Dr.p.v.kamala Kumari

Strain improvement studies for the production of l-asparaginase by beauveria bassiana ss18/41

  • Authors Details :  
  • P.v.kamala Kumari,
  •  
  • G.girija Sankar,
  •  
  • T.prabhakar

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Strain improvement studies were conducted for the production of L-asparaginase from a marine fungus Beauveriabassiana SS18/14 by employing physical and chemical mutagens, in a systemic manner to obtain mutants that have higher L-asparaginase production. The wild strain produced 6.32 IU/mL of L-asparaginase activity while the UV mutant UVF-4 yielded 8.34 IU/mL and nitrous acid mutant UVF4-N-2 exhibited 10.44 IU/mL enzyme activity. The overall strain improvement programme increased L-asparaginase activity 1.65 times with respect to the parent wild strain.


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