Organisations may either belong to the private sector or the public sector. When they are in the private sector, they can be large, small or medium-sized depending on the annual income and the number of workers they hire. Global organisations are developing rapidly because of the need to tap into new markets and production locations. Under the organisational structure, the organisation selected was Nike. It has several functional units whose activities are interrelated. For instance, human resource units ensure that the right personnel for finance or marketing are recruited and promoted. The emergence of new markets in BRIC and the digital revolution are highly relevant to external factors that affect the organisation. As a response, Nike has used social media and the digital revolution to reach customers directly. It, however, needs to take on new markets and products to remain in business.

Zamzam abdelazim

Autophagy is a self-digesting mechanism responsible for removal of damaged organelles, malformed proteins during biosynthesis, and nonfunctional long-lived proteins by lysosome. Autophagy has been divided into three general types depending on the mechanism by which intracellular materials are delivered into lysosome for degradation that is, microautophagy, chaperone-mediated autophagy (CMA), and macroautophagy. In microautophagy cytoplasm material is sequestered through direct invagination to the lysosomal membrane. Whereas in CMA proteins flagged with pentapeptide motif (KFERQ) were selectively degraded through direct translocation into lysosome. Macroautophagy involves the formation of subcellular double-membrane-bound structures called autophagosomes that contain degradable contents of cytoplasm materials and deliver them into lysosomes for breakdown by lysosomal enzymes. The molecular mechanism of autophagy involves several conserved Atg (autophagy-related) proteins. Systems produce modified complexes Atg8-PE and Atg5-Atg12-Atg16 as autophagy regulators. Autophagy is activated in response to diverse stress and physiological conditions. For example, food deprivation, hyperthermia, and hypoxia are mediated by factors like insulin/IGF-1, m-TOR signaling, FOXO transcription factors, and chaperones. The perturbance in autophagy may lead to several types of cancers, myopathies, and neuromuscular disorders. Several autophagy inducers and inhibitors like 3-methyladenine (3-MA), bafilomycin A1, LY294002 (LY), and Velcade have been used to treat disease is an intense field of study.

Kamal singh

The 2019 coronavirus (COVID-19) pandemic is spreading worldwide, with a spectacular increase in death missing any effective therapeutic treatment up to now. Molecular docking is a recognized computational tool to assist in early drug discovery and development. Molecular docking analysis was carried out using 2-(4-(aminomethyl)phenyl)isoindoline-1,3-dione Schiff base conjugates with SARS-CoV-2 protease enzyme and COVID-19 main protease in apo form 6M03). The compounds with the best normalized docking scores to protease enzyme (6LU7) were ARG3 (-8.1 kcal/mole), ARG7 (-8.1 kcal/mole) and ARG6 (-8.0 kcal/mole). The best docking ligands for main protease in apo form (6M03) were ARG7 (-8.7 kcal/mole), ARG6 (-8.6 kcal/mole) and ARG3 (-8.4 kcal/mole). The structural similarity between these conjugates inspired us to perform in silico studies to check their possible binding interactions with essential SARS-CoV-2 proteins. These studies provide insight into the potential binding between Schiff base derivatives and SARS-CoV-2 proteins to provide an insight for finding an effective therapy. Finally, ADMET calculations were performed for the Schiff base compounds to predict their pharmacokinetic profiles.

Mediterranean journal of pharmacy and pharmaceutical sciences

Arisaema jacquemontii Blume (Araceae) is a medicinally important plant for treating different diseases, especially dermatological disorders. Alkaloids, phenols, terpenes, flavonoids, glycosides, and tannins have been reported from this plant. Antioxidant, antifungal, antibacterial and anticancer activities are also shown by Arisaema jacquemontii. The present review attempts to compile all the previous data based on its medicinal uses, phytochemistry and pharmacology reported in the earlier articles.

Dr. salman ahmed

আলোচ্য প্রবন্ধের কালানুক্রমিক উৎস একটি ঔপনিবেশিকতার সীমাবদ্ধতায় থাকা ভূখণ্ড এবং সেই সমাজের মেয়েদের সভা, সমিতি ও আলোচনা সভা গঠন। স্বাধীনতার পূর্বকাল অর্থে, ১৯৪৭ সালের আগে পর্যন্ত সময়কাল। কালের নিরিখে প্রাক – স্বাধীনতা সময়কালের বিস্তার দীর্ঘ হলেও, এর আলোচনার সময়কাল কেবলমাত্র নারী সংগঠনের সূচনা বা উৎসের সময় থেকেই আলোচ্যের। সেই সময়কাল দুভাগে ভাগ করা যায়। এক, এদেশের মেয়েদের সভা – সমিতি গঠনের পূর্বকাল। দুই, এদেশের মেয়েদের সভা – সমিতি গঠনের শুরু। এক্ষেত্রে, আলোচ্য প্রবন্ধের নিরিখে আলোচনা করা যায় দু-প্রকারে। এক, উনিশ শতকের মেয়েদের তৈরি সভা, সমিতি ইত্যাদি। দুই, সমাজ-বহির্ভূত মন্দ মেয়েদের যোগদান করা সভা, সমিতি বা আলোচনা সভা। এক্ষেত্রে ভাষার ব্যবহার সূচিত – সভা হিসেবেই লিখিত ও আলোচিত হবে।

Mou

We present a large-eddy simulation (LES) of saliva particle transport during normal human breathing through the nose and mouth. The flow of the air–saliva mixture is modeled using an Eulerian LES that is coupled with a Lagrangian particle tracking module to obtain trajectories of saliva particles in a room with stagnant air conditions. The coupled Eulerian–Lagrangian simulation yields novel insights into the intricate dynamics of Lagrangian coherent structures (LCS) and fundamental material lines that emerge from the saliva particles' trajectories during several breathing cycles. Further, we systematically compare the quantitative LCS diagnostics of mouth breathing with those of mouth and nose normal breathing. Analyzing the simulation results of human breathing from the mouth and nose, we show that, soon after the first breathing cycle, saliva particles form a series of roll-up vortex rings that propagate forward. The forward propagation of these vortex rings leads to the formation of an asymmetrical primary forefront vortex. The individual vortex rings continuously propagate forward, merging with the forefront vortex, and ascending along the limb of the leading vortex.

Hossein seyedzadeh

“Phyllanthus emblica” known to be amla has role in the skin aging influences the changes in skin, including skin dryness, wrinkle, and irregular pigmentation. Initially the 6 day observation has been taken for the ageing activity to be track to study the TREM2 pathway of “Phyllanthus emblica”. Cellular observation and pathway consideration: The environmental impact of pH, Temperature, Humidity and stability of amla fruits is important for the ageing of cells in neuronal cascade of TREM2 Pathway, while studying the fruits cell cycle. The melanin suppression through inhibition of tyrosinase and tyrosinase-related protein-2 activities, the strong antioxidant, and the potent matrix metalloproteinase-2 in cellular observation of tyrosinase pathway. The study aimed to evaluate the anti-skin aging efficacy of amla.

Wahul umesh

Nuclei segmentation plays an essential role in histology analysis. The nuclei segmentation in histology images is challenging in variable conditions (clinical wild), such as poor staining quality, stain variability, tissue variability, and conditions having higher morphological variability. Recently, some deep learning models have been proposed for nuclei segmentation. However, these models rarely solve the problems mentioned above simultaneously. Most of the information in Hematoxylin and Eosin (H&E) stained histology images is in its channel, and the remaining information is in the spatial domain. We observed that most problems could be solved by considering channel and spatial features simultaneously, e.g., the spatial and channel features provide the solution to the morphological variability and staining variability, respectively. Therefore, we propose a novel spatial-channel attention-based modified UNet architecture with ResNet blocks in encoder layers. The UNet baseline preserves coarse and fine features, thus proving the solution to the tissue variability. The proposed method significantly improves the segmentation performance compared to the state-of-the-art methods on three different benchmark datasets. We demonstrate that the proposed model is generalized for 20 cancer sites, more than any reported literature. The proposed model is less complex than most state-of-the-art models. The impact of the proposed model is that it will help improve further procedures such as nuclei instance segmentation, nuclei classification, and cancer grading.

Ibtihaj ahmad

Here is presented a short review on the medical potency of the most toxic plant of Europe. In many countries it isn't concerned any more as therapeutic agent in medicine due to frequent intoxications. However, in the homeopathy, preparations and patent medicines still contain aconitine and other alkaloids (abundant levels). There exists even a US Patent "ACONITINE COMPOUNDS, COMPOSITIONS, USES, AND PREPARATION THEREOF" (No. US 9,085,536 B2 by du Bois et al. 2015).

Stefan dahl

The establishment of energy-saving and natural resource-saving systems is an important issue and relevant research and development should be accomplished without delay. Making structures lighter is one way to save energy. The study of light metals such as aluminium and magnesium alloys has received much attention. Aluminium alloys are especially attractive because of superior recyclability and workability. However, present structures made of stainless steels cannot be entirely replaced with aluminium alloy structures, taking into account strength, weldability and economics, although it is possible to replace part of a structure with aluminium alloy components. In this case, it is necessary to joint SS 430F steel with Aluminium 6061. Few sound joints have been obtained, owing to the formation of a large amount of brittle intermetallic compounds which were using fusion welding. In the recent years, welding of dissimilar metals by conventional welding techniques has become difficult. The flux used for the welding will create lot of heat which reduces the strength of the welded joints. In order to overcome this, friction welding is more effective in joining dissimilar metals when compared with fusion welding, since it is a solid-state process. Heat is generated in friction welding by conversion of mechanical energy into thermal energy in the interface of work pieces during rotation under pressure. Various ferrous and non-ferrous alloys having circular or non-circular across sections and that have different thermal and mechanical properties which can be joined by the friction welding. Conventional structures made of steel have been replaced by lighter materials, capable of providing high mechanical strength, lower volume of material and good corrosion resistance components such as those used in industries (shipbuilding, light and heavy automotive, electrical, chemical, civil, space and nuclear industry).

Boopathy govindarajan

The current COVID-19 is now endemic on everycontinent and becomes the most challenging outbreaks over centuries, thus millions of people have been infected with the novel coronavirus (SARS-CoV-2), and have contributed to the deaths of more than two millionpeople. Researchers are working continuously to develop safe and effective vaccines that people have started receiving since December 2020. Vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are the most important countermeasure to the COVID-19 pandemic taking into considerationthat vaccines induce a robust immune response

Mediterranean journal of pharmacy and pharmaceutical sciences

The Quantum Teaching learning model is a modification of the various interactions that exist in and around the moment in learning. This study aims to find out more about how to apply Quantum Teaching in measuring students' abilities including cognitive, affective and psychomotor aspects. This research method uses qualitative research methods with the type of research field research. Data collection techniques using observation techniques, interviews, and documentation. While the data analysis is a qualitative analysis model of Miles and Huberman and Saldana which consists of data collection, data condensation, data presentation and drawing conclusions. The results of this study are: (1) Implementation of Quantum Teaching in Class V Thematic Learning at MI Mambaul Ulum Kandangrejo cognitive aspects, namely students are able to think more critically and broadly, students are able to do assignments or exercises and can understand learning well, students able to provide questions and answers properly and appropriately. (2) Implementation of Quantum Teaching in Class V Thematic Learning at MI Mambaul Ulum Kandangrejo aspects in the affective aspect, namely: the curiosity of students increases, students become more focused, students' attitudes become more confident and courageous. (3) Implementation of Quantum Teaching in Class V Thematic Learning at MI Mambaul Ulum Kandangrejo psychomotor aspects, namely: students are able to practice well the learning media is provided, students are able to name the names and parts of the circulatory organs, students are able to show the circulatory organs blood using the medium.

Educare: journal of primary education

It is virtually impossible to mention the phrase ‘project management’ without introducing the concept of risk management. As Hillson (2016, p.11) states, “risks [are] particularly relevant to projects” suggesting that effective management of risk is an integral ingredient for project success. The close link that exists between projects and risks may be deduced by the definition of the word ‘project’. In simple terms, projects refer to unique endeavours undertaken with the aim of achieving desired outcomes. These endeavours typically specific start and completion dates, and involve resource, time and cost constraints. These characteristics imply that projects are intended to deliver identifiable benefits to the organisation; these benefits, however, are not enjoyed immediately even if the project is completed. On the contrary, projects commonly create capabilities that call for operation or utilisation for the actual gains to be generated (Hillson, 2016 p.11). The interpretation of this is that projects have a risk element in that they contain a potential reward and possibility of loss. For this reason, project managers must be well-versed with risk management.

Mohamed sorogy

Service quality in the hospitality industry becomes one of the most important factors for gaining a sustainable competitive advantage and customers’ confidence in the highly competitive marketplace, and therefore service quality can give the hospitality industry a great chance to create competitive differentiation for organisations. It is thus considered as a significant core concept and a critical success factor in the hospitality industry. A successful hotel delivers excellent quality service to customers, and service quality is considered the life of hotel. Many benefits can be achieved by service quality such as establishing customer satisfaction, contributing to business image, establishing customer loyalty, and providing a competitive advantage to a business. Service quality performance can mean different to different people, for example, employees may show higher perceptions of service quality than customers perceived, and thus managers and their employees never like to identify deficiencies in service quality

Mukhles m. al-ababneh

Justificativa e objetivo: O uso inadequado da estatística básica é o maior responsável peloerro de interpretac ̧ão dos artigos científicos. O objetivo deste artigo de revisão foi rever algunstópicos básicos de estatística para alertar autores e leitores sobre a importância do relatoadequado da estatística básica.

Kamal singh

For given condition of (temperature and humidity) of suction air, the delivery air condition depends on the system parameters (depth, radius, length and air mass flow rate), thermo physical properties of the surrounding earth (thermal conductivity and specific thermal capacity) and earth surface environment (ambient temperature, ambient humidity and solar irradiance)[1,3].Sensitivity analysis of system performance is essential for understanding the relative importance of different parameters of design of a optimum system [2,5]. For the steady state periodic input air condition and the performance of the system can be measured in terms of heating potential during the winter period and cooling potential during the summer period. Sensitivity of the system performance parameters (heating potential in winter and cooling potential in summer) to the changes in system parameters or thermo physical properties of the surrounding earth has been analysed and the result is present is in this paper.

Dr h shaheen

Children's vaccinations play a significant role in public health efforts, particularly in reducing morbidity and mortality rates among children worldwide. However, challenges such as the accessibility of healthcare facilities, misinformation, and perceptions continue to affect the achievement of immunization goals in Tanzania and other developing countries. Based on the need to protect the community from diseases that can be prevented by vaccination, this study aimed to assess vaccination coverage and timeliness among children aged 12-23 months who attended postnatal immunization clinics in the Kongwa district located in the Dodoma region, Tanzania. A quantitative cross-sectional study was employed, involving 200 children who visited vaccination clinics along with their caregivers. Data were obtained through a questionnaire prepared and vaccination cards. This current study revealed that 96.0% were fully vaccinated, with 4.0% partially vaccinated, while no children were found to be totally unvaccinated. Timeliness varied across vaccines assed vaccines: 75.0% of Bacillus Calmette-Guérin vaccinated on time, four doses of Oral Polio Vaccine ranged from 74.0-87.0% of on time vaccination. Three doses of the Pentavalent Vaccine and Pneumococcal Conjugate Vaccine had on-time vaccination rates ranging from 79.5% to 86.0%. Two doses of the Rotavirus Vaccine reached on-time rates of 84.5% to 86.0%. 60.5% of people received the Measles and Rubella vaccine, with 35.5% experiencing delays and 4.0% remaining unvaccinated. This study revealed that, despite the national efforts to improve vaccination rates for children, issues such as delays and incomplete immunizations persist. Strategies like community engagement, continuous training for healthcare professionals, and improving healthcare accessibility in remote areas should be reinforced to improve vaccination uptake in Tanzania.

Mediterranean journal of pharmacy and pharmaceutical sciences

Woman constitutes the family, which leads to the development of society and Nation. The social and economic development of women is necessary for the overall economic advancement of any society or a country. Entrepreneurship comprises venture activities that are the center of the recognition of various opportunities, creativity, and innovation in the production process and development of new business models and ventures. Entrepreneurship plays a major role in developing society of a fastdeveloping country like India. In comparison to other countries, the event of women entrepreneurship is extremely low in India, especially in rural areas. However, middle-class women aren't too eager to alter their roles because of fear of social backlash. The growth is more visible among high families in urban areas. Rural women frequently have primary responsibility for agricultural production, additionally to domestic responsibilities and childcare. In developing countries like India where the economic status of women is extremely pathetic especially in rural areas and opportunities of earning are very less. For establishing self-esteem and recognition in society, women are attracted to entrepreneurship. To sustain within the competitive market, businesses administered by women are mainly hooked into internal resources and their capabilities supported which they struggle to compete with the external environment. The present paper endeavors to study the opportunities and challenges of women entrepreneurs. The study aims to analyze the factors that encourage women entrepreneurs. This study is based on secondary data collected from previous research papers, journals given by various research scholars, blogs, and websites. This study concludes that women entrepreneurs should be provided with special training facilities to overcome challenges and for developing their skills and talents.

Mamta gaur

To satisfy user expectations and resource needs, academic libraries are realizing more and more how important it is to integrate innovative technologies. Effective use of technology is essential to educational libraries' success. A thorough analysis finds new trends that university libraries are using to satisfy present demands. In the twenty-first century, libraries are becoming dynamic establishments that meet the changing demands of society. These consist of data literacy, digitization, and the incorporation of augmented and virtual reality technologies. Additionally, libraries are becoming community hubs for educational programs like seminars and lectures. Libraries are helping people navigate the immense ocean of information, and data literacy along with knowledge skills is essential. Services driven by AI are improving client experiences and expediting procedures. With libraries implementing eco-friendly architectural designs & community engagement tactics, sustainability projects are becoming more and more well-known. Libraries are responding to these shifts by creating creative solutions, including collaborations, environmental initiatives, and AI integration, all while overcoming financial limitations. To remain relevant, they are adopting cutting-edge strategies like AI-powered services, collaborations, sustainability, virtual and alternative reality technologies, open data initiatives, maker spaces, & creative labs. Libraries are implementing cutting-edge solutions to address a variety of community needs and encourage lifelong learning, despite obstacles such as limited financing, evolving librarian roles, privacy and security concerns, and adjusting to changing societal standards.

Dr. awadhesh singh gautam

Mano Matram Jagat; Mano Kalpitam Jagat - (“the world is as the mind sees and feels it; the world is as the mind thinks of it” (as qtd. by T.N.Sethumadhavan, 2010). So, our life is in the way we feel and perceive it. Humans are a mixture of emotions and reasons. Reasoning enables them to analyze and judge things with mathematical precision, while emotions help them to understand and empathize others that make them human. Traditionally, people with a high degree of logic and reasoning were believed to be intelligent and. The purpose of the IQ tests was designed to ascertain a person’s intelligence based on the reasoning and the logical aptitude of the person. IQ tests were found to be effective when a person is ‘not’ scared or angry or intrigue about specific things that aroused emotions. Emotions were considered disruptive in nature, which influences the process of thinking of a person (Woodworth, 1940). Mowrer (1960) opined that “emotions are of quite extraordinary importance in the total economy of living organisms and do not deserve being put into opposition with intelligence‟. The emotions are, it seems, themselves a higher order of intelligence.”

Aurora lyrics