Cervical and ovarian cancers contribute significantly to female morbidity and mortality worldwide. The current standard of treatment, including surgical removal, radiation therapy, and chemotherapy, offers poor outcomes. There are many side effects to traditional chemotherapeutic agents and treatment-resistant types, and often, the immune response is depressed. As a result, conventional approaches have evolved to include new alternative remedies, such as natural compounds. Aquatic species provide a rich supply of possible drugs. The potential anti-cancer peptides are less toxic to normal cells and can attenuate multiple drug resistance by providing a productive treatment approach. The physiological effects of marine peptides are described in this review, which focuses on various pathways, such as apoptosis, microtubule balance disturbances, suppression of angiogenesis, cell migration/invasion, and cell viability. The review also highlights the potential role of marine peptides as safe and efficacious therapeutic agents for treating cervical and ovarian cancers.

Dr. salman ahmed

Background: There is great promise for improving nutrition and health thanks to phytonutrients' antioxidant qualities and health advantages. Their capacity to combat oxidative stress and associated illnesses emphasizes the importance of precisely evaluating their antioxidant characteristics. Objective: This study concludes by providing a comprehensive and critical critique of the current approaches to measure the antioxidant activity of phytonutrients. It dives into the fundamentals, benefits, drawbacks, and most recent developments of commonly used antioxidant assays, giving the reader a comprehensive grasp of the topic. This recapitulation of the review's goal in the end reinforces the reader's primary takeaway. Methods: Research on several antioxidant tests, such as FRAP, ORAC, DPPH, and ABTS, is consolidated in this review. It looks at each assay's performance traits, technological advances, and techniques. The review also assesses the incorporation of many assays to thoroughly examine phytonutrient potency and its uses in the food industry and nutritional science. Results: The review shows how antioxidant tests have advanced significantly, improving sensitivity, accuracy, and physiological relevance. It demonstrates how these tests can be used practically to guarantee food quality, create supplements, and offer nutritional advice. The paper also lists the difficulties today, including the intricacy of antioxidant mechanisms, test variability, and the requirement for assay standardization. The practical value of the research is emphasized by highlighting the significance of antioxidant tests for quality assurance, adulteration detection, and shelf life extension in the food business. Discussion: Scientists, doctors, and business experts interested in evaluating and applying phytonutrients will find this review helpful. It emphasizes how crucial it is to improve antioxidant testing to ascertain the possible health advantages and therapeutic uses of phytonutrients. The review highlights the need for increased test sensitivity, accuracy, and relevance while discussing the benefits and drawbacks of the available techniques. It draws attention to the importance of strong and trustworthy antioxidant tests to maximize the use of phytonutrients in food quality control and pharmaceutical research. Prospects: Future directions seek to address the challenges discovered through the development of multidisciplinary research and testing technologies. Novel approaches will advance our knowledge of phytonutrient potency and aid in developing medicines and nutraceuticals. This study highlights the significance of trustworthy assays for understanding and utilizing phytonutrients, providing academics and professionals in the business with vital insights.

Dr. salman ahmed

In view of the on-going global debate about the economics curriculum and its teaching, this paper explores how the faculty responsible for teaching introductory economics at a South African university understand learning and teaching of their subject. We have adopted a qualitative research approach, phenomenography, to complement what we already know from mainstream literature on undergraduate economics education, predominantly published by academic econ- omists using a quantitative methodology. After a phenomenographic analysis of interview data with lecturers and tutors, six conceptions of teaching introductory economics (Economics 1) emerged: (I) team collaboration to implement the economics curriculum; (II) a thorough knowledge of the content; (III) implementing the curriculum in order for students to pass as- sessment; (IV) helping students learn key economics concepts and representations to facilitate learning; (V) engaging students through their real-life economics context to acquire economic knowledge; and (VI) helping students think like economists. These are discussed first in relation to the implications for student learning and second, in a broader context of higher education discourses and educational development

Dr emmanuel ojo

The rate of aging is rapidly increasing and the term of geriatric refers to offer a medical care to elderly people. Drug consumption study on geriatric population is a vital issue since this group is totally neglected in Libya. The aim of this study was to assess drug utilization pattern among elderly patients in terms of world health organization core prescribing indicators and to evaluate the treatment cost. A total of 106 prescriptions were randomly collected from different community pharmacies located in Tripoli during the summer 2019, and were evaluated (total number of prescribed drugs is 359) for their clinical efficacy and safety. The findings revealed that 60 drugs acting on GIT (16.7%), 50 antimicrobial drugs (13.9%), 31 antihypertensive drugs (8.6%) and 30 drugs for respiratory diseases (8.4%) were prescribed to patients who are 65 years old or more. With regard to disease pattern in the elderly Libyan patients, 27 drugs were prescribed for diabetes mellitus (7.5%), 24 drugs for cardiovascular drugs (6.7%) and 14 drugs for anti-hyperlipidemia (3.9%). According to the WHO core drug use indicator pattern, the average number of drugs prescribed per encounter was 3.3. Prescription by generic name was low (41.5%). Antibiotics were 36.8% while injections were 26.6%. Thus, this study suggest that geriatric medicine and rational drug use should strongly be implanted in medical schools and teaching hospitals. Besides, a drug pattern use of the Libyan community is urgently required to avoid drug prescribing errors.

Fathi m. sherif

In the world of yoga there are ―Eight limbs path‖ which helps in different aspects like coordination of body and mind and helps to create positivity of mind and help the body healthy and fit by which the functioning of the body improves. In today‘s modern life various type of disease and deformity takes place most of the things takes place due to unbalanced food, & other. The mind is always wondering and being rebellious, never focusing on the moment. It is the mind job to think, it is relentlessly interpreting everything. That is seen, perceived and experienced and this pattern of habit goes through change to behavior and attitude. Many people who practice yoga do so to maintain their health and well-being, improve physical fitness, relieve stress, and enhance quality of life. In addition, they may be addressing specific health conditions, such as back pain, neck pain, arthritis, and anxiety. Basically yoga has been more effective than control and waitlist control conditions, although not always more effective than treatment comparison groups such as other forms of exercise. More randomized controlled studies are needed in which yoga is compared to active exercise groups. Having established the physical and mental health benefits of yoga makes it ethically questionable to assign participants to inactive control groups. Shorter sessions should be investigated for cost-effectiveness and for daily practice.

Yatendra sharma

This review shares historical glimpses of the art and science of urinary crystal growth in the gel. This successful journey of long and detailed research consists of theoretical and experimental knowledge. The survey consists of historical aspects of crystal growth, the development of urinary crystal growth in the gel as an in vitro urolithiasis model and the application of this model to evaluate prophylactic management against kidney stones.

Dr. salman ahmed

The current study seeks to develop and validate a high-performance liquid chromatography method for atorvastatin diastereomer separation and analysis. In particular, we wish to identify the many diastereomers in atorvastatin, which can help us to better understand their pharmacological properties and provide significant information for pharmaceutical applications. Atorvastatin was chromatographed on a Chiralcel® OD-RH column and n-hexan-2-propanol (95:05 v/v) as the mobile phase, with an injection volume of 10 µL. The solution was pumped at a continuous flow rate of 1 mL/min, with a detection wavelength of 260 nm. The investigation found two peaks with retention times of 3.23 and 3.85 min, respectively. The resolution, capacity, and selectivity factors obtained were Rs = 1.2, k′1 = 3.50, k′2 = 4.37, and α = 1.24.

Mediterranean journal of pharmacy and pharmaceutical sciences

This study aims to examine and compare the levels and patterns of aggressive behavior among higher secondary students in rural, semi-urban, and urban areas. Aggression among adolescents is a significant concern, and understanding its variations across different settings can provide valuable insights for intervention and prevention strategies. The study employs a review-based research design, using articles published between 1993 and 2023 to collect data on aggressive behavior of higher secondary students. For this purpose, a review of the literature was performed by using the search words “aggressive behavior”, “higher secondary students”, “rural”, “semi-urban”, “urban” in the databases like Google Scholar, ResearchGate, Academia, Shodhganga, PubMed, JSTOR and Elsevier for articles. The results will shed light on the prevalence, types, and potential factors influencing aggression in these areas, informing the development of targeted interventions and policy recommendations and statistical analyses will be employed to examine the relationships between variables. Importance and Scope of the Topic: Aggressive behavior is a topic that affects us all. From playground bullies to road rage enthusiasts, aggressive behavior has a significant impact on our daily lives. Understanding the causes and consequences of aggression is crucial in finding ways to prevent and manage such behavior. After all, the world would be a much better place if we all knew how to calm down and express our frustrations in healthy ways.

Abdul jaleel kuzhiyengal mambra

Verbesina encelioides, a plant with a rich history in traditional medicine, is commonly known as golden crownbeard or cowpen daisy. Despite its widespread use, scientific validation of its therapeutic potential, particularly its analgesic and anti-inflammatory effects, remains limited. Our study is designed to comprehensively evaluate the analgesic and anti-inflammatory effects of methanol extracts from various parts (leaves, stems, flowers, and roots) of V. encelioides in animal models. Acute toxicity, antinociceptive effects (heat plate and tail flick tests), and anti-inflammatory activity (carrageenan-induced inflammation) were tested in Swiss albino mice and Wistar albino rats. The acute toxicity assay showed no adverse effects in mice up to 1000 mg/kg, a highly encouraging result. In analgesic studies, V. encelioides extracts showed dose-dependent increases in reaction times similar to aspirin. Different extracts had different effects on paw edema in anti-inflammatory testing; some at first increased inflammation but eventually showed significant decreases, especially at higher dosages. These results offer a positive perspective on V. encelioides' possible medicinal use. These results provide a positive perspective on Verbesina encelioides' possible therapeutic use. The results imply that extracts from the plant, which are abundant in bioactive substances such as flavonoids, phenolics, and alkaloids, may have applications in treating pain and inflammation. These results highlight the plant's medicinal potential and suggest that more research and development could help address pain and inflammation naturally.

Dr. salman ahmed

The need for renewable energy sources in addressing global energy demands is growing, especially in Nigeria where electricity demand often exceeds supply. Solar photovoltaic (PV) systems have become a viable solution, with federal universities in Nigeria, as major electricity consumers, recognizing their potential. However, determining the right size of PV systems for individual faculties within these universities is a complex task. This study attempted to simplify this process by introducing an innovative approach to size PV systems in these faculties. The research method used the Extended Kalman Artificial Neural Network (EKF-ANN) and the Crow Search Algorithm (CSA) to enhance the accuracy of PV system sizing. Data was collected on the study site, load demand, weather conditions, system components, and operational control and systems models to establish sizing criteria. The study focused on the optimal size of a solar PV system at the Faculty of Law building, University of Port-Harcourt, and how to improve its accuracy. The results showed that using global solar insolation parameters, EKF-ANN predicted values for global temperature, flock size, and maximal iteration. This optimized system could generate surplus power for effective grid supply. The study found that the optimal size of the series-connected panels for the Faculty of Law building was 96, 83, 73, and 65 units, with corresponding insolation values ranging from 3.737 to 4.368 kW/m2. It was concluded that the combination of CSA and EKF-ANN in solar PV sizing is suitable for achieving optimal outcomes for energy storage and grid supply. Nonetheless, the study recommended additional investigation into real-time and grid-connected solutions to enhance the proposed approach's effectiveness.

Fxintegrity publishing

The global burden of metabolic disorders, including obesity and type 2 diabetes, necessitates innovative therapeutic strategies. SLU-PP-332, a synthetic agonist of estrogen-related receptor α (ERRα), has emerged as a promising exercise mimetic, demonstrating preclinical efficacy in enhancing mitochondrial biogenesis, insulin sensitivity, and energy expenditure. This brief review synthesizes current knowledge on SLU-PP-332 and related ERRα agonists, highlighting their molecular mechanisms, preclinical outcomes, translational challenges, and ethical considerations. ERRα activation by SLU-PP-332 upregulates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), driving fatty acid oxidation and mimicking exercise-induced metabolic adaptations. However, pan-ERR activity raises concerns about off-target effects such as cardiac hypertrophy and hepatotoxicity. Despite robust preclinical data, clinical translation remains hindered by the absence of human trials and undefined long-term safety. Future research must prioritize isoform-selective agonist design, rigorous clinical validation, and equitable access frameworks.

Mostafa eissa

In addition to the ordinary pharmacists’ role in dispensing and ensuring safety and efficacy of drugs, pharmacy profession is also concerning with clinical services towards community through multidisciplinary approach. In this regard, the clinical pharmacy is an area of pharmacy that concerned with the science and practice of rational drug use in which clinical pharmacist provides patient care that optimizes medication therapy and promotes health, wellness and prevention of diseases. During the recent crises of COVID-19 pandemic, the health systems appeared to be weak worldwide. Health care professionals seem to have nothing to present to their COVID-19 infected patients as no effective medications are approved by the World Health Organization (WHO) yet. Moreover, physicians are worried about the secondary infection for COVID-19 patients, therefore, treatment protocols were designed and mostly applied for critical COVID-19 patients who have been hospitalized in Libya. WHO does not recommend antibiotic therapy or prophylaxis for patients with mild COVID-19 unless symptoms of a bacterial infection exist. This monograph will highlight the widespread use of antibiotics and anticoagulants for COVID-19 patients at Maetiga Hopital in Tripoli, Libya

Mediterranean journal of pharmacy and pharmaceutical sciences

Schizophrenia is treated with antipsychotic drugs and is a chronic neuropsychiatric disorders. The influence of antipsychotics on the cytokine systems may be responsible for their clinical efficacy in schizophrenia. Granulocytopenia and agranulocytosis are severe side effects of antipsychotic therapy. The objective of this study was to estimate incidence of drug-associated agranulocytosis in newly diagnosed schizophrenic patients in and to evaluate the risk factors and outcomes. Seven participants groups were designed. Healthy persons as control. Schizophrenic patients before treatment. Schizophrenic patients after one-month of treatment. Schizophrenic patients after two - month of treatment. Schizophrenic patients after three - month of treatment. Schizophrenic patients after chronic treatments. Schizophrenic patients one month after chronic treatment. This study included screening for the expression and function of circulating leukocyte granulocyte-macrophage colony-stimulating factor receptor, screening of patient's biochemistry and haematology picture. Granulocyte-macrophage colony-stimulating factor expression was decreased after antipsychotic treatment for one month and continued to decrease after two months' treatment. Granulocyte-macrophage colony-stimulating factor expression starts to increase after the two-month treatment and continues increasing to controls or newly diagnosed schizophrenics or after chronic treatment. Complete blood counts were not changed compared. Liver function showed a transient increase in serum alkaline phosphatase after one and two month of treatment. All other parameters were not changed. Kidney function showed that urea and creatinine levels were within the normal range during the different treatments. Concerning lipid profile, low density lipoproteins levels were increased after one month, two months of treatment and after chronic administration of the antipsychotic drugs. It is concluded that antipsychotic treatment produces a decrease in granulocyte-macrophage colony-stimulating factor expression; the decrease reach the maximum effect after two months, then starts to increase back to normal levels. A transient increase in serum alkaline phosphatase in the first two months' treatment. Urea and creatinine levels and lipid profile were within normal range, except low density lipoproteins levels were increased during the two months treatment and after chronic administration of the antipsychotic drugs.

Mediterranean journal of pharmacy and pharmaceutical sciences

Reverence, obedience, and the transmission of traditions/values from one generation to the next are some of the most profound human responsibilities for families, clans, and tribes. One of the values that is transmitted in many cultures is respect for elders. However, the ways values are expressed differ based on culture and religion.

Santosh kumar

Introduction: Mental illness is a global issue that affects various population groups, including university students. Gaining insights into students' perspectives on mental illness plays a vital role in fostering mental health awareness and combating stigma in educational environments Purpose: The present study aimed to investigate Vietnamese undergraduate students’ knowledge, perceptions, and attitudes of mental illness by focusing on the dimensions: (i) the level of knowledge students possess about the causes and manifestations of mental illness, and (ii) their attitudes towards individuals experiencing mental health problems. Methodology: Using a descriptive cross-sectional design, this study involved 350 undergraduate students from five universities in Ho Chi Minh City, Vietnam. Data collection was conducted between June and July 2024 and utilized the Perception Towards Persons with Mental Illness (PWMI) Scale adapted from previous studies. Data analysis was performed using the Statistical Package for Social Science software, version 25 (IBM SPSS, Chicago, IL, USA). Results: The results indicated that approximately 80.6% knew about mental illness, and 70.5% perceived mental illness as a common or quite common phenomenon in Vietnam. Regarding the etiology of mental illness, a significant majority identified "bad things happening to you" as a cause (73.3%), followed by substance abuse (51.4%) and brain disease (50.0%). The findings also revealed that, despite some positive perceptions and attitudes, many responses clustered around the neutral option, particularly for controversial or personal items. Conclusions: The findings of this study underscore the need for targeted educational interventions to foster more informed and compassionate attitudes towards individuals with mental illness among undergraduate students.

Le minh tien

Introduction/aims: Maturity-Onset Diabetes of the Young (MODY) is a monogenic non-autoimmune diabetes with 14 different genetic forms. MODY-related mutations are rarely found in the Tunisian population. Here, we explored MODY related genes sequences among seventeen unrelated Tunisian probands qualifying the MODY clinical criteria. Materials and methods: The GCK and HNF1A genes were systematically analyzed by direct sequencing in all probands. Then, clinical exome sequencing of 4,813 genes was performed on three unrelated patients. Among them, 130 genes have been reported to be involved in the regulation of glucose metabolism, β-cell development, differentiation and function. All identified variants were analyzed according to their frequencies in the GnomAD database and validated by direct sequencing. Results: We identified the previously reported GCK mutation (rs1085307455) in one patient. The clinical features of the MODY2 proband were similar to previous reports. In this study, we revealed rare and novel alterations in GCK (rs780806456) and ABCC8 (rs201499958) genes with uncertain significance. We also found two likely benign alterations in HNF1A (rs1800574) and KLF11 (rs35927125) genes with minor allele frequencies similar to those depicted in public databases. No pathogenic variants have been identified through clinical exome analysis. Conclusions: The most appropriate patients were selected, following a strict clinical screening approach, for genetic testing. However, the known MODY1-13 genes could not explain most of the Tunisian MODY cases, suggesting the involvement of unidentified genes in the majority of Tunisian affected families.

Mariam moalla

While playing the Pathfinder RPG, the Game Master describes the events that occur in the game world, and the players take turns describing what their characters do in response to those events. Unlike storytelling, however, the actions of the players and the characters controlled by the Game Master (frequently called non-player characters, or NPCs) are not certain. Most actions require dice rolls to determine success, with some tasks being more difficult than others. Each character is better at some things than he is at other things, granting him bonuses based on his skills and abilities. Whenever a roll is required, the roll is noted as “d#,” with the “#” representing the number of sides on the die. If you need to roll multiple dice of the same type, there will be a number before the “d.” For example, if you are required to roll 4d6, you should roll four six-sided dice and add the results together. Sometimes there will be a + or – after the notation, meaning that you add that number to, or subtract it from, the total results of the dice (not to each individual die rolled). Most die rolls in the game use a d20 with a number of modifiers based on the character's skills, his or her abilities, and the situation. Generally speaking, rolling high is better than rolling low. Percentile rolls are a special case, indicated as rolling d%. You can generate a random number in this range by rolling two differently colored ten-sided dice (2d10). Pick one color to represent the tens digit, then roll both dice. If the die chosen to be the tens digit rolls a “4” and the other d10 rolls a “2,” then you've generated a 42. A zero on the tens digit die indicates a result from 1 to 9, or 100 if both dice result in a zero. Some d10s are printed with “10,” “20,” “30,” and so on in order to make reading d% rolls easier. Unless otherwise noted, whenever you must round a number, always round down. As your character goes on adventures, he earns gold, magic items, and experience points. Gold can be used to purchase better equipment, while magic items possess powerful abilities that enhance your character. Experience points are awarded for overcoming challenges and completing major storylines. When your character has earned enough experience points, he increases his character level by one, granting him new powers and abilities that allow him to take on even greater challenges.

Kamal singh

The United Kingdom (UK) is a constitutional monarchy where the Head of State is currently the Queen (part of the monarch) rather than the president. The roles, functions, and power are considered via convention, among them being that the monarch should be neutral politically (Bodleian Libraries 2021). The UK has three legal systems for England and Wales, Scotland, and Northern Ireland (Rab 2021). The former two nations use the common law system combining the approval of legislation by parliament, which includes the Monarch, House of Commons, and House of Lords, and the creation of precedents via case law (Rab 2021). The House of Commons is elected the population, with the Prime Minister being a traditional member of the House (Rab 2021). On the other hand, the judiciary is appointed to control the Court System and case law and is separate from the Parliament (Bodleian Libraries 2021). However, these systems are the UK law emanating from applicable laws to the UK, including its citizens. The UK law is summarized in the concept map highlighting the different types of laws governing the UK

Zamzam abdelazim

Extracorporeal membrane oxygenation (ECMO) is an advanced respiratory support that is being adopted as salvage therapy in acute respiratory failure [1]. The widespread use of this technology came as a result of a large multicenter randomized UK study showing a survival benefit for severe acute respiratory distress syndrome (ARDS) patients transferred to an ECMO-capable specialist center [2]. Moreover, improvements in clinical management and advances in technology have gradually changed ECMO from a “rescue therapy of last resort” to a type of standardized therapy for severe impairment with clear indications and contraindications in many specialized centers around the globe, including for the treatment of COVID-19 patients.

Karishma

Identifying the targets for improving antimicrobial prescription and development of antimicrobial stewardship interventions can better serve to combat the situation of antimicrobial resistance. The primary objective was to determine the prevalence of antimicrobial use at tertiary care teaching hospital with both acute and long-term care patients. A periodical point prevalence survey was done in a tertiary care hospital of South India during 2019 using manual and webbased GLOBAL-PPS tool. Of 945 patients eligible for the study, 645 (69.5 %) received at least one antibiotic, with highest rates in the adult surgical ward and pediatrics. Of 645 therapeutic antibiotic prescriptions, 58.6% prescriptions have an infectious indication of them, 62.6% are community-acquired infections. Third-generation cephalosporins were the most prescribed antibiotics. The prevalence of antibiotic use is very high, and our study evidence that the country needs a robust antimicrobial stewardship intervention program.

Vineela chadalavada