The present study evaluates the efficacy of Vilanterol-Fluticasone Furoate (VI-FF) versus Formoterol-Budesonide (FM-BD) combination therapy in stable asthma. Both regimens led to significant improvements in asthma control, as evidenced by marked increases in FEV1 (% predicted) and ACT scores over time. The demographic characteristics, baseline respiratory symptoms, and treatment outcomes were similar between the groups, indicating that both strategies were equally effective for managing asthma. The findings indicate that both VI-FF once daily and FM-BD twice daily therapies enhance lung function and asthma control. Significant improvements in FEV1 (% predicted) and ACT scores were observed in both groups, as confirmed by intention-to-treat (ITT) and perprotocol (PPA) analyses. The equivalent efficacy of VI-FF and FM-BD, combined with the convenience of once-daily dosing, suggests that VI-FF may be preferable for patients who struggle with a twice-daily regimen. These findings highlight VI-FF as a convenient and reliable treatment, particularly can benefit patients with adherence challenges. In conclusion, our study's findings align well with other studies regarding demographic characteristics, baseline symptoms, exacerbation history, hospitalization history, and spirometry results. This consistency reinforces the validity and reliability of our results, suggesting that both VI-FF and FM-BD are effective options for stable asthma. The comparable efficacy supports flexibility in treatment choices, allowing for personalized asthma management. Future research should explore the long-term benefits and adherence patterns associated with these treatments to further optimize asthma management.

Dr k c yadav

The CuS@reduced graphene oxide (CuS/RGO) hybrid nanocomposite was synthesized by facile hydrothermal method and used as a photoelectrode material in photovoltaic applications. In the hydrothermal route, RGO is formed by the reduction of GO with simultaneous formation of CuS/RGO nanocomposites. The CuS/RGO nanocomposites was investigated using powder XRD, TEM, HR-TEM, Raman, XPS, DRS UV–Vis spectroscopy, Photoluminescence (PL) measurements. XRD and TEM results suggest that CuS crystalline with individual spherical like homogeneous nanoparticles sizes in the range of 45–35 nm, which is distributed throughout the RGO sheets. We further construct the flexible photoelectrodes by using CuS and RGO and studied the photovoltaic performance. Photovoltaic parameters, such as short-circuit photocurrent density, open circuit voltage, fill factor and conversion efficiency were found to be 16 mA/cm2 , 0.71 V, 70.1% and 7.81% respectively, for CuS/RGO photoelectrode. The improved photo conversion efficiency of CuS/RGO is due to enhancing the electronic injection ability and reducing the photogenerated charge recombination. These photovoltaic results indicate a simple methodology for the low cost and effortless synthesis of an alternative CuS/RGO photoelectrode in high performance photovoltaic devices.

Dr.k.k.saravanan

This study investigated workforce diversity and secondary school administration in Rivers state. The design for the study was the descriptive survey. Two research questions and two hypotheses were raised to guide the study. Mean and standard deviation statistics were used to answer the research questions while the hypotheses were tested at 0.05 level of significance using z-test statistics. A sample size of 667 respondents, representing 90% of the entire population of 741 principals and vice principals from all the 247 pubic senior secondary schools in Rivers state was drawn using the stratified random sampling technique. A researcher-designed instrument titled Workforce Diversity Management Questionnaire (WOFDIMQ) was used for data collection. The instrument was validated by experts in the area of measurement and evaluation at the University of Port Harcourt. The reliability index determined for the instrument using Cronbach Alpha was 0.82. The findings of the study revealed that secondary school administrators do have some administrative strategies put in place for the management of the diversities among teachers. It was therefore recommended among others, that the government should make some specific provisions that will guide school administrators in the management of diversities among teachers. Also, school administrators should develop operational plans and strategies that are based on their specific peculiarities that will help maximize the advantages of diversities among teachers, while at the same time, minimize the inherent disadvantages.

Fxintegrity publishing

The learning process in the new normal is currently still undergoing a process of adaptation. Where the learning is still limited face-to-face and some others are brave. Process adaptation. This learning requires an NHT learning technique that makes it easier for class II students to understand the concept of social studies learning in the natural and artificial environment as a whole and is able to increase their motivation in learning. The research method uses a quantitative design using a non-equivalent control group design. The variables of this study consisted of independent variables and dependent variables. The population of this study were all second grade students at Anak Saleh Elementary School, while the samples were second grade students who carried out the bold learning process and second grade students who carried out offline learning processes. The data collection used in this study included interviews, questionnaires and observations. The data analysis technique is validity test and reliability test. Analysis of the data used through data coding, data transfer to a computer using prerequisite tests and hypothesis testing. The results of the research show: 1) the level of understanding of the social studies concept of class II students who study with the Numbered Head Together (NHT) learning technique is better than conventional learning techniques of 0.429 (results from the t-test) and 2) the level of motivation to learn social studies of class students II with Numbered Head Together (NHT) learning technique of 0.733 is better than conventional learning which is only 0.704. Surely this is greater than rtable = 0.361.

Educare: journal of primary education

The construct of Leadership entails the process of influencing other people to accomplish specific objectives. However, like love, the construct of Leadership is a universal desire that is virtually difficult to define explicitly (Klingborg, Moore and Varea-Hammond, 2006, p.280). It is characterised by the idea of an individual charisma capable of recruiting followers towards his or her path, promoting team-based problem-solving. Conversely, the concept of Leadership is based on many factors such as; "leaders are made not born", "he was a leader since he was a kid" and "if you have the will power, you can become an effective leader" (Klingborg, Moore and Varea-Hammond, 2006, p.280). However, scholars and organisations tend to focus on Leadership and how leaders impact an organisation. The leadership process entails how an individual influences other(s) to achieve a common goal or mission.

Zamzam abdelazim

AIM: The present cross-sectional questionnaire survey was conducted to assess the knowledge, and perception related to pharmacovigilance and ADR reporting among the B.pharm Final year students. MATERIALS AND METHODS: To assess the demographic details of the pharmacy students, their knowledge and perception toward pharmacovigilance and ADR reporting; a validated pretested questionnaire was used which comprises 11 knowledge-based closed-ended questions and 14 perceptions based agree/disagree questions. RESULT: The questionnaire was distributed to the 150 respondents of B. Pharm final year students who were willing to participate in the study. A response rate of 75% was recorded. The number of female respondents 53.3% was comparatively higher than the male respondents 46.6%. Most of the respondents were between 20 -22 years of age and only 4.7% were of 25 years of age. The average positive response for the knowledge-related statements was found to be 86.5% and the average positive response for the perception-related statements was found to be 70.67%. CONCLUSION: The findings showed adequate knowledge among pharmacy students and positive perception towards pharmacovigilance and ADRs reporting. This survey strongly suggests that there is a great need for increasing knowledge in clinical pharmacy courses and practical exposure to cases in the hospitals through internship programs which are meant to provide a unique opportunity for the pharmacy students that they must learn and practice the skills required for quality ADR reporting

Zeenath banu

To improve education quality and governance, the Higher Education Commission of India (HECI) has proposed four regulatory entities, including the National Accreditation Council (NAC). To build up India as a universal knowledge giant over the next ten years, the policy promotes equitable educational opportunities and transformative initiatives. To significantly improve the standards for higher education in India, quality control, accreditation, & ranking systems become crucial. With an emphasis on quality, employability, and lifelong learning, the National Education Policy-2020 (NEP-2020) seeks to create a flexible, value-based educational system that integrates 21st-century capabilities. India's higher education is currently at a critical juncture, requiring transformation to enhance its overall contribution to society and address social injustices. This involves examining how information is produced and how students are taught to promote sustainability and social responsibility. Higher education institutions must comprehend and address student expectations regarding quality because the service sector is expanding quickly due to liberalization, privatization, and globalization. As a result, evaluating service quality becomes crucial for future enhancements and feedback. The Higher Education Commission of India (HECI) legislation, 2018, was introduced by the Ministry of Human Resource Development toward the end of June with the goal of repealing the University Grants Commission (UGC) Act, 1956, which has been in place for seven decades. The HECI will interchange with the University Grants Commission (UGC), which has been the foundation of India's college and university structure. This transition analyzes the proposed bill and examines its shortcomings. This advocates that the current bill be unsuccessful in reporting the flaws of the previous official; instead, it merely reflects those issues and will not resolve the long-standing problems of low autonomy and subpar instruction in the higher education system. As the new regulator, HECI's strategy isn't very revolutionary. Regulators who encourage centralization of duties to reduce autonomy must be disregarded at moments when Indian institutions are striving to rank highly in the world.

Dr. awadhesh singh gautam

Network on Chips are becoming an important aspect in areas of multiprocessor chip design and high performance computing. Reduction in usage of excess amount of hardware in router design without operating all parameters can improve the performance of the system. The practical review of various routers applied in future of networking is carried out in this paper. Fundamental design considerations and various components involved in router design in terms of communication, energy management and power conversion is summarized in detail. A brief comparison of various routers designed previously has been made along with design aspects for 3D Torus router.

Ashish mulajkar

Neuroblastoma is the most prevalent extracranial solid tumor in pediatric patients, originating from sympathetic nervous system cells. Metastasis can be observed in approximately 70% of individuals after diagnosis, and the prognosis is poor. The current care methods used, which include surgical removal as well as radio and chemotherapy, are largely unsuccessful, with high mortality and relapse rates. Therefore, attempts have been made to incorporate natural compounds as new alternative treatments. Marine cyanobacteria are a vital source of physiologically active metabolites, which have recently received attention owing to their anticancer potential. This review addresses cyanobacterial peptides' anticancer efficacy against neuroblastoma. Numerous prospective studies have been carried out with marine peptides for pharmaceutical development, including research on anticancer potential. Marine peptides possess several advantages over proteins or antibodies, including small size, simple manufacturing, cell membrane crossing capabilities, minimal drug-drug interactions, minimal changes in blood-brain barrier (BBB) integrity, selective targeting, chemical and biological diversities, and effects on liver and kidney functions. We discussed the significance of cyanobacterial peptides in generating cytotoxic effects and their potential to prevent cancer cell proliferation via apoptosis, the activation of caspases, cell cycle arrest, sodium channel blocking, autophagy, and anti-metastasis behavior.

Dr. salman ahmed

Since October 17, 2019, Lebanon has experienced unprecedented popular protests, demanding the departure of the entire political class, accused of being gangrened by corruption. Country paralyzed, institutions closed for more than two weeks, the eyes are turned to universities that have closed their doors but whose community (teachers and students) actively participate in the national jump. This study explores the use of social media by universities in Lebanon during the national revolution using social big data technology on Twitter in comparison to the national usage of twitter. Important information was collected, analyzed and visualized using the R language.

Katia raya

в статье анализируются основные причины и критерии иностранных инвестиций, основная роль внедрения инновационных технологий в рыночную экономику. А также роль иностранных инвестиций в модернизацию экономики Узбекистана.

Ikboljon odashev mashrabjonovich

This research was carried out at SDS Harapan Jakarta. This research aims to unravel the implementation of character education’s values through thematic subject, specifically on Indonesian Language Content. This research uses qualitative descriptive approach to gather research data deeply and thoroughly regarding character education’s value. Data collection was done using interviews, observation, and documentation. Miles and Huberman method was used to analyze data collected with the process of data collection, condensation, data display, and data verification. Triangulation was used to verify the validity of the data. The result of this study revealed that 1) The implementation of character education values in the content of Indonesian Language learning in Class 3 is implemented through reading and writing activities that prioritize the five main values in education according to the Minister of Education and Culture. 2) There are still less-effective efforts to achieve learning objectives. 3) There is still a lack of learning innovations carried out to achieve learning goals. 4) No lesson plans that are not made routinely as a means of evaluating learning. 5) There is still a need for improvement in the application of character education in Indonesian content that is linked to students' real experiences, both through online and offline learning.

Educare: journal of primary education

Cancer is one of the most severe medical conditions in the world, causing millions of deaths each year. Chemotherapy and radiotherapy are critical treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer requires novel, efficacious treatment modalities. Natural remedies offer feasible alternative options against malignancy in contrast to available synthetic medication. Selective killing of cancer cells is privileged mainstream in cancer treatment, and targeted therapy represents the new tool with the potential to pursue this aim. The discovery of innovative therapies targeting essential components of DNA damage signalling and repair pathways, such as ataxia telangiectasia mutated and Rad3-related Checkpoint kinase 1 (ATR-CHK1), has offered a possibility of significant therapeutic improvement in oncology. The activation and inhibition of this pathway account for chemopreventive and chemotherapeutic activity, respectively. Targeting this pathway can also aid in overcoming the resistance of conventional chemo- or radiotherapy. This review enlightens the anticancer role of natural products by ATR-CHK1 activation and inhibition. Additionally, these compounds have been shown to have chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Ideally, this review will trigger interest in natural products targeting ATR-CHK1 and their potential efficacy and safety as cancer-lessening agents.

Dr. salman ahmed

In some countries, a high percentage of the population relies on traditional plants for treating certain diseases. The aim of this study was to investigate the effect of G. alypum extract (GAE) and Alhagj marorum extract (AME) on lipid profiles in experimentally induced hypercholesteremic rats and on the blood pressure of experimentally induced hypertensive rats. Male Wistar rats weighing 200 - 300 g were divided into five groups: group 1 received a normal diet (negative control), group 2 received a high lipid diet containing coconut oil (10 g/kg/day), cholesterol (4 g/kg/day) and cholic acid (0.20 g/kg/day) (positive control), group 3 received a high lipid diet together with clofibrate (50 mg/kg/day), group 4 received a high lipid diet together with AME (200 mg/kg/day) and group 5 received GAE (200 mg/kg/day). The experiment continued for two weeks, then the rats were sacrificed and blood samples were collected for estimation of cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein. To induce hypertension, rats were divided into two groups (n = 8 in each group). Group 1 received normal saline (control) and Group 2 received dexamethasone (0.40 mg/kg, i.p.) for seven consecutive days. Later, the rats were anesthetized using thiopental and the carotid artery was cannulated for recording blood pressure. AME (40 mg/kg) or GAE (40 mg/kg) were injected through a cannula placed into the internal jugular vein at a dose volume of 0.1 ml. Systolic and diastolic blood pressure were measured before and after plant extract administration. The results showed that clofibrate GAE extract and ANE extract significantly decreased cholesterol, triglycerides, low-density lipoprotein and high-density lipoprotein as compared to high-lipid diet-treated rats. Data also indicated that administration of GAE or AME extract significantly decreased systolic and diastolic blood pressure in experimentally induced hypertensive rats. In conclusion, GAE and AME have antihyperlipidemic and antihypertensive activities and further investigation is needed to clarify the mechanism of these effects.

Mediterranean journal of pharmacy and pharmaceutical sciences

A leader is a person, who influences his followers. The role of leader is often associated with managerial concepts, where a leader leads a team of employees, guides them, motivates them and influences them, in such way that the organisational productivity is honed up. A lot emphasis is on the style of leadership, exhibited by the manager, in honing the productivity of the organisation. According to (Hanvey, 2002; Janus, Kopechanski, Cameron, & Hughes, 2007; Morinaka, 2012; Reio & Fornes, 2011), most parents have dreams and hopes about their children and their lives. But, parents of children with special needs, though have, such dreams and hopes, have a harder time meeting these goals. According to Hanvey (2002), these parents need to devote more time and responsibilities, when it comes to raising a child with special needs, like caring for the child’s physical requirements due to his/ her disability, helping them with their physical and social needs and also help them in developing relationships with the others, so that they get a feeling of belongingness. Families with children having special needs undergo a higher level of stress (Gottfried & McGene, 2013). Families that have children with special needs, go through enormous stress levels, at times even financially stressed are they … (Hanvey, 2002; Moriwaka, 2012). But, Current study focusses on the effective leadership role played by a mother during the Pandemic, which is helping the kids, especially the children with special needs in combating the stress, that they are undergoing. A case of a child, diagnosed with autism(a serious behavioural disorder among young children that now occurs at epidemic rates in developing countries like India), since she turned two and how her mother has been helping her adapt to the new normal of staying home for all her activities and coping up with the increased stress levels.

Nandini

In this report, Abacus Ltd employee will offer his client guidelines, another organisation trying to comprehend risk management. Abacus gives a scope of business consultancy administrations to their clients which assist them with developing their business. Abacus's new client wants all individuals from the senior group to comprehend risk management in business and the various kinds of danger (Aven and Renn, 2010).

Zamzam abdelazim

In this article, we study an Inventory Routing Problem with deterministic customer demand in a two-tier supply chain. The supply chain network consists of a supplier using a single vehicle with a given capacity to deliver a single product type to multiple customers. We are interested in population-based algorithms to solve our problem. A Memetic Algorithm (MA) is developed based on the Genetic Algorithm (GA) and Variable Neighborhood Search methods. The proposed meta-heuristics are tested on small and large reference benchmarks. The results of the MA are compared to those of the classical GA and to the optimal solutions in the literature. The comparison shows the efficiency of using MA and its ability to generate high quality solutions in a reasonable computation time.

Mohamed salim amri sakhri

Human resource management is critical for hospitals but is frequently disturbed by employee retention issues. This research aims to determine the influence of compensation, organizational commitment, and work motivation on employee retention at Malahayati Medan. The research method applied is quantitative research by collecting data through questionnaires distributed from July to October 2022. The sampling method used is purposive sampling, with 78 employees as the sample. The data analysis method used is descriptive statistics, coefficient determination, multiple linear regression analysis, and hypothesis testing with t-test and F-test. The results of the t-test are compensation, organizational commitment, and work motivation partially influence employee retention. The results of the F test showed that all independent variables simultaneously influence employee retention and 61.1% of employee retention is influenced by compensation, organizational commitment, and work motivation. It is recommended for companies in similar industries pay attention to the results of this research.

L

Indian Economy is the world's 06 th largest economy (2021 Nominal GDP) and 03 rd largest by purchasing power parity (2021 PPP). Salaried workers are a consistent group of tax paying citizens that give roughly 12% of overall revenue to a government through income tax. Due to which tax planning has assumed special importance for salaried individuals. All taxpayers in India have a variety of tax saving choices. These choices provide a variety of exclusions and deductions that help to reduce the total tax burden. Deductions are provided from Sections 80C through 80U, and qualifying taxpayers can claim them. Hence it is essential for the individual tax payer to know all their possible tax regulations and for tax compliance. It is totally legal and, in fact, a wise option when tax planning is done within the boundaries set by the relevant authorities. However the salaried individuals are not able to plan their taxes which results in opting for the wrong investment options. The objective of the study is to determine the level of awareness among the salaried individual on several tax planning methods offered on professional tax under the income tax act and to identify the factors influencing the tax planning behaviour of the salaried individuals..

Sabir mujawar

Acenocoumarol is the only oral antivitamin K anticoagulant prescribed and marketed in Algeria for the prevention and treatment of thromboembolic diseases. Nevertheless, the difficulty of handling this drug linked to a narrow therapeutic index and to great inter- and intra- individual variabilities of the response to the treatment poses a major public health issue because of its iatrogenic risk. To improve the management of patients on acenocoumarol and optimize its dosage adjustment and reduce iatrogenic secondary to vitamin K antagonists, our main objective work is to assess the knowledge, attitude and practice of health care professionals regarding this anticoagulant agent. We conducted a multicenter descriptive cross-sectional study from April to May 2021. We interrogated 152 health professionals of all ages, all sexes and all grades from different health departments in Oran City (Algeria) prescribing anticoagulants, through a validated questionnaire made up of 26 questions. Statistical analysis was achieved by SPSS version 20 software. Thus, 59.9% were women with a sex ratio of 0.67, 92.8% knew that acenocoumarol belongs to the antivitamin K class, 45.0% chose INR and PT as follow-up parameters, 36.0% chose INR alone and 78.9% were unaware of acenocoumarol dose adjustment algorithms as well as 82.0% were unaware of the existence of pharmacogenetics testing. 54.0% use the recommendations of the HAS for dosage adjustment of patients on acenocoumarol. 07.9% suggested using pharmacogenetic tests to improve the dosage adjustment of acenocoumarol, 06.6% suggested patient follow-up and 05.9% suggested therapeutic patient education as well as 74.3%, wanted to do training on. Therefore, this study highlighted gaps in the medical practice of physicians in terms of dosage adjustment, pharmacogenetics and its impact on dosage optimization. However, the evaluation of their knowledge was considered unsatisfactory. To overcome this lack of knowledge, it seems necessary to make physicians aware of the contribution of pharmacogenetics of acenocoumarol in Algeria.

Mediterranean journal of pharmacy and pharmaceutical sciences