Effects of industrial wastewater on vegetative growth and pigmentation of oil yielding and vegetable crops

When we tested various industrial wastewater samples collected from different industries they shown high amount of toxic chemical components, and the samples are unfit for irrigation or for any kind of activity. Irrigation of untreated wastewater for long time leads to soil pollution by accumulating toxic salts in the soil. The regular growth of plant get effected by this water like improper growth, low chlorophyll content, low carotenoids content, low yield, etc. Three different types of oil yielding plants (Mustard, Ground nut and Sunflower) and three different types of vegetable crops (Tomato, Chilly and Brinjal) has grown by using different industrial wastewater samples. The primitive parameters of vegetative growth (imbibition, seed germination and vigour index) and nutritional components (chlorophyll a, b and carotenoids) have been observed in all the samples after growing for a particular time period. The imbibition test of seed samples in industrial wastewater samples have not shown significant variation compared to imbibition in distilled water sample. All the seeds in all wastewater samples absorbed almost negligible difference but in the percentage of germination there is significant difference. The tests for nutritional compositions have also shown significant decrease in chlorophyll a, b and carotenoids in all varieties.

Veerabhadraswamy AL Veerabhadraswamy al

Social factors influencing mental health: insights, preventive strategies, and policy recommendations

Introduction: Mental health disparities are deeply entrenched within the fabric of societal inequalities, shaped by structural factors that perpetuate intergenerational cycles of disadvantage. Addressing these disparities is crucial for promoting social justice and improving public health outcomes. Aim: This paper aims to synthesize high-quality evidence to elucidate the causal relationships between social determinants and mental health outcomes. It prioritizes pervasive social determinants that influence major mental disorders across the life course and outlines preventive strategies to mitigate these effects. Methodology: A comprehensive literature review was conducted, focusing on publications from the Global North from 2014 to 2024, to explore the influence of social determinants on mental health. Keywords such as "social determinants," "mental health outcomes," "preventive strategies," and "vulnerable populations" guided the search across databases like PubMed and Google Scholar. Results: The review highlights significant associations between mental health and social determinants such as socioeconomic status, racial and ethnic marginalization, and exposure to adverse environments. It underscores the heightened vulnerability of marginalized groups, including refugees, LGBTQ+ individuals, and those living in poverty. The paper introduces a preventive framework to guide primary prevention efforts and reviews both primary and secondary strategies to improve mental health equity. Conclusion: Strategic interventions aimed at the root social causes of mental health disparities can substantially enhance public mental health. This paper provides seven strategic recommendations focused on social justice, offering a roadmap for researchers, policymakers, and public health professionals to address these pressing issues.

Prof.K.C Yadav Prof.k.c yadav

Pengembangan bakat dan minat peserta didik di madrasah ibtidaiyah miftahul muna kesilir banyuwangi

Each student has different potentials from one another, because each person is indeed born with a variety of different talents and has brought out his or her own nature, namely good nature that encourages tawhid and other natural qualities in the form of various innate potentials such as talents, intellectual abilities and others. The research approach used is a descriptive qualitative approach with the type of case study. The techniques used are interviews, observation, and documentation. While the validity of the data used triangulation of techniques and sources. The results of this study indicate: (1) Mina talents at MI Miftahul Muna through recruitment where students choose and register themselves to take part in the extracurricular program. Such as: drumband, dance, qiroat, scout, Pencak Silat, Chess, Volleyball, football, hadrah, singing, fashion, culinary, and calligraphy. (2) Interest talent planning, namely: Learning Implementation Plan, preparing experts who are competent in their fields as well as students recruited through extracurricular registration. Except for the drum band in this case bringing in experts from outside. (3) Implementation of talent and interest development at Madrasah Ibtidaiyah Miftahul Muna Kesilir, which is carried out once a week every Friday unless the drumband is held on Fridays and Sundays and if you want to appear at certain events, you can adjust the trainer's schedule or not. (4) Supervision is carried out directly at the time of the activity and some is carried out in an indirect way such as in this drumband activity because it brings in a trainer and is reported to the Madrasah Head.

EDUCARE: Journal of Primary Education Educare: journal of primary education

Zootherapeutics (animal-based remedies) for urolithiasis: history, current scenario and future dimensions

Animals like plants are also medicinal agents for preventing and curing different health problems worldwide, practically in all human cultures. Zootherapy is ancient and has strong evidence of the medicinal use of animal resources. Different animal body parts and preparations are used in folk medicines. Zootherapy reveals that medical practitioners have always considered animals a source of surprising and numerous therapeutic effects. A high diversity of animals, their parts, and derivative products are used, and this is a heritage that could constitute a fundamental step in the discovery and isolation of natural extracts and new and low-cost alternative drugs from animals. About 12% of people worldwide are affected by different types of urolithiasis; the recurrence rate in females is 47-60%, and in males is 70-80%. According to WHO, 75% of the population relies on traditional medicines to prevent and cure diseases. Hence, there is a need to concentrate on all folk natural products effective in urolithiasis for their pharmacological evaluation and isolation of single drug molecules responsible for anti-urolithiasis activity to develop suitable formulations against urolithiasis.

Dr. Salman Ahmed Dr. salman ahmed

On the impact of debris accumulation on power production of marine hydrokinetic turbines: insights gained via les

We present a series of large-eddy simulations to systematically investigate the impact of debris accumulation on the hydrodynamics and power production of a utility-scale marine hydrokinetic (MHK) turbine under various debris loads lodged on the upstream face of the turbine tower. The turbine blades are modeled using turbine resolving, actuator line, and actuator surface methods. Moreover, the influence of debris on the flow field is captured by directly resolving individual logs and employing a novel debris model. Analyzing the hydrodynamics effects of various debris accumulations, we show that an increase in the density of debris accumulation leads to more flow bypassing beneath the turbine blade. This, in turn, reduces the flow momentum that reaches the MHK blades at the lower depths, inducing significant fluctuation in power production. Further, it is shown that debris-induced turbulent fluctuations contribute to significant variability in the MHK turbine’s power production.

Hossein Seyedzadeh Hossein seyedzadeh

A critical review on mode of action of ayurvedic formulations on jwara

Rasa aushadhis are known for their uniqueness in curing the diseases with a very low dosage. These formulations are divided into two types based on their mode of preparation i.e., Single drug and Compound drug formulations. Based on their origin, the drugs are divided into three types, Herbal, Mineral and Animal. Any of these two or three together is combined to make a compound formulation. Apart from these, the other major factor which is needed for a formulation is the Rasa Panchaka of a Drug. Many of the formulations are being prepared based on their availability, keeping their Rasa Panchaka and Samprapti vighatana in mind. These formulations are designed in such a way that two or more drugs will be having one common quality, or Opposite Qualities or an Antidote of a particular Vishadravya, which can help in curing the disease. So an attempt is made to Review Tribhuvanakeerti Rasa with its Probable mode of action.

Suri abhiram

Effects of thermal processing on the nutritional and antinutritional properties of african yam bean (sphenostylis stenocarpa) seed flours

The study was carried out to evaluate the effects of thermal processing treatments on nutrient and antinutrient contents of African yam bean seed flours. The African yam bean seeds were sorted, cleaned and divided into five equal lots of one kilogram each. Four lots were processed into boiled, blanched, roasted and autoclaved African yam bean flours, while the last lot was processed raw and used as control. The flour samples obtained were analysed for proximate, mineral, vitamin and antinutrient contents using standard methods. The proximate composition of the samples revealed that the flours had a range of 6.14-11.24% moisture, 8.18-14.37% crude protein, 3.06-4.61% fat, 2.04–3.32% ash, 3.18–3.56% crude fibre, 62.90–76.98% carbohydrate and 350.57–368.50 kJ/100g energy, respectively. The mineral composition of the samples showed that the flours contained 128.81–174.16 mg/100g calcium, 88.86–212.20 mg/100g, potassium, 134.71–166.77 mg/100g phosphorus, 89.17 – 122.76 mg/100g, magnesium, 14.28–18-11 mg/100g iron and 3.24–5.59 mg/100g zinc, respectively. The vitamin composition of the flours were 1.15–1.37 mg/100g ascorbic acid, 1.15–135 mg/100g thiamine, 1.19–1.55 mg/100g niacin, 1.34–1.85 mg/100g riboflavin, 1.09–1.29 mg/100g folic acid, 1.37–1.95 mg /100g vitamin A and 1.27–1.66 mg/100g vitamin E, respectively. The results showed that the roasted and autoclaved African yam bean flours generally had higher crude protein, fat, ash, crude fibre, mineral and vitamin contents than the boiled and blanched flour samples compared to the raw sample. The antinutrient composition of the flours also showed that the levels of trypsin inhibitor activity, tannin, phytate, oxalate, saponin and haemagglutinin of the samples were significantly (p<0.05) reduced by boiling, autoclaving roasting and blanching treatments compared to the raw sample. However, the study revealed that the processed African yam bean flours have the potentials to be used as nutrient dense ingredients in the preparation of a wide range of food products than the raw sample especially in both underdeveloped and developing countries where the problems of protein-energy malnutrition and micronutrients deficiencies are prevalent.

OKECHUKWU OBED CHUKWUEMEKA Okechukwu obed chukwuemeka

Technology and isolation in the information period

Technology and Isolation in the Information Period explores the social, political, and legal implications of the group and use of personal information in computer databases. In the Information Period, our lives are documented in digital case books maintained by hundreds (perhaps thousands) of businesses and government agencies. These case books are composed of bits of our personal information, which when assembled together begin to paint a portrait of our personalities. Technology has changed our working practices and now allows us to be connected 24/7. We have the power to Skype clients around the world and email or Tweet work colleagues at weekends, but is there a danger that having connectivity so readily available hinders our efforts to gain a better work/life balance? We often read articles about the correct way to manage technology and how to achieve a happy balance of relaxing away from work and being ‘Always On’ and ‘Always available’. For instance, many people choose a job that allows them to detach from the workplace on evenings and weekends, yet technology makes it difficult for others to switch off. Now, we are huge believers in the ability to use the internet, email, Facebook, Twitter, texting and to pick up the phone and talk to people, but because of technology more people are becoming distracted and losing focus. They can’t escape from the workplace and feel that the office follows them around via their Smartphone which demands attention 24/7. It wasn’t so long ago that when we took a holiday, we would plan ahead, make sure everything was order, inform clients of our absence and brief our teams so we could disappear off to distant shores and happily sit in the sun for a relaxing fortnight, avoiding drinking the local water, eating strange local delicacies and fending of mosquitoes. But I digress … Having technology at hand means that we still have an element of control at our workplace and the ability to deal with issues if they occur. The downside to this is managing that work/life balance again. On one hand the internet is a lifeline, but it can also become a ball and chain if we don’t take the time to unplug from it. Technology allows us to be in two places at once, but when employees struggle to find the right balance between their work and personal lives there is a chance that stress levels can increase leading to a potential loss of productivity and happiness in general. In a recent survey 70% of workers said that technology brings the stress of work into their personal lives. Many Researchers have recommended drawing a line between work communications and home. This not only benefits your well being, but benefits your employer too, as you will be coming back to work refreshed and recharged.

Sunita Singh Sunita singh

Efficacy and safety of generic alendronate for osteoporosis treatment

Background: While osteoporosis increases the risk of fragility fractures, bisphosphonate has been proven to increase bone strengthand reduce the risk of vertebral and non-vertebral fractures. In addition to its efficacy, substituting the brand with generic medication isa strategy to optimize healthcare expenditures. This study aimed to evaluate the efficacy of generic alendronate treatment and assesspotential adverse events in patients with osteoporosis.Materials and Methods: A retrospective review was conducted on 120 patients who met the indications for osteoporosis treatment,received weekly generic alendronate (70 mg) for >1 year, and underwent evaluation through standard axial dual-energy X-rayabsorptiometry (DXA). The outcomes of this study were the percent change in bone mineral density (BMD) at the lumbar spine,femoral neck, and total hip after one year of treatment. The major adverse events occurring during medication that led to thediscontinuation of drug administration were documented.Results: Most patients were female (96.7%) with an average age of 69.0 ± 9.3 years. The percent change in BMD increased at all sitesafter one year of generic alendronate treatment (lumbar spine: 5.6 ± 13.7, p-value <0.001; femoral neck: 2.3 ± 8.3, p-value = 0.023;total hip: 2.1 ± 6.2, p-value = 0.003), with over 85% of patients experiencing increased or stable BMD. Three patients discontinued themedication due to adverse effects: two had dyspepsia, and one had persistent myalgia.Conclusion: Generic alendronate may be considered an effective antiresorptive agent for osteoporosis treatment with a low incidenceof adverse effects

Saran malisorn Saran malisorn

Occurrence and molecular detection of avian coronavirus in selected live bird markets, northwestern, nigeria

Infectious bronchitis (IB) is one of the most common highly infectious viral respiratory diseases of poultry having wide geographical distribution. Yet, little is known about the infection in the northwestern states of Nigeria. In this study, a total of 263 pooled cloacal and tracheal swab samples were collected from apparently healthy avian species (duck, dove, geese, guinea fowl, local chicken, ostrich, parrot, pigeon, peacock, and turkey). The samples were from nine live bird markets in three states (Kaduna, Kano and Jigawa) of northwestern, Nigeria collected from September through November 2017. Total RNAs were extracted directly from the swab samples and screened for infectious bronchitis virus (IBV) using real-time reverse transcription-polymerase chain reaction. An overall prevalence of 38.0% (100/263) was recorded. IB was detected in 70 % (7/10) of the avian species with prevalence of 100 % in dove, local chicken 45.9 %, duck 42.3 %, geese 26.6 %, pigeon 23.5 %, turkey 20.0 % and guinea fowl 6.2 %. Conversely, no detection was made from ostrich, parrot, and peacock. Widespread distribution of IBV was observed and evidence of subclinical infection in seven out of ten (70 %) of the avian species sampled. These avian species harbouring IBV may act as reservoirs with an influence on the ecology and epidemiology of the disease. Continuous surveillance and characterization of the different serotypes in avian species are recommended to inform the adoption of suitable vaccination strategy and control measures for the disease in Nigeria.

Bitrus Inuwa Bitrus inuwa

Screening of salt tolerant and growth promotion efficacy of phosphate solubilizing bacteria.

An attempt was made for screening of salt tolerant against sodium chloride (NaCl) salt and growth promotion efficacy of eight different phosphate solubilizing bacterial (PSB) isolates under in vitro conditions. An efficient isolate which exhibited maximum phosphate solubilization, salt tolerant, Indole-3-Acetic Acid (IAA) production and root colonization potential in maximum concentration of NaCl (7%) was identified as Bacillus cereus based on 16S rRNA sequencing. It was recorded that highest phosphate solubilization in 7% NaCl concentration (70% and 374 μg/mL) in agar plate and broth assay respectively. IAA production was observed to be decreased when salt concentration increases, the isolate showed significant amount of IAA in normal culture media without amendment of NaCl (74.94 μg/mL) and at 7% gradual decrease of IAA production was observed (30 μg/mL). Maximum colonization of isolate in the roots of Zea mays was also observed in the study.

Dr. SARANYA DEVI K Dr. saranya devi k

Public-private sectors’ collaboration in human resource management and curriculum development in the administration of public senior secondary schools in rivers state

The study examined public-private sectors’ collaboration in human resource management and curriculum development in the administration of public senior secondary schools in Rivers State. The study adopted the descriptive survey design. Two research questions and two hypotheses guided the study. The population of the study comprised 281 principals in the 281 public secondary schools in Rivers State. The proportionate stratified random sampling technique was used to draw up sample of 259 principals representing 92.2% of the population of the study (211 male principals and 70 female principals). An instrument titled: Public-Private Sectors’ Collaboration for School Administration Questionnaire (PPSCSAQ) designed in the modified 4-point Likert Scale with a reliability index of 0.87 was used for data collection. The face and content validities were ensured. Mean and standard deviation were used in answering the research question while z-test was used in testing the hypotheses at 0.05 level of significance. The finding of the study showed that to a high extent public-private sectors collaborate in human resource management and curriculum development in the administration of public senior secondary schools in Rivers State. It was recommended among others that the government should provide enabling environment and formulate favourable policies to sustain public-private sectors’ collaboration as it ensures effective human resource management in the state.

FXintegrity Publishing Fxintegrity publishing

Development and experimental characterization of fibre metal laminates to predict the fatigue life

During the last two decades, the concept of Fibre Metal Laminates (FMLs) has been evolved to find solution to the requirement of improving mechanical properties and reducing structural weight of elemental components of aircraft structures. In this work FML is prepared using Al 2024 by placing alternately with glass/carbon/aramid Fibres. From experimental results of FML shows greater advantage in mechanical properties then aluminium monolithic layer and this composite fibre laminates individual. The FMLs tested in this work were made of 3 layers of 2024 T3 aluminium alloy 0.28 mm thickness and fibre mats. The 5-3/2 laminates of size 300x300 mm with 3 mm thick were prepared using Vacuum Assisted Resin Transfer Moulding (VARTM) in cold compaction and test specimen were cut by using abrasive water jet machining as per ASTM Standards. The adhesion between fibre and metal layer will play a major role in strength of FML. By keeping this in consideration FMLs were prepared without blow holes and capable of withstanding delamination while preparing specimens through water jet and during various tests employed. The fracture surfaces of destructed specimens are studied with help Scanning Electron Microscope (SEM) image. Similarly, the numerical simulation of all the tests were done using Ansys APDL 10.0 Software. It is observed that aramid FML have substantially stronger in longitudinal directions. Hence, more priority given in this paper to investigate tensile strength and fatigue life of aramid FML.

Boopathy Govindarajan Boopathy govindarajan

Total, insoluble and soluble oxalate contents of three pakistani legume flours

Oxalate is widely distributed in plant foods as potassium, sodium and ammonium oxalates (water-soluble form) and as insoluble calcium oxalates. Oxalate forms strong chelates with dietary calcium, thus rendering the complex unavailable for absorption and assimilation. It precipitates as insoluble salts accumulating in the renal glomeruli and contributes to the development of renal disorders. The seed flours of Macrotyloma uniflorum (Lam.) Verdc., Phaseolus lunatus Linn., and Phaseolus vulgaris Linn. were investigated for their total, soluble and insoluble oxalate contents by HPLC. The total oxalate content of M. uniflorum, P. lunatus and P. vulgaris was 1.24, 1.77 and 1.71 mg/ g, respectively. The %age of soluble oxalate were M. uniflorum (19.50), P. lunatus (15.08) and P. vulgaris (15.88). Only soluble oxalate is responsible for oxalate absorption (bioavailability) and its excretion. Overall, the total oxalate content is high in legume flour of M. uniflorum, P. lunatus, and P. vulgaris, but the soluble oxalates are very low. Therefore, all these three legumes don't have the adverse effects of oxalate on minerals bioavailability and risk of urolithiasis.

Dr. Salman Ahmed Dr. salman ahmed

Off-label use of misoprostol in obstetric-gynecology patients at a private hospital in banyumas

Using off-label drugs in obstetric-gynecology patients requires caution because of the high risk of pregnancy. Although there is still debate, data profiling its use in clinical practice is lacking. This study aims to observe the use of off-label drugs in obstetrics and gynecology patients in private hospitals, especially the pill Misoprostol. This study used a descriptive observational approach to hospital medical record data. Retrieval of research data retrospectively at Bunda General Hospital (X Hospital) for July 2017 – December 2017 and Sinar Kasih Hospital (Y Hospital) for January 2018 – December 2018. The number of samples was determined using the Slovin formula, with a systematic random sampling technique at X Hospital and total sampling at Y Hospital. The samples were 220 RM at X 130 Hospital and Y 90 Hospital. The research was conducted in the period January 2019 - March 2019. The results were analyzed univariately using several related references. The results showed 26.92% of misoprostol off-label use in X Hospital and 4% in Y Hospital. The off-label drug found was Misoprostol which belongs to the category of off-label indications (Missed Abortion, Incomplete Abortion, Blighted Ovum, and Induction of labor in cases of Serotinus, KPD, and IUFD), off-label doses (50 µg, 100 µg, and 400 µg), and off-label routes of administration (sublingual and vaginal). ​

Much Ilham Novalisa Aji Wibowo Much ilham novalisa aji wibowo

Impact of energy drink consumption on pattern and quality of sleep among students in libyan international medical university

Consumption of energy drinks was significantly associated with sleep problems, which are progressively used regardless of negative health effects particularly among adolescents and young adults. The goal of this study is to examine the relationship between energy drinks and sleep patterns on college students by more than one parameter. Target number of students was taken to be 1 000 participants and the study reached 434 participants were invited via self-administered questionnaire at Libyan International Medical University students during 2020 and 2021 in all levels which consisted of 20 questions and the main measurements are dependency, negative effect of energy drink and effect of energy drink on sleep. The results showed that the consumption prevalence rate of energy drinks amongst participants is 59.4%. The majority of participants enrolled in this study are male (52.5%) and 47.5% were female students. In conclusion: energy drinks consumption is a risk factor of poor sleep quality between Libyan International Medical University students. An awareness must be increased about energy drinks consumption to confirm the relation to sleep quality and general health.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Pdf - attention is all you need

The dominant sequence transduction models are based on complex recurrent or convolutional neural networks that include an encoder and a decoder. The best performing models also connect the encoder and decoder through an attention mechanism. We propose a new simple network architecture, the Transformer, based solely on attention mechanisms, dispensing with recurrence and convolutions entirely. Experiments on two machine translation tasks show these models to be superior in quality while being more parallelizable and requiring significantly less time to train. Our model achieves 28.4 BLEU on the WMT 2014 Englishto-German translation task, improving over the existing best results, including ensembles, by over 2 BLEU. On the WMT 2014 English-to-French translation task, our model establishes a new single-model state-of-the-art BLEU score of 41.0 after training for 3.5 days on eight GPUs, a small fraction of the training costs of the best models from the literature.

Kamal Singh Kamal singh

Design and development of framework for big data based smart farming system

Improving the agricultural productivity is an imminent need to meet the food requirement of constantly growing population rate. It can be gracefully satisfied if the farming process is integrated through technologies such as big data and IoT. The integration of agricultural processes with modern technologies has emerged as the smart agriculture technology. This research work is focused on proving the suitability of the big data analytics for smart agricultural processes in terms of increasing production and quality of yields with less resources and overhead. This research paper expounds the extensive review carried out on the related works in smart agricultural farming, challenges in implementing the smart farming technologies at large scale, followed by the conceptual framework model for the effective implementation of big data together with IoT devices in smart farming.

Dr H Shaheen Dr h shaheen

Efficacy of vilanterol-fluticasone furoate versus formoterol-budesonide combination therapy in stable asthma

The present study evaluates the efficacy of Vilanterol-Fluticasone Furoate (VI-FF) versus Formoterol-Budesonide (FM-BD) combination therapy in stable asthma. Both regimens led to significant improvements in asthma control, as evidenced by marked increases in FEV1 (% predicted) and ACT scores over time. The demographic characteristics, baseline respiratory symptoms, and treatment outcomes were similar between the groups, indicating that both strategies were equally effective for managing asthma. The findings indicate that both VI-FF once daily and FM-BD twice daily therapies enhance lung function and asthma control. Significant improvements in FEV1 (% predicted) and ACT scores were observed in both groups, as confirmed by intention-to-treat (ITT) and perprotocol (PPA) analyses. The equivalent efficacy of VI-FF and FM-BD, combined with the convenience of once-daily dosing, suggests that VI-FF may be preferable for patients who struggle with a twice-daily regimen. These findings highlight VI-FF as a convenient and reliable treatment, particularly can benefit patients with adherence challenges. In conclusion, our study's findings align well with other studies regarding demographic characteristics, baseline symptoms, exacerbation history, hospitalization history, and spirometry results. This consistency reinforces the validity and reliability of our results, suggesting that both VI-FF and FM-BD are effective options for stable asthma. The comparable efficacy supports flexibility in treatment choices, allowing for personalized asthma management. Future research should explore the long-term benefits and adherence patterns associated with these treatments to further optimize asthma management.

Dr K C Yadav Dr k c yadav

A study of association between chronic liver disease and thyroid function tests at a tertiary care hospital in western uttar pradesh

ABSTRACT Background: One of the many functions of the liver is the synthesis of carrier proteins and hormone metabolism, and liver diseases have been linked to a variety of endocrine disorders. Aim:The study's goal was to look at the spectrum of chronic liver disease and the relationship between thyroid profile and severity of liver damage in a tertiary hospital. Methods and materials: The current study was a single-center, tertiary care hospital-based,case-control study that included 50 cases of liver cirrhosis/chronic liver disease and 50 age/sex matched healthy controls (chosen at random from relatives attending OPD with patients). Thyroid function tests were performed and results were compared between cases and controls.Result : This study included 50 cases of liver cirrhosis/chronic liver disease and 50 healthy controls.The mean age and gender of cases and controls were comparable, and the difference was not statistically significant. The majority of cases (76%) had alcoholic liver cirrhosis, with the remainder having non-alcoholic liver cirrhosis (16%) and chronic viral hepatitis (8%). As per Child-Pugh Score, the majority of cases (40%), followed by Child-Pugh C (32%) and Child-Pugh A (28%). In the current study, free T3, free T4, and TSH levels were compared between cases and controls, and abnormal values were found in cases, indicating a statistically significant difference. Serum thyroid profile abnormalities were observed as Child-Pugh Score Classes advanced, and the difference was statistically significant for free T3 and free T4. Conclusion: As compared to healthy subjects, patients with liver cirrhosis had abnormally high levels of circulating thyroid hormone, and severe abnormalitieswere linked to an advanced Child Pugh score. Derangement in thyroid profile is common in patients with cirrhosis of liver. Low free T3 and T4 levels are associated with more severe liver injury and may be used for prognostication in patients with cirrhosis of liver. Keywords: chronic liver disease; NAFLD, cirrhosis, Liver function tests; Free T3 and T4; TSH;

Tapas Tripathi Tapas tripathi

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