The phrase, "The world is ageing, but India has youth on her side," has been a soothing phrase. The average age of the Indian population will be 29 at the conclusion of this decade. As a result of this "demographic dividend," India is expected to account for a quarter of the world's additional increase in working population by 2040. There are 430 million people in our current workforce (ages 15 to 64). India will add 480 million people to its current workforce of 430 million in the next 20 years. Education is the most important tool for converting this demographic dividend into a sustainable economic resource and unlocking human capital's hidden potential. The suggested article attempts to identify gaps and loopholes in the education system utilising the basics of the Capability Approach as a comprehensive mechanism of evaluation and strategies to solve the aforementioned problems, allowing us to take advantage of our country's large demographic dividend.

Dr. amarjeet singh

For many decades, the lean concept has been praised for improving efficiency, maximizing productivity, and minimizing waste in manufacturing operations. Lean production is expected to create an industrial ecosystem that is more cost-efficient and accountable for optimizing resources and processes. However, in the context of lean manufacturing, new challenges have emerged as a result of the recent emphasis on sustainability. This study aims to show several criticisms of lean implementation and propose a holistic approach to achieve a more sustainable operation. The green-lean model, sustainable manufacturing, agile supply, and Lean 4.0, are approaches for integrating lean practices and sustainability. This will foster a culture of continuous improvement, employee empowerment, long-term collaboration with suppliers, added value for customers, and increased innovation in the economy.

L

This study intends to describe assessment strategies for young students' online learning. The participants in this descriptive qualitative study were 15 primary school principals and 35 teachers teaching Years 4 and 5 in urban and rural schools on the island of Lombok, West Nusa Tenggara Province, who volunteered their participation after undergoing comparable procedures. Using operational concepts of assessment of learning for online learning, class observation, and interview were organized. The content and structure validity of the measures were evaluated in accordance with the developmental periods of young learners. The findings showed that the teachers assessed the primary students' cognitive, psychomotor, and affective domains interactively during the online class meetings, in their portfolio, and through attitude direct observation. Several assessment strategies were advocated to circumvent the shortcomings of online learning. A criterion-referenced evaluation was used to conduct the analysis. The theoretical implications of the findings suggest that the various assessment procedures adopted have decreased the negative washback of online exams; however, further research is required to determine the consistency of the outcomes of online tests with other types of evaluation.

Darrel ocampo

This work was focused on identification and evaluation of process parameters of modified nanoprecipitation method, for fabrication of lomustine nanoparticles, with the aim of reducing cancer cell viability at low concentration of lomustine. The parameters controlling particle size, mostly in nanosize, were solvent/nonsolvent composition and emulsification speed of homogenizer along with aqueous phase volume. This controlled particle size is below 250 nm. The stabilizer concentration controlled particle size is within 68 nm ± 0.89 to 137 ± 0.94 nm with PDI 0.06 ± 0.008 to 0.25 ± 0.001. But, the stabilizer addition mode showed more uniform size distribution with PDI 0.085 ± 0.004. Entrapment efficiency was maintained well above 47 ± 0.23%. The drug release pattern was monophasic with controlled release over 24 hrs. In the method used, drug content was affected by ratio of polymer to drug to organic solvent, as well as homogenization speed and time. Percentage viable cells of L132 human lung cancer cell line remained, were only 5% at 100 μg/ml lomustine equivalent PLA nanoparticles.

Archana mehrotra

The human body has been theorized in many ways, including the entire notion of the woman as a human creation. It is generally agreed that this concept refers to our perceptions, thoughts, and feelings about our bodies, which influence our behaviour about our bodies. The article examines numerous authors whose individual genealogies meet on the common ground of identity theory and women's lives and is supported by a theoretical framework based on conceptions of identity, body-image and self-image in women and feminist discourse. This paper probes into the concepts of identity in women through the literary canvas of Dr. Bhabendra Nath Saikia and demonstrates the effects of body image and self-image on the development of identity. Of course, an extensive discussion of the short stories of Dr. Saikia is beyond the scope of this paper. The aim of this paper is to analyse the concepts through the two short stories short titled "Dhura Xaap" (ঢ োৰো সোপ 1958) and "Sringkhol" (শ ৃংখল, 1970) by Dr, Bhabendra Nath Saikia. The paper seeks to explore the concepts of self-image, identity and body image through three female characters ‘Chandrika’, ‘Janeki’ and ‘Ambika’.

Banani das

The incorporation of lomustine, a hydrophobic anticancer drug into PLGA nanoparticles by interfacial deposition method was optimized. Based on the optimal parameters, it was found that lomustine-PLGA nanoparticles with acceptable properties could be obtained. Optimization of formulation variables to control the size and drug entrapment efficiency of the prepared nanoparticles seems to be based on the same scientific principles as drug-loaded nanoparticles prepared by nanoprecipitation, solvent evaporation method. The process was the most important factor to control the particle size, while both the drug-polymer interaction and the partition of drug in organic and aqueous phases were the crucial factors to govern the drug entrapment efficiency. PLGA concentration at lower level (100 mg), 1:5 organic phase: aqueous ratio, 1%w/v PVA concentration, 3%w/v pluronic F68 achieved smaller particle size. Additionally, L:G ratio of PLGA 75:25, lower volume of organic solvent (1:10 organic phase: aqueous phase), higher initial drug content (10mg) enhanced the drug entrapment efficiency and maintained lomustine concentration in blood for an extended time period, elevated lomustine concentration in lungs and slowed the elimination of lomustine. The biodistribution profiles of prepared nanoparticles in albino mice showed higher plasma drug concentration for longer period of time, elevated drug concentration in lungs and slow elimination from kidney. No toxic effects of prepared nanoparticles were observed in histopathological examination of lungs and kidney. The systematic investigation reported here promises the development of PLGA nanoparticles loaded with lomustine when tested in Lung Cancer cell line L132 and toxicological/ histopathological studies in albino mice.

Archana mehrotra

Sentiment analysis and opinion mining is a branch of computer science that has gained considerable growth over the last decade. This branch of computer science deals with determining the emotions, opinions, feelings amongst others of a person on a particular topic. Social media has become an outlet for people to voice out their thoughts and opinions publicly about various topics of discussion making it a great domain to apply sentiment analysis and opinion mining. Sentiment analysis and opinion mining employ Natural Language Processing (NLP) in order to fairly obtain the mood of a person’s opinion about any specific topic or product in the case of an ecommerce domain. It is a process involving automatic feature extractions by mode of notions of a person about service and it functions on a series of different expressions for a given topic based on some predefined features stored in a database of facts. In an ecommerce system, the process of analyzing the opinions of customers about products is vital for business growth and customer satisfaction. This proposed research will attempt to implement a model for sentiment analysis and opinion mining on Twitter feeds. In this paper, we address the issues of combining sentiment classification and the domain constraint analysis techniques for extracting opinions of the public from social media. The dataset that was employed in the paper was gotten from Twitter through the tweepy API. The TextBlob library was used for the analysis of the tweets to determine their sentiments. The result shows that more tweets were having a positive subjectivity and polarity on the subject matter.

Dr. chandrashekhar uppin

This paper aims to study the restructuring and change management of SARHS, which in turn will be accompanied by some complex, difficulties and discussions that may include personnel emotion, which must be taken into account. We will guide SARHS managers by conducting a comprehensive study of majority factors that will affect the success of the process, considering and covering all views. Which will result in the dismissal of some employees and the closure of their jobs permanently in the new job structure. The study will include many theories, models and justified recommendations to be followed to ensure a successful and safe restructuring and management change free from unresolved impediments and difficulties that could lead to a setback. Finally, restructuring is not a result but the beginning of a new process

Mohamed sorogy

Fetus-in-fetu represents an extremely unusual condition where a malformed parasitized twin with an organized vertebral column is present within the body of its host, leading to a variety of symptoms due to its mass effect. Its pathogenesis and features differ from both teratoma and fetiform teratoma. Detailed radiological evaluation helps in the assessment of the local anatomy and in planning the surgical procedure. The clinical features of a 9-month-old female with progressive abdominal distension and feeding difficulties are described. A firm, non-tender leftsided abdominal mass on palpation was found to be a well-defined encapsulated retroperitoneal lesion with bony structures resembling a vertebral axis on abdominal sonography and computed tomography. Surgical excision revealed an encapsulated mass containing rudimentary limb buds, hair, and partially developed vertebral elements. Histopathology confirmed the diagnosis of fetus in fetu. The postoperative course was uneventful, and the patient remained asymptomatic on follow-up.

Karishma

Background: Shilajit is a historically valued natural substance with promising but still preliminary scientific support for urinary and diabetic health, yet its growing popularity risks exploitation and exaggerated claims without rigorous human clinical validation. This study investigates the therapeutic effects of Yemeni Shilajit sourced from Dhamar, Ma’rib, and Raymah on hemolytic anemia experimentally induced in rabbits using phenylhydrazine. Methods: Twelve male rabbits were divided into four groups: a control group and three treatment groups, each receiving Shilajit from one of the three regions. Anemia was induced via subcutaneous injection of phenylhydrazine hydrochloride, and treatment was administered orally at a dose of 125 to 250 mg/kg twice daily. Hematological parameters—including packed cell volume (PCV), hemoglobin concentration (Hb), red blood cell (RBC) count, and glucose-6- phosphate dehydrogenase (G-6-PD) activity—were evaluated at various intervals. Results: showed that Shilajit from Dhamar and Raymah significantly increased PCV, Hb, RBC count, and G-6-PD enzyme activity (p < 0.05), suggesting notable anti-anemic effects and potential for restoring hematological parameters to near-normal levels. In contrast, Ma’rib Shilajit exhibited limited efficacy, with significant improvement only in hemoglobin levels. Phytochemical analysis confirmed the presence of essential amino acids and bioactive compounds, such as fulvic acid and dibenzo-α-pyrones, which likely contribute to Shilajit’s therapeutic action. Conclusions: The study concludes that purified Shilajit from Dhamar and Raymah holds promise as a natural remedy for hemolytic anemia, supporting its traditional use and warranting further investigation for pharmacological applications.

Karishma

Ascorbic acid (vitamin C) is a water-soluble vitamin; it is present in the highest concentration in the brain. Ascorbic acid in high doses acts as a potential treatment for various neuropathological and psychiatric conditions. Flumazenil is a benzodiazepine antagonist; it competitively inhibits the activity of benzodiazepine and non-benzodiazepine substances that interact with benzodiazepine receptors site on the GABA/benzodiazepine receptor complex. This study aims to investigate the effect of flumazenil on the anxiolytic action of ascorbic acid using an elevated plus maze model of anxiety in rats. Male Albino Wistar rats weighing between 250 and 320 grams were used. Rats were divided into four equal groups of seven rats each and treated as follows: Group I, the control group received a single dose of 1.0% tween 80; Group II treated with a single dose of 125 mg/kg ascorbic acid; Group III was injected by a single dose of 1.0 mg/kg flumazenil; Group IV received a combination treatment of 125 mg/kg ascorbic acid and 1.0 mg/kg flumazenil. Behavioural measurements using a plus maze were scored 30 min after the administration. The parameters scored are the time spent on the open and closed arms, the lines and number of entries into open and closed arms, and the anxiety measure. Ascorbic acid decreased anxiety measure and increased the total lines and total number of entries; this effect was abolished by the administration of flumazenil with ascorbic acid. Thus, ascorbic acid produces an anxiolytic-like effect in rats; this effect was abolished by flumazenil administration with ascorbic acid. This may indicate that the GABA/benzodiazepine receptor complex has to be stimulated to produce the anxiolytic effect.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background: Hypertension (HTN) is defined as a blood pressure (BP) ≥140/90 mm Hg. The prevalence and mortality from HTN, globally and locally, have been on the increase since the 1980s. This study aimed to detect young adults (18-40 years) in Enugu State who are hypertensive, in order to raise the awareness that HTN is also common in young adults. Its early diagnosis and management could help to reverse the trend in the number of cases of HTN in Nigeria which had been predicted could hit 39.1 million by 2030 if the present trend is allowed to continue. Methods: Participants were administered with structured questionnaire. Their BPs, heights and weights were measured using sphygmomanometer, stadiometer and scale balance respectively. Data were analyzed as proportions, Pearson product moment correlations and Chi square tests using MaxStat (version 3.60) statistical software. Results: The overall prevalence of HTN was 21.3%; 20.7% in the 18-29 years age group; 25.9% in the 30-40 years age group; 24.3%, in males; and 20.3% in females. Pearson product moment correlation coefficient r between age and HTN=0.462, between sex and HTN=0.328, between family history and HTN = 0.513, between salt intake and HTN=0.613, between BMI and HTN=0.152, between physical activity and HTN=0.293, between smoking and HTN=0.308. Conclusions: HTN in young adults is more common than previously thought and if unmanaged in early life usually progresses to HTN later in life.

Emmanuel umegbolu

Now-a-days there is a renewed interest in drugs of natural origin simply because they are considered as green medicine and are always safe. The advantage of natural drugs is their easy availability, economic and less or no side effects they have been used in traditional medicine practices. In the present investigation some medicinal weeds were analyzed, it includes Centella asiatica, Phyllanthus niruri, Argemone mexicana, Amaranthus viridis, Asclepias currasavica, Cyperus iria and Portulaca oleraceae. All the eight medicinal weeds collected during field visits were subjected to study organoleptic features, macroscopic studies, powder analysis, physicochemical limits and fluorescence analysis, single and double staining techniques.

Veerabhadraswamy al

As it is increasingly being reported from India, we carried out a prospective study of patients with culture-proven melioidosis from south India, examining clinical, laboratory features, epidemiological data, risk factors, treatments, outcomes at three and six months, and factors associated with mortality.Between 2014 and 2018, 31 cases were identified. Diabetes (83.9%) and alcohol abuse (58.1%) were common risk factors. Musculoskeletal, skin and soft tissue manifestations together constituted 48.4% of presentations, while 29% had pneumonia. During the intensive phase, 74.2% received one of three recommended antibiotic regimes, but 51.6% did not receive continuation treatment. Pneumonia and lack of continuation treatment were independently associated with a high mortality of 25.8%. Hot spots for melioidosis exist in India, and there is considerable diversity of presentation, including skin, soft tissue, musculoskeletal and neurological involvement. High rates of bacteraemia are shown.

Aneesh basheer

COVID-19 pandemic has spread all over the world and has caused psychological impacts. Medical students are known to be vulnerable population, experiencing higher levels of anxiety, depression and other psychological disorders compared to non-medical students. The nature of life changes like what happened and still happening during the pandemic have its impact on mental health of the students. The aim of this study was to identify the psychological impacts of COVID-19 on medical students among different universities to develop profiles to characterize students' anticipated levels of psychological impacts during the pandemic. Also, to search for potential risk factors that could make students more likely to experience these impacts. An online survey was filled by medical students (n = 100) at faculties of medicine, dentistry, pharmacy and medical sciences of different universities: University of Benghazi, Libyan International Medical University, Omar Almokhtar University, Cairo University and Alexandria University. The students were taken to the further analysis. Thus, 55% of the participants had psychological impacts due to the pandemic and 17% had severe effect. Some of these impacts were actually positive as a large number (58%) of the participants felt relaxed during the pandemic. Multiple stressors were identified that contributed to the increased levels of stress, anxiety and depression. These included concern about academic performance (80%), concern about self/dear-one’s health (90%), difficulty with concentration (46%), disruption to sleeping patterns (78%), increased social isolation (26%), disruption to eating patterns (48%), changing in the living environment (26%), financial difficulties (34%) increased class workload (20%) depressive thoughts (37%) and suicidal thoughts (07%). In conclusion, the study indicates that COVID-19 pandemic have positive and negative impacts on medical students. Thus, it is suggested that measures need to alleviate students’ stress, which might have harmful effects in different aspects.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background Osteoarthritis (OA) is a significant global health concern and is characterized by the degeneration of joint structures, leading to pain, stiffness, and functional limitations It is estimated that 654.1 million individuals are affected by osteoarthritis worldwide, with females, especially those older than 60 years of age, being the population most impacted. However, there remains a gap in understanding the awareness of knee osteoarthritis among specific populations, such as the Palestinian community in the West Bank, thus, highlighting the need for targeted research to address this health disparity. Methods A cross-sectional survey was conducted in the West Bank from August to September 2024. Participants were recruited from 11 cities and a validated questionnaire adapted from a previous study was used to collect the data. The reliability of the questionnaire was assessed using Cronbach’s alpha, yielding a value of standard alpha = 0.71, which is an acceptable value. The survey collected demographic data, clinical characteristics, knowledge of osteoarthritis risk factors, symptoms, and attitudes towards treatment options. R Statistical Software was used for data analysis, which included descriptive statistics, chi-square tests, and logistic regression to explore the relationships between demographic factors and osteoarthritis knowledge, whereby a p-value of ≤ 0.05 was set up as a significance level. Results A total of 725 valid responses were included in our study. Among the participants, 569 were female, predominantly aged 25 or younger (66%, n = 479), and 62% (n = 450) were single. Knowledge assessment revealed that 80% (n = 580) recognized knee osteoarthritis as a chronic disease, while only 51% (n = 369) understood its impact on joint involvement. The majority identified high BMI (87%, n = 632), advancing age (94%, n = 683), and previous knee injury (72%, n = 520) as risk factors, although only 42% (n = 306) acknowledged genetics as one. Most participants were aware of the management strategies, including analgesics (70%, n = 510) and physiotherapy (80%, n = 579). However, 66% (n = 478) scored low for overall knowledge regarding knee osteoarthritis. Conclusion This study emphasizes the critical importance of raising awareness and knowledge about osteoarthritis within the Palestinian community. Despite being widely known as a long-term issue, there are still noticeable gaps in the understanding of the joint impact, potential risks, and effective treatment methods for osteoarthritis. The use of informal sources highlights the importance of specific educational programs by healthcare providers.

Mohamad banat

Abstract Background: Hansen’s disease is a chronic infectious disease with a wide range of clinical manifestations. The clinical diagnosis must be confirmed by histopathological and bacteriological studies in order to adequately manage the condition and prevent drug resistance. Aim: To perform a clinico-histopathological correlation of skin lesions in all patients with a clinical suspicion of Hansen’s disease. Materials and methods: A retrospective, hospital based, cross-sectional study was conducted in the Department of Pathology, Father Muller Medical College, Mangalore. Skin biopsies of all suspected cases of Hansen’s disease received over a period of three and a half years were included in the study. Haematoxylin and eosin, Fite-Faraco stained sections of all cases were reviewed. The cases were classified according to Ridley–Jopling classification into TT, BT, BB, I, BL, and LL. Clinical details of the patient, including type and site of lesion were obtained from the patient’s medical records. Clinico-histopathological correlation was done for all the cases. In addition, wherever available, the corresponding slit-skin smears were also included. Results: A total of 76 cases were clinically diagnosed as Hansen’s disease. Clinico- histopathological correlation was seen in 33/76 cases (43.42%). The most common histological subtype of Hansen’s was Borderline Tuberculoid (BT) - 24/76 cases (31.58%). Maximum agreement was seen in Mid-borderline leprosy (92.11%). Fite Faraco stain was positive in 21 out of 76 cases. Slit skin smears were available for 55 cases and positive in 20 cases. Conclusion: Due to clinical and morphological overlap, it is imperative to correlate the clinical, histopathological and bacteriological index results in order to accurately subtype the categories in Hansen’s disease.

Archana

At present, numerous approaches have been verified and suggested in relation to the innovation policy formulation of the enterprise. However, less attention is paid to regions in the developing world. An attempt is made in this thesis towards that direction. I argue that from the system of innovation theory perspective, innovation policy practice for regions in the developed world is a problem solving based process, due to the path dependency of innovation policy and the development level of advanced economies. For this purpose, the article proves the possibility of every company’s making much more profit by realizing and improving effective innovative management in the developing economy. And, it will be calculated and assessed the correlation link between the costs of innovation and total revenues of the world’s most innovative companies. In the end, it will be done some conclusions and discussions of nowadays innovators practice.

Ikboljon odashev mashrabjonovich

The issue of deliberate forest fires that set illegally in Indonesia by plantation companies in their slashand-burn forests to clear lands for lucrative palm oil plantations and its caused transboundary haze became a hot issue for discussion. These fires have a negative influence on Indonesia and its neighbourhood countries, especially on their financial and human resources such as environment, economy, properties, and people. Using the right strategies in responding to any crisis determines the success of its management and coping with that crisis with minimal losses. This study aimed to examine the communication crisis response by Indonesia to this crisis by using image repair theory. Also, this study examined how image repair strategies were used by Indonesia. This study analysed the content of news stories from the website of the New Straits Times newspaper. The time frame of this study was from 2015 to 2019. A total of 87 news stories have pertained to Indonesian response, and 37 stories included image repair strategies. Among the strategies of image repair theory, corrective action strategy was the most dominant with 70%, followed by 10.8% for each shift the blame and attack accuser. The least used strategies were mortification and simple denial with 5.4% and 2.7% respectively.

Mohammed fadel arandas

This study was carried out to evaluate the effects of thermal processing techniques on the nutrient and antinutrient contents of pigeon pea (Cajanus cajan) flours. The pigeon pea seeds were sorted, cleaned and divided into five equal lots of 0.5kg each. Four lots of pigeon pea seeds were processed into blanched, boiled, roasted, and autoclaved pigeon pea flours, while the fifth lot was processed raw and used as control. The raw and thermally processed samples obtained were analysed for nutrient and antinutrient composition using standard methods. The proximate composition of the samples showed that the flours had a range of 8.61 - 11.46 % moisture, 21.13 - 23.94 % crude protein, 1.26 - 1.68 % fat, 5.12 – 6.10 % crude fibre, 1.74 – 2.97 % ash, 55.56 – 60.41 % carbohydrate and 333.45 - 342.75 kJ/100g energy, respectively. The mineral composition showed that the flours contained 86.24 – 144.72 mg/100g calcium, 137.80 – 170.33 mg/100g magnesium, 125.86 - 156.76 mg/100g potassium, 66.66 – 95.62 mg/100g sodium, 4.38 – 6.64 mg/100g iron and 130.27 – 178.29 mg/100g phosphorus, respectively. The vitamin content of the flours were 3.09 - 4.33 mg/100g ascorbic acid, 0.05 - 0.17 mg/100g thiamine, 0.03 - 0.21 mg/100g riboflavin, 0.13 - 0.28 mg/100g niacin, 3.21 - 6.25 mg/100g vitamin A and 1.10 - 2.70 mg/100g vitamin E, respectively. The antinutrient composition of the flours also showed that the levels of trypsin inhibitor, tannin, phytate, oxalate, saponin and haemagglutinin ranged from, 2.30 – 5.61 Tiu/mg, 0.81 – 1.5mg/100g, 1.12 - 4.18mg/100g, 0.48-4.01 mg/100g, 1.28 – 3.66 mg/100g and 1.30 – 7.44 Hiu/g, respectively. Therefore, the study showed that thermally processed pigeon pea flours could be used as nutrient dense ingredients in the preparation of a wide range of foods for children, adolescents and aged adults especially in developing countries where the problems of protein-energy malnutrition and micronutrients deficiencies are prevalent than the raw sample.

Okechukwu obed chukwuemeka