Bhaishajya kalpana is an art and science of preparing and dispencing medicine. Guggulu is a Niryasa (oily latex) achieved from small tree called Indian bedellium. Botanical name is commiphora mukul. Guggulu is an amorphous, translucent, solid adhesive, oleo-gum resin is produced by the process of gummosis from its plant. Many other Ayurvedic classics have mentioned various formulations of Guggulu for the treatment of various ailments. Bhashajya ratnawali followed various kalpana use for formuations. Guggulu kalpana is secondary formulations of bhaishajya kalpana. . Guggulu is one among the best binding agents and its used as single or compound drug in the form of pills, Formulations which contains Guggulu as main ingredient, they can be called as Guggulu kalpana. Here in Bhaishajya Ratnawali, Guggulu is used in yoga for both purposes, as a base and as well as medicament also.In bhaishajya Ratnavali Guggulu when modified into different formulations. It can also be used in many diseases along with different combinations of drugs with their anupana, Guggulu kalpana beneficial in treating many diseases. The Guggulu Kalpana is indicated in almost all the strotovikaras and also a number of research works have been proved the wide range of action of Guggulu .

Suri abhiram

The study of molluscan animals is called Malacology and the study of molluscan shell is called as conchology. The scaling of metabolic rates with body mass is one of the best known and most studied characteristics of aquatic animals. We studied here how body size is related to rate of oxygen consumption, ammonia excretion and O: N ratio in Freshwater Bivalve Mollusc Lamellidens marginalis species in an attempt to know how body size specific changes affect their metabolism. The freshwater bivalve molluscs with specific body size i.e. small (76-79 mm in shell-length) and large (90-94 mm in shell-length) were chosen for experimental work from Bhima River at Siddhatek on April and May during summer. The adult bivalve molluscs with small body size reported high value in rate of oxygen consumption and O: N ratio but rate of ammonia excretion was low value in small body sized bivalves compared to large ones. The results are discussed in the flush of metabolic processes in fresh-water bivalve molluscs.

Dr. pritesh ramanlal gugale

Background: The deliberate postponement of significant academic assignments with due dates is known as academic procrastination. The undesirable habit known as procrastination is the inability to start or finish a task within the allotted time, which results in detrimental effects on students' future employment, as well as stress, guilt, poor academic achievement, and low self-esteem. Method: Descriptive Research design was adopted for a study to assess the Variables influencing Nursing students' Academic Procrastination at selected Nursing college of Bhopal, M.P. Sample size 60 B.Sc. Nursing students. Result: Result revealed that majority of students were females, 27 out of 60 were in age group of 20-21yeras, 25 (41.6%) were studying in B.Sc. N 3rd year. Most of students resided in Rural area (36), 54 out of 60 belong to nuclear family and 35 mothers of students were educated as compared to 51 fathers. The mean score and SD of influencing variables of academic procrastination were as follows Personal variable was 2.6 ± 0.48, Environmental 2.26 ± 0.71, and Academic was 1.78 ± 0.41. Majority of nursing students 39 (65%) were moderately affected by Personal variables, Environmental variables affected 23 (38%) students moderately and academic variables affected 17 (28%) students moderately. Only Personal factor had more effect on 5 students as compared to none in other two variables. Conclusion: The study concluded that Environmental and personal factor had more effect on Academic procrastination as compared to academic variables.

Dr k c yadav

A simple one pot synthesis has been developed for the synthesis 1,4-dihydropyridine using an efficient and reusable silica supported MgO solid catalyst by condensation of dimedone, ethyl acetoacetate, aldehyde and ammonium acetate in methanol as a solvent at room temperature. The reactions could be carried out under mild reaction conditions with very good yield of polyhydroquinoline, up to 92%. This catalyst could be recycled very easily, which makes this methodology environmentally benign.

Shilpa sangle

Marine algae have been known and utilized since the ancient era. It is the source of chemical compounds mainly useful as a food for their richness in protein, fatty acids, minerals and vitamins. Physiologically active compounds also have a great potential to play an important role in cosmetics, medicine and pharmaceutical aid. In this review, the information provided will play an essential role in future medicinal and cosmeceutical production.

Dr. salman ahmed

Urolithiasis is a common worldwide problem with high recurrence. This review covers the forty-one (41) antiurolithiatic plants of the Rosaceae family that are used in 14 countries. Hopefully, this review will be helpful for the general public and attract the scientific world for antiurolithiatic drug discovery.

Dr. salman ahmed

A study to evaluate the influence of body mass index, life styles and dietary habits on blood pressure among the nursing students at selected nursing college of Vijayapur. The objective of the study is to assess relationship of life style factors, body mass index and dietary habits with blood pressure. A sample of 500 nursing students was included in the study. The study result showed there is significant association between body mass index, life style dietary habits and blood pressure

Shwetha hitnal

The bioactive phytochemicals are the most important bioactive compounds against insect herbivores. These phytochemicals produced by many legumes and react herbivore attacks. Therefore, keeping in mind the said facts, this review discusses the potential use of bioactive compounds like Proteinase inhibitors, trypsin inhibitors, lectins, vicillins (7S storage proteins), phenolics, amino acids, sugars and a-amylase inhibitors in legume plants as most important weapons that confer resistance against herbivorous insects. These inhibitors inhibiting proteases present in the larval gut and has insecticidal potential against insect pests. This review demonstrates the potential of natural phytochemicals from legume plants and or artificially diet incorporate to inhibit the development of pathogens and insect pests. Thus, legumes can be used to produce phytochemicals as bio-pesticides and minimize or avoid the use of agrochemicals in crop protection. This ability making them interesting bioactive for next generation of sustainable pesticides for more sustainable agriculture.

Dr. babu lal jat

Brain tumors (BTs) are deadly diseases that can strike people of every age, all over the world. Every year, thousands of people die of brain tumors. Brain-related diagnoses require caution, and even the smallest error in diagnosis can have negative repercussions. Medical errors in brain tumor diagnosis are common and frequently result in higher patient mortality rates. Magnetic resonance imaging (MRI) is widely used for tumor evaluation and detection. However, MRI generates large amounts of data, making manual segmentation difficult and laborious work, limiting the use of accurate measurements in clinical practice. As a result, automated and dependable segmentation methods are required. Automatic segmentation and early detection of brain tumors are difficult tasks in computer vision due to their high spatial and structural variability. Therefore, early diagnosis or detection and treatment are critical. Various traditional Machine learning (ML) techniques have been used to detect various types of brain tumors. The main issue with these models is that the features were manually extracted. To address the aforementioned insightful issues, this paper presents a hybrid deep transfer learning (GN-AlexNet) model of BT tri-classification (pituitary, meningioma, and glioma). The proposed model combines GoogleNet architecture with the AlexNet model by removing the five layers of GoogleNet and adding ten layers of the AlexNet model, which extracts features and classifies them automatically. On the same CE-MRI dataset, the proposed model was compared to transfer learning techniques (VGG-16, AlexNet, SqeezNet, ResNet, and MobileNet-V2) and ML/DL. The proposed model outperformed the current methods in terms of accuracy and sensitivity (accuracy of 99.51% and sensitivity of 98.90%).

Mehdhar s. a. m. al-gaashani

Fruits are indispensable in today’s world owing their tremendous health benefits. Cucumber and watermelon are commonly consumed fruits worldwide. In this study, antioxidant potential of crude methanol extract of different concentrations of cucumber and watermelon were screened for antioxidant activity using total phenolic content, ferric reducing power (FRAP), ferric thiocyanate (FTC) tests and free radical scavenging (DPPH) assay. They are good source of calcium, magnesium and copper with appreciable amounts of vitamin C (143.360 ± 101.400 mg/100 g) for cucumber and vitamin A (90.980 ± 22.860 mg/100g; 29.475 ± 0.575 mg/100 g) for both watermelon and cucumber respectively. It was found that polyphenolics compounds were maximum in watermelon (87.04 ± 0.55 mg/g GAE in concentration 100 mg/mL). The extracts showed a potent DPPH free radical scavenging activity; cucumber had maximum percentage inhibition at 20 µg/mL concentration (29.2%) compared to watermelon at 40 µg/mL concentration (13.5%). These fruits also exhibited fairly good antioxidant activity with in both FRAP (0.517 mg/100 g; 0.317 mg/100 g) and FTC (17.2%; 31%) methods for watermelon and cucumber respectively.

Svedbergopen

AIM: The present cross-sectional questionnaire survey was conducted to assess the knowledge, and perception related to pharmacovigilance and ADR reporting among the B.pharm Final year students. MATERIALS AND METHODS: To assess the demographic details of the pharmacy students, their knowledge and perception toward pharmacovigilance and ADR reporting; a validated pretested questionnaire was used which comprises 11 knowledge-based closed-ended questions and 14 perceptions based agree/disagree questions. RESULT: The questionnaire was distributed to the 150 respondents of B. Pharm final year students who were willing to participate in the study. A response rate of 75% was recorded. The number of female respondents 53.3% was comparatively higher than the male respondents 46.6%. Most of the respondents were between 20 -22 years of age and only 4.7% were of 25 years of age. The average positive response for the knowledge-related statements was found to be 86.5% and the average positive response for the perception-related statements was found to be 70.67%. CONCLUSION: The findings showed adequate knowledge among pharmacy students and positive perception towards pharmacovigilance and ADRs reporting. This survey strongly suggests that there is a great need for increasing knowledge in clinical pharmacy courses and practical exposure to cases in the hospitals through internship programs which are meant to provide a unique opportunity for the pharmacy students that they must learn and practice the skills required for quality ADR reporting

Zeenath banu

The motto behind the keenness of urban areas has become unmistakable in current cities because of the rise of installed and associated shrewd gadgets, frameworks, and innovations. It is possible to connect every object to the Internet. As a result, in the impending Internet of Things era, the “Internet of Vehicles-IoV” will play a critical role in newly developed dazzling urban communities. The IoV can possibly address different traffic and street wellbeing issues successfully to forestall deadly crashes. In any case, a specific test of IoV, particularly in “Vehicle-to-Vehicle” as well as “Vehicle-to-Infrastructure” communications, guarantees quick, in order to transmit securely and exact performance of the information. The above effort is modifying Blockchain innovation for continuous application called RTA to meet “Vehicle-to-Every thing-V2x” communications problems in order to overcome these challenges. As a result, the main goal of the study is to develop a Blockchain-based IoT framework for establishing communication security and creating a completely decentralized computing platform. Research methodology used here is divided into two major sections. In the part 1 presented below, authors discuss the traceability and optimization over Merkle trees. The second section deals with implementing an actual blockchain with our optimized Merkle tree as the underlying technology to represent a distributed trust based ledger.

Dr h shaheen

Abstract: Recent studies on hydrogels have shown them as promising biomaterials for numerous applications involving tissue engineering, drug-screening, drug-delivery, and 3-D bioprinting because they show unique physicochemical properties. The ability of these structures to hold large amounts of water is because of their hydrophilic nature that provides a soft and hydrated environment like natural tissues. This makes them ideal for mimicking the extracellular matrix and supporting cell growth and proliferation. In tissue engineering, hydrogels might be used to create scaffolds that promote cell growth and facilitate tissue regeneration. Hydrogels can also be engineered in such a way that they intimate the mechanical and biochemical in vivo characteristics making them a versatile tool for applications in tissue engineering. Hydrogels are being used in drug screening, as they can be functionalized with different biochemicals in order to match the microenvironment of specific tissues. This allows researchers to study how drugs interact with cells and tissues in-vitro conditions, which can lead to more efficient strategies for drug development. For applications in drug delivery hydrogels are designed to release drugs in a sustainable and controlled way, improving the drug efficacy and reducing the toxicity of drugs. Designing can also be done in a way that they can target specific tissues and cells making them a promising tool for personalized medicine. Hydrogels are being used in 3-D bioprinting, where they serve as bio-inks that can be fabricated into complex structures with high precision. In comparison to conventional technologies, this is a promising technique that allows the construction of complex three-dimensional structures in a sequential manner by a computeraided system. One major challenge in bioprinting is finding such material that is suitable for printing and also satisfies the mechanical strength requisite for tissue engineering applications. That is where hydrogels serve as the most appropriate model and have encouraging or favorable operation potential as cell-affable materials. This technique has revolutionized tissue engineering by allowing researchers to create functional tissues and organoids and spheroids. Overall, hydrogel-based tissue engineering, drug screening, drug delivery, and 3D bioprinting are exciting areas of research with great potential to significantly impact different areas of medicine and biology.

Deepika pal

Treatment planning for oral squamous cell carcinoma (OSCC) is based on the clinical TNM (Tumor, Node and Metastasis) classification. This system operates on the assumption that small tumours without clinical spread have a better prognosis than larger tumours with metastases. However, it is a well-known fact that some tumours with the same clinical staging show different growth patterns and clinical behaviour. This makes the prognosis for patients with OSCC difficult to predict on the basis of clinical staging alone. Although many histopathological characteristics of OSCC have been identified as prognostic factors, none is believed to be completely infallible. Therefore, a great need exists for more reliable prognostic markers, which will assist in treatment decisions. It is now well documented that several molecular events of significance for tumour spread, such as gain and loss of adhesion molecules, secretion of proteolytic enzymes, increased cell proliferation and initiation of angiogenesis occur at the tumour–host interface or invasive front, where the deepest and presumably most aggressive cells reside. This review describes the various molecular events and interactions, which take place in the invasive front of the OSCC, and elucidates their role as prognostic markers.

Mohit sharma

Community acquired pneumonia is a prevalent disease in the Emergency Department (ED). The literature reveals that clinical practice could not be related with guidelines recommendations. The aim of this study is to determine the impact of the implementation of the recommendations of the Spanish society of Emergency Medicine in the Hospital Clínico Universitario Lozano Blesa (Zaragoza) ED in the management of community acquired pneumonia. Use of Pneumonia Severity Index (PSI) estimation was used to assess the adherence. This study was carried out from December, 2014 to February, 2015. Data was compared with the previous two months. The indicators management (discharge or admission decision, adequacy and anti-biotherapy) as well as the incidence of PSI estimation before and after the intervention in these parameters were evaluated. 209 patients were included, 97 before the intervention and 112 after the intervention. No significant differences were observed in the calculation of PSI. A significant decrease of admissions was observed after the intervention in the patients in whom the PSI was calculated (68.8% vs. 45.0%, p < 0.05). A greater use of the Observation Room was aimed at those patients in whom the PSI was calculated (06.3% vs. 17.5%, p < 0.05). PSI calculation significantly increased antibiotic prescription adherence (88.9% vs. 75.2%, p < 0.05). There were no modifications in the prescription after the intervention. In conclusion, PSI is a useful and effective measure to achieve a greater adherence to the recommendations. However, despite the positive trend in the use of the PSI and its interpretation, a low-intensity intervention is not sufficient to generalize its use.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background: There is a lack of adequate data about the prevalence and types of tuberculosis (TB) disease in Hadramout Al-Sahel, Yemen. Hence, this study aimed to investigate the prevalence, types, and outcomes of TB disease in Hadramout Al-Sahel, Yemen. Materials and Methods: This cross-sectional study was conducted at the National TB Program (NTP) center in the city of Al Mukalla, Hadramout, Yemen. The study enrolled TB patients from different districts of Hadramout Al-Sahel who had registered at the NTP center between January 1 and December 31, 2021. Results: A total of 127 new active TB cases were recruited, including 102 (80.3%) with pulmonary TB (PTB) and 25 (19.7%) with extra PTB (EPTB). The overall prevalence of TB disease in 2021 was 12.7 new TB cases per 100,000 population, while the median age of the study population was 38 years. The majority of cases (23.6%) belonged to the age group of 35–44 years. There were 85 (66.9%) males, and most patients (74; 58.3%) were identified in Al Mukalla City. EPTB was detected in 25 (19.7%) patients, with pleural effusion being the most frequent manifestation, found in 12 (48.0%) patients. All patients received 4-agent anti-TB therapies; 99 (77.9%) patients received anti-TB therapy for 6 months; 9 (7.1%) patients received anti-TB therapy for 9–12 months; 8 (6.3%) patients died during treatment; and 11 (8.7%) patients were lost during follow-up. The majority of patients (108; 85%) were cured on completion of treatment. Conclusion: The prevalence of TB in Hadramout Al -Sahel was 12.7 cases per 100,000 population. Males were affected more than females; the pleura was the most commonly affected extrapulmonary site; and 85% of cases were cured. The results indicated the need to support the Al Mukalla NTP center, by providing more resources for improved TB reporting and for conduct of surveillance to detect new TB cases among high risk groups. Health authorities are also urged to provide state hospitals with the equipment needed for TB diagnosis.

Karishma

Introduction and importance: Human echinococcosis, also known as‘hydatid cyst,’ constitutes a zoonotic parasitic disease attributed to Echinococcus granulosus or Echinococcus multilocularis. Primary af ictions occur in the liver and lungs, whilst the implication of alternative organs remains infrequent. The clinical presentation can vary, and large cysts may cause compression symptoms and complications. This case involved a 21-year-old Palestinian female with three large hydatid cysts in the liver, causing compression of adjacent structures and unique clinical manifestations. Case presentation: A female aged 21 arrived with signs of heart palpitations, shortness of breath, tiredness, and pain in the right upper abdomen, alongside a background of infertility. During routine pre-IVF ultrasound, three liver hydatid cysts were unexpectedly found, leading to a referral to the surgical department. Laboratory tests and imaging con rmed this diagnosis. The surgery involved cyst aspiration, hypertonic saline injection, and marsupialization. Post-surgical complications were managed as they occurred. The symptoms lessened afterward, and a successful pregnancy was achieved 9 months post-surgery. Clinical discussion: Zoonotic infection by cystic echinococcosis (CE) primarily engages the liver and lungs. The progression of symptoms is contingent upon cyst placement and resultant pressure on adjacent tissues. Diagnosis requires imaging alongside serological assays, while large cysts necessitate surgical intervention. Conclusion: The presented case underscores the complexity of managing multiple extensive liver hydatid cysts, highlighting the necessity to consider hydatid disease amidst patients presenting with indeterminate symptoms, particularly within endemic zones. An extensive surgical strategy produced positive outcomes, illustrating the signi cance of prompt intervention for symptom alleviation and sustained patient health.

Mohamad banat

Business nowadays has no boundaries of time, place, or information, so any firm must evaluate its performance regularly to ensure long-term viability. This study aims to determine the impact of employees’ motivation and job training on company performance in a family business called PT Anugrah Mandiri. It is an automotive spare parts distribution company in Medan, Indonesia established in 2010. As a family business run by many family members, PT Anugrah Mandiri tends to undervalue the importance of providing motivation and delivering practical training to its employees. This results in most employees being overwhelmed, and the business performance is decreasing. As this study's quantitative research method shows, motivated and skilled employees are the keys to a successful firm. The instruments used to collect data are questionnaires about employees’ motivation, job training, and company performance, and then processed using SPSS. Saturation sampling is used as the sampling method by administering the questionnaires to 50 employees of PT Anugrah Mandiri. The data analysis tool in this study is a multiple linear regression by carrying out a classic assumption test continued by testing the partial hypothesis or t-test, the simultaneous hypothesis test or the F test, and the calculation of the coefficient of determination. The statistical result shows that company performance increases by 0.422 and 0.384 when employees’ motivation and job training increase by 1 unit. All hypotheses in this research are accepted, and it can be concluded that employees’ motivation and job training influence company performance.

L

Trachoma is a Neglected Tropical Disease (NTD) and one of the most common ocular contagious diseases, caused by different serovers such as A, B, Ba ,C of bacterium Chlamydia trachomatis that occurs recurrently. Most infants are adversely affected from chronic keratoconjunctivitis, leading to blindness in later life. Epidemiological studies in 2023 revealed that approximately 115.7 million people were at risk of trachoma, but presently it has been declined to almost 103.2 million. Basically this disease is predominant in least developed or developing nations with high poverty. Preventive measures being implemented by the World Health Organization (WHO) , popularly known as ‘SAFE’ strategy: S for surgery, A for antibiotic dissemination, F for facial cleanliness, and E for environmental improvements. Now-a-days it is effectively and extensively applied; that’s why number of active patients are reduced drastically, but trachoma-free world creation should be the principal and researches will make it possible.

Diptarup mallick

Project management plays significant roles to the success of the project. The aim of the study is to review and analyze latest literature on the effects of triple constraints on the project outcome. The study is based on the secondary method whereas literatures are collected form the google scholar ranging from 2010 to 2023. After reviewing the literature, the study concludes a number of findings. The quality of the project is highly depended on the time and budget. However, inadequate management, stakeholders involvement are also play crucial roles towards project success. The study concludes a number policy recommendations.

Nazim ullah