High-Performance Liquid Chromatography (HPLC) is a frequently utilized analytical method that has numerous characteristics, including high selectivity, sensitivity, and a reduced time requirement. Upon using this fabulous technique, the limit of detection is reduced, and the accuracy, precision, reliability, and specificity can be expanded. This technique plays a crucial role in both qualitative and quantitative analysis throughout the various stages of drug production, from the initial discovery of the drug to its excretion from the body. The role of High-Performance Liquid Chromatography (HPLC) in pharmaceutical analysis during various stages of drug discovery, production, and clinical use, including drug pharmacokinetics, is reviewed and discussed in detail. This provides an overview of the benefits of High-Performance Liquid Chromatography from the chemical, pharmaceutical, and clinical perspectives.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background: The legume pod borer, Helicoverpa armigera (Hübner), is one of the most damaging crop pests, including pigeonpea. Host plant resistance is a component of pest management and therefore, we standardize a nylon bag No-Choice Bioassay technique to screen for resistance to H. armigera under field conditions. Methods: Pigeonpea plants were infested with 24 h old 1, 2, 3, 4 and 5 larvae per plant inside the nylon bag. Observations were recorded on pod damage, larval survival, larval weight, pupation, adult emergence, and fecundity after 10 days. Result: Pigeonpea varieties AL-201, H03-41 and PAU-881 exhibited lower pod damage (15.89 to 19.77%) and larval weight (12.02 to 13.82 mg). The expression of resistance to H. armigera was associated with trichome density, pod wall thickness and higher amount of phenolic compounds and condensed tannins. Lower trichome density and thin pod walls and higher amounts of sugars rendered the varieties Paras, Manak and Pussa-992 more susceptible to H. armigera. Nylon bag assay can be used to screen and select pigeonpea cultivars for resistance to H. armigera.

Dr. babu lal jat

Since the WHO declared COVID-19 a pandemic on March 11, 2020, all countries worldwide have taken precautions to combat this pandemic, except for Yemen. The civil war and resulting humanitarian crises have diverted the attention of the Yemeni people and authorities away from COVID-19, potentially leading to the escalation of the pandemic. Following the initial denial, the internationally recognized government and the de facto authority of the Houthis acknowledged the first COVID-19 cases on March 11, 2020 and May 13, 2020, respectively. With only half of the Yemeni hospitals and medical facilities being fully operational, the authorities and humanitarian groups are working together to end the crisis. Due to paucity of information on the real number of cases in the country attributed to various reasons, no one can predict the future in this country, which will be most likely worse unless the civil war stops, and the humanitarian groups with the authorities need to work hard to strengthen the health system to prepare it for the current and all upcoming health crisis and pandemics.

Karishma

Territorial disputes in the South China Sea have long been one of the most critical and complex issues of security between south-east Asian states and China. The competition for maritime rights has emerged as the most important security issue in the east Asia. The powerful states have a tendency for domination. The smaller states may not show their dominating behavior over other states, but they have tendency to maximize their relative power by making alliance with great power or by other means. Since the smaller states are not capable enough individually to ensure their own security or to use military force against threatening power, they have tendencies to join in alliances or in other words to create balance of power to ensure their own security. This study attempts to analyze the behavior of small states and to find out which theory matches with the behavior. The behavior of small states like Vietnam and the Philippines cannot be well-explained by the realist approach. They behave to make their existent clear and safeguard themselves only. Making allies with great powers as well as economic ties simultaneously with other economic powers render their behavior of having peaceful coexistent with everyone.

Muhammad faruq-uz-zaman

The most important factor that affects the crop production in terms of nutritional content of foliar plants is the global climate change. Herbivore’s growth, development, survival and geographical distribution all are determined by elevated CO2 and temperature. The interactions between herbivores and plants have changed due to increasing level of CO2 and temperature. The effect of high CO2 and temperature on grain legume plant which change in to plant physiology (e.g., nutritional content, foliage biomass) and how it change in herbivory metabolism rate and food consumption rate. Plant injury is determined by two factors viz. resistance and tolerance and both are influenced by greater CO2 and temperature. Legumes are an important source of food and feed in the form of proteins and also improve the soil environment. The repercussions of the abiotic factors mentioned above needs discussion among the scientific community. We may able to limit the negative repercussions of stated factors in future breeding projects by harnessing the practical favourable impacts and by including such influences of elevated CO2 and temperature on pulses productivity. The extensive research is necessary to overcome the negative effects of high CO2 and temperature on insect-plant interaction

Dr. babu lal jat

This study outlines the different kinds of information resources available, the current situation of digital preservation, the requests of librarians and users, and offers recommendations, although limited, for future research on storage mediums, transfers, conversions, and general management techniques. Libraries worldwide have had to address a number of concerns related to digital information preservation, including organizational, resource, legal, and technical ones. Despite the fact that libraries have been exploring a variety of preservation techniques, including emulation, migration, and technology preservation, there is still a need for a preservation approach that is both financially realistic and widely accepted. Digital content access is ensured over time through a combination of rules, strategies, and actions known as digital preservation. An information resource is any component of a computer system that is only partially available; an electronic resource is information that can be stored as electrical signals; and a web resource is a data source that is accessible over the World Wide Web. It is important to preserve information of long-term value so that future generations can access it. This is the goal of information source preservation. Formal preservation programs have been launched for conventional resources in document, microform, photographic, and, to a lesser extent, audio-visual formats by numerous large libraries, information centers, and archives in recent decades. The field of digital preservation is still quite experimental and fraught with the dangers of using unproven techniques. The introduction of digital preservation adds to the challenge facing documents and library services in maintaining a legacy of documents in traditional formats.

Dr. awadhesh singh gautam

Efforts to understand the causes of poverty, how poverty is perceived have become important in the fight to mitigate poverty. In Vietnam, studies on the attitudes of poverty in specific populations, such as Vietnamese students, are rare. Thus, this dataset reports the results collected from 180 social work students and non-social work students of Ho Chi Minh City Open University through attitudes toward poverty and poor people in Vietnam. The Attitude toward Poverty Short Form 21-item scale, developed by Yun & Weaver, was used for the data collection. The survey results showed that when looking for causes of poverty, social work students and non-social work students put the most emphasis on structural factors of poverty. However, social work students, compared with non-social work students, consider personal deficiency and stigma more important. In future, this dataset can serve as a reference source for comparative studies on student’ attitudes toward poverty and impoverished persons and for social work education.

Le minh tien

COVID-19 pandemic has spread all over the world and has caused psychological impacts. Medical students are known to be vulnerable population, experiencing higher levels of anxiety, depression and other psychological disorders compared to non-medical students. The nature of life changes like what happened and still happening during the pandemic have its impact on mental health of the students. The aim of this study was to identify the psychological impacts of COVID-19 on medical students among different universities to develop profiles to characterize students' anticipated levels of psychological impacts during the pandemic. Also, to search for potential risk factors that could make students more likely to experience these impacts. An online survey was filled by medical students (n = 100) at faculties of medicine, dentistry, pharmacy and medical sciences of different universities: University of Benghazi, Libyan International Medical University, Omar Almokhtar University, Cairo University and Alexandria University. The students were taken to the further analysis. Thus, 55% of the participants had psychological impacts due to the pandemic and 17% had severe effect. Some of these impacts were actually positive as a large number (58%) of the participants felt relaxed during the pandemic. Multiple stressors were identified that contributed to the increased levels of stress, anxiety and depression. These included concern about academic performance (80%), concern about self/dear-one’s health (90%), difficulty with concentration (46%), disruption to sleeping patterns (78%), increased social isolation (26%), disruption to eating patterns (48%), changing in the living environment (26%), financial difficulties (34%) increased class workload (20%) depressive thoughts (37%) and suicidal thoughts (07%). In conclusion, the study indicates that COVID-19 pandemic have positive and negative impacts on medical students. Thus, it is suggested that measures need to alleviate students’ stress, which might have harmful effects in different aspects.

Mediterranean journal of pharmacy and pharmaceutical sciences

This work was focused on identification and evaluation of process parameters of modified nanoprecipitation method, for fabrication of lomustine nanoparticles, with the aim of reducing cancer cell viability at low concentration of lomustine. The parameters controlling particle size, mostly in nanosize, were solvent/nonsolvent composition and emulsification speed of homogenizer along with aqueous phase volume. This controlled particle size is below 250 nm. The stabilizer concentration controlled particle size is within 68 nm ± 0.89 to 137 ± 0.94 nm with PDI 0.06 ± 0.008 to 0.25 ± 0.001. But, the stabilizer addition mode showed more uniform size distribution with PDI 0.085 ± 0.004. Entrapment efficiency was maintained well above 47 ± 0.23%. The drug release pattern was monophasic with controlled release over 24 hrs. In the method used, drug content was affected by ratio of polymer to drug to organic solvent, as well as homogenization speed and time. Percentage viable cells of L132 human lung cancer cell line remained, were only 5% at 100 μg/ml lomustine equivalent PLA nanoparticles.

Archana mehrotra

The study was carried out to evaluate the effects of thermal processing treatments on nutrient and antinutrient contents of African yam bean seed flours. The African yam bean seeds were sorted, cleaned and divided into five equal lots of one kilogram each. Four lots were processed into boiled, blanched, roasted and autoclaved African yam bean flours, while the last lot was processed raw and used as control. The flour samples obtained were analysed for proximate, mineral, vitamin and antinutrient contents using standard methods. The proximate composition of the samples revealed that the flours had a range of 6.14-11.24% moisture, 8.18-14.37% crude protein, 3.06-4.61% fat, 2.04–3.32% ash, 3.18–3.56% crude fibre, 62.90–76.98% carbohydrate and 350.57–368.50 kJ/100g energy, respectively. The mineral composition of the samples showed that the flours contained 128.81–174.16 mg/100g calcium, 88.86–212.20 mg/100g, potassium, 134.71–166.77 mg/100g phosphorus, 89.17 – 122.76 mg/100g, magnesium, 14.28–18-11 mg/100g iron and 3.24–5.59 mg/100g zinc, respectively. The vitamin composition of the flours were 1.15–1.37 mg/100g ascorbic acid, 1.15–135 mg/100g thiamine, 1.19–1.55 mg/100g niacin, 1.34–1.85 mg/100g riboflavin, 1.09–1.29 mg/100g folic acid, 1.37–1.95 mg /100g vitamin A and 1.27–1.66 mg/100g vitamin E, respectively. The results showed that the roasted and autoclaved African yam bean flours generally had higher crude protein, fat, ash, crude fibre, mineral and vitamin contents than the boiled and blanched flour samples compared to the raw sample. The antinutrient composition of the flours also showed that the levels of trypsin inhibitor activity, tannin, phytate, oxalate, saponin and haemagglutinin of the samples were significantly (p<0.05) reduced by boiling, autoclaving roasting and blanching treatments compared to the raw sample. However, the study revealed that the processed African yam bean flours have the potentials to be used as nutrient dense ingredients in the preparation of a wide range of food products than the raw sample especially in both underdeveloped and developing countries where the problems of protein-energy malnutrition and micronutrients deficiencies are prevalent.

Okechukwu obed chukwuemeka

In the direction of computer globalization and digitization, India is rapidly developing education and information technology. People are taught how to invest in deposits, postal investments, government bonds, gold systems and bonds, and the private sector. The world in which we now live has been completely transformed by technology. The study indicates that there are more than 4 billion active Internet users worldwide, or nearly half of the world's population. Our lives are now faster, easier to manage, and more enjoyable thanks to modern technology. This paper focuses in experiencing and developing a stock application using PHP, React JS, NodeJS and CSS . All the stock data is stored in a MYSQL database. On the other side for developing machine language application python code is used to convert the data into csv format for machine learning algorithms. The investor is presented with a login screen in the python environment where they must enter their user name and password. The stock dashboard shows the investor's current stock holdings, as well as online stocks' their current price, percentage change in stocks, sensex, nifty, bonus, rights, IPO's, annual report etc. statistical methods are used as software modules for the investor, and with a single click of a button, they can compare and contrast their own stocks with online stocks, as well as the trend in the stock market position in order to decide whether to buy, hold, or sell the stocks. Data visualization component is used for comparison of various stocks, and by clicking of a button, stock prediction are displayed whether to hold, buy or sell in future according to the market trend. The trader must log in using their user name and password. The trader will browse the client current market price of all stocks, buying and selling stocks, contract note, client margin, e-off market transactions, ledgers, journals, commission of buying and selling stocks, and so on. In future strategy the stock application programming is converted by a portable mobile application by using python packages like Kivy, PyQt, or even Beeware's Toga library.

Dr.n.r.ananthanarayanan

Purpose: The study aims to explore all possible morphological features of calcium oxalate monohydrate and calcium oxalate dihydrate crystals and their habits in case of inhibition. Methods: The study was carried out on a glass slide to observe the growth and inhibition of calcium oxalate monohydrate (COM) crystals by using infusions (5-20%) of Macrotyloma uniflorum (Lam.) Verdc, Phaseolus lunatus Linn. and Phaseolus vulgaris Linn. The reagents of the double diffusion gel technique were used for this purpose. Results: Calcium oxalate crystals are divided into three types: calcium oxalate monohydrate, dihydrate, and trihydrate. These types are further divided into sub-types based on their morphology. In the case of calcium oxalate monohydrate (COM), these crystals are donuts, dumbbells, needles, platy, prismatic, rosette, round edges and X-shaped. Calcium oxalate dihydrate (COD) is the elongated large rods and tetragonal bipyramidal forms. In the present study, dendritic or arborescent (tree-like platy crystals) were observed for the first time as part of a COM growth. Long chain loose agglomerates and compact aggregated crystals are the typical pattern of calcium oxalate crystals. All tested infusions caused growth inhibition of calcium oxalate crystals. Smaller nucleation zones and defective shapes of the grown crystals are declared different growth inhibition patterns. Conclusion: This study gives extensive information about morphology, aggregation and growth inhibition of calcium oxalate crystals.

Dr. salman ahmed

This study investigated the formulation, implementation, and performance implications of an artificial neural network–particle swarm optimization (ANN–PSO) based energy scheduling framework for a 150kW hybrid micro-grid. The analysis focused on two hybrid configurations, namely micro gas turbine–fuel cell (MGT–FC) and solar photovoltaic–battery storage system (PV–BSS), with emphasis on optimal dispatch behaviour and system efficiency under dynamic load and generation conditions. MATLAB was used to simulate ANN-based forecasting of hourly load and distributed energy resource outputs, which were subsequently optimized using PSO over multiple iterations to achieve balanced supply–demand scheduling. 4-in-1 visualization techniques were employed to capture convergence behaviour, transient response, dispatch stability, and efficiency dynamics across operating scenarios. Results showed that both hybrid systems achieved convergence within 20–24 PSO iterations, with scheduled power maintained within 50–120kW despite injected disturbances of ±20–30kW. The MGT–FC configuration demonstrated smoother dispatch profiles and faster fitness convergence, while the PV–BSS system exhibited greater variability due to intermittency, compensated by storage dispatch. Efficiency analysis revealed that optimal ANN–PSO scheduling sustained MGT–FC efficiency within 83–89%, whereas PV–BSS efficiency ranged between 41–72%, peaking during high-irradiance periods. Overall, the findings established that ANN–PSO-based scheduling enhanced operational stability and efficiency in both configurations, while highlighting the superior resilience of the MGT–FC hybrid under identical dynamic conditions. The study concluded that intelligent optimization provides a viable pathway for improving micro-grid performance in developing communities and industrial off-grid applications, where reliable and efficient decentralized power supply remains critical. It was therefore recommended among others that power system engineers and industrial energy planners in developing economies adopt ANN–PSO frameworks for real-time micro-grid dispatch to improve efficiency, resilience, and adaptability of decentralized energy systems serving communities and industrial loads.

Fxintegrity publishing

Cet article s’articule autour de la question de la satire chez Sony Labou Tansi dans La vie et demie. Conscient de la complexité de la notion de la satire dans le temps et chez les spécialistes, il nous a semblé judicieux de confiner notre étude dans le strict cadre de la satire entendue comme genre et non comme esprit ou mode. Nous avons démontré que la satire dans La vie et demie se justifie par la présence des topiques qui fonctionnent comme une signature du genre. L’argumentation a mis un accent sur la dimension rhétorique de la satire en parlant des formes de comique mises en place dans La vie et demie, lesquels participent à l’étayage de la satire politique du Guide providentiel et de ses nuisibles descendants. Aussi, avons-nous souligné que la dimension rhétorique de la satire se justifie par la présence de la ménagerie. L ’imagerie animale qui permet de caractériser les personnages de Sony Labou Tansi emprunte à la faune sauvage sa diversité des bêtes.

Assanvo

Introduction: The right lung has two fissures, an oblique and a horizontal, dividing it into three lobes namely the upper, middle, and lower. The nature of the fissure is of great importance in planning operative strategy for thoracoscopic pulmonary resection where an the incomplete fissure may contribute to post-operative air leakage Aim: To assess the gross morphological features of the right lung with special emphasis on the completeness of horizontal fissure. Material & Method: Material for the present study comprised of right lungs obtained from 50 well-embalmed adult human cadavers of both the sexes dissected as a part of 1 MBBS curriculum in the Department of Anatomy, Govt. Medical College, Amritsar. Results: Horizontal fissure was found to be complete in only 10% of the lungs while in rest 90% it was either incomplete or absent. Conclusion: Inferable from the huge variation in nonappearance or partial appearance of horizontal fissure in the right lung and to the absence of an acceptable classification of fissures, an endeavor has been made to give one such classification. In like manner, the horizontal fissure is evaluated from Grade zero to IV contingent on its absence and profundity from coastal surface to the hilum. Each evaluation is additionally divided into 3 subgrades relying on the culmination or incompleteness of these fissures with respect to their length.

Dr kulbir kaur

The purpose of this study is to evaluate activities of the corporate citizens in Tanzania and find the best way of aligning CSR initiatives to attain mutual benefits between the organizations and general public. A total of 45 organizations, both for profit and not for profit, were engaged in this study from four different industries. The study used semi-structured interview guide to collect data and a focused group discussion was organized. Contents analysis was used to categorize the responses into five major themes, as discussed in the main document. The findings reveal that CSR is still at its initial stage and much has to be done for the corporations to draw the best out it. Keywords Strategic CSR Value Organization and Society

Dr. omary swallehe

Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection caused more than five million deaths throughout the world and more than five thousand deaths in Libya, a little is known about the mortality rate and the risk factors for death from this serious infectious disease in Libya. Thus, it is aimed in this study to identify the potential risk factors for mortality from SARS-CoV-2 infections among 176 Libyan COVID-19 patients in Zawia city. This research is a retrospective cohort study that was conducted on 176 randomly selected volunteers who had been infected with SARS-CoV-2 during a period of December 2020 to February 2021 in Zawia city, Libya. Following filling the prepared validated questionnaire by COVID-19 patients, the data was analyzed to determine the previously mentioned risk factors. The mean age (SD) of the total 176 participated COVID-19 patients was 45.06 (± 17.7) and the mortality rate among these total involved cases (mild to severe cases) was 10.8%. It is found that the mortality among the severe COVID-19 cases was 41.3% and the mean age (SD) of COVID-19 deaths was 69.1 years (13.8) and 73.7% of them were 60 years old or older. In addition, it is found that 63.2% of the SARS-CoV-2 deaths were females and 78.9% of them had a positive history of chronic diseases. Moreover, it was found that the most common chronic diseases among COVID-19 deaths are diabetes mellitus and hypertension (73.3% and 53.3%, respectively). Collectively, it is concluded that COVID-19 elderly female patients aging 60 years or older with a positive history of chronic disease are more likely at high risk for death from SARS-CoV-2 infection among the participated COVID cases.

Mediterranean journal of pharmacy and pharmaceutical sciences

The rate of oxygen consumption was measured in mercury chloride treated freshwater fish, cyprinus carpio for 96h and compared to control group. The present investigation showed that average oxygen rate was decreased in all treated animal as compared to controlled group. Behavioural changes was also recorded in both concentration. The behavioural alterations observed like surfacing, erratic movement, increased mucous secretion, decreased opercular movement and loss of balance. The present study revealed that, mortality rate increased with increases in concentration.

.vijay digambar suryawanshi

India's hotel and hospitality industry occupancy decreased significantly in the first quarter of 2020, as the outbreak of COVID-19 affects different segments of the market. The outbreak of the novel coronavirus (COVID-19) has inflicted a blow on industries around the world, but maybe none as devastating as hospitality and travel. Depending on the length of the pandemic, companies across the industry adjusted growth forecasts for 2020, estimated profits to be conservatively 40-50 percent lower than expected before the outbreak. The effect on hospitality demand is greater than many other sectors, but even among hotels, air and cruise ships, and restaurants it is varied. Hotels and airlines operate at half capacity, with both business and leisure travelers canceling scheduled trips and not arranging any for the near future.The present article aims to study some novel practices for the survival of hospitality industries once the lockdown is over.

Ketan chande

Social Network sites are one of the most prominent websites used in almost every facet of life. A social network reflects relationships among social entities, including acquaintances, co-workers, or co-authors. With the extreme success of Social networks, the misuse has also been escalated and unlocked the way for various illegal behavior and security threats. Social Network anomaly detection has become a critical topic to be explored by researchers. The nature of the input data is a significant aspect of an anomaly detection technique. In the field of anomaly detection in the social network, input networks can be classified as static or dynamic, Attributed or unattributed. The number of nodes and the connections between the nodes in static networks would not change with time. Attribute networks are pervasive in various domains and constitute a vital element of modern technological architecture, where node attributes support the topological structure in data exploration. While social networks build up over time, evaluating them as if they had been static is very beneficial. Numerous studies have been done for Anomaly detection, but to the best of our knowledge, research in static attributed anomaly detection has been very limited. This review tries to portray earlier research on detecting anomalies for social static attributed networks and thoroughly discusses state-of-the-art embedding approaches

Mohd haroon