Immunoglobulin G4-related disease (IgG4-RD) is a rare and new but increasingly recognized immune-mediated fibroinflammatory condition known to affect multiple organs. The diagnostic approach is challenging, as there is no single investigation to confirm the diagnosis, which requires the integration of clinical, biochemical, and radiographic manifestations with classic histopathologic features to establish the diagnosis. The histology of IgG4-RD is determined by a dense lymphoplasmacytic infiltrate, storiform fibrosis, and obliterative phlebitis in the presence of an increased level of IgG4 in most patients. The first line of treatment is systemic glucocorticoids, but adverse effects of the drug, suboptimal response, and disease recurrences on reduction or termination of therapy highlight the need for an alternative therapy such as rituximab, which appears to be a promising alternate agent in the treatment of IgG4-RD; however, its efficacy needs to be evaluated in large clinically controlled trials.

Karishma

This study presents a comprehensive bibliometric analysis of household consumption research in Maharashtra from 2017 to 2023, highlighting shifts in academic focus before and after the COVID-19 pandemic. The analysis explores key research trends, including foundational theories like the Keynesian consumption function and Engel’s law, while examining how themes such as income-consumption relationships, inequality, and economic resilience have evolved. Through citation network analysis, publication trends, and thematic evolution, we identify the most influential works, authors, and institutions that have shaped this field. Pre-pandemic research centered on established economic concepts, exploring factors like income distribution, economic growth, and household debt as predictors of consumption. However, post-2020, there is a marked shift towards understanding financial resilience, the impact of income shocks, and the role of government interventions in stabilizing consumption patterns during crises. This transition reflects an adaptation of traditional consumption models to account for pandemic-induced economic disruptions, emphasizing financial literacy and digital transformation as critical areas of study. Our findings contribute to a deeper understanding of the drivers of household consumption research in Maharashtra, providing insights into the socio-economic factors that influence spending behaviors in both stable and volatile conditions

Nandini jagannarayan

The decision of the government of India to allow foreign direct investment in higher education is based on a consultation paper prepared by the commerce ministry, which is marked by arguments, perverse logic and forced conclusions. FDI in any field does not have an attached objective of fulfilling social agenda of the welfare state. It is guided by profit and market. This would result in commoditization of education. As per past most foreign institutes invest in technical courses which market needs rather than in quality education and research which is important for creating and developing human resource. There is a shortage of funds in higher education sector. Here are not many ways in which this investment in this sector can be increased in this sector domestically. Since a large number of students go abroad for their higher education, it is sensible to allow foreign universities to set up their campuses here, in India. This would help in arresting the outflow of monetary and human capital. Further, foreign higher educational institutes would create competition with the local institutes making them internationally competitive this article examines the issues and financial compulsions, presented in the consultation paper

Dr gedam kamalakar

Urolithiasis is a common worldwide problem with high recurrence. This review covers the forty-one (41) antiurolithiatic plants of the Rosaceae family that are used in 14 countries. Hopefully, this review will be helpful for the general public and attract the scientific world for antiurolithiatic drug discovery.

Dr. salman ahmed

Vigna aconitifolia (Jacq.) Marechal. (Papilionaceae) is a medicinally important plant used for treating different diseases, especially dermatological disorders. Alkaloids, phenols, flavonoids, and phytic acid have been reported in this plant. Vigna aconitifolia also exhibits antioxidant, antidiabetic, and hypocholesterolemic activities. The present review attempts to compile all the previous data based on its medicinal uses, phytochemistry and pharmacology reported in the earlier articles.

Dr. salman ahmed

NA

Priyanka

The rate of oxygen consumption was measured in mercury chloride treated freshwater fish, cyprinus carpio for 96h and compared to control group. The present investigation showed that average oxygen rate was decreased in all treated animal as compared to controlled group. Behavioural changes was also recorded in both concentration. The behavioural alterations observed like surfacing, erratic movement, increased mucous secretion, decreased opercular movement and loss of balance. The present study revealed that, mortality rate increased with increases in concentration.

.vijay digambar suryawanshi

Pharmacy education has evolved from the outdated changing 5 to 4 year dispensing pharmacy program that focus on the medicines value the compounding and dispensing to patient-oriented pharmacy program (Pharm D) that focus on patient, experiential learning (practicum courses), evidence -based program that does foster critical thinking, and clinical reasoning skills [1] and improving patient care.

Mediterranean journal of pharmacy and pharmaceutical sciences

Introduction: Study was conducted with an objective of investigating the inhibitory effect of Phaseolus lunatus seeds extract on three enzymes (α-amylase, maltase and glucoamylase) involved in diabetes. The disadvantages related to the use of synthetic drugs make it necessary to search for alternative medicines from medicinal plants. One therapeutic approach for treating postprandial hyperglycaemia is to decrease the plasma glucose level, which can be attained by lowering the starch hydrolysis by digestive enzymes such as α-amylase, maltase and glucoamylase. The use of synthetic antidiabetic agents caused gastrointestinal side effects. Methods: Hence, the research was aimed to evaluate the potential of Phaseolus lunatus seeds extract to inhibit α-amylase, maltase and glucoamylase as a possible mechanism of hypoglycemia caused by this plant with fewer side effects. Phaseolus lunatus, also known as Lima bean, is native to Tropical America and grown worldwide. Lima bean has been prescribed traditionally to treat different diseases, including diabetes. Result: The results of the present study showed that Phaseolus lunatus seeds extract has exerted both time and concentration-dependent Significant inhibitory effects on these digestive enzymes might be due to the cumulative impact of phytoconstituents in the plant extract. Conclusion: Therefore, it can be said that the part mechanisms by which Phaseolus lunatus exhibited its antidiabetic activity might be through inhibiting this digestive enzyme.

Dr. salman ahmed

A 22-year-old Indonesian woman was admitted through the emergency department with a 10-day history of  fever associated with chills. Other medical history was unremarkable. On examination, she appeared ill; BP 95/60 mmHg, pulse 105/min, and temperature 39.5°C. Abdominal examination showed splenomegaly; examination of the heart, lungs, and nervous system was unremarkable.

Karishma

Artificial Intelligence (AI) is rapidly transforming the landscape of supply chain management, offering unprecedented opportunities for optimization, efficiency, and innovation. This white paper explores the various applications of AI in supply chain operations, highlighting its potential to revolutionize the way businesses manage inventory, logistics, demand forecasting, and more. Through real-world examples and case studies, we demonstrate how AI-driven technologies are reshaping traditional supply chain practices and driving competitive advantage in today's dynamic marketplace.

Kalpak

Technology is very important in this day and age. There are so many fields that use technology, one of which is in the field of education. Even though Indonesia is still in a situation of the Covid-19 pandemic, education must remain number one by maximizing technology, especially in the field of communication. In this study discussed the role of technology during the distance learning process, especially for students at the SD / MI level. The formulation of the problems in this study are (1) How is the distance learning process using educational technology media for SD / MI students during the Covid-19 pandemic?; (2) What are the problems that occur in the distance learning process using educational technology media for SD / MI students during the Covid-19 pandemic?; (3) What is the solution to problems in the distance learning process by using educational technology media for SD / MI students during the Covid-19 pandemic? While the method used to answer the formulation of the problem is qualitative research with an analytic description approach, interviews and literature study, the focus of which is the role of technology and educational media for students at the SD / MI level during the Covid-19 pandemic. The results showed that the distance learning process was carried out using Zoom Cloud Meeting media, WhatsApp group and Google Classroom. The problem that occurs during the distance learning process is usually a signal problem that is not good and sometimes students feel bored when doing online learning so they are playing, lying down, and eating snacks. The solution that the teacher takes to overcome this problem is to provide weekend projects on Saturdays and Sundays. Tehnologi merupakan hal yang sangat penting di masa sekarang ini. Banyak sekali bidang yang memanfaatkan teknologi, salah satunya di bidang pendidikan. Meskipun Indonesia masih berada dalam situasi pandemi Covid-19, namun pendidikan harus tetap di nomor satukan dengan memaksimalkan teknologi khususnya bidang komunikasi. Di dalam penelitian ini dibahas mengenai peran teknologi selama proses pembelajaran jarak jauh terutama bagi peserta didik pada tingkat SD/ MI. Rumusan masalah dalam penelitian ini yaitu (1) Bagaimana proses pembelajaran jarak jauh dengan menggunakan media teknologi pendidikan bagi Siswa SD/MI di Masa pandemi Covid-19?; (2) Apa saja permasalah-permasalahan yang terjadi dalam proses pembelajaran jarak jauh dengan menggunakan media teknologi pendidikan bagi Siswa SD/MI di Masa pandemi Covid-19?; (3) Bagaimana solusi permasalahan dalam proses pembelajaran jarak jauh dengan menggunakan media teknologi pendidikan bagi Siswa SD/MI di Masa pandemi Covid-19? Metode Penelitian yang digunakan adalah penelitian Kualitatif dengan pendekatan deskripsi analitik, wawancara dan studi literatur kepustakaan. Hasil penelitian ini menunjukkan (1) proses pembelajaran jarak jauh dilakukan dengan menggunakan media Zoom Cloud Meeting, Whatsapp grup dan Google Classroom. (2) Permasalahan yang terjadi pada saat proses pembelajaran jarak jauh adalah adanya kendala sinyal yang kurang bagus dan terkadang siswa merasa bosan ketika sedang melakukan pembelajaran daring sehingga mereka sambil bermain, tiduran, dan memakan cemilan. (3) Solusi yang dilakukan oleh guru untuk mengatasi permasalahan tersebut adalah dengan memberi weekend project di hari Sabtu dan Ahad.

Educare: journal of primary education

Newborn or neonate denotes to an infant in the first few days after birth. They are not small children when it comes to medicinal use and formulation development. Neonates include term, post-term and preterm babies. The neonatal period for preterm newborn infants is defined as the day of birth through to the expected date of delivery plus 27 days. The majority of drugs used in sick newborns receiving intensive care are unlicensed and off-label, exposing infants to a greater risk of adverse drug reactions (ADRs). This study is extremely important due to the presence of a variety of drug information sources if used together lead to medication errors. From this point of view, this approach is suggested to eliminate or minimize these varieties. Where the most important challenges in neonatal intensive care unit (NICU) is proper and correct calculations and administration. Drug-related events in a hospital setting are the highest cause of recorded errors such as in the USA and UK

Mediterranean journal of pharmacy and pharmaceutical sciences

Keeping an in depth tab of recent folks or folks on chair with bound health conditions for his or her health and safety is a very important task. With maturity, weak bones and weakness because of alternative health connected problems could lead to will increase risk of falling. A supervisor might not continually be on the market with them and if correct assistance is not provided at the correct time it should cause larger health considerations which will need extra resources for treatment. For this purpose we've projected a wise IOT Fall Detection System exploitation acceptable sensors that square measure integrated facilitate|to assist} report these incidents to assist avail help at the correct time to forestall additional injury to health. The same system uses sensors like associate degree measuring system to live the speed of the person, a rotating mechanism to live the person’s orientation so as to live their stability, a load sensing element once the system is employed by an individual employing a chair to live their weight, a Wi-Fi module and a microcontroller that sends the general readings to alert the involvedthose that shall give with the right suggests that to assist the person in want. The microcontroller receives all the info from the sensors and perpetually transmits and monitors the acceleration and also the orientation of the person. Any fast abrupt modification within the system which will result from a fall is taken into account as a ‘fall’ and is reported . a serious concern would be that not all fast movement may end up from a fall and be thought of as a matter of concern. To avoid this warning a napbutton is provided to snooze the system. This button will be ironed before a definite time say 15-30 seconds to prevent the system from causation the alert, thus avoiding any confusion and panic. this method will be mounted to the person’s chair or will be created compact to be created into a wearable device which will be worn on the hand.

Dr h shaheen

In order to overcome the carcinogenic ‘polycyclic aromatic hydrocarbon’ emission from aromatic oils, which are restricted in European countries since 2010, various efforts have been made to replace the aromatic oil in rubber-based compounds either fully or partially. The authors in the present work have used liquid isoprene rubber (LIR50 or LIR) as a reactive plasticizer in natural rubber (NR) compound at different loadings (2, 4, 6 and 8 phr) and have studied its effect on viscosity, curing characteristics and physico-mechanical properties. These results were compared with the control compound containing conventional aromatic oil as plasticizer. From the experimental data, it was noticed that, the minimum torque for control compound was 0.33 dNm and that for LIR based compounds ranged between 0.16 to 0.56 dNm. The LIR based compounds exhibited slightly higher Mooney viscosity but offers the same scorch safety. The study supports the utility of LIR as a promising alternative, as revealed by the comparable rheological and physico-mechanical properties attained with the usage of appropriate quantity of LIR, unlike the other alternatives of the previous investigations that usually showed a property difference. Keywords: aromatic oil, liquid rubber, reactive plasticizer, safe processing oil.

Chandresh m. p.

This research was conducted to form students to be more disciplined in maintaining time, especially in prayer, as well as to strengthen aqidah and increase the worship of students of Madrasah Ibtidaiyah Salafiyah Syafi'iyah. The focus of this research is: 1) How to plan the prayer chapter of fiqh learning through audio-visual media for students of Class IV Madrasah Ibtidaiyah Salafiyah Syafi'iyah Ajung, 2) How to implement the prayer chapter of fiqh learning through audio-visual methods for students of Class IV Madrasa Ibtidaiyah Salafiyah Syafi 'iyah Ajung, 3) How is the evaluation of fiqh learning in the prayer chapter for fourth grade students of Madrasah Ibtidaiyah Salafiyah Syafi'iyah Ajung. This research uses qualitative research with descriptive qualitative research. Determination of research subjects in this study was carried out purposively. Data collection techniques used observation, interviews, and documentation. Analysis of the data, the researcher used the data analysis model of the Miles, Huberman, and Saldana models including: Data Condensation (Condensation), Data Presentation (Display), Conclusions Drawing. The validity of the data in this study used source triangulation and technical triangulation. The results showed that: 1) The use of audiovisual media was very relevant in learning fiqh in the prayer chapter 2) Active, innovative, creative, effective and fun learning made students enthusiastic and enthusiastic in learning and not boring. 3) the completeness of learning facilities and infrastructure is very influential in the evaluation stage including summative evaluation and formative evaluation, input evaluation, process evaluation and output evaluation. Penelitian ini dilakukan untuk membentuk peserta didik lebih disiplin dalam menjaga waktu khususnya dalam shalat, serta memantapkan aqidah dan meningkatkan ibadah peserta didik Madrasah Ibtidaiyah Salafiyah Syafi’iyah. Fokus penelitianini adalah: 1) Bagaimana Perencanaan Pembelajaran fiqih bab sholat melalui media audio visual bagi peserta didik Kelas IV Madrasah Ibtidaiyah Salafiyah Syafi’iyah Ajung, 2) Bagaimana Pelaksanaan pembelajaran fiqih bab sholat melalui metode audio visual bagi peserta didik Kelas IV Madrasah Ibtidaiyah Salafiyah Syafi’iyah Ajung, 3) Bagaimana evaluasi pembelajaran fiqih bab sholat bagi peserta didik kelas IV Madrasah Ibtidaiyah Salafiyah Syafi’iyah Ajung. Penelitian ini menggunakan penelitian kualitatif dengan jenis penelitian kualitatif deskriptif. Penentuan subyek penelitian dalam penelitian ini dilakukan secara purposive.Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Analisis data, peneliti menggunakan model analisis data model Miles, Huberman, dan Saldana meliputi: Kondensasi Data (Condensation), Penyajian Data (Display), Penarikan Kesimpulan (Conclusions Drawing). Keabsahan data dalam penelitian ini menggunakan triangulasi sumber dan triangulasi teknik.Hasil penelitian menunjukkan, bahwa: 1) Penggunaan media audiovisual sangat relevan dalam pembelajaran fiqih bab sholat 2) Pembelajaran aktif, inovatif, kreatif, efektif, dan menyenangkan membuat peserta didik semangat dan antusias dalam belajar serta tidak membosankan. 3) kelengkapan sarana dan prasarana pembelajaran sangat berpengaruh pada tahap evaluasi meliputi evaluasi Sumatif dan evaluasi Formatif evaluasi input, evaluasi proses dan evaluasi output.

Educare: journal of primary education

The market for tertiary educational institutions, most especially for private universities, is highly competitive. The competitive nature of the market requires that Private Universities (PUs) step up their performance so as to remain competitive despite the major structural and market differences between them and public universities in the provision of tertiary education. The need for private universities to remain competitive in this turbulent market, calls for some careful examination of the factors that would enable private universities to enhance their performance. In this respect, this study sought to examine the effects of management competence, firm-level institutions, and human resource management (HRM) bundles on the performance of private universities in Ghana. Underpinned by the RBV and AMO theories, the study tested four hypotheses that sought to explain the relationships between the key variables of the study. The study was implemented using a quantitative research design. Out of the sixteen private universities sampled, thirteen private universities responded. The main research instrument was a structured questionnaire. Out of 230 questionnaires administered, 127 completed questionnaires were received and used for analysis. Collected data was analyzed using descriptive and inferential statistics (regression analysis) with the aid of SPSS software version 20 and AMOS version 23. Research findings from the tests of hypotheses established that management competence positively and significantly affected performance of private universities in Ghana. Though the study found that the composite variables of firm-level institutions and HRM bundles did not moderate the relationship between management competence and PU performance, the skills bundles (which is a component of the HRM bundles) significantly moderated the management competence – PU performance relationship in such a way that at high levels of skills bundle, management competence influences PU performance more than at low levels of skills bundle. Based on the findings of the study, it is recommended that PUs in Ghana institute competence acquisition and utilization policies, maintain appropriate firm-level institutions and HRM bundles and match these to their competence development strategies.

Cyril domeyelle dery

Emesis is defined as a forceful expulsion of stomach contents via the mouth. The adverse effects of available anti-emetic drugs potentiate us to evaluate natural products to explore effective natural anti-emetics with fewer side effects. The fruits of Illicium verum Hook. f. were selected for anti-emetic activity based on their folkloric use against gastrointestinal complaints. Crude methanolic extract and its aqueous, dichloromethane, ethylacetate and hexane fractions were evaluated using the copper sulphate-induced chick emesis model. Emesis was induced by the oral administration of copper sulfate 10 ml/kg body weight and metoclopramide (150 mg/kg p.o.) as a standard anti-emetic drug. The anti-emetic effect was observed by calculating the mean decrease in the number of retches compared to that of the control. Methanolic extract and its fractions were tested at 25, 50 and 75 mg/kg oral doses. Among all tested fractions, ethyl acetate showed the highest (94.46%), and hexane showed the lowest (56.30%) anti-emetic activity at 50 mg/kg. Further, isolation and purification from the same fractions are in process to discover effective natural anti-emetic compound(s) with less unwanted effects.

Dr. salman ahmed

Phycochemical and pharmacological studies were carried out on Ulva fasciata Delile. The ash content was found to be 20.4812 % dry weight, moisture content 14.5514 %, and total fat content as 0.1878% and 0.49341 %. Total carbohydrate was found to be 54.5301-54.2246% dry weight, phenolic content was found to be 0.022%, flavonoids were found to be 0.0313%, and tannins were 0.00003 %. Ulva fasicata showed central analgesic activity and significant anti-inflammatory activity at 400 mg/kg bw.

Dr. salman ahmed

Objective: Pyrazolopyrimidines are heterocyclic molecules containing nitrogen as the main composition, and hence, they exhibit pharmacological efficacy. They are analogs of purines so that possessing wide applications in the field of medicinal chemistry. The main objective of this study is to synthesize different derivatives of pyrazole-pyrimidine classes by adopting simple methodology as well as by employing green chemistry. The purpose of the synthesis of these molecules is to study the antitumor activity against Ehrlich ascites carcinoma (EAC) cell lines. Methods: After literature studies, it makes us to involve in the research of synthetic organic chemistry, especially to synthesize new compounds of pyrazolopyrimidines. We are reported solvent-free synthesis of pyrazolo [3,4-d]-pyrimidine-thiones through ethyl acetoacetate, hydrazine hydrate, thiourea, and different benzaldehydes. An ionic liquid 2-methyl-imidazolium-oxalate catalyzed the reactions under ultrasonication bath. Both conventional and ultrasonic methods were employed and comparison studies have been made. It was found that ultrasonic method completed the reaction quicker than the conventional method. All the synthesized compounds were confirmed their structures by 1 HNMR, Fourier transform infrared, 13C-NMR, and elemental analysis spectra. The compounds were tested for in vitro anticancer activity against EAC cell lines. Most compounds revealed significant anticancer activity relative to doxorubicin as a positive control with inhibitory concentration (IC50) values. Results: Ultrasonication method is a simple method under which all the reactions were completed at faster time (<7 min) compared to the convention method. Among eight molecules, 8a and 8d completed the reactions at a faster rate. We reported IC50 values of all the molecules, in which 8e and 8g were exhibited excellent potency against EAC cell lines at different concentrations .

Dr ganesh n yallappa