Industry 5.0 is still a developing concept, but it is expected to leverage a range of advanced technologies to facilitate human-machine collaboration and enable more customized and sustainable manufacturing.This research paper tried to discuss the opportunities and challenges in the implementation of Industry 5.0. It primarily explored the need to transform from Industry 4.0 to Industry 5.0. The research paper further studied the technologies needed for the implementation on Industry 5.0 and also the principles of Industry 5.0.

Dr. kishor bholane

A leader is a person, who influences his followers. The role of leader is often associated with managerial concepts, where a leader leads a team of employees, guides them, motivates them and influences them, in such way that the organisational productivity is honed up. A lot emphasis is on the style of leadership, exhibited by the manager, in honing the productivity of the organisation. According to (Hanvey, 2002; Janus, Kopechanski, Cameron, & Hughes, 2007; Morinaka, 2012; Reio & Fornes, 2011), most parents have dreams and hopes about their children and their lives. But, parents of children with special needs, though have, such dreams and hopes, have a harder time meeting these goals. According to Hanvey (2002), these parents need to devote more time and responsibilities, when it comes to raising a child with special needs, like caring for the child’s physical requirements due to his/ her disability, helping them with their physical and social needs and also help them in developing relationships with the others, so that they get a feeling of belongingness. Families with children having special needs undergo a higher level of stress (Gottfried & McGene, 2013). Families that have children with special needs, go through enormous stress levels, at times even financially stressed are they … (Hanvey, 2002; Moriwaka, 2012). But, Current study focusses on the effective leadership role played by a mother during the Pandemic, which is helping the kids, especially the children with special needs in combating the stress, that they are undergoing. A case of a child, diagnosed with autism(a serious behavioural disorder among young children that now occurs at epidemic rates in developing countries like India), since she turned two and how her mother has been helping her adapt to the new normal of staying home for all her activities and coping up with the increased stress levels.

Nandini

The aim of this study was to examine university students’ fear of success from the perspective of positive psychology. Two objectives were addressed: first, analyzing the relation between fear of success, optimism, self-esteem, self-efficacy, and search for meaning in life; second, exploring the variance of the fear of success, taking into account the affective dimension of the self (self-esteem) and search for meaning in life. The results confirmed that fear of success was positively related to search for meaning, and negatively to optimism, self-esteem, and self-efficacy. The variance of the fear of success was explained by the self-esteem and search for meaning in life. Implications for school psychologists were discussed.

Elena stănculescu

Study DesignA multicenter retrospective study. ObjectivesTo determine the rate of Apex facet fusion in children with Early Onset Scoliosis treated surgically with the Active Apex Correction (APC) technique. MethodsSeventeen patients were treated with the APC technique as index surgery for Early Onset Scoliosis with more than 1 year of follow-up. A 3D CT scan was done to determine the facet fusion rate in the deformity’s apex controlled with posterior tethering. ResultsThe average follow-up time was 26.4 months (12-56), Average age at index surgery was 81.2 months (30-132), and average number of surgeries done 1.3. Apical vertebrae studied for facet fusion were the 3 vertebrae in the apex in each patient that were subjected to posterior tethering according to the APC technique. In total they were 86 apical vertebrae (172 Facets studied with 86 convex side, 86 concave side). Our observations showed that 29 facet joints were fused (16% of the total facets studied),15 were on the convex, 14 on the concave side (no statistically significant difference). Regarding the facet joint distance in the non-fused facets was 0.99 mm on the convex side and 1.08 mm on the concave side with no statistical significance difference. ConclusionAPC for Early Onset Scoliosis achieves apical growth modulation and control utilizing posterior tethering without inducing fusion. This study demonstrated that APC is an effective non-fusion technique through the low incidence of facet fusion levels at the Apex, limiting the crankshaft phenomena seen in cases with apex control through arthrodesis.

Mohamad banat

English Corner extracurricular activities are one of the choices for students to be able to learn English with more fun. Through the English Corner extracurricular program, the Madrasah provides provisions for its students to face the era of the industrial revolution 4.0. The purpose of this research is to add insight and to know the mechanism of the English corner extracurricular through the development, implementation, assessment, and evaluation of the English corner extracurricular in the 4.0 revolution era at MI Roudlotul Ulum Banyuwangi. This type of research is qualitative research with a descriptive design. Data collection techniques using interviews, observation, and documentation. Data analysis used the concept of Miles and Huberman. The validity of the data was measured by means of triangulation of sources and techniques. The results showed that 1). The development of the English corner extracurricular in facing the 4.0 industrial revolution pays attention to human resources, needs, infrastructure, talents, and interests. 2). The implementation of the English corner extracurricular is almost the same as learning in general and is made more relaxed so that it is more comfortable in its implementation. 3). This English corner extracurricular assessment uses a written manual assessment, after which it is recapitulated and entered into the Digital Report Card Application (ARD). 4). This English corner extracurricular evaluation is carried out every six months or at the end of the semester, taking into account the development and implementation that was carried out in the previous semester.

Educare: journal of primary education

The purpose of this study is to evaluate activities of the corporate citizens in Tanzania and find the best way of aligning CSR initiatives to attain mutual benefits between the organizations and general public. A total of 45 organizations, both for profit and not for profit, were engaged in this study from four different industries. The study used semi-structured interview guide to collect data and a focused group discussion was organized. Contents analysis was used to categorize the responses into five major themes, as discussed in the main document. The findings reveal that CSR is still at its initial stage and much has to be done for the corporations to draw the best out it. Keywords Strategic CSR Value Organization and Society

Dr. omary swallehe

Emesis encompasses the forceful expulsion of the stomach's contents via the mouth or sometimes the nose. The adverse effects of currently available anti-emetic agents potentiate the natural product researchers to explore natural anti-emetics with fewer side effects. The presented communication reviews the anti-emetic effect of two hundred and forty-five plants belonging to seventy-eight families in different parts of the world. It also outlined the anti-emetic effect of plant extracts and isolated secondary metabolites studied through a variety of animal models of emesis. The reported anti-emetic plants in different countries and cultures and the scientific studies on extracts may help in the identification of promising single chemical compound(s) that may be used as potential leads for developing safe anti-emetic agents in future. Moreover, the reported secondary metabolites having the same effect may open the door for the search for the same secondary metabolites from other natural sources. This review will provide useful information for discovering natural anti-emetic compounds and fill the gaps in knowledge.

Dr. salman ahmed

The international opioid crisis highlights the important role of pharmacists in prevention, using their availability and drug knowledge to prevent abuse. In this study, the knowledge, attitudes, and practices of Mangalore pharmacists towards preventing opioid abuse were assessed. From February to March 2025, a cross-sectional survey was done among 203 pharmacists aged 18-46 years in Mangalore using a pre-tested structured questionnaire. Data were analyzed using the Chi-square test, and thematic analysis of qualitative feedback. Pharmacists showed high knowledge, with 93.6% identifying opioids' mechanism as binding to CNS receptors correctly, 78.8% identifying naloxone's role in reversing overdose, and 70.0% knowing prescription drug monitoring programs' usefulness. Attitudes were optimistic, with 92.6% considering patient education a primary responsibility, 92.1% identifying multiple visits to the pharmacy as misuse, and 93.1% supporting medication-assisted treatment. The practice was active, with 93.1% checking prescription drug monitoring programs for suspected misuse and 69.0% advising take-back programs, but 43.8% associated early refills with misuse. Mangalore pharmacists show strong knowledge, attitudes, and practice against opioid abuse, being very strong in education and medication-assisted treatment support but having voids in misuse detection (for example, recognition of early refill) and naloxone confidence. Stronger training, better prescription drug monitoring program access, and policy adjustments can enhance their role in India's opioid strategy. Pharmacists are presented as front-line champions of opioid misuse prevention in this study, with implications for localized harm reduction.

Mediterranean journal of pharmacy and pharmaceutical sciences

Among the consequences of armed conflict, the effect on the mental health of the civilian population is one of the most significant aspect of psychiatric disorders. Studies of the general population show a positive increase in the incidence and prevalence of mental disorders. This study is aimed to determine the relationship of the national crisis on the mental health conditions of university students and their academic performance. Specifically, this study was aimed to evaluate the national crisis effects on the mental health and the academic performance as well as the association of the national crisis, mental health and academic performance. 40 sample size of pharmacy students at the academic year 2019-2020 at Attahadi University, Tripoli, Libya were used in this study and a survey of validated questionare for mental health was considered. The findings revealed that the effects of national crisis on the mental health of the students disclosed the verbal interpretation of rarely grade. Indeed it can be found that mental health of the students was not of greatly affected in this sample. The academic performance of the students disclosed that academic year levels one and three have verbal interpretation of good and academic year level two has fair. Though the academic performance of the students did not show a verbal interpretation of weak or very weak. It is still worthwhile to note that none of them has reached the very good and the excellent performance. It can be concluded that a need for the students coping strategies be enhanced for them to reach their maximum potential with their academic performance. This study shows also that a weak positive relationship among the variables. Though it’s not that high, indeed, the mental health of the students can be a predictor to their academic performance.

Mediterranean journal of pharmacy and pharmaceutical sciences

Systemic onset juvenile idiopathic arthritis (SoJIA) is a rare inflammatory disorder. It is the severest form of juvenile idiopathic arthritis, and complications occur most commonly in this type. Non-responsiveness to standard therapy with corticosteroids and disease-modifying antirheumatic drugs is not uncommon. Interleukin-1 beta (Il-1β) has been shown to be a main contributor to the pathogenesis of SoJIA. Anakinra, a recombinant Il-1β receptor antagonist, was shown to be effective in small cohorts of therapy-resistant adult and pediatric still's patients. This study aimed to evaluate the real-world efficacy, steroid-sparing effect, and safety profile of anakinra in patients with SoJIA at a tertiary care center in Libya. A retrospective case series was conducted on patients with SoJIA treated with anakinra at the Tripoli Children's Hospital between 2010 and 2017. Data on demographic characteristics, disease activity, corticosteroid dosage, concomitant medications, and adverse events were collected at baseline and at 1-, 3-, 6-, and 12-month post-treatment. 13 patients were treated with anakinra with a mean age of 9.4±4.6 years at anakinra initiation and a female-to-male ratio of 2: 1. All patients were on corticosteroids and 92.3% on methotrexate at treatment initiation. The proportion of patients achieving inactive disease (Jadas 10=0) increased over time. A marked steroid-sparing effect was observed: the number of patients requiring high-dose steroids (>0.5 mg/kg/day) decreased from 100% at baseline to 7.6% at 12 months, and 53.8% successfully discontinued corticosteroids entirely. All patients experienced injection site reaction, and macrophage activation syndrome occurred in 15.4% as a side effect after treatment initiation. But no severe infections or fatalities occurred. Reasons for discontinuation included remission (46.1%), drug unavailability (23.0%), inefficacy (15.3%), and side effects (15.3%). Anakinra demonstrated significant efficacy in inducing rapid disease control and reducing corticosteroid dependence in patients with refractory SoJIA, with a manageable safety profile

Mediterranean journal of pharmacy and pharmaceutical sciences

Étudier les phénomènes grammaticaux actuels sans s’interroger sur la longue trajectoire historique qui a servi de support et de canal au français moderne manquerait de pertinence. En effet, une telle étude permet une meilleure compréhension des phénomènes linguistiques contemporains. Ainsi, notre domaine de recherche, la linguistique diachronique, met l’accent sur les connaissances étymologiques de la langue. Il s’agira, pour les besoins de l’article, de rendre compte de l’évolution morphologique du présent de l’indicatif depuis le latin jusqu’au français moderne. Notre curiosité nous poussera à nous interroger sur les raisons qui expliquent l’écart morphologique du présent de l’indicatif entre le latin et le français moderne. En sus, l’étude des variations diachroniques du présent de l’indicatif renseigne sur les formes actuelles de ce temps verbal. Du latin au français moderne, le présent de l’indicatif subit des flottements aussi bien dans ses radicaux que dans ses désinences. Ceci met en chef l’écart formel existant entre le présent latin et celui du français actuel. Toutefois, les phonèmes subirent des transformations selon qu’ils étaient toniques ou atones, radicaux ou désinentiels. Certaines formes se sont maintenues avec modification ou non de sons; d’autres ont complètement disparues du système. Suivant un ordre chronologique et des lois phonétiques cohérentes, nous montrerons que les formes actuelles du temps le plus usuel du système, le présent, ne sont pas le fruit du hasard. De ce fait, la langue moderne gagnerait à revisiter la morphologie des temps verbaux depuis leur origine pour mieux asseoir les difficultés liées à la conjugaison et fournir une explication authentique sur les variations de forme jusque-là ignorées par certains.

Assanvo

The city that never sleeps, a vibrant tapestry of dense neighborhoods and relentless energy, has long grappled with the pervasive challenge of air pollution. The very dynamism that defines the city – its traffic, buildings, and industry – contributes to ambient concentrations of fine particulate matter (PM2.5) and ground-level ozone (O3), pollutants known to exact a heavy toll on public health. [1-3] An extended analysis of environmental health data from 2005 to 2019, meticulously compiled by the town Department of Health and Mental Hygiene (DOHMH), offers a crucial lens through which to view the city's journey: a narrative marked by significant public health victories interwoven with stark, persistent environmental injustices. [4] This fifteen-year period reveals not just the efficacy of targeted interventions but also the deeply entrenched disparities that continue to leave vulnerable communities uneasy. Thus, the aforementioned challenge provides a very important lesson to address similar problems around the globe, especially in the crowded urban areas.

Karishma

India's hotel and hospitality industry occupancy decreased significantly in the first quarter of 2020, as the outbreak of COVID-19 affects different segments of the market. The outbreak of the novel coronavirus (COVID-19) has inflicted a blow on industries around the world, but maybe none as devastating as hospitality and travel. Depending on the length of the pandemic, companies across the industry adjusted growth forecasts for 2020, estimated profits to be conservatively 40-50 percent lower than expected before the outbreak. The effect on hospitality demand is greater than many other sectors, but even among hotels, air and cruise ships, and restaurants it is varied. Hotels and airlines operate at half capacity, with both business and leisure travelers canceling scheduled trips and not arranging any for the near future.The present article aims to study some novel practices for the survival of hospitality industries once the lockdown is over.

Ketan chande

The present study aims to shed some light on the gains from consolidation exercise in terms of profitability of banks. Through the application of paired t-test, we arrived at the result that the consolidation of banks did improve the profitability of banks in India. The increase in profitability of banks under study is due to an increase in employee turnover and the subsequent reduction in operating expenses. Merger and acquisition programmes in Indian banks cannot be regarded as a false step if the benefits of it accrue to all stakeholders.

Akhil antony

Efforts to understand the causes of poverty, how poverty is perceived have become important in the fight to mitigate poverty. In Vietnam, studies on the attitudes of poverty in specific populations, such as Vietnamese students, are rare. Thus, this dataset reports the results collected from 180 social work students and non-social work students of Ho Chi Minh City Open University through attitudes toward poverty and poor people in Vietnam. The Attitude toward Poverty Short Form 21-item scale, developed by Yun & Weaver, was used for the data collection. The survey results showed that when looking for causes of poverty, social work students and non-social work students put the most emphasis on structural factors of poverty. However, social work students, compared with non-social work students, consider personal deficiency and stigma more important. In future, this dataset can serve as a reference source for comparative studies on student’ attitudes toward poverty and impoverished persons and for social work education

Le minh tien

A major hallmark of Parkinson's disease is loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The pathophysiological mechanisms causing this relatively selective neurodegeneration are poorly understood, and thus experimental systems allowing to study dopaminergic neuron dysfunction are needed. Induced pluripotent stem cells (iPSCs) differentiated toward a dopaminergic neuronal phenotype offer a valuable source to generate human dopaminergic neurons. However, currently available protocols result in a highly variable yield of dopaminergic neurons depending on the source of hiPSCs. We have now developed a protocol based on HBA promoter-driven transient expression of transcription factors by means of adeno-associated viral (AAV) vectors, that allowed to generate very consistent numbers of dopaminergic neurons from four different human iPSC lines. We also demonstrate that AAV vectors expressing reporter genes from a neuron-specific hSyn1 promoter can serve as surrogate markers for maturation of hiPSC-derived dopaminergic neurons. Dopaminergic neurons differentiated by transcription factor expression showed aggravated neurodegeneration through α-synuclein overexpression, but were not sensitive to γ-synuclein overexpression, suggesting that these neurons are well suited to study neurodegeneration in the context of Parkinson’s disease.

Sameehan mahajani

The purpose of this study was to determine the attitudes, expectations, experiences, and barriers that physicians in Tripoli hospitals experienced when working alongside Clinical Pharmacists (CPs). A descriptive self-administered questionnaire was used for the study, and participants were selected from several Tripoli hospitals. Most of the respondents agreed that CPs are an essential part of patient care teams and that they have the legal authority to review a patient's medication regimen and response. More than half of respondents believe CPs must be responsible for the medications they prescribe to patients. Half of the respondents agreed that CPs should be encouraged to play a more active role in hospitals and other healthcare facilities. The majority of participants agreed that CPs should participate in managing drug side effects and almost half agreed that CPs can contribute to decisions about drug interactions. By a low agreement rate, 42.7% of respondents thought CPs were specially qualified to counsel patients on drug therapy. A similar low trend was observed, with 40.9% agreeing to provide pharmacists with additional responsibility and authority in clinical departments, in contrast, 54.5% expressed their concern about the clinical responsibility of CPs in clinical practice. A minority of physicians agreed that Physicians should consult pharmacists in selecting the best pharmacological treatment. At the same time, the majority think that pharmacists lack clinical skills and 61.8% feel that physicians are unable to communicate effectively with CPs. 43.6% acknowledged that the traditional opposition between the two professions was a barrier to interprofessional collaboration while the absence of pharmacy space in clinical settings was cited by 39.1%. A majority of respondents agreed that physicians and pharmacists may improve their interprofessional collaboration by raising their awareness about it. A minority of respondents thought that laws and regulations governing physician collaboration should be put in place to promote effective collaboration between physicians and CPs. The study discovered that although most physicians endorse the introduction of clinical pharmacy services in hospitals and believe that physicians and pharmacists can collaborate on many tasks, respondents were not as impressed with the CPs' performance and believed that they lacked the professionalism required to carry out clinical responsibilities successfully. To facilitate the growth of clinical pharmacy services, laws and regulations must be put in place.

Mediterranean journal of pharmacy and pharmaceutical sciences

Introduction and importance: Human echinococcosis, also known as‘hydatid cyst,’ constitutes a zoonotic parasitic disease attributed to Echinococcus granulosus or Echinococcus multilocularis. Primary af ictions occur in the liver and lungs, whilst the implication of alternative organs remains infrequent. The clinical presentation can vary, and large cysts may cause compression symptoms and complications. This case involved a 21-year-old Palestinian female with three large hydatid cysts in the liver, causing compression of adjacent structures and unique clinical manifestations. Case presentation: A female aged 21 arrived with signs of heart palpitations, shortness of breath, tiredness, and pain in the right upper abdomen, alongside a background of infertility. During routine pre-IVF ultrasound, three liver hydatid cysts were unexpectedly found, leading to a referral to the surgical department. Laboratory tests and imaging con rmed this diagnosis. The surgery involved cyst aspiration, hypertonic saline injection, and marsupialization. Post-surgical complications were managed as they occurred. The symptoms lessened afterward, and a successful pregnancy was achieved 9 months post-surgery. Clinical discussion: Zoonotic infection by cystic echinococcosis (CE) primarily engages the liver and lungs. The progression of symptoms is contingent upon cyst placement and resultant pressure on adjacent tissues. Diagnosis requires imaging alongside serological assays, while large cysts necessitate surgical intervention. Conclusion: The presented case underscores the complexity of managing multiple extensive liver hydatid cysts, highlighting the necessity to consider hydatid disease amidst patients presenting with indeterminate symptoms, particularly within endemic zones. An extensive surgical strategy produced positive outcomes, illustrating the signi cance of prompt intervention for symptom alleviation and sustained patient health.

Mohamad banat

Stability studies ensuring the maintenance of product quality, safety and efficacy throughout the shelf life are considered as pre-requisite for the acceptance and approval of any pharmaceutical product. These studies are required to be conducted in a planned way following the guideline issused by ICH, WHO and or other agencies. Importance of various methods followed for stability testing of pharmaceutical products, guideline issued for stability testing and other aspects related to stability of pharmaceutical products have been presented in a present review.

Prachi barbhaiya

The most successful and cost effective method for control the COVID-19 pandemic is the vaccination. Currently, there are different COVID-19 vaccine introduced into Libyan market. This study aimed to evaluate and compare the acceptance of COVID-19 vaccine among general population and students in Benghazi city. A cross sectional survey was conducted during March 2021 among 440 respondents (240 general populations and 200 students) using a self-administered questionnaire. The results were considerably similar among the two groups of participants. Only 10.9% said that they infected with COVID-19 during the pandemic period. About two thirds of the respondents agreed to be vaccinated against COVID-19 when available whereas the majority said they would wait some time before taking the vaccine (71.4%). Approximately, one third of the participants preferred the Sputnik vaccine, 24% preferred the Pfizer and BioNTech and 19.2% preferred Oxford (AstraZeneca) vaccine. More than a half (55.9%) of the participants are refused to pay for the vaccine. The majority of the respondents do not think the vaccine alone will be enough in protection against the COVID-19 (79.8%). There was no significant association between general population, students and the COVID-19 vaccine acceptance (p = 0.776). Additionally, there was no significant correlations between socio-demographic data and attitudes of the respondents with the acceptance of COVID-19 vaccine (p > 0.05), except for using hand sanitizers daily was significantly associated among the general population (p = 0.008). In conclusion, although, the general population and students have a good acceptability to the COVID-19 vaccine, more education health programs and promotion are wanted to reduce the vaccine hesitancy by declaring the importance of the vaccine, showing sufficient data stabilize the vaccine safety.

Mediterranean journal of pharmacy and pharmaceutical sciences