The purpose of this study is to explore the impacts of foreign cartoons programs on the social behavior and attitude of Pakistani Children. It is forecasting different cartoon programs 24/7; hence, children spend most of their leisure in front of the television. All these cartoon characters affect the social life and psyche of the children and induce positive and negative mannerism in their daily lifestyles. It has found that one of the most disturbing factor is that the ferocity in children today is increasing rapidly due to following their favorite violent cartoon characters which are even different from their culture and societal norms. The issue is violence is what they see in every cartoon program in one or the other way. Their Guardians are unaware that these cartoons they let their children watch are destroying their parenting as negative forces are attacking the innocent minds of this generation. The study gives the insight of why and what is happening with non-parametric statistics studied and used for thorough analysis. The behavioral outcome of the kids like, imitating their preferred animation character, utilizing various dialects, watching the TV as opposed to deciding on outdoor games and being difficult about getting precisely the same outfits and embellishments as their adored character. This contextual analysis features the disturbing circumstance that guardians are uninformed of. There is something other than mimicking the particular character. The only traits of watching these foreign cartoon characters is that it might damage their own customs and they wildly become to believe these characters as their role models.

Zaki hasan

Bauhinia racemosa Lam. is a tall tree growing throughout Sri Lanka, China, India, and Pakistan. Various parts of the plant have great medicinal potential in folklore medicine and are used for diarrhoea, fever, skin diseases, cough, malaria, etc. Analgesic, anti-inflammatory, antipyretic, antispasmodic, antiulcer, cytotoxicity and hypotensive activities of Bauhinia racemosa have been reported. Different parts of this plant contain β-amyrin, β-sitosterol, kaempferol, quercetin, scopoletin, scopolin and tannins

Dr. salman ahmed

Abstract Background. Numerous studies have found that various core muscles are involved in subjects with chronic low back pain. The evidence for profiles of respiratory muscle involvement in normal low backache subjects has not been reviewed explicitly for low back pain. Aims. The study’s primary objective was to scientifically analyze, condense, and to evaluate the evidence for the involvement of respiratory muscles in subjects suffering from chronic low back pain. Methods. This evaluation procedure will trail the guidelines of PRISMA and MOOSE. The assessors will use a custombuilt tool to extract data from the studies, regardless of the methodology used. A modified Downs and Black index will be used to assess the superiority of the methods used in the selected studies. Results. This index evaluates the characteristics of the subjects, the timing of the outcomes, and the characteristics of the interventions, and quantitative, formal analysis, so-called meta-analysis, is performed if necessary. The study’s effect, including the evidence, will be determined using the GRADE a framework for a systematic approach. Earlier research has found that core muscles are involved, and the interventions are tailored to include deficiencies and intrusions that target specific muscle groups. Conclusion. As an additional component that can be targeted by clinical practitioners in their day-to-day practice and added to rehab programmes, this systematic review protocol will summarise the list of evidence available for the rehabilitation of low back ache and highlight the involvement of respiratory muscles in lowback ache subjects. Keywords: chronic low back pain, diaphragmatic breathing exercises, respiratory muscles.

Nagaraj sibbala

This research paper examines the dynamic interplay between social movements and Indian politics to assess their importance in shaping the socio-political landscape of the nation. In recent decades, India has witnessed the rise of various social movements, from grassroots activism to large-scale protests, each with distinct goals and socio-political implications. This study uses a multidimensional approach that combines historical analysis, case studies, and theoretical frameworks to reveal the complex connections between social movements and political transformations. The research begins by delving into the historical context of social movements in India, highlighting their evolution from the pre-independence era to the present. By examining key movements such as India's independence struggle, the Chipko movement, anti-corruption protests and farmers' agitations, this paper seeks to identify recurring patterns, strategies and outcomes across periods. The study further examines the impact of social movements on policy-making, political discourse and institutional reforms. By analyzing specific cases where social movements have influenced legislative decisions or brought about political change, the research aims to assess the tangible results of grassroots activism on the functioning of Indian democracy. The role of social media and technology in amplifying the voices of social movements is also explored, emphasizing their transformative influence on public opinion, mobilization and information dissemination. This study uses a comparative analysis of movements with varying degrees of success to distinguish the factors that contribute to their effectiveness and endurance. the research presents a comprehensive assessment of the role played by social movements in shaping Indian politics. By synthesizing historical perspectives, contemporary case studies and theoretical insights, this article contributes to a nuanced understanding of the complex relationship between social activism and political change in the Indian context. The aim of the findings is to inform policy makers, scholars and activists about the potential of social movements as catalysts for positive social transformations and democratic development.

Dr gedam kamalakar

Arisaema jacquemontii Blume (Araceae) is a medicinally important plant for treating different diseases, especially dermatological disorders. Alkaloids, phenols, terpenes, flavonoids, glycosides, and tannins have been reported from this plant. Antioxidant, antifungal, antibacterial and anticancer activities are also shown by Arisaema jacquemontii. The present review attempts to compile all the previous data based on its medicinal uses, phytochemistry and pharmacology reported in the earlier articles.

Dr. salman ahmed

Background: Pandemics are known to cause poor mental well-being and an increased risk of mental disorders. The foremost concern emerging from different aspects of COVID-19 is its impact on mental health. There were many surveys conducted on the general population related to the effect of COVID-19 and few studies on its psychological impact but there is sparse literature on how the containment measures affected the psychiatric patients. Objective of the study was to investigate whether the COVID-19 related lockdown affected the subjective mood and behavior of psychiatric patients and their caregivers. The secondary purpose is to assess the difficulties encountered in procuring medicines and the effect of non-availability of homoeopathic medicines if any. Methods: A cross-sectional survey was conducted on mentally ill patients and their care-givers in the Outpatient Department of Psychiatry in National Homoeopathy Research Institute in Mental Health (NHRIMH), Kottayam. Respondents were evaluated with a specially framed questionnaire containing 22 questions to assess the effect of lockdown on psychiatric patients and their caregivers, who attended the OPD after the COVID-19 related lockdown. The data generated through the study are analysed and presented in this article. Results: Out of the total 548 participants (M-65.9%, F-34.1%) who responded to the survey, 290 (53%) cases expressed that they were distressed to be under lockdown. 26.5% of the clients reported worsening of mental health conditions during lockdown compared to pre-lockdown. 54.2% of the patients found difficulty in procuring homoeopathic medicines during Lockdown. Conclusions: Authorities should consider the ways of limiting the effects of confinement on mentally ill patients and their caregivers by developing strategies to mitigate the adverse consequence of the pandemic.

Dr deepthi gilla

The significance of fermentation is gaining more relevance due to the need for better preparation of plants, the desire for better plant constituents, and the aim for the preservation of medicinal plants. Hence, this study sets out to determine and compare the pH, proximate composition, chemical constituents, antioxidant, and antimicrobial effects of 3-day and 7-day fermented seeds of Nigella sativa. The fermentation of the seed was done for 3 and 7 days using 2.5% sugar. The pH of the sample declined from 3.5 to 3.45 during the fermentation. The proximate composition (moisture, ash, lipid, protein, and carbohydrates) was higher for the 3-day fermented sample while fiber was higher for the 7-day sample. The phytochemical constituents (tannins, saponins, phenols, alkaloids, flavonoids, phytates, oxalates, terpenoids, steroids, and glycosides) were higher for the 3-day than the 7-day sample. The Gas Chromatography-Mass spectrometry technique showed peaks that were characterized as 17 and 20 constituents on days 3 and 7 of the sample, respectively. The antioxidant capacity (ranging from 35.50% to 82.69% for the 3-day and from 37.50% to 84.99% for the 7-day sample) varies by the increasing concentration (7.81 mg/mL to 1000 mg/mL) of the sample. The diameter of zones of inhibition tested at different concentrations (25 mg/mL, 50 mg/mL, and 100 mg/mL) showed varying degrees of activity against Proteus vulgaris and Staphylococcus aureus. The zones obtained were higher 8-10 mg/mL against Staphylococcus aureus and 10-12 mg/mL against Proteus vulgaris for the 7-day fermented sample while 8.0 to 9.0 mg/mL was obtained for the 3-day fermented against Staphylococcus aureus and 8.0 to 10.0 mg/mL against Proteus vulgaris. Overall, the results of this study indicated that fermentation contributed to enhancing the bioactive components and antioxidant capacity of the fermented seeds of N. sativa thereby supporting the use of fermentation in the production of value-added functional foods.

Mediterranean journal of pharmacy and pharmaceutical sciences

Developmental venous anomalies (DVAs) are congenital vascular malformations often found incidentally on neuroimaging. This case report describes a 37-year-old female with chronic headaches and an incidentally discovered DVA in the left frontal lobe. Magnetic resonance imaging (MRI) revealed a classic "caput medusae" pattern without hemorrhage or associated cavernous malformation. This case highlights the importance of recognizing DVAs as incidental findings, differentiating them from other causes of chronic headaches, and understanding the significance of associated imaging findings.

Karishma

This brief inspects the situation with research in Indian advanced education and offers an outline of the idea of undergrad (UG) research as a method for change. The article endeavors a short survey of the public authority endeavors to further develop advanced education examination, and underlines the restrictions of their degree just as their ramifications. Through a sweeping audit of existing experimental and subjective investigations, this concise shows the advantages and effects of UG research on improvement of insightful characteristics in understudies also its impact on foundations. At last, it suggests methods of drafting this idea in the current arrangement of undergrad schooling in India, in view of remedies by the Chamber on Undergrad Exploration

Dr gedam kamalakar

Worldwide, the threat created by antibiotic resistance to public health calls for immediate action. Antibiotic resistance is one of the main causes of the emergence and spread of dispensing of antibiotics without a prescription. This study aims to investigate the dispensing of antibiotics without a prescription and the reason behind that in the community pharmacy in Libya. The study was randomized analytical conducted between March and April 2023 among pharmacists and assistant pharmacists employed by community pharmacies in various Libyan areas Tripoli, Zawia, and Sabratha. The data were analyzed by Fisher's exact and Chi-square tests to predict the determinations of dispensing antibiotics without prescriptions. In this study, a total of 293 participants were included, 63 had been excluded because they did not meet the inclusion of the study. The remaining 230 were enrolled for final analysis, most of them were female subjects (70.7%). Findings showed that 78.7% of the participants consulted with patients about the reason for requesting a specific type of antibiotic, while 68.7% dispensed antibiotics with probiotics. Study participants with 2 - 4 years' work experience were 76.6% higher toward dispensing of antibiotics without a prescription (P=0.683). The major reason for dispensing antibiotics without prescriptions were pharmacists knowledgeable enough to give a patient antibiotics without a prescription (68.3%). In Libya, misuse of antibiotics by the public is widespread. People can purchase antibiotics without prescription. Thus, dispensing of antibiotics without a prescription in community pharmacies is an alarming issue in Libya which can increase antibiotics resistance. Pharmacists' knowledgeable is high in dispensing patients antibiotics without a prescription, but patient pressure and financial issues are the major reasons behind dispensing antibiotics without a prescription. It can be recommended that the importance of antimicrobial stewardship and the need for ongoing education support for community pharmacy professionals is of importance.

Mediterranean journal of pharmacy and pharmaceutical sciences

In health care delivery systems, if you are not part of the solution, then you must be part of the problem. Over the last few decades, clinical pharmacy encourages pharmacists and pharmacy support staff to move their focus from product-oriented role towards new direct engagement with patients, to make the most of the benefits that patients obtain from the medicine they take, or the problems they encounter with their medicines use. In the USA, pharmacists’ participation in physicians ward rounds was shown to reduce adverse drug events by 78% and 66% in general medical and intensive care settings [1. 2]. A study covering 1 029 US hospitals indicated that centrally based and patient-specific clinical pharmacy services are associated with reduced mortality rates [3]. The services involved were medicine information, clinical research performed by pharmacists, active pharmacist participation in resuscitation teams and pharmacists undertaking admission medication histories. New pharmacists’ roles in healthcare systems around the globe have moved and developed significantly over the past few years, particularly with expansion of the scope of practice which allows pharmacists to focus on the clinical aspects of direct patient care [4, 5]. Pharmacists are drug therapy experts of health care team. Therefore, pharmacists, today, are the arbiters of effective and safe use of medicines. Medication therapy management is one of the major areas in which physicians more and more rely on pharmacists to benefit their patients.

Mediterranean journal of pharmacy and pharmaceutical sciences

Objective: Pyrazolopyrimidines are heterocyclic molecules containing nitrogen as the main composition, and hence, they exhibit pharmacological efficacy. They are analogs of purines so that possessing wide applications in the field of medicinal chemistry. The main objective of this study is to synthesize different derivatives of pyrazole-pyrimidine classes by adopting simple methodology as well as by employing green chemistry. The purpose of the synthesis of these molecules is to study the antitumor activity against Ehrlich ascites carcinoma (EAC) cell lines. Methods: After literature studies, it makes us to involve in the research of synthetic organic chemistry, especially to synthesize new compounds of pyrazolopyrimidines. We are reported solvent-free synthesis of pyrazolo [3,4-d]-pyrimidine-thiones through ethyl acetoacetate, hydrazine hydrate, thiourea, and different benzaldehydes. An ionic liquid 2-methyl-imidazolium-oxalate catalyzed the reactions under ultrasonication bath. Both conventional and ultrasonic methods were employed and comparison studies have been made. It was found that ultrasonic method completed the reaction quicker than the conventional method. All the synthesized compounds were confirmed their structures by 1 HNMR, Fourier transform infrared, 13C-NMR, and elemental analysis spectra. The compounds were tested for in vitro anticancer activity against EAC cell lines. Most compounds revealed significant anticancer activity relative to doxorubicin as a positive control with inhibitory concentration (IC50) values. Results: Ultrasonication method is a simple method under which all the reactions were completed at faster time (<7 min) compared to the convention method. Among eight molecules, 8a and 8d completed the reactions at a faster rate. We reported IC50 values of all the molecules, in which 8e and 8g were exhibited excellent potency against EAC cell lines at different concentrations .

Dr ganesh n yallappa

This study investigated utilization of information communication technology for the improvement of personnel economics in the administration of public secondary schools in Rivers state. The study had two objectives, with corresponding research questions and hypotheses. A descriptive survey design was employed, and the population consisted of 11,258 secondary school teachers from 258 public senior secondary schools in Rivers state, with 4,127 males and 7,131 females. A sample of 383 teachers (163 males and 220 females) was drawn from 15 public senior secondary schools using the Taro Yamane Formula and a two-stage sampling technique of stratified and simple random sampling. Data was collected using a self-structured questionnaire titled "Utilization of Information and Communication Technology and Personnel Economics in Secondary School Administration." The questionnaire underwent face and content validation by three experts and demonstrated good reliability with a Cronbach Alpha coefficient of 0.82. Research questions were answered using mean and standard deviation, while inferential statistics utilized the z-test. The findings indicated a significant difference between male and female teachers in their perceptions of ICT utilization for teachers' supervision and evaluation, highlighting the potential for ICT to improve personnel economics in the administration of public secondary schools in Rivers state. Based on these findings, it can be concluded that implementing various ICT-based strategies such as developmental supervision, contextual supervision, clinical supervision, and collaborative forms of developmental supervision could enhance the effectiveness of teaching staff and overall school productivity in public secondary schools in Rivers state.

Fxintegrity publishing

Community acquired pneumonia is a prevalent disease in the Emergency Department (ED). The literature reveals that clinical practice could not be related with guidelines recommendations. The aim of this study is to determine the impact of the implementation of the recommendations of the Spanish society of Emergency Medicine in the Hospital Clínico Universitario Lozano Blesa (Zaragoza) ED in the management of community acquired pneumonia. Use of Pneumonia Severity Index (PSI) estimation was used to assess the adherence. This study was carried out from December, 2014 to February, 2015. Data was compared with the previous two months. The indicators management (discharge or admission decision, adequacy and anti-biotherapy) as well as the incidence of PSI estimation before and after the intervention in these parameters were evaluated. 209 patients were included, 97 before the intervention and 112 after the intervention. No significant differences were observed in the calculation of PSI. A significant decrease of admissions was observed after the intervention in the patients in whom the PSI was calculated (68.8% vs. 45.0%, p < 0.05). A greater use of the Observation Room was aimed at those patients in whom the PSI was calculated (06.3% vs. 17.5%, p < 0.05). PSI calculation significantly increased antibiotic prescription adherence (88.9% vs. 75.2%, p < 0.05). There were no modifications in the prescription after the intervention. In conclusion, PSI is a useful and effective measure to achieve a greater adherence to the recommendations. However, despite the positive trend in the use of the PSI and its interpretation, a low-intensity intervention is not sufficient to generalize its use.

Mediterranean journal of pharmacy and pharmaceutical sciences

Rationale: Trisomy 18, often known as Edwards syndrome. It is a common chromosomal disorder characterized by the presence of an extra chromosome 18. Unfortunately, survival past the first year is quite rare, and there are only a few reports of individuals living long-term without needing corrective surgery. This case sheds light on an unusual situation where a patient survived for an extended period despite having severe congenital heart defects. Patient concerns: A 5-year-old girl, already diagnosed with trisomy 18, was admitted to the hospital after experiencing a cough and diarrhea that started after she began taking a nutritional powder supplement. The patient had a history of admission to neonatal intensive care for 1 month due to transient tachypnea of the newborn, mild retractions, and grunting. Additionally, she had intrauterine growth restrictions, dysmorphic features, and hypotonia. Diagnoses: Clinical examination revealed dysmorphic features, hypoxia, and a cardiac murmur. Chest radiography reveals central infiltration with cardiothoracic ratio 60%. Genetic testing confirmed the presence of trisomy 18, and an echocardiogram showed multiple congenital defects with significant right ventricular hypertrophy. Interventions: Initial management began with administering oxygen, performing metabolic tests, and a chest x-ray. However, because of ongoing low oxygen levels linked to her heart defects and pulmonary hypertension, long-term home oxygen therapy was initiated. A comprehensive supportive care with multidisciplinary team support was the main management. Outcomes: Throughout her treatment, oxygen saturation did not exceed 85%, and the patient’s development has remained severely delayed, with no significant motor or cognitive milestones. The patient had a long life expectancy for her complex heart defects, but eventually died of cardiac arrest. Lessons: This case shows the possibility of prolonged survival in trisomy 18, even with severe congenital heart defects, emphasizing the importance of multidisciplinary management and family-centered counseling. Documenting such cases expands understanding of this syndrome and guides long-term care strategies.

Mohamad banat

Abstract---In contemporary society, most females are deprived of proper education, healthcare, job opportunities, etc., to uphold family customs, patriarchal dominance, and occasionally negligence towards the feminine gender. According to researchers, gender inequalities in health care, especially in eye care, are evident between accessing the care and getting treatment in developing countries. Therefore, we aim to measure the gender-wise eye-care follow-up regularity in accessing long-term glaucoma consultation among various age groups with a sample size of 564 in Delhi-NCR, India. The age groups (in years) are 15-29 (Group I), 30-44 (Group II), 45-59 (Group III), 60-74 (Group IV), and 75 and above (Group V). Groups I to V show, intragroup males have higher odds of getting regular eyecare by 20% (OR 1.20, 95% CI 0.413 to 3.4871), 2.08% (OR 1.0208, 95% CI 0.4637 to 2.2472), 3.4% (OR 1.034, 95% CI 0.6369 to 1.6787), 8.46% (OR 1.0846, 95% CI 0.6783 to 1.7344), and 45.83% (OR 1.4583, 95% CI 0.4575 to 4.6484) respectively. The probable causes of gender-wise irregularity are lack of seriousness, financial limitations, dependency, loneliness due to widowhood, etc. To make eye-care services equally accessible to everyone, healthcare agencies should first take various progressive policies to overcome gender-wise socio-economic barriers.

Dr. ashwani kumar ghai

The transportation problem is widely applied in the real world. This problem aims to minimize the total shipment cost from a number of sources to a number of destinations. This paper presents a new method named Dhouib-Matrix-TP1, which generates an initial basic feasible solution based on the standard deviation metric with a very reduced number of simple iterations. A comparative study is carried out in order to verify the performance of the proposed Dhouib-Matrix-TP1 heuristic.

Souhail dhouib

The present study describes the use of an aqueous solution containing a blend of hydrotropic solubilizing agents (mixed hydrotropic substance’s solution) as a successful solvent system utilizing the concept of mixed hydrotropy for spectrophotometric analytical estimation of various conventional formulations as well as novel drug delivery systems. Frusemide, a poorly water-soluble drug, was estimated by application of mixed hydrotropic solubilization method. There was more than 15-fold enhancement in aqueous solubility of frusemide in a solution of blend of hydrotropic agents which consisted of 30% urea, 13.6% sodium acetate and 11.8% sodium citrate. This solvent mixture was employed to solubilize the drug from the fine powder of tablet formulations as well as the niosomes of frusemide. The selected λmax for spectrophotometric estimation was 333 nm. The hydrotropic agents used in the analysis and additives used in the manufacture of tablets and preparation of niosomes did not interfere in the analysis. Statistical data proved the accuracy, reproducibility and precision of the proposed method. The results suggested that proposed method is new, rapid, simple, accurate, and reproducible as well as employed aqueous solvent instead of organic solvents in estimation of drug from the dosage forms.

Archana mehrotra

The mechanical properties of different polymer matrix composites are discussed in this research study. These composites are multiphase materials in which reinforcing elements and a polymer matrix are suitably combined. The mechanical properties of 18 PMCs, including nylon 66 reinforced with 5, 15, and 25% wt% silicon carbide (SiC) and nylon 66 reinforced with 5, 15, and 25% wt% boron carbide (B4C), were evaluated using an injection moulding technique at three different injection pressures in this study. The optimization of process parameters like reinforcement material, reinforcement quantity, and injection pressure to maximize the tensile and impact strength of nylon 66 composites are the main focus of this study. It is observed that the specimens 25% SiC with an injection pressure of 90 MPa has optimised tensile strength, while the specimen 5% B4C with an injection pressure of 90 MPa has optimised impact strength.

Boopathy govindarajan

Aerva lanata species belonging to Amaranthaceae family (a.k.a mountain knot grass/Gorakha Ganga is a perennial shrub. It is self-pollinating, bisexual plant having globose like structure has various phytochemical constituents. Among the 28 species of Aerva, medicinal properties are likely to be present in Aerva lanata, Javanica and Persica varieties. Traditionally it was used in treating cough, dysuria, hemiplegic migraine and kidney related disorders. Flavonoid glycosides such as Kaempferol, Isorhamnetin, quercetin, flavanone are major phytoconstituents and minor constituents are apigenin, narcissin, ferulic acid, syringic acid and vanillic acid. Alkaloid glycoside includes Ervine, aervine etc. Aerva lanata has much more beneficial activities like demulcent, diuretic, ulcer wounds, rheumatism, Anti-malarial. Pharmacological studies included that aerva species has beneficial properties of antimicrobial, anti-urolithiasis, antiulcer, anti-asthmatic, acute kidney injury, anti-diarrheal activity, antioxidant, antihyperglycemic, hypolipidemic and antiulcer. Aerva lanata has promising role in the treatment of various diseases and metabolic disorders due to its higher antioxidant effect and other such constituents thereby providing better healthcare. Various such constituents are to be analyzed properly and to ensure that it was suffice to exhibit the pharmacological activity. Analytical methods are to be used promptly to find various concentration of substances present in the alcoholic extract of Aerva lanata plant.

Ankul singh