In the name of Allah, Most Gracious, Most Merciful. Blessed be He in Whose hands is Dominion; and He over all things hath Power;- He Who created Death and Life, that He may try which of you is best in deed: and He is the Exalted in Might, Oft-Forgiving;- He Who created the seven heavens one above another: No want of proportion wilt thou see in the Creation of (Allah) Most Gracious. So turn thy vision again: seest thou any flaw? Again turn thy vision a second time: (thy) vision will come back to thee dull and discomfited, in a state worn out. And we have, (from of old), adorned the lowest heaven with Lamps, and We have made such (Lamps) (as) missiles to drive away the Evil Ones, and have prepared for them the Penalty of the Blazing Fire. For those who reject their Lord (and Cherisher) is the Penalty of Hell: and evil is (such), Destination. When they are cast therein, they will hear the (terrible) drawing in of its breath even as it blazes forth, Almost bursting with fury: Every time a Group is cast therein, its Keepers will ask, “Did no Warner come to you?” They will say: “Yes indeed; a Warner did come to us, but we rejected him and said, ´Allah never sent down any (Message): ye are nothing but an egregious delusion!´” They will further say: “Had we but listened or used our intelligence, we should not (now) be among the Companions of the Blazing Fire!” They will then confess their sins: but far will be (Forgiveness) from the Companions of the Blazing Fire! As for those who fear their Lord unseen, for them is Forgiveness and a great Reward. And whether ye hide your word or publish it, He certainly has (full) knowledge, of the secrets of (all) hearts. Should He not know,- He that created? and He is the One that understands the finest mysteries (and) is well-acquainted (with them). It is He Who has made the earth manageable for you, so traverse ye through its tracts and enjoy of the Sustenance which He furnishes: but unto Him is the Resurrection. Do ye feel secure that He Who is in heaven will not cause you to be swallowed up by the earth when it shakes (as in an earthquake)? Or do ye feel secure that He Who is in Heaven will not send against you a violent tornado (with showers of stones), so that ye shall know how (terrible) was My warning? But indeed men before them rejected (My warning): then how (terrible) was My rejection (of them)? Do they not observe the birds above them, spreading their wings and folding them in? None can uphold them except (Allah) Most Gracious: Truly (Allah) Most Gracious: Truly it is He that watches over all things. Nay, who is there that can help you, (even as) an army, besides (Allah) Most Merciful? In nothing but delusion are the Unbelievers. Or who is there that can provide you with Sustenance if He were to withhold His provision? Nay, they obstinately persist in insolent impiety and flight (from the Truth). Is then one who walks headlong, with his face grovelling, better guided,- or one who walks evenly on a Straight Way? Say: “It is He Who has created you (and made you grow), and made for you the faculties of hearing, seeing, feeling and understanding: little thanks it is ye give. Say: “It is He Who has multiplied you through the earth, and to Him shall ye be gathered together.” They ask: When will this promise be (fulfilled)? – If ye are telling the truth. Say: “As to the knowledge of the time, it is with Allah alone: I am (sent) only to warn plainly in public.” At length, when they see it close at hand, grieved will be the faces of the Unbelievers, and it will be said (to them): “This is (the promise fulfilled), which ye were calling for!” Say: “See ye?- If Allah were to destroy me, and those with me, or if He bestows His Mercy on us,- yet who can deliver the Unbelievers from a grievous Penalty?” Say: “He is (Allah) Most Gracious: We have believed in Him, and on Him have we put our trust: So, soon will ye know which (of us) it is that is in manifest error.” Say: See ye?- If your stream be some morning lost (in the underground earth), who then can supply you with clear-flowing water?
Oecophylla longinoda has some reported medicinal uses, including antimicrobial, analgesic, and anti-inflammatory activities. This study was designed to investigate the Oecophylla longinoda methanol extract to evaluate the toxicity profiles of its acute and sub-acute effects. The experiments were conducted to determine the oral median lethal dose (LD50) and other gross toxicological manifestations on an acute basis. In the first phase of the acute toxicity study, three per group were administered Oecophylla longinoda at single oral doses of 10, 100, and 1000 mg/kg body weight, and 1600, 2900, and 5000 mg/kg of Oecophylla longinoda in the second phase. In the sub-acute studies, the mice were orally administered 2.5 g/kg Oecophylla longinoda per day for 14 consecutive days. Rat body weight and fluid intake were recorded during the 14 days. The rat kidney, heart, liver, and blood sera were obtained for weight, histological, and biochemical markers including glucose, cholesterol, proteins, triglycerides, enzymes including ALT, AST, and ALP, as well as electrolytes (sodium and potassium) examinations. Results show that the methanol extract of Oecophylla longinoda is safe, and no significant changes in the biochemical markers that indicate harmful effects on the kidney and liver were observed in mice. However, the liver showed slight changes while the kidneys and heart remained healthy in mice exposed to Oecophylla longinoda. The no-observed-adverse-effect limit was 5000 mg/Kg body weight/day.
Mediterranean journal of pharmacy and pharmaceutical sciences
Recently, the definition of cardiorenal syndrome (CRS), a condition with a complicated pathogenesis, has been revised. Logically, CRS syndrome should be classified according to the initial organ that is injured, resulting in damage to another organ. Hence, there are only three main categories of CRS. Category one includes acute and chronic CRS. Category two involves renal-cardiac syndrome (RCS), which can be classified as acute or chronic. The third category represents secondary CRS, referred to as cardio-reno-cardiac syndrome (CRCS), which can be subdivided into acute and chronic CRCS. In this part of our series, we will discuss the epidemiology, pathophysiology, diagnosis, treatment, and prevention of acute CRS. We retrieved articles published on acute CRS using different keywords and phrases between January 2019 and June 2025 to achieve these goals.
The study examined psychological predictors and mediators of teacher subjective well-being. Participants included 174 teachers from urban middle and highschools. The first objective was to explore the psychological correlates of the teacher SWB: self-esteem, general self-efficacy (core self-evaluation), teacher self-efficacy, optimism (cognitive trait related to the psychological well-being), and perceived social support (psychosocial trait related to the psychological wellbeing. The second objective was to investigate the mediating role of self-efficacy in the association between optimism and subjective well-being. The third objective was to explore the mediating role of teacher self-efficacy in the relation between perceived social support and teacher subjective well-being. Correlation, linear regression and mediation model analyses through the Sobel test were computed. Results confirmed the research assumptions. The findings of this study enhance the understanding of personal factors associated with teacher subjective wellbeing. The constructs linked to subjective well-being (predictors and mediators) could be target of school psychologists’ interventions, in order to have more engaged and performing teachers in schools. The findings were discussed in the context of designing the interventions for enhancement of the subjective wellbeing among teachers.
Long periods of free-movement Restrictions may negatively affect Cardio-Pulmonary fitness and health. As, the COVID-19 virus primarily affects Respiratory system, and also associated with cardiovascular disease, can induce the following complications like thrombosis, myocardities, Interstitial pulmonary fibrosis, diffuse alveolar damage and persistent decline in lung function, as the lung capacity decreases it may results in decrease in Cardio Pulmonary endurance. The Present study investigated changes after the COVID-19 confinement in total distance covered in 6 minutes by patients and correlation between 6 minutes walk test vs. oxygen saturation; Results suggest that the Mean ± SD of age is 43.4 ± 10.8years. Male: Female 1:0.5.Mean ± SD of total distance walked in 6 minutes by patients is 443.5 ± 55 compared with Hypothetical mean (normative value) is 571 ± 90.Correlation between Total distance walked in 6 minutes vs. oxygen saturation is r = 0.055.
The methanol extract of the whole alga Hypnea pannosa J. Agardh was subjected to antifungal screening. It showed low activity against Aspergillus flavus Link ex Gray 1821.
The current study used the chick emesis model to explore the anti-emetic effect of the methanolic extract of Acalypha ornata Hochst—roots. Emesis was induced by the oral administration of copper sulfate to male chicks. Acalypha ornata root extract (150 mg/kg orally) showed an anti-emetic effect and was compared with the reference drug chlorpromazine
The bioactive phytochemicals are the most important bioactive compounds against insect herbivores. These phytochemicals produced by many legumes and react herbivore attacks. Therefore, keeping in mind the said facts, this review discusses the potential use of bioactive compounds like Proteinase inhibitors, trypsin inhibitors, lectins, vicillins (7S storage proteins), phenolics, amino acids, sugars and a-amylase inhibitors in legume plants as most important weapons that confer resistance against herbivorous insects. These inhibitors inhibiting proteases present in the larval gut and has insecticidal potential against insect pests. This review demonstrates the potential of natural phytochemicals from legume plants and or artificially diet incorporate to inhibit the development of pathogens and insect pests. Thus, legumes can be used to produce phytochemicals as bio-pesticides and minimize or avoid the use of agrochemicals in crop protection. This ability making them interesting bioactive for next generation of sustainable pesticides for more sustainable agriculture.
Justificativa e objetivo: O uso inadequado da estatística básica é o maior responsável peloerro de interpretac ̧ão dos artigos científicos. O objetivo deste artigo de revisão foi rever algunstópicos básicos de estatística para alertar autores e leitores sobre a importância do relatoadequado da estatística básica.
Medicinal plants have been known for thousands of years and are highly esteemed worldwide as a rich source of therapeutic agents for preventing and curing diseases. Nowadays, a large number of the population suffers from gallstones. The gall stones problem is increasing significantly due to changes in living styles and conditions, i.e. industrialization and malnutrition. Medicinal plants have been used for centuries due to their cultural acceptability, efficacy, safety and lesser side effects than synthetic drugs. The review aims to gather information on the plants utilized in various parts of society against gallstones. The information is useful for ordinary people and the scientific community to carry out further phytochemical, pharmacological and toxicological studies to discover new, effective and safer molecules against gallstones.
Use of chemical fungicide to control plant diseases causes several adverse effects such as, development of resistance in the pathogen, residual toxicity, pollution to the environment etc. So an alternative way to overcome the usage of dreadful chemicals is very important. The use of plant extracts as biofungicide is one of the popular and effective method. Araucaria columnaris is a commonly seen ornamental plant known as Christmas tree. It’s a South African species, under the family Araucariaceae. Hence, in the present study, the plant resin extract was tested in-vitro against major plant pathogensby preliminary bioassay. It was found that up to 95% reduction of mycelium growth was observed against major phytopathogens such as Fusarium oxysporyum, Rhizoctoniasp, Cylindrocladiumsp, Alternariasp, and Colletrotricum sp., causing tomato wilt, damping off, foliage blight, and leaf blight diseases in economically important plants. Up to our knowledge it is the first report showing the antifungal activity of Araucaria columnaris resin as antifungal agent. By using this valuable tree, further work will be done to formulate commercial biofungicide.
The transportation problem is widely applied in the real world. This problem aims to minimize the total shipment cost from a number of sources to a number of destinations. This paper presents a new method named Dhouib-Matrix-TP1, which generates an initial basic feasible solution based on the standard deviation metric with a very reduced number of simple iterations. A comparative study is carried out in order to verify the performance of the proposed Dhouib-Matrix-TP1 heuristic.
Background: Lichen planus (LP) is a papulosquamous cutaneous disorder that manifests as intensely itchy violaceous flat-topped polygonal papules and plaques. To compare the efficacy of topical clobetasol propionate 0.05% versus topical tacrolimus 0.1% in the treatment of LP. Methods: This prospective Comparative Study was conducted at the Dermatology Department, Services Institute of Medical Sciences (SIMS)/Services Hospital, Lahore, from May 1, 2022, to April 30, 2023. Ethical approval was obtained from the institutional review board at the Department of Dermatology, SIMS/Services Hospital, Lahore. A total of 80 patients were selected after fulfilling the selection criteria. The study participants were placed into two groups, A and B. In group A, the patients were advised to use the topical application of clobetasol propionate (0.05%) ointment twice daily. In group B, tacrolimus ointment (0.1%) was used twice daily. Treatment response was assessed at 3 weeks, and then finally efficacy was evaluated at 6 weeks. Results: Treatment efficacy was observed in 34 patients (42.5%). Group A (Clobetasol) demonstrated a significantly higher efficacy of 55% compared to 30% in Group B (Tacrolimus; p = 0.024). Conclusions: The 0.05% clobetasol propionate topical formulation demonstrated superior efficacy in treating LP compared to 0.1% topical tacrolimus. Further validation of these findings through large-scale clinical trials is warranted.
Mano Matram Jagat; Mano Kalpitam Jagat - (“the world is as the mind sees and feels it; the world is as the mind thinks of it” (as qtd. by T.N.Sethumadhavan, 2010). So, our life is in the way we feel and perceive it. Humans are a mixture of emotions and reasons. Reasoning enables them to analyze and judge things with mathematical precision, while emotions help them to understand and empathize others that make them human. Traditionally, people with a high degree of logic and reasoning were believed to be intelligent and. The purpose of the IQ tests was designed to ascertain a person’s intelligence based on the reasoning and the logical aptitude of the person. IQ tests were found to be effective when a person is ‘not’ scared or angry or intrigue about specific things that aroused emotions. Emotions were considered disruptive in nature, which influences the process of thinking of a person (Woodworth, 1940). Mowrer (1960) opined that “emotions are of quite extraordinary importance in the total economy of living organisms and do not deserve being put into opposition with intelligence‟. The emotions are, it seems, themselves a higher order of intelligence.”
The domestication of animals and cultivation of crops have been essential to human development throughout history, with the agricultural sector playing a pivotal role. Insufficient nutrition often leads to plant diseases, such as those affecting rice crops, resulting in yield losses of 20-40% of total production. These losses carry significant global economic consequences. Timely disease diagnosis is critical for implementing effective treatments and mitigating financial losses. However, despite technological advancements, rice disease diagnosis primarily depends on manual methods. In this study, we present a novel Self-Attention Network (SANET) based on the ResNet50 architecture, incorporating a kernel attention mechanism for accurate AI-assisted rice disease classification. We employ attention modules to extract contextual dependencies within images, focusing on essential features for disease identification. Using a publicly available rice disease dataset comprising four classes (three disease types and healthy leaves), we conducted cross-validated classification experiments to evaluate our proposed model. The results reveal that the attention-based mechanism effectively guides the Convolutional Neural Network (CNN) in learning valuable features, resulting in accurate image classification and reduced performance variation compared to state-of-the-art methods. Our SANET model achieved a test set accuracy of 98.71%, surpassing current leading models. These findings highlight the potential for widespread AI adoption in agricultural disease diagnosis and management, ultimately enhancing efficiency and effectiveness within the sector.
Community pharmacist plays an essential role in educating the epileptic patients about their disease and medications. Improving the patient’s awareness may lead to improve their compliance and decrease drug-drug interaction and ultimately improve their quality of life. Pharmacist can detect the emergence of health problems and can help prevent progression of comorbidities. Considering the complexity of treating epilepsy and the lack of information about pharmacists’ contributions to epilepsy management, pharmacist performed pharmaceutical counselling, pharmaco-therapeutic follow-up and systematic measurement and evaluation of findings and increase medication adherence of patient with epilepsy. This study was aimed to assess the community pharmacist's knowledge about epilepsy and their treatment by antiepileptic drugs in Libya. The design of the study is a cross sectional study. The knowledge was collected through a questionnaire which included 35 questions divided into three sections: demographic data, general information about epilepsy and information about epilepsy and antiepileptic drugs. The questionnaire was prepared and validated by consultant training in Ali Omer Asker Hospital in Tripoli for two months. The findings indicate that over 200 patients are altered viewed, of whom, only epileptic patients were observed. The majority of the participants were female, qualification degree BSc and years of experience from one to five years. Unfortunately, some of the participants (40.0%) had poor knowledge and about 60.0% of them had good knowledge. This study indicates that the importance of community pharmacist in Libya requires more improvement to achieve the existing function and that the impact of continuous study of everything related to diseases and medicines is important to obtain a qualified pharmacist who can become an effective agent for a change.
Mediterranean journal of pharmacy and pharmaceutical sciences
в статье анализируются основные причины и критерии иностранных инвестиций, основная роль внедрения инновационных технологий в рыночную экономику. А также роль иностранных инвестиций в модернизацию экономики Узбекистана.
This book presents more than 600 eye-catching structural geological photographs and explanatory descriptions, from different Indian terrains. This book will enable easy identification of deformation features, one of the most important tasks in structural geology at the meso- and micro-scales.
The paper aims to discuss the process of change management and how change affects organizations' functioning. Using the chosen case studies about different organizations that have successfully undergone change management, the report will highlight the drivers of change and their impact on the organization's behaviour. Also, change management is not easy, and there are specific barriers that can affect the organization's smooth functioning during managing change. Also, the leadership approaches that can help the organization in change management will be discussed.
The increasing prevalence of Artificial Intelligence (AI) in creating content signifies a notable change in the digital communication landscape. While the broader effects on widespread media platforms have been extensively discussed, the specific consequences within specialized online communities remain less explored. These communities, frequently founded and established on shared interests, mutual confidence, and perceived genuineness, are particularly susceptible to alterations in the origin and trustworthiness of content. This paper challenges three questions: (1) How AI content affects credibility perceptions, (2) Verification methods used by communities, (3) Consequences for trust dynamics. A hypothetical framework would be used to investigate the potential impact of AI-produced content on the dynamics of trust and credibility within these focused digital environments. By drawing upon existing academic work in media studies, the behavior of online communities, and the concept of source credibility, a theoretical model and outline a potential research strategy were encouraged to examine how the presence, identification, and interpretation of content authored by AI might modify member interactions, processes for verifying information, and the overall unity of the community. The hypothetical outcome suggests that the subtle integration of AI content could diminish perceived authenticity, complicate established indicators of trust, and potentially lead to the fragmentation or decline of communities that depend on authentic human connection and collective expertise. The article concludes by considering the ramifications for those who manage communities, design platforms, and participate as members, stressing the importance of greater openness and digital literacy in navigating the evolving digital media landscape.