Dynamic capability has been used as the basis for organizations to build digital transformation to stay competitive in the market. This literature review aims to determine the significance of dynamic capability and digital transformation in family businesses. Using a systematic literature review methodology and utilizing the Dimensions database, three articles that met the criteria and fulfilled the goal of the review were selected. The findings indicate that family businesses have important dynamic capabilities that can aid their survival and expansion through digital transformation. Therefore, family business owners and managers should be able to identify and effectively use their dynamic capabilities to implement digital transformation in their business operations.

L

Ascaris lumbricoides infestation is a worldwide common soil-transmitted helminths infection mainly affecting children in the developing and low socioeconomic status countries where the transmission is by contamination of soil by human feces or use of untreated feces as fertilizer [1]. However, it is rare in Qatar, and most cases have been reported among non-Qatari residents who visited their home country while on vacation. In this report, we presented a case of A. lumbricoides infection in a preschool child who arrived in Qatar after a trip to the Gaza strip.

Karishma

The past few decades have witnessed several attempts to establish renowned medical journals in the Republic of Yemen. Some of these initiatives were successful but fell short of the researchers’ expectations, because they failed to meet international standards of scholarly writing in the medical field. Recently, the civil war has dashed any hopes of launching such a journal from within the country. We believe that this is the right time to establish a new peer-reviewed medical journal of high standards which meet the expectations of all Yemeni researchers across the board, from both within and outside the country. As a result of enormous efforts, discussions, and extensive collaboration, we have now been able to finalize the structure and content of the Yemen Journal of Medicine (YJM). Files

Karishma

Worldwide, cardiovascular diseases (CVDs) are the leading cause of mortality, demanding innovative therapeutic strategies. Nanomedicine offers promising solutions through nanoparticle-mediated drug delivery, enhancing precision, efficacy, and safety. This review examines nanocarriers, including liposomes, polymeric nanoparticles, and dendrimers, for targeted CVD treatment, encompassing coronary artery disease, atherosclerosis, and myocardial infarction. This review highlights advances in theranostics, gene therapy, and stimuli-responsive systems while addressing challenges related to biocompatibility and clinical translation. Nanotechnology holds transformative potential for CVD management, enabling personalized and least invasive treatments.

Karishma

Purpose: Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic disorder mostly characterized by gonadotropins release and/or action deficiencies. Both isolated (idiopathic hypogonadotropic hypogonadism) and syndromic (Kallmann) forms are identified depending on the olfactory ability. Clinical and genetic heterogeneities of CHH have been widely explored, thus improving our understanding of the disease's pathophysiology. This work aims to (1) provide a detailed clinical and hormonal description of normosmic CHH patients and (2) identify the mutation linked to the studied phenotype. Participants and methods: We investigated three affected patients with normosmic CHH, belonging to a consanguineous Tunisian family. Patients underwent an insulin-induced hypoglycemia test. We performed whole exome sequencing to identify the causal mutation. Results: At first diagnosis, a total gonadotropic deficiency was identified in all patients. The insulin-induced hypoglycemia test has also revealed a reduced cortisol secretion and complete growth hormone deficiency. At 20.8 years, one female exhibited a spontaneous recovery of the hypothalamic-pituitary-adrenal axis function, unlike her affected siblings who still depend on corticosteroid replacement therapy. Herein, we identified a novel homozygous nonstop mutation (c.1195T>C) in KISS1R gene in all affected subjects. This mutation led to the substitution of the physiologic stop codon by an arginine (p.X399R). Conclusions: Our study highlights the importance of the KISS1R signaling, in gonadotropin-releasing hormone neurons, in the control of reproductive function. Additionally, our data suggests a complex central and peripheral metabolic control of puberty, through the hypothalamic KISS1R signaling. We suggest a mutual link between the hypothalamic-pituitary-gonadal, -adrenal, and -somatotropic axes.

Mariam moalla

The primary cause of many fatalities is hypertension (high blood pressure). Many hypertensive patients are not even aware that they have the condition. As a result, hypertension is sometimes referred to as a silent killer. Until the harmful effects of high blood pressure, such as myocardial infarction, stroke, renal abnormalities, and vision problems, are identified, hypertension is typically asymptomatic. Without the use of herbs and dietary control, conventional medication therapy could not be enough to treat hypertension. The growing number of persons with high blood pressure can be effectively treated using alternative medicine. Numerous alternative therapies, such as diet, exercise, stress management, vitamins, and herbs, have been proven to be effective in lowering high blood pressure. There are several medications available to treat this disorder however popular antihypertensive medications typically have a long list of adverse effects. Numerous active ingredients with pharmacological and preventative qualities found in medicinal plants can be used to treat hypertension. This review discusses an overview of important medicinal plants and phytochemicals with hypotensive or antihypertensive effects.

Mediterranean journal of pharmacy and pharmaceutical sciences

Scientific research is an extremely important element in higher education. Nearly all undergraduate students at the university are required to take research courses in the formation process. Therefore, the current paper aims to explore Vietnamese undergraduate students’ attitudes towards research. To measure attitudes towards research, the study used Papanastasiou’s Revised Attitude Towards Research (R-ATR) scale (2014). This psychometric proprieties scale consisted of 13 items with three factors: research usefulness (4 items), research anxiety (5 items), and positive research predispositions (4 items). Data were collected by a questionnaire survey on a convenient sample of 520 undergraduate students from six universities in Vietnam. Descriptive and inferential statistics were used to analyze the data. The findings indicated that the students’ attitudes were high in the factor of research usefulness and positive research predispositions. However, in the factor of anxiety, the attitudes were moderate. In addition, the public undergraduate students had significantly more positive attitudes towards research than the private undergraduate students. Similarly significant results were found for gender, year of study, and research experience.

Le minh tien

Computer-assisted disease diagnosis is cost-effective and time-saving, increasing accuracy and reducing the need for an additional workforce in medical decision-making. In our prior research, we trained, tested, and compared the accuracies of nine optimizable classification models to diagnose and predict eight anaemia types from Complete Blood Count (CBC) data. This study aimed to improve these classification models by oversampling the original imbalanced dataset with four algorithms related to the Synthetic Minority Over-sampling Technique (SMOTE). The results showed that the validation accuracy increased from 99.22% (Ensemble model) to 99.57% (Tree model), and most importantly, the False Discovery Rate (FDR) for the anaemia type with the highest FDR decreased from 23.1% to 1.5%.

Ladislav végh

Acenocoumarol is the only oral antivitamin K anticoagulant prescribed and marketed in Algeria for the prevention and treatment of thromboembolic diseases. Nevertheless, the difficulty of handling this drug linked to a narrow therapeutic index and to great inter- and intra- individual variabilities of the response to the treatment poses a major public health issue because of its iatrogenic risk. To improve the management of patients on acenocoumarol and optimize its dosage adjustment and reduce iatrogenic secondary to vitamin K antagonists, our main objective work is to assess the knowledge, attitude and practice of health care professionals regarding this anticoagulant agent. We conducted a multicenter descriptive cross-sectional study from April to May 2021. We interrogated 152 health professionals of all ages, all sexes and all grades from different health departments in Oran City (Algeria) prescribing anticoagulants, through a validated questionnaire made up of 26 questions. Statistical analysis was achieved by SPSS version 20 software. Thus, 59.9% were women with a sex ratio of 0.67, 92.8% knew that acenocoumarol belongs to the antivitamin K class, 45.0% chose INR and PT as follow-up parameters, 36.0% chose INR alone and 78.9% were unaware of acenocoumarol dose adjustment algorithms as well as 82.0% were unaware of the existence of pharmacogenetics testing. 54.0% use the recommendations of the HAS for dosage adjustment of patients on acenocoumarol. 07.9% suggested using pharmacogenetic tests to improve the dosage adjustment of acenocoumarol, 06.6% suggested patient follow-up and 05.9% suggested therapeutic patient education as well as 74.3%, wanted to do training on. Therefore, this study highlighted gaps in the medical practice of physicians in terms of dosage adjustment, pharmacogenetics and its impact on dosage optimization. However, the evaluation of their knowledge was considered unsatisfactory. To overcome this lack of knowledge, it seems necessary to make physicians aware of the contribution of pharmacogenetics of acenocoumarol in Algeria.

Mediterranean journal of pharmacy and pharmaceutical sciences

L’émergence des territoires et l’épuisement des saltus stimulent des questions foncières longtemps restées en veilleuse. Au T ogo en général et spécifiquement dans l’Ouest de la Région des Savanes, la terre est une propriété privée des lignages. Le droit foncier y repose sur la prééminence du droit du premier occupant et matérialisé par une divinité appelée Tingban. L’insuffisance des preuves de prééminence et l’authenticité des fétiches, source de droit, opposent souvent les collectivités. La présente étude décrit l’épuisement des ressources foncières et analyse les conflits fonciers qui opposent les collectivités dans l’Ouest de la Région des Savanes. La méthodologie adoptée repose sur l’observation participante, la recherche documentaire et les entretiens. Les résultats révèlent de nombreuses disputes socio-foncières qui opposent les lignages, les villages et les cantons. Les collectivités contestent entre elles, les droits de paternité sur les terres dans 74% des cas alors que 26% des querelles foncières sont dus aux remises en cause des limites des propriétés collectives. Ces contestations plongent leurs racines dans la complexité du droit foncier coutumier fondé sur la prééminence du droit du premier occupant. Elles sont aussi liées à la non maîtrise des limites des domaines fonciers lignagers et des territoires cantonaux respectivement par les descendants, les chefs de villages et les chefs de cantons.

Assanvo

Researchers have developed several authentication techniques for route predictions based on user requirements. These techniques estimate the shortest path and available resources in vehicular communication networks. In the current research, the existing authentication techniques for vehicular communication are compared and their inadequacies are identified. Then, new authentication technique based on route forecasting are presented for vehicular communication networks, with the service provider anticipating alternate routes for customers if the current routes have more network traffic congestion. By presenting the most efficient route, the suggested model allows users to maximise their time efficiency. Using A* algorithm, VCN agent seeks path with less network traffic congestion. This algorithm determines the shortest path between a source and a destination. Users are provided with several options by the service provider. User accepts the finest option that meets their needs. This method allows the service provider to deliver at least 15 routes within three seconds. This strategy is beneficial when a significant number of vehicles are stuck in traffic and consumers require network resources to utilise their time effectively.

Vartika agarwal

“Phyllanthus emblica” known to be amla has role in the skin aging influences the changes in skin, including skin dryness, wrinkle, and irregular pigmentation. Initially the 6 day observation has been taken for the ageing activity to be track to study the TREM2 pathway of “Phyllanthus emblica”. Cellular observation and pathway consideration: The environmental impact of pH, Temperature, Humidity and stability of amla fruits is important for the ageing of cells in neuronal cascade of TREM2 Pathway, while studying the fruits cell cycle. The melanin suppression through inhibition of tyrosinase and tyrosinase-related protein-2 activities, the strong antioxidant, and the potent matrix metalloproteinase-2 in cellular observation of tyrosinase pathway. The study aimed to evaluate the anti-skin aging efficacy of amla.

Wahul umesh

Patent foramen ovale (PFO) is a prevalent congenital cardiac anomaly. It is increasingly acknowledged as a significant factor in cryptogenic ischemic stroke, especially among young adults experiencing otherwise unexplained cerebrovascular incidents. This review summarizes recent advances in the epidemiology, pathophysiology, diagnostic strategies, and management of PFO-related stroke. The article examines the intricate mechanisms of PFO-associated strokes, including paradoxical embolism, in situ thrombus formation, and atrial cardiopathy, while emphasizing the significance of anatomical risk factors like large shunt size and atrial septal aneurysm. The clinical implications of PFO in various disorders, such as migraine with aura, decompression sickness, and high-altitude pulmonary edema, are also analyzed. Diagnostic modalities such as echocardiography and transcranial Doppler are compared, focusing on their sensitivities and procedural details. The review focuses on evidence-based methods for medical, interventional, and device-based closure of PFO, highlighting patient selection and ongoing controversies. The ongoing uncertainties surrounding causal relationships, risk stratification, and optimal therapy highlight the necessity for continued research. This review offers a current synthesis for clinicians and researchers addressing the challenges associated with the evaluation and management of PFO in stroke prevention. To achieve the aims of the article and make it concise, PubMed, Google, EMBASE, Google Scholar, and Scopus were searched for original and review articles published in the last 10 years. Several keywords, phrases, and texts were utilized.

Karishma

This research aims to evaluate the optimization of network security forensic tools on virtual router (VR) traffic. The methodology used includes the selection of several forensic tools on the Windows operating system such as Wireshark, Windump, and Network Miner, with testing in a virtual network environment. Testing, includes simulating various attack scenarios to assess the effectiveness of threat detection, performance of forensic tools, and impact on network performance. The main results show that the tools have varying detection capabilities with variations in resource usage and impact on network latency. Network traffic has been successfully recorded using the Win-dump tool in the static-forensics method, the Wireshark tool and Network Miner in the live-forensics method. The evaluation results of the meta-router network forensic recording tool recommend Win-dump as a recording tool that does not burden the Windows operating system with memory usage of 1696 kb while the Wireshark and Network Miner applications are recorded at more than 20MB. Based on this research, the static forensic method which have been built with meta-router objects can be used by investigators to detect cyber attacks. Proper selection and configuration of forensic tools is critical to achieving a balance between security and network performance, and specific adjustments to network requirements can increase the effectiveness of threat detection and mitigation.

Firmansyah yasin

Now-a-days there is a renewed interest in drugs of natural origin simply because they are considered as green medicine and are always safe. The advantage of natural drugs is their easy availability, economic and less or no side effects they have been used in traditional medicine practices. In the present investigation some medicinal weeds were analyzed, it includes Centella asiatica, Phyllanthus niruri, Argemone mexicana, Amaranthus viridis, Asclepias currasavica, Cyperus iria and Portulaca oleraceae. All the eight medicinal weeds collected during field visits were subjected to study organoleptic features, macroscopic studies, powder analysis, physicochemical limits and fluorescence analysis, single and double staining techniques.

Veerabhadraswamy al

Potassium Bromate (KBrO3) is an oxidative agent capable of causing hematological alterations and other toxic effects. Amaranthus Viridis (Inine) is a medicinal plant traditionally used for various therapeutic purposes. This study investigated the ameliorative effect of ethanol extract of Amaranthus viridis (Inine) on the haematological parameters in potassium bromate (KBrO3) intoxicated Albino Rats. Thirty (30) rats divided into six (6) groups consisting of five rats each, group one as the normal control, group two as the negative control (50 mg/kg of KBrO3 only), group three Vitamin C (100 mg/kg) + 50 mg/kg of KBrO3and group four to six (200 mg/kg, 400 mg/kg, and 800 mg/kg) respectively. KBrO3 exposure significantly altered some haematological indices in the rats indicating a haematotoxic effects. The results showed a dose-dependent improvement in several haematological parameters upon coadministration of Amaranthis viridis occurred. The red blood cell count (RBC), packed cell volume (PCV), haemoglobin concentration (Hb), and white blood cell count (WBC) exhibited notable recovery in comparison to the KBrO3-treated group. Platelet count (PLT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) also demonstrated positive alterations in response to the extract. The group receiving the highest dose of the leaf extract (800 mg/kg) alongside KBrO3 displayed the most significant improvement in the aforementioned parameters, indicating a potential dose-dependent protective effect against KBrO3-induced haematotoxicity. These findings suggest the potential therapeutic efficacy of Amaranthus viridis extract in mitigating KBrO3-induced hematological alterations.

Okechukwu obed chukwuemeka

The mechanical heart valve prosthesis with a caged ball has been around for 60 years. It has since experienced changes and adjustments. The Starr–Edwards (SE) valve was a pioneer and was taken out of clinical use in the late 2000s. SE is reportedly close to or has reached the age of 50, according to numerous sources from around the globe. The author’s observations and review of the literature about thrombogenicity, pannus formation, left ventricular outflow tract obstructions, and infective endocarditis in the SE valves, which were reportedly higher before its clinical ending, were only an overestimation and were not supported by scientific data. However, it was less discussed in the article, along with potential benefits. The main reasons for its demise were its obtrusive size and unattractive shape. There have been several successful implantations of these valves in Asian nations and reports of fewer primary failures and unexpected cardiac fatalities. Therefore, there is a need for extensive data gathering, documentation, and more recent studies on these valves to prepare for a prospective revival of use with newer research, mainly when long-term durability is considered.

Karishma

During the last two decades, the concept of Fibre Metal Laminates (FMLs) has been evolved to find solution to the requirement of improving mechanical properties and reducing structural weight of elemental components of aircraft structures. In this work FML is prepared using Al 2024 by placing alternately with glass/carbon/aramid Fibres. From experimental results of FML shows greater advantage in mechanical properties then aluminium monolithic layer and this composite fibre laminates individual. The FMLs tested in this work were made of 3 layers of 2024 T3 aluminium alloy 0.28 mm thickness and fibre mats. The 5-3/2 laminates of size 300x300 mm with 3 mm thick were prepared using Vacuum Assisted Resin Transfer Moulding (VARTM) in cold compaction and test specimen were cut by using abrasive water jet machining as per ASTM Standards. The adhesion between fibre and metal layer will play a major role in strength of FML. By keeping this in consideration FMLs were prepared without blow holes and capable of withstanding delamination while preparing specimens through water jet and during various tests employed. The fracture surfaces of destructed specimens are studied with help Scanning Electron Microscope (SEM) image. Similarly, the numerical simulation of all the tests were done using Ansys APDL 10.0 Software. It is observed that aramid FML have substantially stronger in longitudinal directions. Hence, more priority given in this paper to investigate tensile strength and fatigue life of aramid FML.

Boopathy govindarajan

The present study aimed to explore the possible morphological features and growth patterns of calcium oxalate monohydrate crystals. The study was carried out on a glass slide under the microscope. The results showed that the calcium oxalate monohydrate crystals may be arborescent, donut, dumbbell, needles, platy, prismatic, rosette, round edges, loose agglomerates and compact aggregates. The study provides detailed information about calcium oxalate monohydrate crystals' morphology and aggregation patterns.

Dr. salman ahmed

The present review was written to describe the effects of the COVID-19 pandemic on followup and treatment process of gynecological cancers and breast cancer in accordance with current literature, guidelines from national and international cancer associations. Recommendations were provided based on the consensus conference model. In the follow-up and treatment process of gynecological cancers and breast cancer, there are many factors, such as the clinical course of patient, the possibility of an emergency of the patient, the stage of the cancer and the current status of the chemotherapies. Although opinions in all types of cancer differ among themselves, general beliefs are postponement of non-urgent surgical operations, re-evaluation of chemotherapy processes, postponing appointments for new nonurgent diagnoses, reducing the length of hospital stay of patients in emergency procedures, conducting consultations by telemedicine or telephone, treatment of patients with COVID-19 suspicions after 15 days, planning biopsies or surgeries according to the staging status of cancers and planning conferences as video conferences in cases that require a multidisciplinary approach. Patients diagnosed with cancer during the COVID-19 pandemic should not be lost, followup and treatment should be continued without disruption, patients should be remembered to be in the high-risk group in this process and necessary hygiene measures should be taken in both follow-up and treatment concerning risks and COVID-19 pandemics.

Reyhan aydin doğan