This study investigated the formulation, implementation, and performance implications of an artificial neural network–particle swarm optimization (ANN–PSO) based energy scheduling framework for a 150kW hybrid micro-grid. The analysis focused on two hybrid configurations, namely micro gas turbine–fuel cell (MGT–FC) and solar photovoltaic–battery storage system (PV–BSS), with emphasis on optimal dispatch behaviour and system efficiency under dynamic load and generation conditions. MATLAB was used to simulate ANN-based forecasting of hourly load and distributed energy resource outputs, which were subsequently optimized using PSO over multiple iterations to achieve balanced supply–demand scheduling. 4-in-1 visualization techniques were employed to capture convergence behaviour, transient response, dispatch stability, and efficiency dynamics across operating scenarios. Results showed that both hybrid systems achieved convergence within 20–24 PSO iterations, with scheduled power maintained within 50–120kW despite injected disturbances of ±20–30kW. The MGT–FC configuration demonstrated smoother dispatch profiles and faster fitness convergence, while the PV–BSS system exhibited greater variability due to intermittency, compensated by storage dispatch. Efficiency analysis revealed that optimal ANN–PSO scheduling sustained MGT–FC efficiency within 83–89%, whereas PV–BSS efficiency ranged between 41–72%, peaking during high-irradiance periods. Overall, the findings established that ANN–PSO-based scheduling enhanced operational stability and efficiency in both configurations, while highlighting the superior resilience of the MGT–FC hybrid under identical dynamic conditions. The study concluded that intelligent optimization provides a viable pathway for improving micro-grid performance in developing communities and industrial off-grid applications, where reliable and efficient decentralized power supply remains critical. It was therefore recommended among others that power system engineers and industrial energy planners in developing economies adopt ANN–PSO frameworks for real-time micro-grid dispatch to improve efficiency, resilience, and adaptability of decentralized energy systems serving communities and industrial loads.

Fxintegrity publishing

We reported a case of cyclophosphamide (CYP)-induced posterior reversible encephalopathy syndrome (PRES) in a 26-year-old previously healthy male patient who was presented to the emergency department with a history of fever, shortness of breath, and hemoptysis. After extensive investigations, including bronchoscopy and autoimmune screening, he was diagnosed with renalpulmonary syndrome. The diagnosis of CYP-related PRES was based on the development of neurological clinical picture supported by magnetic resonance imaging findings. The dose of CYP was decreased to 75 mg/day, and the patient’s symptoms improved after 3 days.

Karishma

Industry 5.0 is still a developing concept, but it is expected to leverage a range of advanced technologies to facilitate human-machine collaboration and enable more customized and sustainable manufacturing.This research paper tried to discuss the opportunities and challenges in the implementation of Industry 5.0. It primarily explored the need to transform from Industry 4.0 to Industry 5.0. The research paper further studied the technologies needed for the implementation on Industry 5.0 and also the principles of Industry 5.0.

Dr. kishor bholane

Introduction: Apophyseal avulsion fractures of the pelvis predominantly occur in adolescent athletes due to skeletal immaturity. The anterior inferior iliac spine (AIIS) is a rare but characteristic site of injury. Case Presentation: We report the case of a 15-year-old male football player who sustained a traumatic avulsion of the right AIIS. The diagnosis was confirmed radiologically, and the patient was managed conservatively. Results: The clinical course was favorable, with a return to sports at three months. Conclusion: Early diagnosis and conservative management typically allow full recovery in most cases.

Mohamed mokhtar jmal

Since October 17, 2019, Lebanon has experienced unprecedented popular protests, demanding the departure of the entire political class, accused of being gangrened by corruption. Country paralyzed, institutions closed for more than two weeks, the eyes are turned to universities that have closed their doors but whose community (teachers and students) actively participate in the national jump. This study explores the use of social media by universities in Lebanon during the national revolution using social big data technology on Twitter in comparison to the national usage of twitter. Important information was collected, analyzed and visualized using the R language.

Katia raya

Multimedia data encryption attempts to prevent unauthorized disclosure of confidential multimedia information in transit or storage. Security of multimedia files attracts more and more attention and many encryption methods have been proposed in literature. If we call a multimedia data stream (message) plaintext , the process of transforming the plaintext into unintelligible data stream is referred to as multimedia encryption (MME) where the encrypted message (data stream) is often named ciphertext. The process of transforming the ciphertext back into plaintext is termed decryption. We propose a new block cipher based on randomized key of size n × n where n is the block size and the block undergoes n 2 iterations with the plaintext. Every iteration generates the pseudo cipher text. The encryption process generate the ciphertext C with the help of the randomized key. The decryption apply the key in reverse order on the cipher text, to get back the plain text. This work deals with the problem of efficient multimedia data encryption.

S arul jothi

Cryopreservation is a process that preserves intact living cells, tissues or any other biological constructs by cooling and storing the samples to very low temperatures in order to maintain their viability and to save them for future use. At very low temperatures, enzymatic and chemical activities that may cause harm to the biological material are effectively stopped. Cryopreservation methods look to reach very low temperatures without causing further harm caused by the creation of ice crystals during freezing. Cryopreservation human samples for storage including variety of diseases such as cancer, genetic and degenerative disorders and bio-banking. This review aims to describe and highlight dimethyl sulfoxide in cryopreservation. Dimethyl sulfoxide is a non-toxic solvent and is one of the most commonly used pharmaceutical agent with a varied range of pharmacological actions including membrane penetration, anti-inflammatory effects and local analgesia as well as weak bacteriostatic. The main use of dimethyl sulfoxide is a vehicle for some drugs to enhancing the action of the drug and helping penetration of other drugs into the skin. However, dimethyl sulfoxide has been the cryopreservative agent of choice in situation to its exceptional performance in mitigating freezing-related damages. It is frequently used in cell banking applications as a cryoprotectant. When added to media, it prevents intracellular and extracellular crystals from forming in cells during the freezing process. There has been a concern over the toxicity of dimethyl sulfoxide and its potential side effects in different highly concentration after administration to patients. Therefore, there has been growing demand for robust dimethyl sulfoxide for cryopreservation method that can improve safety and maintain potency and efficacy

Mediterranean journal of pharmacy and pharmaceutical sciences

Food nutrients are essential for the growth and development of human. In several parts of the world, Cocoyam (Colocasia esculenta), is a tropical root crop cultivated for food formulations and consumption by humans. This study was conducted to assess the nutritional evaluation (weight gain, protein efficiency ratio, net protein retention, and biological value) of the processed cocoyam, soya bean (Glycine max) flours and their blends by feeding trials using Albino rabbits. The sun-dried samples were milled to size (sieve with 25 µm aperture size) to obtain homogenous flours. Blends were obtained with various ratios according to the percentage of soya bean/cocoyam flours. The biological value, protein efficiency ratio, and net protein retention were analysed using standard methods for the calculations. Net protein retention of soya bean flour was higher than that for cocoyam flour. The highest biological value was given by the 50% blend, while the lowest was given by the control diet. The higher the protein efficiency ratio values, the higher the protein quality. The highest protein efficiency ratio value was given by soya bean flour, while the lowest value was from Cocoyam flour. The best blend of Cocoyam and soya bean flours obtained based on chemical and nutritional evaluations was the 50% blend of soya bean and Cocoyam flours.

Mediterranean journal of pharmacy and pharmaceutical sciences

The diversity of reactogenicity and its variation in terms of risk and prevalence among populations had raised the need to study and evaluate the reactogenicity of different COVID-19 vaccines in our region. Thus, this study aimed to estimate the prevalence of reactogenicity of COVID-19 vaccines and compare the three vaccines (AstraZeneca-Oxford, Sinovac and sputnik V). An analytical cross-sectional study was conducted using a semi-structured telephonic interview with a sample size of 430 individuals who received one of the included COVID-19 vaccines (AstraZeneca, Sinovac or sputnik V) and were recorded at one of the vaccination centers' records that were affiliated with Aljamail Department of the National Centre for Disease Control, Libya. 410 Libyan participants met the inclusion criteria and were enrolled in the final analysis. The study has shown that 57.3% (CI 52.7-62) of the participants had at least one reactogenic event. Pyrexia (40.7%), headache (27.3%) and fatigue (19.5%) were the most common reactogenic events. In conclusion: the study found that reactogenic events were mild to moderate and the COVID-19 vaccines were safe and encouraged our community to be vaccinated. However, prospective studies with larger sample sizes, longer follow-up and inclusion of important laboratory parameters such as IgG and IgM immunoglobulins are recommended to better understand the relationship between the reactogenicities of COVID-19 vaccines with immunity system development and the factors associated with it.

Mediterranean journal of pharmacy and pharmaceutical sciences

The Cellular Manufacturing is adopted in batch type manufacturing industries nowadays for their production with increased productivity, less cost and time with effective control. The proposed optimization model is used to determine the cost of machine cells, i.e., machine duplication, part subcontract, inter intra cellular movements cost and cost of production associated with machine cell, such as machine reconfiguration and part inventory considering machine flexibility for various time periods. Initially, mathematical model is proposed to calculate machine cell cost with and without considering machine flexibility and then another lpp integer model is proposed to calculate the machine cell production and associated cost for the changes in time period, part type and volume considering machine flexibility. The manufacturing data in the incidence matrix and machine cell, part family data in the block diagonal form are given as input to the optimization programming language Cplex and the output are given for the two mathematical models. The data related to machine duplication, part subcontract, inter intra cellular movement; machine reconfiguration and part inventory are given. Two dimensional shop floor layouts are presented in rectilinear coordinates for all the problems for easy analysis of material movement length and shop floor area

S ramesh

Experiment was carried out to standardize the artificial diet for mass rearing of Helicoverpa armigera (Hübner) under laboratory conditions. The average length and breadth of egg was 0.51±0.06 mm, 0.46±0.37 mm and 0.52±0.03 mm, 0.48±0.62 on artificial and natural diet. The average length and breadth of first, second, third, fourth and fifth instar larvae was 1.40±0.09 mm, 0.46±0.02 mm and 1.42±0.01 mm, 0.47±0.16 mm and 4.03±0.22 mm, 0.66±0.07 mm and 4.31±0.01 mm, 0.89±0.25 mm and 8.19±0.36 mm, 1.57±0.63 mm, and 10.29±0.72 mm, 1.87±0.91 mm and 18.70±0.44 mm, 2.78±0.040 mm and 20.15±0.03 mm, 3.17±0.55 mm and 26.01±0.19 mm, 4.09±0.39 mm and 27.32±0.027 mm, 5.88±0.69 mm, respectively with the average duration of 2.69±0.32 and 2.54±0.29, 3.77±0.65 and 3.79±0.11, 3.88±0.49 and 3.72±1.23, 5.35±0.55 and 5.72±0.91 and 6.61±0.008, 6.46±1.07 days, respectively on artificial as well as on natural diet. The average length and breadth of adult male and female was 18.01±0.48 mm and 35.09±1.25 mm, 18.51±1.04 mm and 38.11±1.37 mm, 19.00±0.18 mm and 19.10±0.49 mm, 37.75±1.27 mm and 41.23±1.69 mm, respectively. The average pre-oviposition, oviposition and post-oviposition period was 2.52±0.86 and 2.76±0.84 days, 4.93±0.78 and 5.08±0.90 days and 0.65±0.49 and 0.79±0.93 days, respectively. The total life cycle of male and female was 40.50±2.29 and 41.81±1.89 days and 42.59±1.77 and 43.80±1.93 days.

Dr. babu lal jat

This study was carried out to evaluate the effects of thermal processing techniques on the nutrient and antinutrient contents of pigeon pea (Cajanus cajan) flours. The pigeon pea seeds were sorted, cleaned and divided into five equal lots of 0.5kg each. Four lots of pigeon pea seeds were processed into blanched, boiled, roasted, and autoclaved pigeon pea flours, while the fifth lot was processed raw and used as control. The raw and thermally processed samples obtained were analysed for nutrient and antinutrient composition using standard methods. The proximate composition of the samples showed that the flours had a range of 8.61 - 11.46 % moisture, 21.13 - 23.94 % crude protein, 1.26 - 1.68 % fat, 5.12 – 6.10 % crude fibre, 1.74 – 2.97 % ash, 55.56 – 60.41 % carbohydrate and 333.45 - 342.75 kJ/100g energy, respectively. The mineral composition showed that the flours contained 86.24 – 144.72 mg/100g calcium, 137.80 – 170.33 mg/100g magnesium, 125.86 - 156.76 mg/100g potassium, 66.66 – 95.62 mg/100g sodium, 4.38 – 6.64 mg/100g iron and 130.27 – 178.29 mg/100g phosphorus, respectively. The vitamin content of the flours were 3.09 - 4.33 mg/100g ascorbic acid, 0.05 - 0.17 mg/100g thiamine, 0.03 - 0.21 mg/100g riboflavin, 0.13 - 0.28 mg/100g niacin, 3.21 - 6.25 mg/100g vitamin A and 1.10 - 2.70 mg/100g vitamin E, respectively. The antinutrient composition of the flours also showed that the levels of trypsin inhibitor, tannin, phytate, oxalate, saponin and haemagglutinin ranged from, 2.30 – 5.61 Tiu/mg, 0.81 – 1.5mg/100g, 1.12 - 4.18mg/100g, 0.48-4.01 mg/100g, 1.28 – 3.66 mg/100g and 1.30 – 7.44 Hiu/g, respectively. Therefore, the study showed that thermally processed pigeon pea flours could be used as nutrient dense ingredients in the preparation of a wide range of foods for children, adolescents and aged adults especially in developing countries where the problems of protein-energy malnutrition and micronutrients deficiencies are prevalent than the raw sample.

Okechukwu obed chukwuemeka

The aim of this work was to prepare chitosan nanoparticles loaded with antineoplastic drug Lomustine (LCNPs), by ionic-gelation method with homogenization. The nanoparticles were characterized for particle size, polydispersity index (PDI), surface morphology, encapsulation efficiency, in-vitro drug release and cytotoxicity on human lung cancer cell line L132 by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The particle size, zeta potential and encapsulation efficiency of prepared nanoparticles ranged from 75±1.1 to 637±1.6 nm (PDI from 0.05±0.001 to 0.18±0.007), 37.2±0.21 to 53.8±0.18 mV and 66.74±1.4 to 98.0±1.8% re- spectively. The particles were spherical in shape with smooth surface in scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images. Mechanical shearing by homogenization treatment significantly changed the nanoparticle size. The drug release rate was biphasic and diffusion controlled over the 8 h. LCNPs greatly inhibited the growth of the L132 cancer cell line used in this study in comparison to the native Lomustine (LMT).

Archana mehrotra

Epithelial cells, lining the skin and internal organs, play a crucial role as protective barriers and regulators of substance transport. Traditionally, these cells were not considered to employ electrical signaling for communication. However, recent investigations have unveiled that epithelial cells generate slow electrical signals, termed the "silent scream," in response to injury, thus challenging conventional views of intercellular communication. A recent experimental investigation provided compelling evidence for this phenomenon, demonstrating the ability of these cells to transmit electrical signals over considerable distances within the epithelium. The research utilized microelectrode array chips to precisely detect subtle electrical events in keratinocytes and Madin-Darby Canine Kidney (MDCK) cells, revealing spiking activity characterized by slow propagation speeds, distinct from the rapid action potentials of neurons. The mechanisms underlying this novel signaling are explored, focusing on the involvement of mechanosensitive ion channels, calcium signaling, and Adenosine triphosphate (ATP) release. Calcium ions, well-established intracellular messengers, appear to play a central role in this biological phenomenon. Integrating this newly discovered communication mode into the existing understanding of skin cell biology reveals a more intricate picture of how skin senses and responds to its environment. The implications of this finding extend to various facets of skin physiology and pathology, including wound healing, inflammation, and skin aging. In wound healing, where endogenous electric fields guide cell migration and promote repair, this unique type of electrical signaling potentially plays a crucial part. Furthermore, aberrant electrical signaling might contribute to chronic inflammatory conditions, and age-related changes in this signaling could underlie the functional decline observed in aged skin. The potential for other environmental stressors to trigger the epithelial-generated electric signals also warrants investigation. The exploration concludes by discussing potential technological applications, such as bioelectric sensors and enhanced wound healing therapies, and future research directions aimed at further elucidating the molecular mechanisms and functional roles of this non-excitable cell electrophysiology.

Karishma

The gold standard anesthesiologic procedure for urgent femur fracture surgery is Spinal Anesthesia. It is not always feasible because of patients' severe comorbidities and difficulties in optimizing drug therapy in the appropriate time frame such as discontinuation of anticoagulant drugs. The use of four peripheral nerve blocks (tetra-block) can be a winning weapon when all seems lost. We present, in this case series, three Caucasian adult femur fractures (an 83-year-old woman, a 73-year-old man, and a 68-year-old woman) with different and major comorbidities (cardiac or circulatory disorders on anticoagulants therapy that were not discontinued on time; breast cancer and others) underwent the same anesthesiologic approach in the urgent setting. Ultrasound peripheral nerve blocks, that is femoral, lateral femoral cutaneous, obturator, and sciatic with parasacral approach were successfully performed in all patients who underwent intramedullary nailing for intertrochanteric fracture. We evaluated the adequacy of the anesthesia plane, postoperative pain control with the VAS scale, and the incidence of postoperative side effects. Four peripheral nerve blocks (Tetra-block) can be alternative anesthesiologic management in urgent settings, in patients where drug therapy cannot be optimized, as in antiplatelet and anticoagulant therapy.

Dario cirillo

The Sigma Delta Analog to Digital Converter (SD-ADC) with passive analog components is presented. The digital blocks required for creating the samples with required sample rate and word length from the 1 bit ADC output are presented. The digital filters are initially modeled in MATLAB Simulink and validated in frequency domain. Further they are synthesized to Xilinx Spartan-6 FPGA technology. The synthesis results report clock speeds up to 300MHz. The simulation results are used to validate the principle and verify the performance of SD-ADC. The results demonstrate a promising technology area of realizing SD-ADC as a reconfigurable block on FPGA to meet several signal processing applications with sampling rates up to few hundreds of KHz

P.a. harsha vardhini

Over the recent years, cloud computing has emerged as a powerful means for providing automated healthcare facilities. Cloud helps in massive sharing of information between doctors and hospitals using Electronic Health Records. This major transformation has changed the way doctors and hospitals deliver quality and effective service to their patients. Using Cloud storage inhealthcare services has revolution- ized health industry, making it more efficient. Apart from the primary driving factors of cloud like flexibil- ity in cost of maintenance, infrastructure and development, on-demand scalability of storage centers and pay on use schemes are proven to be most effective. More and more digitalization of data causes breech of security and privacy.Because healthcare information is a highly sensitive data which cannot be com- promised,the future of healthcare relies in providing secure and trustworthy sharing of data by safe- guarding privacy and trust. This paper gives an extensive review of the existing security mechanisms for Cloud based healthcare systems.

Dr.c.priya

Background: Parkinson’s disease (PD) is one of the most common, disabling neuro-degenerative disorders. The disease has a significant clinical impact on patients, families, and caregivers through its progressive degenerative effects on mobility and muscle control. Available treatments for PD have varied results. Although there are anecdotal reports of improvement with Homoeopathy, there is a dearth of literature concerning usefulness in management of PD Objectives: To assess the usefulness of ultrahigh dilution of Zinc in the management of PD. Methods: A case of PD under standard care and refractory to treatment visited Out- Patient Department and was assessed with and Unified Parkinson’s Disease Rating Scale (UPDRS). As per the classical Homoeopathic guidelines Zincum metallicum 200 was prescribed after Repertorization. Results: UPDRS total score of 112 at baseline turned to 40 at the end of 1 year and 7 at the end of two years, in spite of reduction in the conventional medicines. Patient was on Stage 3 of Modified Hoehn and Yahr staging at the baseline and turned to Stage O in duration of 21 months. SEADL score has turned from 40% to 100%. Conclusion: Homoeopathic medicine Zincum met. is a valuable adjuvant in the management of Parkinson’s disease.

Dr deepthi gilla

Background: Evidence has suggested that school-based physical activity programs (SBPAPs) including structured physical education, extracurricular sports, and activity-based learningenhance memory and other cognitive functions. However, evidence on whether Indian adolescents can achieve improved cognition or increased academic performance also remains scarce. This study aimed to examine the relationship between SBPAPs and academic performance among Indian adolescents. Methods: A cross-sectional, mixed study was carried out from October 2024 to March 2025 in public and private secondary schools in Haryana and Punjab, north India. A total of 300 students aged 13 to 17 years were divided into an intervention group (n = 150) who participated in structured physical activity (PA) of at least 150 minutes per week and a comparison group (n = 150) who were involved in less than 30 minutes of PA per week. Academic performance was assessed in terms of composite scores of core subjects, while the level of PA was measured using the Physical Activity Questionnaire for Adolescents. Independent samples t-tests, one-way analysis of variance (ANOVA), and Pearson’s correlation analysis were all used for quantitative data handling. Qualitative data gathered from focus group discussions and key informant interviews with a subsample (n = 30) were thematically analyzed. Results: There were no significant differences in baseline demographics between the groups (p > 0.05). Compared with the comparison group, the intervention group showed significantly higher academic scores (mean = 76.4%, SD = 7.8; mean = 70.6%, SD = 8.4) with a moderate-to-large effect size (t = 6.30, p < 0.001, d = 0.72). A one-way ANOVA found that academic performance differed significantly among PA intensity levels (F(2,297) = 19.44, p < 0.001). There was a moderate positive correlation between PA levels and academic achievement (r = 0.44, p < 0.01). Qualitative findings corroborated quantitative data, showing that physically active students displayed improved concentration, emotional regulation, and academic motivation. Conclusions: Partaking in structured SBPAPs significantly increases Indian adolescents’ academic performance. These findings imply the necessity of including physical education in the academic curriculum as a low-cost, scalable method for supporting both cognitive growth and educational achievement.

Karishma

Fragaria nubicola (Hoof. f) Linn. (Rosaceae) is a medicinally important plant commonly called Wild strawberry. Traditionally, it has been used to treat different diseases. The study was carried out to compile all the previous data in review form based on its distribution, traditional medicinal uses, pharmacology and phytochemistry

Dr. salman ahmed