Good prescription writing is essential for dispensing the right drug formulation and dose. When prescriptions are not legible, inaccurate and do not include complete information, there is a possibility of prescribing errors occurring, which leads to adverse events. Poor handwriting is another important issue that makes the information unclear; especially look-alike drug names that may be confused by the pharmacist. World Health Organization has issued a practical manual for Good Prescribing that includes the essential information that should be included in a prescription. In this study, we attempt to investigate the problem of bad prescribing habits in out-patient prescriptions in Benghazi, Libya. Two hundred seventy-five out-patient prescriptions were collected from two private pharmacies on four consecutive days. These prescriptions were scanned for any errors or missing information depending on the standard criteria established by World Health Organization in its practical manual "Guide to Good prescribing". The collected data were processed and statistically analyzed by using SSPSS to calculate the percentage of missing information. Eleven percent (11.0%) of the prescriptions had no address or name of the prescriber on them while 58.0% had no date written on them and in 21.0% the prescriber did not sign the prescription. The age of the patient was only written on 38.0% of the prescriptions. The name of the medication was not clearly written in 18.0% of the prescriptions, while the dosage form of the medication was not written at all in 18.0% and not clearly written in 20.0% of the prescriptions. The total amount of the prescribed drug was not written in 30.0% of the prescriptions. It is to conclude that prescribers included in this study wrote prescriptions with a lot of missing and unclear information as per WHO guidelines for a good prescribing. This shows the weak attitude of Libyan prescribers toward the different aspects of “Good Prescribing”.

Mediterranean journal of pharmacy and pharmaceutical sciences

A simple, rapid, sensitive reversed-phase high-performance liquid chromatography method was developed and validated for simultaneous measurement of albendazole and praziquantel with an internal standard, simvastatin, at single wavelength of 225 nm. Chromatographic separation was performed on an Enable C18 column (250 mm × 4.6 mm, 5 μm: Spinco Biotech Pvt Ltd) and a mobile phase consisting of acetonitrile:water (60:40, v/v) with 10% orthophosphoric acid to adjust the pH to 3.2, at a flow rate of 1.0 ml/min. The calibration curve was linear (r2 ≥ 0.999) over the concentration range 0.05–8.0 μg/ml. The concentrations of simvastatin was 1.0 μg/ml. The limit of quantification was 0.05 μg/ml for both albendazole and praziquantel. No interference was found by the excipients in the synthetic mixture. The proposed methods were validated as per International Conference on Harmonisation guidelines for linearity, accuracy, precision and robustness for estimation of albendazole and praziquantel in bulk and in a synthetic mixture, and the results were found to be satisfactory.

Prasanna pradhan

This review was aimed to describe a new approach of healthcare performance strategy based on individual genetic variants. Personalized medicine is a model for health care which is a combination of preventive, personalized, participatory and predictive measures. It is an approach for a better treatment by identifying the disease causing genomics makeup of an individual. This work features key advancements in the improvement of empowering advances that further the objective of customized and precision medication and the remaining difficulties that, when tended to, may produce phenomenal abilities in acknowledging genuinely individualized patient consideration. Customized treatment for patients determined to have strong tumors has brought about a few advances as of late. To improve a multi-drug approach ready to coordinate DNA and RNA adjustment, proteomics and metabolomics will be essential. The execution of translational examinations dependent on fluid biopsy and organoids or xenografts to assess molecular changes because of clonal weight produced because of the utilization of target specialists or tumor heterogeneity would help in the recognition of systems of opposition, proposing opportunities for novel mixes. The investigation of massive data in oncology can profit altogether from being engaged by artificial intelligence and machine learning strategies.

Mediterranean journal of pharmacy and pharmaceutical sciences

Cet article s’articule autour de la question de la satire chez Sony Labou Tansi dans La vie et demie. Conscient de la complexité de la notion de la satire dans le temps et chez les spécialistes, il nous a semblé judicieux de confiner notre étude dans le strict cadre de la satire entendue comme genre et non comme esprit ou mode. Nous avons démontré que la satire dans La vie et demie se justifie par la présence des topiques qui fonctionnent comme une signature du genre. L’argumentation a mis un accent sur la dimension rhétorique de la satire en parlant des formes de comique mises en place dans La vie et demie, lesquels participent à l’étayage de la satire politique du Guide providentiel et de ses nuisibles descendants. Aussi, avons-nous souligné que la dimension rhétorique de la satire se justifie par la présence de la ménagerie. L ’imagerie animale qui permet de caractériser les personnages de Sony Labou Tansi emprunte à la faune sauvage sa diversité des bêtes.

Assanvo

Background: This manuscript presents an audit focused on assessing the extent of drug wastage and associated costs linked to the disposal of unused intravenous agents within the operating theatres of a tertiary care hospital. The study aims to carefully look at drug wastage, figure out why it happens, and propose strategies for optimizing resource utilization and cost-efficiency in clinical settings. Materials and Methods: This audit is a prospective observational study carried out in a tertiary care hospital. The amount of drug loaded preoperatively, the amount of drug utilized, the amount of drug unutilized and discarded, the total quantity of drug wasted, and the cost related to the wastage were calculated in percentage. Results: The maximum wastage of loaded drugs was seen with atropine (100%), followed by ephedrine (93.6%), propofol (52.5%), phenylephrine (35.2%), atracurium (28.6%), dexmedetomidine (27.8%), fentanyl (16.8%), vecuronium (16.2%) and morphine (6.4%). The cost analysis revealed that 36.3% of the total loaded drugs were wasted amounting to Rs.46903.54. The cost of wastage of propofol was maximum with Rs.14006 which is 29.8% of total cost wastage followed by atracurium 21%(Rs.9856), dexmedetomidine 18.4%(Rs.8687.5), ephedrine 14.7%(Rs.6919), phenylephrine 10.4%(Rs.4910), fentanyl 3.7%(Rs.1780), atropine 1.9% (Rs.906), vecuronium 1.2% (Rs.563.76), Morphine 0.18% (Rs.85.28). Conclusion: In our audit, the maximum drug wastage was observed with atropine (100%) amounting to Rs.906, and the cost of wastage was maximum with propofol amounting to Rs.14006 which was 29.8% of the total cost of wastage. Our audit underscores the importance of proactive management of drug wastage and disposal costs in healthcare settings, particularly within operating theatres where intravenous agents play a crucial role in patient treatment. By conducting a comprehensive audit and proposing targeted interventions, healthcare institutions can optimize resource utilization, enhance sustainability, and ultimately improve patient outcomes.

Kamal singh

Background and Objectives: Research by medical students in Yemen is limited both in terms of quantity and quality. In this light, the early recruitment of medical students into research activities can encourage them to become academically adept and professionally renowned physicians. Therefore, the aim of this study was to evaluate the knowledge, attitudes, and obstacles regarding medical research among medical undergraduates in the Faculty of Medicine and Health Sciences, Ibb University, Yemen. Materials and Methods: For the purpose of this study, a cross-sectional survey was conducted among medical students at the Faculty of Medicine and Health Sciences, Ibb University, Yemen. This survey involved medical students at their 3rd, 4th, 5th, and 6th academic years, who participated in this study from August 01, 2022, to September 30, 2022. The permission to conduct the survey was obtained from the Dean of the Faculty of Medicine and Health Sciences, Ibb University. The data gathered from the survey were analyzed using descriptive statistics. Results: About 174 (92.6%) respondents completed the survey questionnaire. The mean age of these respondents was 23.34 years. Notably, most of them demonstrated low levels of concomitant knowledge despite having positive attitudes toward medical research. Only a few students agreed with the following statements in the questionnaire: there is allotted time to pursue research (14.9% agreed); there is adequate training in research methodology (12.1% agreed); there are sufficient reward/motivations for participation in research (9.2% agreed); there is adequate training on writing a manuscript (9.2% agreed); there is adequate training on the performance of simple statistical analysis (10.4% agreed); research mentors are readily available (16.6% agreed); and it is easy to obtain a permit to conduct research from an institution (20.7% agreed). In addition, less than half of the respondents agreed with the statement that adequate medical research facilities exist in Yemen (39.1%). Conclusion: Most of the respondents in this study showed low levels of knowledge regarding research, despite having positive attitudes toward it. The primary barriers hindering research practices were the following: lack of allotted time to pursue research, lack of adequate training on writing a manuscript, and lack of training on the performance of simple statistical analysis. Moreover, the survey respondents noted a lack of research mentors and difficulties in getting approval for conducting research from their institution.

Karishma

Pneumonia is an acute pulmonary infection that can be caused by bacteria, viruses, or fungi. It infects the lungs, causing inflammation of the air sacs and pleural effusion: a condition in which the lung is filled with fluid. The diagnosis of pneumonia is tasking as it requires a review of Chest X-ray (CXR) by specialists, laboratory tests, vital signs, and clinical history. Utilizing CXR is an important pneumonia diagnostic method for the evaluation of the airways, pulmonary parenchyma, and vessels, chest walls among others. It can also be used to show changes in the lungs caused by pneumonia. This study aims to employ transfer learning, and ensemble approach to help in the detection of viral pneumonia in chest radiographs. The transfer learning model used was Inception network, ResNet-50, and InceptionResNetv2. With the help of our research, we were able to show how well the ensemble technique, which uses InceptionResNetv2 and the utilization of the Non-local Means Denoising algorithm, works. By utilizing these techniques, we have significantly increased the accuracy of pneumonia classification, opening the door for better diagnostic abilities and patient care. For objective labeling, we obtained a selection of patient chest X-ray images. In this work, the model was assessed using state-of-the-art metrics such as accuracy, sensitivity, and specificity. From the statistical analysis and scikit learn python analysis, the accuracy of the ResNet-50 model was 84%, the accuracy of the inception model was 91% and lastly, the accuracy of the InceptionResNetv2 model was 96%.

Dr. chandrashekhar uppin

Hydatidosis is a parasitic zoonosis caused by the larval form of Echinococcus granulosus, endemic in the Mediterranean basin, the Middle East, and South America. [1] While this pathology primarily affects the liver (50-70%) and lungs (20-30%), [2] vesicular localization is exceptionally rare, representing merely 0.1% of all hydatid localizations. [3] This rarity significantly complicates preoperative diagnosis, often leading to intraoperative discovery.

Karishma

Cyperus esculentus (tiger nut) seed is the parent of many products like flour, milk, starch, and oil. All these share similar and sometimes better properties when compared to similar products obtained from other sources. This study aimed to produce and characterize a cream made from oil extracted from tiger nuts. The proximate analysis was tested by the established methods and data obtained show that tiger nut powder has a moisture content (14.50%), an ash (1.98%), a fat (51.27%), a protein (8.47%), fiber (13.94%) and carbohydrate (9.98%). The oil from the tiger nut was extracted using the hot press method, the tiger nut oil had an 8.00% yield. The oil was used to produce a body cream which was characterized and tested for its antibacterial activity. Its antibacterial activity showed inhibition against Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, and Pseudomona aeruginosa. The characterization tests gave results of 1735.80 cP for viscosity, moisture content (1.07%), pH of 6.10, ash (5.11%), volatile matter (94.89%), electrical conductivity (390 µS/cm), spreadability at 30oC was 145.28 g.cm/s, at 35oC was 149.41 g.cm/s and 152.25 g.cm/s at 40oC. The cream was checked for stability and found to be stable at different temperatures. It was checked for allergens and it exhibited some level of allergic reactions. Physicochemical analysis of the golden-brown oil indicated the specific gravity (0.98), density (0.98 g/ml), acid value (1.82 mg/KOH/g), iodine (37.75 mg), peroxide (2.00 meq/kg), saponification (236.32 mg/KOH/g), free fatty acid (0.91%) and refractive index (1.46). The GC-MS analysis identified a total of 22 compounds. Oil, with the major constituents being palmitic acid (13.70%), oleic acid (18.50%), oleamide (31.25%), acexamic acid (4.68%), stearic acid (2.99%), squalene (2.87%) by composition. The study reveals that oil from tiger nut seed is useful when applied in the production of body creams and has possible uses in the production of antibacterial ointments.

Mediterranean journal of pharmacy and pharmaceutical sciences

The methanol extract of the whole alga Hypnea pannosa J. Agardh was subjected to antifungal screening. It showed low activity against Aspergillus flavus Link ex Gray 1821.

Dr. salman ahmed

This study aims to see and determine the effect of transformational leadership and competence of PT Waruna Shipyard Indonesia on employee performance through job satisfaction as intervening variable. This research was conducted at PT. Waruna Shipyard Indonesia, located on Bagan Deli Street, Medan Belawan District, North Sumatra. This research was conducted of the month of August 2019-January 2020. The data analysis tool by structural equation modeling (SEM) with smartpls program. The population is employees at PT. Waruna Shipyard Indonesia in 2019, namely as many as 134 employees. This study used slovin formula for the sampling, calculations sample were respondents is 100 permanent employees of PT. Waruna Shipyard Indonesia. Thus taken 30 respondents outside of the sample to validity and reliability test instrument for testing questionnaires. Based on structural equation modeling (SEM) analysis, transformational leadership and competence have positive and significant effect on employee performance with job satisfaction as intervening variable at PT. Waruna Shipyard Indonesia. The contribution of transformational leadership, competence, and job satisfaction explains the employee performance variable of 0.724 or 72.40%. The remaining 0.276 or 27.60% is effect by other independent variables not examined in this study.

L

Bhaishajya kalpana is an art and science of preparing and dispencing medicine. Guggulu is a Niryasa (oily latex) achieved from small tree called Indian bedellium. Botanical name is commiphora mukul. Guggulu is an amorphous, translucent, solid adhesive, oleo-gum resin is produced by the process of gummosis from its plant. Many other Ayurvedic classics have mentioned various formulations of Guggulu for the treatment of various ailments. Bhashajya ratnawali followed various kalpana use for formuations. Guggulu kalpana is secondary formulations of bhaishajya kalpana. . Guggulu is one among the best binding agents and its used as single or compound drug in the form of pills, Formulations which contains Guggulu as main ingredient, they can be called as Guggulu kalpana. Here in Bhaishajya Ratnawali, Guggulu is used in yoga for both purposes, as a base and as well as medicament also.In bhaishajya Ratnavali Guggulu when modified into different formulations. It can also be used in many diseases along with different combinations of drugs with their anupana, Guggulu kalpana beneficial in treating many diseases. The Guggulu Kalpana is indicated in almost all the strotovikaras and also a number of research works have been proved the wide range of action of Guggulu .

Suri abhiram

Chronic kidney disease is a public health problem affecting people worldwide. This study was aimed to examine the characteristics of patients with chronic kidney disease and to identify prevalence of drug-related problems among Libyan patients. This is a descriptive retrospective study carried out in Southern-west part of Libya, Sebha City. Information abstraction forms were used for collection of data. The investigators reviewed the medications, medical records and laboratory data to identify drug-related problems.1 000 patients' files during 2019-2020 were examined and only 120 files were selected for this study. The majority of the participants were male (73, 61.0%) and the mean age was 56.1 years. 576 comorbidities among the selected patients were identified (73.61%) and the average number per patients was 4.8 concurrent diseases. There were 1 350 medications prescribed and the average of prescribed drugs per patient was 11.25. The majority of patients use more than 10 drugs (64, 53.3%) and the average length of staying in the hospital was 5.58 days. 502 drug-related problems were identified with an average of 4.18 per patient. Untreated conditions such as Hyponatremia and anemia were the highest rate of drug-related problems identified (199, 39.6%) followed by improper drug selection (82, 16.3%) such as cefotaxime, vancomycin and aminoglycoside for chronic kidney disease and drug use without indications such as antibiotics (68, 13.5%) and over-therapeutic dose such as metoclopramide(63, 12.5%). In conclusion, all the patients have polypharmacy and the majority have comorbid conditions and chronic kidney disease with frequent drug-related problems, thus, to lower the incidence rate of drug-related problems, therapeutic interventions are needed. Subsequently, it is a crucial to involve clinical pharmacist in hospital to improve the care of patient with chronic kidney disease.

Mediterranean journal of pharmacy and pharmaceutical sciences

Tuberculosis is communicable disease which is common and often deadly infectious disease caused by mycobacterium tuberculosis. Tuberculosis continues to be a major public health problem in the world. The aim of this study is to assess prevalence and associated risk factors of pulmonary tuberculosis. Treatment and development of multidrug-resistant tuberculosis were also considered. Drugs for Pulmonary tuberculosis confirmed cases used in calculating tuberculosis prevalence in Libya which is obtained from archive department of Abu Seta Hospital. Data obtained from 427 files during 2019 determine the incidence and epidemiology of tuberculosis in Libya. For a total of 427 confirmed cases of pulmonary tuberculosis, about 75.0% of the cases were male and most of the patients (55.0%) were within the age group of 20 - 40 years old. Of the study patients, 114 patients (26.7%) were viral infected and most of the viral infected cases were in the age group of 20 - 40 years and the majority of this age group patients (n = 41, 53.2%) were infected with HIV/HCV, while the least percentage in this group age were infected with HIV/HBsAg (01.3%). Among 427 cases, 73 cases (17.1%) were comorbid with other chronic diseases. Of the 73 cases, 54 cases (74.0%) were diabetes mellitus whereas only 1.4% of them had bronchial asthma, Parkinsonism and renal failure. The drug therapy of active tuberculosis disease needs combination chemotherapy to escape the selection of naturally occurring drug-resistant mutants. Amongst current anti tuberculosis drugs, the rifamycins hold the highest potential for shortening treatment and improving effects. Prevalence of smear positive tuberculosis and bacteriologically confirmed that a high rate of tuberculosis among unemployed population. This study reported that the highest incidence rate is found in people who are smokers.

Mediterranean journal of pharmacy and pharmaceutical sciences

This mathematical model forms machine cells, optimises the costs of unassigned machines and components, and designs the shop floor cell layout to have minimal movement of materials. The complete similarity measure algorithm forms machine cells and part families in a refined form. Later, exceptional elements are eliminated in the optimisation model by using machine duplication and sub-contracting of parts. Then the shop floor layout is designed to have optimised material movements between and within cells. An evaluation of the cell formation algorithm’ performance is done on the benchmark problems of various batch sizes to reveal the process’s capability compared with other similar methods. The data of machining times are acquired and tabulated in a part incidence matrix, which is used as input for the algorithm. The results from the linear programming optimisation model are that costs are saved, machines are duplicated, parts are sub-contracted, and there are inter- and intra-cellular movements. Finally, the output of the inbound facility design is the floor layout, which has machine cell clusters within the optimised floor area.

S ramesh

Alzheimer Disease is a chronic neurological brain disease. Early diagnosis of Alzheimer illness may the prevent the occurrence of memory cellular injury. Neuropsychological tests are commonly used to diagnose Alzheimer’s disease. The above technique, has a limited specificity and sensitivity. This article suggests solutions to this issue an early diagnosis model of Alzheimer’s disease based on a hybrid meta-heuristic with a multi-feed-forward neural network. The proposed Alzheimer’s disease detection model includes four major phases: pre-processing, feature extraction, feature selection and classification (disease detection). Initially, the collected raw data is pre-processed using the SPMN12 package of MATLAB. Then, from the pre-processed data, the statistical features (mean, median and standard deviation) and DWT are extracted. Then, from the extracted features, the optimal features are selected using the new Hybrid Sine cosine firefly (HSCAFA). This HSCAFA is a conceptual improvement of standard since cosine optimization and firefly optimization algorithm, respectively. Finally, the disease detection is accomplished via the new regression- based multi-faith neighbors’ network (MFNN). The final detected outcome is acquired from regression-based MFNN. The proposed methodology is performed on the PYTHON platform and the performances are evaluated by the matrices such as precision, recall, and accuracy.

Dr. rajasekhar butta

During the last few years, the pharmacy profession has expand significantly in terms of professional services delivery and now has been recognized as an important profession in the multidisciplinary provision of health care. The paper highlights the current scenario The Pharmacy profession in health care system. Pharmacist is a backbone that strengthens to health care system. Different roles of Pharmacist in different sectors of pharmacy profession like Industrial, academic s, community health, clinical research, drug design and discovery, developing NDDS etc. In nutshell pharmacist play an integral part of health care system. “Physician gives medicine to the patients but life to medicine given by pharmacist”

Kamal singh

Financial literacy education is a lifelong asset that every individual needs to function and fit well in modern-day society. It provides the financially savvy better decision making, best investment alternatives and family wellbeing. Unfortunately, most consumers especially in this part of our world appear relatively less active and less confident in participating meaningfully in the financial sector due to a lack of knowledge about the complex nature of financial products and services and indeed the risk that goes with them. As a contribution in addressing this problem, this study looked at financial literacy education and its implication on the economic and social life of the teacher in the Upper East Region of Ghana. With a descriptive survey design, 118 participants responded to questionnaires. Results showed low levels of financial literacy among participants which can negatively affect their daily financial management. It is therefore definite that the financially literate has the advantage to undertake prudent alternative investment decisions and is able to make informed retirement planning. Being financially illiterate adversely affects one’s life in relation to the culture of savings, expenditure pattern, investment decisions and budgeting skills, making the individual economically insecure. The study has policy frontier implications; policymakers in the financial sector, governments, non-governmental organisations and equity owners are encouraged to come to the aid of consumers, especially teachers, by way of introducing professional teacher development programmes specifically tailored at uplifting their financial literacy knowledge and skills.

Juabin matey

Self-medication with antibiotics is becoming a trend that threats the health systems worldwide through developing bacterial resistance which is associated with high health care costs and increased rate of morbidity and mortality. The main objective of this study is to assess antibiotic self-medication practice among Libyan university pharmacy students. This is a cross-sectional study conducted among pharmacy students at Sabratha University in the western region of Libya. A validated questionnaire was used to collect relevant data which were statistically analyzed. A total of 170 undergraduate Pharmacy students participated in the study during spring 2021. About 80% of the participants reported the use of antibiotics without consulting a physician. The major reason for using antibiotics was to get a quick relief of emergency conditions which was reported by 35% of the students. About 25% of the students used antibiotics to relieve their pains and aches. The most commonly used antibiotic was amoxicillin (55%). Most antibiotics were obtained over the counter from community pharmacies (85%). Half of the participants were not sure if they can advise patients to use antibiotics without a prescription, although 60% of them believed that it was good practice. In conclusion, prevalence of antibiotic self-medication among university pharmacy undergraduate students is high. Thus, serious interventions are required to ensure safe and effective use of antibiotics among the population in Libya.

Mediterranean journal of pharmacy and pharmaceutical sciences

Rasa aushadhis are known for their uniqueness in curing the diseases with a very low dosage. These formulations are divided into two types based on their mode of preparation i.e., Single drug and Compound drug formulations. Based on their origin, the drugs are divided into three types, Herbal, Mineral and Animal. Any of these two or three together is combined to make a compound formulation. Apart from these, the other major factor which is needed for a formulation is the Rasa Panchaka of a Drug. Many of the formulations are being prepared based on their availability, keeping their Rasa Panchaka and Samprapti vighatana in mind. These formulations are designed in such a way that two or more drugs will be having one common quality, or Opposite Qualities or an Antidote of a particular Vishadravya, which can help in curing the disease. So an attempt is made to Review Tribhuvanakeerti Rasa with its Probable mode of action.

Suri abhiram