Elevated arterial blood pressure is the most important public health problem in developed countries. It often leads to lethal complications if left untreated. Brewer's yeast is celebrated for its various beneficial effects, including a possible hypotensive effect. Thus, the anti-hypertensive effects of brewer’s yeast were investigated. The hypertensive model was done by a once-weekly intraperitoneal injection of dexamethasone at a dose of 25 mg/kg combined with drinking a 1.0% sodium chloride solution containing 0.2% KCl and 2.0% glucose for six weeks. The blood pressure was measured by the rat carotid artery cannulation preparation. Different doses of brewer's yeast dissolved in distilled water were injected into the internal jugular vein, with measurement of blood pressure at each time. To explore the mechanism of the hypotensive effect of yeast, the yeast cardiac effect was verified by the use of isolated perfused rabbit heart preparations using different antagonists. It was found that dexamethasone elevated systolic blood pressure to 178.3±11.6 and diastolic blood pressure to 133.3±16.6 from normal levels of 115.0±9.1 for systolic and 74.0±4.1 for diastolic. The gradual increase in intravenous yeast doses ranging from 0.05 to 0.40 effectively lowered systolic and diastolic blood pressure in rats with normal pressure, bringing them to approximately 80.0±05.6 mmHg for systolic and 40.0±3.5 mmHg for diastolic. While doses exceeding 0.04 resulted in a drop in systolic pressure to 60.0±3.9 mmHg, diastolic pressure became unrecordable. The administration of the 0.20 dose resulted in unrecordable blood pressure. In hypertensive rats, a decrease in blood pressure was observed with doses ranging from 0.60-1.0 mg, leading to a reduction to 110.0±2.8 mmHg for systolic and 52.0±9.9 mmHg for diastolic pressures. Doses exceeding 1.0 mg further lowered systolic and diastolic pressures to 20.0±3.9 mmHg. There was a mild increase in heart rate with no change in cardiac force of contraction. This effect was not mediated through beta, calcium receptors, or the histamine effect. The findings show that the yeast has a dose-dependent blood pressure-lowering effect. The mechanism of the chronotropic effect is possibly due to its direct action.

Mediterranean journal of pharmacy and pharmaceutical sciences

Several diseases affect maize plants and one among them is black bundle disease, causal organism of which is yet to be confirmed with conflicting reports appearing in literature. In the present work, an effort was made to record the disease incidence by carry out filed surveys in Southern most district of Karnataka state, India and also to isolate and identify the causal organism. The surface sterilized pith tissue from the infected plants was cultured on PDA medium to identify the organism in the affected vascular tissue. The isolated tissue produce Cephalosporium acremonium which was confirmed based on morphological characters. In addition, Simplicillium sp. and Macrophomina phaseolina were also isolated from the same infected plant material and suspected to have participated in the disease development. In accordance with several reports in literature, Cephalosporium acremonium was tested and confirmed as the causal organism of disease in green house experiments by following the Koch’s postulates. This is in contrast with some earlier reports, wherein the exact symptoms of black bundle disease were reported as barren stalks in corn caused by Fusarium sp. The simplicillium sp. which had morphological similarity with C. acremonium and had an ambiguous taxonomic status in literature was confirmed as a distinct species through PCR based diagnosis.

Veerabhadraswamy al

Diabetes mellitus (DM) is a complex and chronic illness requiring continuous medical care. Type 2 diabetes (T2D) is commonly associated with obesity, hypertension, and a tendency to develop thrombosis, and an increase risk of cardiovascular diseases (CVD). Diabesity is a term used to indicate the coexistence of obesity and DM. Diabesity increases as obesity is an emerging epidemic in modern societies, the co-incidence with DM is also rising, so a joint plan of anti-obesity and anti-hyperglycemia for the management approaches. Therefore, this study aimed to identify the impact of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on body weight and glycemic response in obese Libyan patients with T2D at the National Diabetes Centre in Tripoli, between July 2013 and May 2022. This prospective study included obese adults with T2D who were newly prescribed GLP-1RA therapy for six months with dulaglutide once weekly or liraglutide once daily. The study included 170 diabetic patients who were started on GLP1-RA as add on therapy to their treatment, with a regular follow-up with dietitian and their physicians to adjust their glucose-lowering medications, then comparing the effect of these agents on body weight and the level of glycated hemoglobin before and after 24 weeks of treatment. Most of the patients (n = 99, 58.23%) were in the age period from 54 to 74 years old and 101 of whom were female subjects (59.4%), with a mean duration of DM equal to 8.8 ± 7.3 years. The patients were divided randomly into two groups, the first group included 110 patients who received liraglutide pens showed a significant reduction in HbA1c from 9.6% (± 1.54) to 7.4% (± 1.03) by p < 0.001 and a significant weight loss from 88.3 kg (± 10.68) to 80.8 kg (± 11.83) by p < 0.001. The reported adverse events were in 23 cases of minor hypoglycemia due to gastrointestinal upset. The other group included 60 patients for dulaglutide pens and showed significant decrease in HbA1c = 9.6% (± 1.54) to 7.1% (± 1.2) by p < 0.05 and a significant reduction of bodyweight from 88.3 kg (± 10.68) to 83.8 kg (± 16.3) by p < 0.05. The reported adverse events were mild transient gastrointestinal distress for the initial week of a start and then subside with regular intake. Whereas, 115 patients (67.6%) with HbA1c above 10.0% before starting therapy, no patient with HbA1c above 10.0% after six months of both GLP-RA agents therapy. Thus, the uses of GLP-RA as add-on therapy for obese patients with T2D significantly improved glycaemic control with less hypoglycaemia, accordingly, reduce insulin requirement for blood glucose control and loss in body weight. It can thus be concluded that GLP-1RA therapy is an effective treatment option when used in obese patients with DM.

Mediterranean journal of pharmacy and pharmaceutical sciences

The current study was designed to explore the anti-inflammatory effects of the crude hexane and ethanol extracts of the leaves and male flowers of Luffa cylindrica (L.) Roem., (sponge gourds) to validate its folk use. These extracts produced significant anti-inflammatory effects (p.o.) at doses of 500, 750 and 1000 mg/kg b.w. in carrageenin-induced paw oedema in rats compared to those obtained with indomethacin. The results of the present study provide evidence for the anti-inflammatory properties of the leaves and male flowers of Luffa cylindrica, which have potential therapeutic applications for inflammatory diseases.

Dr. salman ahmed

Effective project management requires an understanding of how stakeholders are impacted by project failure. It draws attention to the effects on those involve finances, reputations, and emotions, assisting organizations in risk avoidance and fostering stakeholder satisfaction, trust, and long-term success. The purpose of this study is to provide proactive risk management, stakeholder involvement, and project result strategies. In order to compile this study, we have used a number literature reviews ranging from 2004 to 2023. The study's findings show that project failure results in significant financial losses, harms reputation, has legal ramifications, affects employee wellbeing, stifles relationships with stakeholders, stifles innovation, and endangers communities and the environment. By Adopting proactive risk management, strong governance, open communication, employee support, stakeholder involvement, strategic resource allocation, and social and environmental responsibility to reduce these negative effects and achieve sustainable project outcomes. The policymakers, practitioners and academia should focus risk factors those are associated with the project failure and hance manage a good harmony among the stakeholders.

Nazim ullah

This study explores the influence of education, length of service, professionalism, and ethics on the professional values of public relations practitioners in Malaysia. A total of 427 questionnaires were distributed to public relations practitioners in Malaysia, and 322 questionnaires were returned. The study included 61% female respondents, and 39% male respondents. The study analyzed and identified the influence of professionalism and ethics on professional values of public relations practitioners. Additionally, the study examined whether education and experience influence professional values through professionalism, and code of ethics. Six hypotheses were tested to answer the research questions. The results from this study fully supported the hypotheses indicating that professionalism and ethics had an influence on professional values of public relations practitioners. The results also showed that education influenced both professionalism and ethics, and length of service influenced both professionalism and ethical practice.

Mohammed fadel arandas

Context: Menstruation is one of the most basic characteristic features of girls and inadequate knowledge of adolescent girls about menstruation can result in faulty menstrual hygiene management (MHM) and inappropriate dietary management both of these can causes diseases which is a major threat for adolescent health in developing countries like Bangladesh. Aim: To identify current knowledge, attitudes, and practices related to menstruation and menstrual hygiene management (MHM) among adolescent girls. Settings and Design: It is a descriptive cross-sectional study conducted in Jashore, Bangladesh. Methods and Materials: A pre-formed, pre-tested questionnaire was used. The questionnaire-based survey was conducted among randomly selected 250 adolescent girls between 10 and 19 years. Statistical analysis used: Data were analyzed statistically by Microsoft office excels and SPSS windows version 16 software programs. Results: Among 250 adolescent girls majority had their menarche between 12 and 15 years of age, 70% of adolescent girls of this study belonged to lower class families. This study revealed that 85% of the respondents had regular menstruation whereas 15% had irregular menstruations also. Most of them faced different types of Premenstrual syndrome including 76% from headache, 80% from lower abdominal pain, and 62.5% from fatigue and weakness. Only 56% had previous knowledge about puberty before attaining menarche. There was a statistically significant correlation between the mother’s education and the knowledge of participants about menstruation at puberty. All the participants used to bath and wash hand after changing pads whereas 80.8% used to avoid all types of exercises. Almost 94% of respondents used to dispose of their napkins properly. The micro-nutrient deficiency was also common; especially 49.2% were suffering from Iron deficiency and 69.6% from folic acids deficiency. Conclusion: Awareness programs regarding both menstrual hygiene and dietary management can aid to alleviate some complications during puberty and ensure better health for adolescent girls.

Arafat hassan razon

Objective: This study fills an important research gap by focusing on the effectiveness of low-impact exercise in Parkinson's disease (PD), taking into account the different challenges faced by people with varying degrees of disease severity. Motivation: Unlike generic investigations into exercise and PD, our research prioritizes low-impact activities, considering safety concerns related to balance deficits and coordination challenges in the PD population. The study aligns with a patient-centred approach, aiming to provide a safer alternative to traditional exercise modalities. Approach: Conducting a comprehensive literature review, we conducted an online literature search on various databases, specifically investigating about low-impact exercises on both motor and non motor symptoms in PD individuals. Review process involved capturing diverse intervention types, durations, frequencies, and intensities. Findings: The amalgamation of diverse outcome measures, including UPDRS, Berg Balance Scale, TUG, 6MWT, and PDQ-39, showcased the multifaceted impact of low-impact exercises on both movement related and non-movement related symptoms. Notably, aerobic exercises being treadmill walking, cycling, and group sessions, emerged as pivotal interventions, demonstrating improvements in gait, balance, flexibility, and overall quality of life for PD individuals. Conclusion: While acknowledging limitations, such as potential publication bias and a focus on aerobic exercises, this study provides meaningful decision making information for clinicians and researchers. Future research should diversify interventions and methodologies to enhance the evidence base and address nuanced aspects of low-impact exercises in PD management. The results of this review contribute to the existing body of knowledge regarding the nuanced benefits of personalized low-impact exercise for Parkinson's disease.

Nagarjuna narayanasetti

cASUARINA EQUSITIFOLA IS A FAST GROWING EVERGREEN TREE GROWN BY FARMERS UNDER AGROFORESTRY SYSTEMS IN tAMILNADU state of Southern India

Dr. saranya devi k

Industrial waste is one of the most essential sources of contamination in the environment. Chromium (Cr) is a toxic heavy metal, a major contaminant in tannery wastes and its accumulation in soil and water is a major environmental concern today. In the present study, an attempt was made and investigated the status of different beneficial microbes particularly plant growth promoting rhizobacteria (PGPR) from tannery sludge samples collected from tannery effluent treatment plant at Dindugal, Tamil Nadu, India. Experiments were conducted and evaluated their chromium heavy metal tolerance abilities and plant growth promoting activities under in-vitro. Based on molecular analysis, the PGPRs were identified as Achromobacter xylosoxidans (LK391696), Azotobacter vinelandii (LK391702) and. The production of IAA was found to be high by Achromobacter xylosoxidans (46μg/ml) followed by Azospirillum lipoferum (30μg/ml). Phosphate solublization activity was also found to be positive in all these PGPR isolates. Significance of these results revealed that there is a possibility of using these potential PGPRs for bioremediation of chromium contaminated sites and also as good plant growth promoter.

Dr. saranya devi k

Our society is reflected through the media, which represents what society is like and how it functions. The sole medium that serves to keep people informed is media, whether it is written, electronic, or on the web. It also serves to amuse, educate, and inform the audience about current events. Our society's voice is now dominated by the media. A number of media platforms have brilliantly stirred the views of the younger generation and other segments of our society. The study's goal is to examine the media's involvement and efficacy throughout the demonetization process. The study's major goals are to look into the role of the media in informing people about the demonetization process and its consequences. The study will contribute to a better understanding of the role of the media in conveying information on significant problems and how individuals learn about current events. In Lucknow's South City and Eldeco neighborhood, a poll of 300 persons was held. The researchers devised a data gathering interview plan that took into account the function and type of media in raising public awareness. The convenience sampling method was used in the research investigation. The study focuses on media consumption patterns and behaviour throughout the demonetization period.

Dr. amarjeet singh

Stakeholder plays significant roles in project success. They ensure clear communication of project goals, contribute to decision-making, and demonstrate commitment, increasing the likelihood of successful outcomes. They also act as advocates within their organizations, generating buy-in and support. The main purpose of this paper is to identify and discuss the roles of shareholders in a project success. The paper is conceptual in nature and uses a number literatures ranging from 2007 to 2023 from a good number of journals. After scrutinized the literature review, the paper concludes a number of findings. The findings implies that stakeholders in a project is crucial for its success and sustainability. Stakeholders play a significant role in ensuring the performance of the project. Project managers need to acquire stakeholder management skills to address the communication requirements of stakeholders. This is important for the success of the project. The paper recommend that policymakers, practitioners and academia have to ensure the expectations and make a balance among the stakeholders.

Nazim ullah

As one of the flow-based passive sorting, the hydrodynamic filtration using a microfluidic-chip has shown to effectively separate into different sizes of subpopulations from cell or particle suspensions. Its model framework involving two-phase Newtonian or generalized Newtonian fluid (GNF) was developed, by performing the complete analysis of laminar flow and complicated networks of main and multiple branch channels. To predict rigorously what occurs in flow fields, we estimated pressure drop, velocity profile, and the ratio of the flow fraction at each branch point, in which the analytical model was validated with numerical flow simulations. As a model fluid of the GNF, polysaccharide solution based on Carreau type was examined. The objective parameters aiming practical channel design include the number of the branches and the length of narrow section of each branch for arbitrary conditions. The flow fraction and the number of branches are distinctly affected by the viscosity ratio between feed and side flows. As the side flow becomes more viscous, the flow fraction increases but the number of branches decreases, which enables a compact chip designed with fewer branches being operated under the same throughput. Hence, our rational design analysis indicates the significance of constitutive properties of each stream.

Myung-suk chun

The Fourth Industrial Revolution (4IR), internet definition is considered as growing out of the third industrial revolution, but is considered a new era rather than a continuation because of the explosiveness of its development and the disruptiveness of its technologies. It is not a new phenomenon that many South African manufacturers are facing important talent challenges when organising their business. Diverse IT skill sets, improved skills blend and a rearrangement of skills are necessary. It is undisputed that 4IR requires a highly skilled workforce, and one which South Africa, regrettably, has been struggling to produce. It was the purpose of the study to gain an understanding of what Essential Employee Knowledge Management and Re-Skilling is needed in the South African Automotive Industry towards 2030 with regards to the Fourth Industrial Revolution (4IR). Methodology: Firstly, an environmental scanning was performed, examining pertinent literature, thereafter a case study approach was used was used to describe the true experiences of assembly workers and their immediate supervisors in a South African automotive plant. Results: The automotive industry is extremely robust and skilled employees are essential. From the study, the major solution to remedy low competence was continuous skills transfer through highly structured cross-functional skill development programmes. Conclusion: The study results cannot be generalised but do give an insight into what the current situation is in an automotive industry in South Africa.

Luyolo mahlangabeza

Vitamin C causes a significant change in pharmacological effects of some drugs which may lead to unpredictable responses. Vitamin C-haloperidol interaction has not been confirmed in vivo. This study was aimed to investigate the influence of vitamin C on some pharmacological effects of haloperidol (extrapyramidal side effects caused by the antipsychotic haloperidol). Albino male mice (n = 24, body weight of 20 - 40 gm) were divided into four groups and each of consists of six mice. Group I (control): given 1% Tween 80 solution, group II: given vitamin C in a dose of 100 mg/kg, group III: given haloperidol (2 mg/kg), while group IV: given a combination of vitamin C and haloperidol. All the treatments were given by intraperitoneal route of administration. Three sub-acute doses of different treatments were given at 24:0, 5:0, 1:0 hour before scoring. Parameters scored were catalepsy, ptosis, rigidity and akinesia. The experiment was repeated using vitamin C in a dose of 500 mg/kg. Both doses of 100 and 500 mg/kg of vitamin C significantly antagonized the effect of haloperidol by decreasing all the tested parameters. The results indicate that vitamin C decreases extrapyramidal side effects caused by the antipsychotic haloperidol and show that it successfully decreases catalepsy, ptosis, rigidity and akinesia in mice.

Mediterranean journal of pharmacy and pharmaceutical sciences

The primary cause of many fatalities is hypertension (high blood pressure). Many hypertensive patients are not even aware that they have the condition. As a result, hypertension is sometimes referred to as a silent killer. Until the harmful effects of high blood pressure, such as myocardial infarction, stroke, renal abnormalities, and vision problems, are identified, hypertension is typically asymptomatic. Without the use of herbs and dietary control, conventional medication therapy could not be enough to treat hypertension. The growing number of persons with high blood pressure can be effectively treated using alternative medicine. Numerous alternative therapies, such as diet, exercise, stress management, vitamins, and herbs, have been proven to be effective in lowering high blood pressure. There are several medications available to treat this disorder however popular antihypertensive medications typically have a long list of adverse effects. Numerous active ingredients with pharmacological and preventative qualities found in medicinal plants can be used to treat hypertension. This review discusses an overview of important medicinal plants and phytochemicals with hypotensive or antihypertensive effects.

Mediterranean journal of pharmacy and pharmaceutical sciences

The novel coronavirus pandemic is affecting the whole world and it is predicted that the process will continue for a long time. The health, economic and social problems caused by this process have greatly affected women as well. In addition to the problems endured by the general population, women are facing additional challenges involving their reproductive health, pregnancy, childbirth and postpartum period. Women are trying to deal with a range of concerns, from difficulties in accessing family planning services to being unable to meet their own basic reproductive health needs. Under the pandemic conditions, it has become increasingly difficult for social services to respond sensitively to women's particular needs. The needs of coronavirus patients take precedence, and the women’s needs remain in the background. Women are facing stress, anxiety, fear, as well as disease. So, midwifery practices need to be revised to adapt to the pandemic conditions. This revision must involve not only technical issues but also psychosocial adjustments. Women have been demanding home births on social media, and this is a subject that require some legal regulations. Respect for women's birth is one of their most fundamental rights. National criteria should be developed to accommodate the support structures needed for a home birth. The social support that midwives offer women during pregnancy, childbirth and the postpartum period, play a key role. Since it is important to increase the awareness of midwives in this regard, this article deals with women's needs for social support and possible midwifery approaches for supporting women through their pregnancy, childbirth, and the postpartum period.

Reyhan aydin doğan

Background: Many individuals today use herbs as a drug alongside medicine and non-physician-recommended medications, as herbs are thought to be natural and safe. However, many herbs can potentially interact with other drugs, causing hazardous effects and diminished therapeutic effects of different prescriptions. Objective: It ought to be comprehended that herbal drugs contain multiple active compounds in different percentages, which can change the enzymatic frameworks, transporters, and physiological processes. Methods: Data on pharmacokinetic drug interactions with herbal products were searched using different search engines, such as Google Scholar, Scopus, and ScienceDirect. Results: This worldwide increment in herbal drug popularity has risen concerning HDIs. These PD or PK interactions are particularly significant for medications. Assessment of herbal drug interactions is complex because of inconsistency in herbal drug composition and frequently meagre information on active constituent pharmacokinetics. These restrictions are further bewildered by the differing points of view concerning herbal product regulation. Conclusion: It is concluded that a basic assessment of certain pharmacokinetic HDI is needed to settle on educated choices regarding patient safety. The expanding comprehension of HDPKI will direct more attention to potential interactions.

Dr. salman ahmed

Emesis encompasses the forceful expulsion of the stomach's contents via the mouth or sometimes the nose. The adverse effects of currently available anti-emetic agents potentiate the natural product researchers to explore natural anti-emetics with fewer side effects. The presented communication reviews the anti-emetic effect of two hundred and forty-five plants belonging to seventy-eight families in different parts of the world. It also outlined the anti-emetic effect of plant extracts and isolated secondary metabolites studied through a variety of animal models of emesis. The reported anti-emetic plants in different countries and cultures and the scientific studies on extracts may help in the identification of promising single chemical compound(s) that may be used as potential leads for developing safe anti-emetic agents in future. Moreover, the reported secondary metabolites having the same effect may open the door for the search for the same secondary metabolites from other natural sources. This review will provide useful information for discovering natural anti-emetic compounds and fill the gaps in knowledge.

Dr. salman ahmed

Le 05 décembre 2012, les pratiques et expressions culturelles liées au balafon des communautés sénoufo du Mali, du Burkina Faso et de la Côte d’Ivoire ont été inscrites sur la Liste représentative du patrimoine culturel immatériel de l’humanité. Le tafal-djéguélé est une pratique et expression culturelle liée au balafon des Sénoufo de Côte d’Ivoire. Deux raisons principales fondent son usage : amener les laboureurs à la houe à se surpasser d’une part, et magnifier les valeurs des senambélé1 d’autre part, notamment celles en rapport avec le labour étant donné que le sénoufo est agriculteur par essence. Toutefois, en raison de certains changements sociaux, le tafal-djéguélése pratique de moins en moins. Cette situation prive le senanw d’aujourd’hui d’un cadre majeur d’enseignement et de diffusion de valeurs, et pose ainsi la question de leur transmission aux générations actuelles et futures. Cet article vise à démontrer comment la faible pratique du tafal-djéguélé empêche de nos jours la transmission de "valeurs- références" en pays sénoufo, mais aussi à proposer des pistes de solutions.

Assanvo