Poor water quality and lack of access to improved sanitation continue to pose a significant threat to human health. The burden of disease analysis suggests that lack of access to safe water supply, sanitation and hygiene is the third most significant risk factor for poor health in developing countries with high mortality rates. Diarrhoea is the leading disease associated with unsafe water supply, sanitation and hygiene and is responsible for the deaths. The study observed that out of the 150 respondents, 37% are 31-40 years, followed by 20-30 years with 32%. 130 (86.7%) respondents have got married, and 61% of the respondents are female. 85% adopted the nuclear family system, and 50% of respondents are illiterates in the study areas. 85% of respondents are daily wage earners, 37%are earnings rupees between 2000-2500 per month. 27% of respondents are landless labours, and 37% of households possess below 2 acres of land. 40% of respondents suffer from health problems, and 44% consume rice as their staple food. 62% of respondents have debts, and 33% got from money lenders. 62% of respondents do not have toilet facilities and go open defecation. 92% of respondents stated that toilet makes dignity, saves time and energy, saves their children school days, makes adolescent girls privacy, save wage loss, and toilet makes quality life.

B suresh lal

Right of entry to finance, especially by the poor and susceptible groups, is an essential indispensable for employment, economic development, poverty mitigation and social up-liftment. Here lies the importance of financial inclusion. Financial inclusion or inclusive financing is the deliverance of financial services at affordable costs to sections of disadvantaged and low income segments of the society. The Government of India has taken a number of initiatives so that the banks can serve the poor in a hassle-free manner. With a view to spreading the services to poor and weak groups Andhra Bank plays a vital role in financial inclusion. Keeping this view, the authors have attempted to discuss the role of Andhra Bank towards Financial Inclusion as the main purpose of this paper. It also analyses the performance of the Andhra Bank in terms of its deposits, advances, income, expenditure, profitability etc..

Dr tatayya bommali

Strain improvement studies were conducted for the production of L-asparaginase from a marine fungus Beauveriabassiana SS18/14 by employing physical and chemical mutagens, in a systemic manner to obtain mutants that have higher L-asparaginase production. The wild strain produced 6.32 IU/mL of L-asparaginase activity while the UV mutant UVF-4 yielded 8.34 IU/mL and nitrous acid mutant UVF4-N-2 exhibited 10.44 IU/mL enzyme activity. The overall strain improvement programme increased L-asparaginase activity 1.65 times with respect to the parent wild strain.

Dr.p.v.kamala kumari

Geotextiles have been successfully used for reinforcement of soils to improve the bearing capacity. In this study geotextile as a tensional material have been used for reinforcement of granular soils. Laboratory California Bearing Ratio (CBR) tests were performed to investigate the load-penetration behavior of reinforced soils with geotextile. Samples of granular soil are selected and tested without reinforcement. Then CBR tests were performed by placing geotextile in one or two layers at various depths in soil sample. The effect of the number of geotextile on the increase in bearing capacity of reinforced granular soil is discussed.

Mayura

Vietnam, in many ways, remains a Confucian nation. The Confucian heritage touches many aspects of people’s lives. In this context, homosexuals do not face severe punishments, but face social stigma or public misunderstanding. Same-Sex Marriage is also not accepted because of limited legal support. Therefore, there is a need to study attitudes towards same-sex marriage in Vietnam. The purpose of this article was to validate a Vietnamses version of the Attitudes Toward Same-Sex Marriage Scale (ATSM) designed by Pearl & Galupo (2007) in a Vietnamese population. The sample in this study was 570 students from six universities in Ho Chi Minh City, Vietnam. The data collection method used was face-to-face questionnaire. Students completed the Attitudes Toward Same-Sex Marriage Scale and other variables in the questionnaire. The respondent’s characteristics also explored through the survey include: gender, what year students are from, religion of the students, what region students are from and their ethnicity. The study found the Vietnamese translation of the ATSM scale both reliable and valid and suitable for research use.

Le minh tien

Background: Breast cancer is a commonly found malignancy worldwide in women, and effective treatment is regarded as a substantial clinical challenge even in the presence of several options. Extensive literature is available that demonstrates polyphenols, the richly introduced phytopharmaceuticals, as anticancer agents. Among these polyphenols, resveratrol, silibinin, quercetin, genistein, and curcumin are reported to have tremendous potential against breast cancer. However, till now, no comprehensive survey has been found about the anticarcinogenic properties of luteolin against breast cancer. Scope and approach: This review targeted the available literature on luteolin in the treatment of breast cancer, its effects in combination with other anticancer drugs, and possible mechanisms. Key findings and conclusion: Lutein's outstanding therapeutic potential in the treatment of breast cancer has been recorded not just as a chemopreventive and chemotherapeutic agent but also complemented by its synergistic effects with other anti-cancer therapies such as cyclophosphamide, doxorubicin, and NSAIDs such as celecoxib and possible underlying mechanisms. Ideally, this review will open new dimensions for luteolin as an effective and safe therapeutic agent in diminishing breast cancer.

Dr. salman ahmed

Environmental factors are known to influence carcinogenesis. Pollutants, such as heterocyclic amines (HAs) and polycyclic aromatic hydrocarbons (PAHs) are examples of environmental borne procarcinogens. Procarcinogens are not active carcinogens although, they require bio-activation, via enzymes such as cytochrome P450 (CYP) to transform to active product. CYP1A1 isoform, regulated by aryl hydrocarbon receptor (AhR) plays a significant role in the bio-activation of PAHs and HAs. AhR has multiple co-activators and co-repressors for AhR that have been identified S remarkably. Silencing mediator for retinoid and thyroid hormone receptors (SMRT) was designated as a major co-repressor for AhR. In the present study, it is examined the effect of SMRT over expression on the cyp1a1 mRNA levels in murine hepatoma Hepa 1c1c7 cell line. Hepa 1c1c7 cells were maintained in Dulbecco’s Modified Eagle Medium (DMEM) and competent cells have successfully been produced using calcium chloride method. Cells were transformed using plasmid DNA and Lipofectamine. TCDD (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin) was employed as an inducing agent for CYP1A1. The total cellular RNA was isolated and real-time PCR of Cyp1a1 was conducted. A statistical analysis was conducted by using one-way analysis of variance followed by Student-Newman-Keuls test. The results showed that cells transfected with the co-repressor SMRT has lower TCDD-mediated induction of cyp1a1 mRNA without affecting constitutive Cyp1a1 mRNA levels, i.e., SMRT was able to significantly decrease inducible Cyp1a1 mRNA levels in Hepa 1c1c7 cells. The present findings also demonstrated that calcium chloride is a convenient method for routine transformation. Thus, this study opens a new avenue for the management of carcinogenesis involving CYP1A1 inducing carcinogens.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background: Avicenna, as the Persian physician, made a significant contribution to the field of medical sciences, especially surgery, in the 10th and 11th centuries AD. Methods: In the present paper, Avicenna's translated quoted words were shared about his surgical practice. Indexing databases of PubMed and Google Scholar were searched using keywords like Avicenna, surgery, and anesthesiology to find related papers and documents. Results: The first portion comprises some of the most commonly used simple and compound herbal preparations to produce general and local anaesthetics before the surgery and as dental anaesthetic agents. In the second portion, practices regarding surgical management for skull fractures, spinal trauma, bone fractures, cataracts, incurable urinary retention, bladder calculi, haemorrhoids, cancer, as well as endotracheal intubation and tracheostomy, have also been incorporated. Finally, it ends up with practices regarding the use of natural products as postoperative dressing for traumatic and surgical wounds and after cataract surgery. Conclusion: Based on the recent investigations, the findings of this review study will provide a brief insight into Avicenna’s Canon of Medicine and the sciences of anesthesiology and surgery.

Dr. salman ahmed

A burning sensation on eating spicy foods purportedly supports the role of capsaicin, an active component of chili peppers, in the etiology of oral submucous fibrosis (OSF). Although the mast cell mediators and activated P2X receptors induce a constant burning sensation through an ATP-dependent mechanism, it is the activation of the transient receptor potential vanilloid 1 (TRPV-1) receptor by capsaicin that aggravates it. The molecular basis for the burning pain in OSF is thus attributable to the activation of TRPV1. There is overwhelming evidence that confirms capsaicin has more of a protective role in attenuating fibrosis and is potentially therapeutic in reversing conditions linked to collagen accumulation. The activation of TRPV-1 by capsaicin increases intracellular calcium ([Ca2+]i), upregulates AMP-activated protein kinase (AMPK) and Sirtuin-1 (SIRT-1), to enrich endothelium-dependent vasodilation via endothelial nitric oxide synthase (eNOS). The induction of vasodilation induces antifibrotic effects by alleviating hypoxia. The antifibrotic effects of capsaicin are mediated through the upregulation of antioxidant enzymes, downregulation of inflammatory genes and suppression of new collagen fibril formation. Capsaicin also demonstrates an anticarcinogenic effect by upregulating the cytotoxic T cells and downregulating regulatory T cells through the inhibition of angiogenesis and promotion of apoptosis. Judicious administration of capsaicin with an appropriate delivery mechanism may have therapeutic benefits in reducing pain sensation, rendering antifibrotic effects, and preventing the malignant transformation of OSF. This paper provides an overview of the molecular basis of capsaicin and its therapeutic application as an antifibrotic and anticarcinogenic agent for the treatment of OSF

Mohit sharma

Undergraduate students’ attitudes towards Artificial Intelligence (AI) in developing countries like Vietnam are rarely explored despite AI’s increasing presence in higher education. This study aims to investigate the attitudes of undergraduate students towards AI. A quantitative research method was used, involving a self-reported survey questionnaire. The sample consisted of 460 undergraduate students (196 males and 264 females) from five public and private universities in Ho Chi Minh City, Vietnam. Data collection took place through a cross-sectional survey in November and December 2023. The General Attitudes Towards Artificial Intelligence Scale (GAAIS), originally developed and validated in English by Schepman and Rodway (2020), was adapted to Vietnamese for this study. The scale comprised 20 items to evaluate students’ attitudes towards AI. Data analysis included descriptive statistics, Cronbach’s alpha coefficient, t-tests, and one-way Analysis of Variance (ANOVA). The results indicated a Cronbach’s Alpha value of 0.705 for the total variable, demonstrating acceptable reliability. Consequently, Vietnamese undergraduate students displayed moderately positive attitudes towards AI. The findings also revealed no significant difference in attitudes based on gender, but there was a notable variation based on the student’s year of study at university.

Le minh tien

Three commonly used legumes, Macrotyloma uniflorum (Lam.) Verdc., Phaseolus lunatus Linn., and Phaseolus vulgaris Linn. were subjected to determine their minerals and phytic acid contents to correlate their nutritional and medicinal properties. The atomic absorption spectroscopic method was used to quantify essential minerals, while the spectrophotometric method was used for phytic acid estimation. Fe, Mg, Mn, P and Zn were recorded in reasonable quantities, Ca and Cu in moderate, and K in small amounts in the seed flours of all the three tested legumes. Maximum Fe and Zn content (0.38 and 0.40 mg/g) were recorded in P. vulgaris, while M. uniflorum delivered high content of Mg, Mn, P and Ca (0.21, 0.20, 77.94 and 0.04 mg/g) and 0.04 mg/g Cu was recorded in P. lunatus. The highest level of phytic acid (37.00 mg/g) was recorded in M. uniflorum at 519 nm. The estimated quantities of minerals and phytic acid provide an excellent opportunity to conclude that all three tested legumes could be used as food to achieve nutritional and health-related functional benefits.

Dr. salman ahmed

Digital data is growing enormously as the year passes and therefore there is a need of mechanism to protect the digital contents. Image watermarking is one of the important tools for the human to provide copyright protection and authorship. For achieving the ideal balance between imperceptibility and robustness, a robust blind color image watermarking employing deep artificial neural networks (DANN), LWT and the YIQ color model has been presented. In the suggested watermarking method, an original 512-bit watermark is applied for testing and a randomly generated watermark of the same length is used for training. PCA is used to extract 10 statistical features with significant values out of 18 statistical features, and binary classification is used to extract watermarks here. For the four images Lena, Peppers, Mandril, and Jet, it displays an average imperceptibility of 52.48 dB. For the threshold value of 0.3, it does an excellent job of achieving good balance between robustness and imperceptibility. Except for the gaussian noise, rotation, and average filtering attacks, it also demonstrates good robustness against common image attacks. The results of the experiment demonstrate that the suggested watermarking method outperforms competing methods.

Manoj kumar pandey

A 28-year-old female presented with recurrent chronic abdominal pain. An abdominal ultrasound revealed cholelithiasis, characterized by two large stones and several smaller ones. Laboratory tests including liver function tests were within normal limits. A laparoscopic cholecystectomy revealed an enlarged dark black liver, with round margins suggestive of Dubin Johnson syndrome (Figure 1) , while the Gallbladder was distended with multiple calculi inside. Successful laparoscopic cholecystectomy was done with a liver biopsy. Histopathology of the gallbladder revealed chronic cholecystitis. A liver biopsy confirmed the diagnosis of Dubin Johnson Syndrome. The follow-up was uneventful.

Karishma

Background and Objective: Health care workers (HCWs) are at the highest risk of contracting COVID-19, so their knowledge about the disease and their preventive attitude and practice toward COVID-19 are of concern. The present study aimed to assess the knowledge, attitudes, and practices of HCWs toward COVID-19 in Al-Thawra Hospital, Ibb Governorate, Yemen. Materials and Methods: We conducted a cross-sectional survey among HCWs in Al-Thawra Hospital, Ibb, Yemen, from January 1 to March 31, 2022. Results: Of the 80 participants, 50 (62.5%) were males and 30 (37.5%) were females with a mean age of 29.33±7.86 years. About 51.2% of respondents were aware that sneezing is a recognized symptom of COVID-19, while most were unaware of the extrarespiratory symptoms of the disease, such as diarrhea and confusion. About 28.7% of respondents believed that eating or contacting wild animals would result in infection by the COVID-19 virus, with the majority (71.3%) agreeing that wearing a well-fitting face mask effectively prevents COVID-19 infection. Approximately 48 respondents (60.0%) believed that washing hands could prevent contracting COVID-19, and only 31 (38.7%) agreed that if a patient shows signs and symptoms of COVID-19, they can confidently participate in that patient’s treatment. In response to avoid COVID-19, about 23 respondents (28.7%) had always gone to crowded places, and 35 (43.6%) had always worn face masks at every contact with patients, while only 14 (17.5%) of participants refrained from shaking hands and 37 (46.3%) always washed their hands before and after handling each patient. Conclusion: This study showed that most respondents have poor knowledge regarding the clinical picture of COVID-19 and its mode of transmission as most of them failed to detect an extrapulmonary manifestation of COVID-19 and were unaware of the possibility of transmission of the disease from wildlife. In addition, the attitude and preventive practice of the respondents were unsatisfactory in containing the transmission of the disease.

Karishma

In the construction industry lot of natural sand is being used in the preparation of concrete. Levels of natural sand are depleting day by day. The cost of natural sand is also increasing every day. Therefore, there is a need for alternative materials to natural sand. In this study, exfoliated vermiculite is replacing natural sand partially. Vermiculite at 5%, 10%, and 15% is used for replacement. The concrete cubes are cast for M 30 grade to determine the optimal percentage of replacement of natural sand by vermiculite. In this study, coarse aggregate used includes both normal aggregate and recycled aggregate. The water-cement ratio of 0.45 is adopted. The durability tests conducted include the sulfate resistance Test and the chloride resistance test. The cost analysis was also done and results are presented. The test results are promising when vermiculite was used to replace natural sand at 10%.

Kiran kumar narasimhan

Numerous initiatives to rely on new renewable energy sources, such solar electricity, have been sparked by the increased interest in global warming. With an increase in home photovoltaic (PV) panels that are available to the public, more precise calculations of energy generation are now possible. Segmenting satellite images offers a straightforward and inexpensive way to categorize solar panels..This work suggests a method for classifying and segmenting solar panels that combines the watershed algorithm with deep learning approaches. First, a Convolutional Neural Network (CNN) architecture with the ResNet, EfficientNet, and Inception architectures is used for classification. Through the fine-tuning of pre-trained networks on a heterogeneous dataset of solar panels, transfer learning improves performance. The categorization model recognizes solar panels in a variety of settings with accuracy, making maintenance and monitoring easier. After classification, the watershed method uses intensity gradients to precisely delineate solar panels from the background. Tasks like defect detection and layout optimization are made easier when deep learning-based classification and watershed segmentation are combined. The outcomes of the experiments show how well the suggested method performs in terms of segmenting and classifying solar panels under various circumstances. A flexible automated solar panel management solution is provided by the combination of deep learning and the watershed algorithm, which promotes increased sustainability and efficiency in solar energy systems.

Bakka arun kumar

Artificial Intelligence (AI) is rapidly transforming the landscape of supply chain management, offering unprecedented opportunities for optimization, efficiency, and innovation. This white paper explores the various applications of AI in supply chain operations, highlighting its potential to revolutionize the way businesses manage inventory, logistics, demand forecasting, and more. Through real-world examples and case studies, we demonstrate how AI-driven technologies are reshaping traditional supply chain practices and driving competitive advantage in today's dynamic marketplace.

Kalpak

Marketing has now adopted technologies in the attempt to increase brand recognition. Due to the COVID-19 pandemic, many companies suffer, yet many even reap more profits, such as e-commerce. The purpose of this research is to figure out whether Celebrity Endorsement, Advertising Appeal, and Electronic Word of Mouth have influence towards customer’s Purchase Decision in one of popular e-commerce in Indonesia called Bukalapak. Through the non-probability sampling type, particularly purposive sampling approach, one hundred respondents are taken as samples. The method in this research is descriptive and causal, and the research type is quantitative research. The data analysis methods used are descriptive statistics, coefficient of correlation, coefficient of determination, linear regression analysis and hypothesis testing through T-Test and F-Test. The T-test shows that Celebrity Endorsement, Advertising Appeal, and Electronic Word of Mouth partially influence the Purchase Decision. The F-Test result shows that all independent variables simultaneously influence Purchase Decision. Out of all, Celebrity Endorsement has the biggest influence on Purchase Decision. The value of coefficient of determination obtained is as much as 80.6% indicating that the customer’s Purchase Decision in Bukalapak is explained by Celebrity Endorsement, Advertising Appeal, and Electronic Word of Mouth. The recommendation given is to ensure the company uses talented and well-known celebrity endorsers, design attractive and unique advertisement, and maintain satisfactory performance to encourage complimentary reviews on its platform.

L

Infectious bronchitis (IB) is one of the most common highly infectious viral respiratory diseases of poultry having wide geographical distribution. Yet, little is known about the infection in the northwestern states of Nigeria. In this study, a total of 263 pooled cloacal and tracheal swab samples were collected from apparently healthy avian species (duck, dove, geese, guinea fowl, local chicken, ostrich, parrot, pigeon, peacock, and turkey). The samples were from nine live bird markets in three states (Kaduna, Kano and Jigawa) of northwestern, Nigeria collected from September through November 2017. Total RNAs were extracted directly from the swab samples and screened for infectious bronchitis virus (IBV) using real-time reverse transcription-polymerase chain reaction. An overall prevalence of 38.0% (100/263) was recorded. IB was detected in 70 % (7/10) of the avian species with prevalence of 100 % in dove, local chicken 45.9 %, duck 42.3 %, geese 26.6 %, pigeon 23.5 %, turkey 20.0 % and guinea fowl 6.2 %. Conversely, no detection was made from ostrich, parrot, and peacock. Widespread distribution of IBV was observed and evidence of subclinical infection in seven out of ten (70 %) of the avian species sampled. These avian species harbouring IBV may act as reservoirs with an influence on the ecology and epidemiology of the disease. Continuous surveillance and characterization of the different serotypes in avian species are recommended to inform the adoption of suitable vaccination strategy and control measures for the disease in Nigeria.

Bitrus inuwa

Micro-level assessment of vulnerability to climate change creates basis for policy formulation. The study specifically ascertained the levels and determinants of vulnerability to climate change among selected food crop farmers. Data collected were analysed using descriptive statistics and ordinary least square regression analysis. The result revealed that 15.95%, 68.97% and 15.08% of the households were highly vulnerable, moderately vulnerable and less vulnerable to climate change respectively. This implies a varied effect on crop farmers. The result also showed that amount saved, extension contacts, household expenditure and value of crop were significant at 1% level. The study recommended the provision of basic amenities and soft loans to farmers as well as an improvement in extension services. It also advocated the introduction of effective climate change mitigation and adaptive measures to boost agricultural output in their area.

Comfort chikezie