biotin-labeled peptide cross-linking assay. In the TG2 amine incorporation activity, all of food extracts display a significant inhibition effect towards the human recombinant transglutaminase2 (hrTG2) and guinea pig transglutaminase 2 (gplTG2) (20 - 50% of inhibition). While in the TG2 cross-linking activity, the majority of food extracts displayed an inhibition effect on the gplTG2 cross-linking activity (50 - 70% of inhibition) but only the strawberry and kale extracts showed an effect on hrTG2 activity (40 - 50% of inhibition). The inhibition of TG2 activity can be considered as a potential therapeutic target in the treatment of CD.

Mediterranean journal of pharmacy and pharmaceutical sciences

Human resource management is critical for hospitals but is frequently disturbed by employee retention issues. This research aims to determine the influence of compensation, organizational commitment, and work motivation on employee retention at Malahayati Medan. The research method applied is quantitative research by collecting data through questionnaires distributed from July to October 2022. The sampling method used is purposive sampling, with 78 employees as the sample. The data analysis method used is descriptive statistics, coefficient determination, multiple linear regression analysis, and hypothesis testing with t-test and F-test. The results of the t-test are compensation, organizational commitment, and work motivation partially influence employee retention. The results of the F test showed that all independent variables simultaneously influence employee retention and 61.1% of employee retention is influenced by compensation, organizational commitment, and work motivation. It is recommended for companies in similar industries pay attention to the results of this research.

L

Critical race theory (CRT) is an intellectual movement that seeks to understand how white supremacy as a legal, cultural, and political condition is reproduced and maintained, primarily in the US context. While CRT is part of a much longer research tradition investigating race and racism, which includes such key fgures as W. E. B. Du Bois, Frantz Fanon, Angela Davis, Audre Lorde, Gloria Anzaldúa, Cherríe Moraga, and many more, CRT distinguishes itself as an approach that originated within legal studies (in part building from and responding to critical legal studies); aims to be a vehicle for social and political change; has been adopted interdisciplinarily across many fields, including perhaps most notably education; and, in certain contexts, has come to be the umbrella term for studies of race and racism generally. CRT originated as an extension and critique of critical legal studies (CLS). It was also an outgrowth of Marxist critical theory that challenged the rationality, impartiality, and purpose of the legal system. According to the tenets of both CRT and CLS, the legal system is a political and ideological institution that, in part, rationalizes and justifies the existence of the state. Te legal system also requires mastery of an arcane and intentionally inaccessible vocabulary and a set of knowledge and power processes that limit ordinary people’s access to it. Te arbiters of law pretend to rely on reason but actually rely on subjective, politically motivated, culturally biased, and quasi-religious rationale for making and enforcing their decisions. CRT maintains the critique of legalistic thinking found in critical legal studies, but then adds a framework for understanding white supremacy as an immutable fact of a neocolonial state, as well as a praxis for changing it. What separates CRT from other forms of racial critique is that, “Unlike most of the earlier genres of race cholarship, critical race scholarship does not treat race as an independent variable; rather, it regards race as a site of struggle” (Orbe & Allen, 2008, p. 209).

Kamal singh

Corporate social responsibility (CSR) is a self-regulating business model that helps a company be socially accountable—to itself, its stakeholders, and the public. Reliance Foundation (RF) is a not-for-profit organization established by RIL to bring about changes in Indian society seamlessly. CSR is for the community, it is equally valuable for a company. CSR activities can help forge a stronger bond between employees and corporations, boost morale and help both employees and employers feel more connected with the world.

Vidya bhat

Parkinson’s disease is a common movement disorder associated primarily with oxidative stress-mediated degeneration of dopaminergic neurons. Earlier studies showed that Sorghum bicolor-based supplement (SbS) exhibited antioxidant and neuroprotective activities and might likely rescue the death of dopaminergic neurons in Parkinson’s disease. This study examined the effect of SbS on rotenone-induced Parkinsonian-like motor deficits in rats and the involvement of oxidative stress and pro-inflammatory cytokines. Rats were divided into six groups and treated orally with sunflower oil (vehicle-control), rotenone (2.5 mg/kg) alone or in combination with each dose of SbS (50, 100, and 200 mg/kg) and levodopa-carbidopa (10 mg/kg) on an alternate day for 28 days. The changes in motor functions were evaluated on day 28 and the brain concentrations of oxidative stress biomarkers and pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-6) were determined. Rotenone caused motor deficits by impaired locomotor activity in the open field test and induced catalepsy in the bar test, which were attenuated by SbS. Rats pretreated with SbS had reduced brain levels of malondialdehyde, nitrite, and pro-inflammatory cytokines compared to rotenone controls. SbS mitigated rotenone-induced depletion of reduced glutathione and antioxidant enzymes in the rat brain. The results suggest that SbS ameliorated rotenone-induced Parkinsonian-like motor dysfunctions by reducing neuronal oxidative stress and pro-inflammatory cytokines in rats.

Mediterranean journal of pharmacy and pharmaceutical sciences

Justificativa e objetivo: O uso inadequado da estatística básica é o maior responsável peloerro de interpretac ̧ão dos artigos científicos. O objetivo deste artigo de revisão foi rever algunstópicos básicos de estatística para alertar autores e leitores sobre a importância do relatoadequado da estatística básica.

Kamal singh

A zoonotic disease is an infectious disease caused by pathogens such as bacteria, virus, rickettsia, fungi, parasite or prion that has been transmitted from an animal, especially a vertebrate to human beings. Usually, the first infected human transmits the infectious agent to other humans very rapidly; it is one of the important concerns of zoonoses. The World Health Organization (WHO) currently list the Emerging infectious diseases (EID) of epidemic issues in their research and development blueprint as COVID-19 (Corona viruses), Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS), Ebola and Marburg viruses (Filovirus), Crimean Congo haemorrhagic fever (Nairo virus), Lassa Fever (Lassa virus), Nipah (Henipa virus ), Rift Valley fever (Phlebo virus) and Zika (Flavi virus). Due to the deadly pandemics facing by the globe, it is essential to understand the way of transmission of emerging viruses, its mode of infection and important measures to eliminate or control them from the world is essential. However, mankind overcomes so many deadly viruses with the help of scientific knowledge, through vaccination, new therapies, drugs etc. Nowadays, viral zoonoses like rabies (Lyssa virus) are 100% preventable through vaccination and medication even though, humans face lots of new threats especially emerging zoonosis diseases like Covid19. This review summarized the major zoonotic viruses affecting human beings, their source, pathogenicity and its important ways to overcome the transmission of microbes from animal to humankind.

Dr. saranya devi k

For utilization of a certain biomass it is necessary to know its chemical composition. The present study is qualitative crude chemical analyses of nutritional value (crude compounds) such as acidity, starch, carohydrates, iron and calcium etc. from stem extracts of Tinospora cardifolia, Centella asiatica, Clerodendrum inerme and leaf extract of Ocimum sanctum, Lawsonia inermis and Piper nigrum were conducted and also separate the pigments by TLC methods. The results revealed that Tinospora cardifolia, biomolecules like starch and carbohydrates were present and elements like iron and calcium were absent. In Centella asiatica indicated the absence of biomolecules like starch and carbohydrates and only one molecules, i.e., calcium is present and iron is absent. Similarly, in Clerodendrum inerme, biomolecules like starch were absent and carbohydrates were present. Both the elements iron and calcium were absent in Clerodendrum plant extracts. In Ocimum sanctum, starch is absent carbohydrates are present, iron and calcium are absent. In Lawsonia inermis, the results are similar to Ocimum sp. i.e., only carbohydrates are present remaining starch, iron and calcium are absent in Ocimum leaf extract. Interestingly, in Piper nigrum, all chemical compounds are totally absent. Related to pigments analysis highest distance travelled pigments are carotenoids (4.3 cm) in O. sanctum and highest numbers of pigments were founded in C. inerme with six pigments and least number of pigments was recorded in O. sanctum (four) and L. inermis (four). Meanwhile, the highest Rf value recorded in O. sanctum and P. nigrum with 0.97 (chlorophyll a). Among the seven pigments in six species carotenoids, chlorophyll a and xanthophylls are common to all species but chlorophyll b, lutein, anthocyanin and lawsonin are rare to occurs in these six species for example Lawsonin occur only in P. nigrum.

Veerabhadraswamy al

Poor water quality and lack of access to improved sanitation continue to pose a significant threat to human health. The burden of disease analysis suggests that lack of access to safe water supply, sanitation and hygiene is the third most significant risk factor for poor health in developing countries with high mortality rates. Diarrhoea is the leading disease associated with unsafe water supply, sanitation and hygiene and is responsible for the deaths. The study observed that out of the 150 respondents, 37% are 31-40 years, followed by 20-30 years with 32%. 130 (86.7%) respondents have got married, and 61% of the respondents are female. 85% adopted the nuclear family system, and 50% of respondents are illiterates in the study areas. 85% of respondents are daily wage earners, 37%are earnings rupees between 2000-2500 per month. 27% of respondents are landless labours, and 37% of households possess below 2 acres of land. 40% of respondents suffer from health problems, and 44% consume rice as their staple food. 62% of respondents have debts, and 33% got from money lenders. 62% of respondents do not have toilet facilities and go open defecation. 92% of respondents stated that toilet makes dignity, saves time and energy, saves their children school days, makes adolescent girls privacy, save wage loss, and toilet makes quality life.

B suresh lal

Nilai-nilai Nasionalisme yang diterapkan peserta didik dalam kegiatan pembelajaran di Madrasah Ibtidaiyah Maarif Condro Jember seringkali terkesan dikesampingkan. Hal ini dilihat dari kurangnya kesadaran peserta didik terhadap nilai moral dan Nasionalisme, seperti tidak mentaati peraturan sekolah, tidak menghargai teman, membolos, tidak mampu menghafal sila pancasila serta lagu Indonesia raya. Masih dijumpai peserta didik berperilaku dan bersikap belum baik atau masih rendah terhadap nilai-nilai nasionalisme. Penelitian ini bertujuan untuk mendeskripsikan: 1) Strategi internalisasi nilai nasionalisme pada pembelajaran PPKN di Madrasah Ibtidaiyah Maarif Condro Jember. 2) Penerapan nilai karakter nasionalisme yang dilakukan pada pembelajaran PPKN di Madrasah Ibtidaiyah Maarif Condro Jember. Hasil penelitian menunjukkan bahwa: 1) Strategi internalisasi nilai-nilai nasionalisme dalam pembelajaran PPKN ini adalah mamasukkan nilai-nilai nasionalisme dalam pembelajaran PPKN melalui pendekatan-pendekatan yang mampu diterima oleh peserta didik agar peserta didik bisa menjadi warga negara yang baik dan bisa memberikan kontribusi dalam memajukan bangsanya dimasa depan. 2) Penerapan nilai karakter nasionalisme dalam pembelajaran PPKN melalui mediator keteladanan guru dan kegiatan praktik langsung melalui pengalaman belajar seperti model pembelajaran, metode pembelajaran, bahan ajar, dan evaluasi pembelajaran. Perilaku berkarakter nasionalis yang diaktualisasikan dalam kehidupan sehari-hari di sekolah oleh siswa yaitu disiplin, cinta tanah air, semangat kebangsaan, cinta damai, peduli lingkungan, menghargai prestasi, dan toleransi.

Educare: journal of primary education

For a long time, cardiovascular diseases have been the leading cause of death worldwide. Machine learning has found significant usage in the medical field as it can find patterns in data. Classification models can help cardiologists to diagnose heart diseases and minimize misdiagnosis accurately. In this paper, we explored a dataset related to heart disease and compared the accuracy of 43 machine learning classification models. The dataset for this research was downloaded from Kaggle; it contained 1190 observations, 11 features (age, sex, chest pain type, resting blood pressure, serum cholesterol, fasting blood sugar, resting electrocardiogram results, maximum heart rate achieved, exercise induced angina, oldpeak, the slope of the peak exercise ST segment) and a binary target variable (no heart disease or observed cardiovascular disease). For data exploration, preprocessing, training, testing, and predictor importance analysis, we used MATLAB R2004a software and the Classification Learner app included in this software. Before training machine learning classification models, we divided the dataset into a training set (90% of observations) and a test set (10% of observations). To prevent overfitting during the training of classification models, 10-fold cross-validation was used. The result showed that the best accuracy was reached with an optimized ensemble classification model (validation accuracy: 0.9262 and test accuracy: 0.9580). After calculating the permutation importance of each feature, we observed that the most important feature among all 11 features was the slope of the peak exercise ST segment.

Ladislav végh

Background: Evidence has suggested that school-based physical activity programs (SBPAPs) including structured physical education, extracurricular sports, and activity-based learningenhance memory and other cognitive functions. However, evidence on whether Indian adolescents can achieve improved cognition or increased academic performance also remains scarce. This study aimed to examine the relationship between SBPAPs and academic performance among Indian adolescents. Methods: A cross-sectional, mixed study was carried out from October 2024 to March 2025 in public and private secondary schools in Haryana and Punjab, north India. A total of 300 students aged 13 to 17 years were divided into an intervention group (n = 150) who participated in structured physical activity (PA) of at least 150 minutes per week and a comparison group (n = 150) who were involved in less than 30 minutes of PA per week. Academic performance was assessed in terms of composite scores of core subjects, while the level of PA was measured using the Physical Activity Questionnaire for Adolescents. Independent samples t-tests, one-way analysis of variance (ANOVA), and Pearson’s correlation analysis were all used for quantitative data handling. Qualitative data gathered from focus group discussions and key informant interviews with a subsample (n = 30) were thematically analyzed. Results: There were no significant differences in baseline demographics between the groups (p > 0.05). Compared with the comparison group, the intervention group showed significantly higher academic scores (mean = 76.4%, SD = 7.8; mean = 70.6%, SD = 8.4) with a moderate-to-large effect size (t = 6.30, p < 0.001, d = 0.72). A one-way ANOVA found that academic performance differed significantly among PA intensity levels (F(2,297) = 19.44, p < 0.001). There was a moderate positive correlation between PA levels and academic achievement (r = 0.44, p < 0.01). Qualitative findings corroborated quantitative data, showing that physically active students displayed improved concentration, emotional regulation, and academic motivation. Conclusions: Partaking in structured SBPAPs significantly increases Indian adolescents’ academic performance. These findings imply the necessity of including physical education in the academic curriculum as a low-cost, scalable method for supporting both cognitive growth and educational achievement.

Karishma

Lateral epicondylitis, commonly known as Tennis Elbow, affects approximately 1-3% of the population. Despite the absence of histological evidence of inflammation in the affected tissue, the term “epicondylitis” implies inflammation. The Extensor Carpi Radialis Brevis (ECRB) muscle is primarily affected, and the condition is attributed to excessive use of this muscle. Non surgical treatment options, such as rest, physiotherapy, cortisone injection, platelet-based therapies, and restricted movements, are recommended. Surgical intervention is suggested for cases involving physical impairment or chronic pain. This review aims to provide healthcare professionals with an understanding of the condition, including its causes, symptoms, diagnosis, and treatment planning options.

Saran malisorn

Brilliant Grid is intended to incorporate progressed correspondence/organizing innovations into electrical power frameworks to make them ''more intelligent''. The current circumstance is that a large portion of the power outages and voltage lists could be forestalled in the event that we have better and quicker specialized gadgets and advancements for the electrical matrix. To make the flow electrical force lattice a Smart Grid, the plan and execution of another correspondence framework for the lattice are two significant fields of examination. Be that as it may, Brilliant Grid projects have just been proposed as of late and a couple of recommendations for forward-looking necessities and starting exploration work have been offered in this field. No efficient audits of correspondence/organizing in Smart Grids have been led at this point. In this manner, we direct an orderly survey of correspondence/organizing innovations in Smart Grid in this paper, including correspondence/organizing engineering, distinctive correspondence innovations that would be utilized into this design, nature of administration (QoS), upgrading the use of resources, control and the board, and so forth.

Dr.a.shaji george

Tobacco smoking negatively affects the quality of saliva and affects many biological parameters including salivary α-amylase enzyme activity. Salivary α-amylase enzyme is essential for the catabolism of carbohydrates. Forty- five healthy male volunteers aged between 18 and 69 years (40.0 ± 15.0) were divided into two groups, namely, the control group (n = 21) and the cigarette smoker group (n = 24). The effect of smoking on salivary α-amylase enzyme activity depends on the number of smoked cigarettes per day and the type of cigarettes as well as the period for how long the person smoking tobacco cigarettes was investigated. Different methods were used to analyze the activity of salivary α-amylase enzyme including the dinitrosalicylic acid method (standard colorimetric method). The results showed a significant increase (P < 0.05) in salivary α-amylase activity in Libyan smokers compared to the non-smokers in the morning and night, also, the findings showed a significant decline in salivary α-amylase activity during the increasing smoking period. The activity of salivary α-amylase in the young age smokers group increases in morning and night compared to the non-smokers group. There is no change in the activity of salivary α-amylase in the middle and older adult groups in the morning and night compared to young smokers group. In conclusion, smoking for a long period time more than 20 cigarettes per day decreases the activity of salivary α-amylase in Libyan subjects.

Mediterranean journal of pharmacy and pharmaceutical sciences

his study explored the English Language Teaching appraisal of teachers in the trifocal Philippine education system in the Bicol Region as a basis for policy and advancement programs. This study used the descriptive-comparative-associational method using a content-validated and reliability-tested questionnaire. The frequency and percentage technique, weighted mean, Chi-Square, and Anova Test of Variance were used in the data treatment. Findings revealed that ELT teachers were predominantly females with 73.97%, CHED, 80.21%, DepEd, and 71.43% TESDA along age groups of early and mid-30s and 46 years above. They served the agencies for less than 10 years, mostly married. Professionally, these teachers were still pursuing post-graduate education and attending training. Along with appraisals on their professional and work responsibility, ELT Trifocal teachers very evidently performed their professional and work responsibilities; on the delivery system, respondents conveyed the mastery and application of theoretical and pedagogical knowledge; on their communicative competencies, they were classified as experts. Meanwhile, there was no significant difference among ELT teachers’ appraisal in the three systems (F–value 2.21< t-value 3.35; 5% level of significance). It follows that Philippine education has maintained an undeviating quality of ELT teachers regardless of which system of education they belong. The result showed no variations in ELT competencies despite differences in modalities, urgencies, and the attainment of quality education. Findings also unveiled that the ELT teachers’ appraisal and integration of ICT to language teaching are directly associated with their age, sex and civil status, and educational attainment. The higher the educational attainment, the higher the integration of ICT in language teaching. With these results, a policy development for the Professional Advancement Program in ELT was crafted.

Darrel ocampo

Jobelyn® is a multi-functional natural dietary supplement made from Sorghum bicolour with very high anti-oxidant and anti-inflammatory capacities. The study investigated the role of Jobelyn® in the attenuation of oxido-inflammatory markers induced by tramadol use, abuse and discontinuation over 17 days in rats. The experimental observational study was carried out using male adult albino rats weighing between 100 and 170 g. The experimental design involved five groups. Rats were randomly divided into groups of five, consisting of group 1 (normal control rats), and group 2 (rats treated with tramadol at 40 mg/kg/day) were administered for 10 days and discontinued for seven days. Group 3 administered incremental doses of tramadol from 40 mg/kg/day to 100 mg/kg/day over 10 days and discontinued for seven days. A similar treatment protocol was administered for group 4 and group 5 but were treated with Jobelyn® at a dose of 200 mg/kg/day at the discontinuation phases for seven days. Behavioral assessments (elevated plus maze model of anxiety and open field model of locomotor activity) and biomarkers of oxido-inflammatory stress were assessed. Tramadol-treated groups had significant anxiety responses and locomotory deficits in comparison to the control group. Tramadol-treated groups had significant elevations of nitrites and malondehyde and reduced enzymatic markers such as catalase, glutathione, reduced glutathione, superoxide dismutase, G-s-transferase, glutamic acid decarboxylase and increased activity of acetylcholinesterase when compared to control group. Administration of Jobelyn® attenuated the responses and ameliorated the oxido-inflammatory biomarkers similar to levels in control group. Tramadol induces oxido-inflammatory stress markers in the prefrontal, striatum and hippocampus in rats. Anxiety and locomotory behavioral actions on tramadol treatment were elevated despite discontinuation for seven days. Thus, Jobelyn® at 200 mg/kg/day ameliorated oxido-inflammatory markers induced by tramadol and decreased anxiety responses in albino rats.

Mediterranean journal of pharmacy and pharmaceutical sciences