Attempts have been made to formulate controlled release drug dosage forms using chitosan as a release controlling polymer. Granules of combination of chitosan, hydroxylpropyl cellulose, lactose, starch and Ibuprofen were prepared by wet granulation method using 1.0% lactic acid solution. The granules were physico-chemically characterized in terms of density, porosity, angle of repose, carr’s index and housner ratio and was found to be free flowing with good compressibility. FTIR spectroscopy was used and confirmed that there is no interaction between the drug and the added polymers. In vitro release of Ibuprofen, in phosphate buffer at pH 7.4, showed a steady and slow increase in the percentage of drug released over 24 hours as the percentage of chitosan was increased in the formulations compared to that from commercial tablets which released over 80.0% of their content in only two hours. The kinetic analysis using different mathematical models of the data revealed that the release kinetics of the drug form these formulations is somewhere between diffusion controlled, Fickian (anomalous) and non-Fickian which refers to a combination of diffusion and erosion controlled release. Thus, the high correlation coefficient of the data of drug release from most granules when zero order kinetics was applied revealed that there is a constant drug release with time for 24 hours.

Mediterranean journal of pharmacy and pharmaceutical sciences

Abstract- The injection of the PV Grid power into an electric grid affects the power quality. The influence of the PV Grid in the grid system concerning the power quality measurements and the norms followed according to the guidelines specified in the International Electro technical Commission standard, are the active and reactive power variations, variation of voltages, flicker, harmonics and electrical behavior of switching operations. The work study demonstrates has overall good functional characteristics, better performance and faster response than existing systems. The proposed system of having STATCOM is smaller in size and less costly when compared to the existing system. In this proposed system static compensator (STATCOM) is connected at a point with a battery energy storage system to reduce the power quality issues. The effectiveness of the proposed scheme gives the reactive power demand of load and the induction generator. Simulation is done by using MATLAB / SIMULINK-Sim power system software.

Deepak patel

The use of Capsicum annum L. for culinary purposes dates back centuries. Its medicinal benefits have also been investigated in the past few days. Analgesic and anti-inflammatory activity in 4 different colored (green, yellow, orange, and red) sweet bell peppers (Capsicum annuum L.) were investigated in 200 and 400 mg/kg doses. Current research is directed at authenticating whether Capsicum can be used as an analgesic and anti-inflammatory, comparing the effects of the most used analgesic aspirin. The effects of ethanol extract of Capsicum annum L. were determined for analgesic activity by acetic acid-induced writhing, tail immersion and hot plate test. Animals were divided into ten groups (n=7): (1) Control (2) CAG 200 (3) CAG 400 (4) CAR 200 (5) CAR 400 (6) CAO 200 (7) CAO 400 (8) CAY 200 (9) CAY 400 (10) Standard. All the extracts given intraperitoneally in rat hind paws of seven animals in each treatment group received 200, 400 mg/kg. Acute toxicity was also determined by increasing the dose to 3000 mg/kg, which showed no evidence of mortality. A statistical calculation was performed using SPSS software to compare the effects of aspirin and Capsicum extract. Positive results were obtained as compared to the control group; the analgesic effect was statistically significant (P˂ 0.05). These observations revealed that the fresh fruit extract of four kinds of Bell pepper at 200 mg/kg and 400 mg/ kg possesses anti-inflammatory and pain-suppressing activities possibly mediated via PG synthesis inhibition.

Dr. salman ahmed

ABSTRACT Objective: The objective of the present study was to develop an HPLC analytical method and to perform in vivo study of Emblica officinalis and Aegle marmelos extracts for antioxidant and antidiabetic activity. Methods: The phytochemical analyses, total phenolic content (TPC), TLC, DPPH assay were performed for freeze-dried Emblica officinalis fruits aqueous extract (EOFAE) and Aegle marmelos leaves ethyl acetate extract (AMLEAE). The active constituents present in both extracts were estimated by using HPLC system having Hibar® Results: Tannins, saponins, carbohydrate, glycosides are found in EOFAE; coumarins and flavonoids are found in AMLEAE and quinones, phenols are present in both extracts. The values of TPC present in standard gallic acid, EOFAE and AMLEAE were found to be 485.7, 315.6, 300.7 mgGAE/g, respectively. R C18 column [250 x4.6 mm, 5 µm] and UV detector (264 nm). A gradient mobile phase (acetonitrile and water with 0.1% trifluoroacetic acid) was used at a flow rate of 0.8 ml/min. In vivo antioxidant, antidiabetic activity of both extracts was conducted on male albino Wistar rats for 21 d in streptozotocin-induced diabetic rats (42 rats; n=6). The antidiabetic activity was measured by blood glucose level and biochemical parameters i.e. total cholesterol, triglycerides and total protein. Oxidative stress was measured by antioxidant biomarkers i.e. SOD, GSH, lipid peroxidation by thiobarbituric acid reactive substances method on the liver of the experimental rat. f Conclusion: The present study showed that the EOFAE and AMLEAE treated group III with (EOAM) low dose of 500 mg/kg body weight has potent antioxidant and antidiabetic activity. values obtained by TLC of EOFAE and AMLEAE were found to be 0.41 and 0.50, respectively. The values of % inhibition shown by EOFAE and AMLEAE in DPPH assay were found to be 97.8%±2 and 95.2%±2, respectively. The values of retention time of EOFAE and AMLEAE by HPLC analysis were found to be 4.59 and 5.28 min, respectively. Histopathological examination of the liver was revealed that low dose EOAM (containing of EOFAE 250+AMLEAE 250 mg/kg body weight) administered once a daily for 21 d showed significant activity (P˂0.001) with biochemical parameters and antioxidant biomarkers. Keywords: Emblica officinalis, Aegle marmelos, Antioxidant, Antidiabetic activity, streptozotocin, HPLC

Snehal

Nine fruit morphological traits were studied in ten stands of Jatropha curcas spread in eight forest divisions of Uttarakhand. Variation was examined at stand level as well as at tree level. Significant differences were found among stands for fruit length, fruit diameter, pericarp weight per fruit, seed: fruit weight ratio, kernel: fruit weight ratio and pericarp: fruit weight ratio traits while all morphological traits showed significant differences among trees within stands. The estimation of the variance components, however, revealed that the fruit traits, especially weight traits viz. fruit weight, total seed weight per fruit and total kernel weight per fruit have negligible contribution from stands and small contribution from trees. Maximum variation was found among fruits within trees (i.e. at fruit level or error). Pericarp weight per fruit and fruit ratio traits (i.e. seed: fruit weight ratio, kernel: fruit weight ratio and pericarp: fruit weight ratio) were affected to small extent by stand per se. The repeatability of all fruit traits at tree level were also low to moderate (0.105 to 0.278)

Kshitij malhotra

Online distance learning policies were formulated and implemented among some Malaysian universities long ago, but their value emerged since COVID- 19. Emanating from the diffusion of innovation theory, this study examined the perception of higher education students on the influence and relationship between six independent variables (compatibility, observability, relative advantage, complexity, trialability, and digital skills) and one dependent variable (digital literacy). A total of 524 respondents were sampled, comprising students from six public and private Malaysian universities. The findings from the correlation analysis show a significant positive relationship between the six independent variables and the dependent variable. Meanwhile, in the regression analysis, three of the independent variables (observability, trialability, and digital skill) have a significant and positive effect on digital literacy. This study placed the diffusion of innovation in a specific context that supports designing online distance learning and digital literacy policies

Mohammed fadel arandas

While today, he was ready to serve 1.4 million meals for schoolchildren, Mr.CC Das, Program Director, Akshaya Patra Foundation from Bangalore also faced the challenges 15-years before its establishment like any other start-up. Similar was the case of Mr.Trilok Gautam, Executive Supervisor, who was working in a remote village called Baran in Rajasthan. On his visit during the mid-day meal preparation, he was inspecting the quality of meal, where women were busy in preparing food. They were preparing bread by rolling the dough, while few were chopping vegetables with utmost hygienic care. Cleaner, safer, quality meal was to be prepared and served for 1,500 poor students. These children earlier used to go hungry from the school. On November 28th 2001, Supreme Court of India gave a verdict and directed the State Government and Union Territories to provide mid-day meal to every child in Government and Government-assisted primary schools. The Right to Food Law emerged as a fundamental right, enforced due to constitutional amendment under Article 32 of the constitution. Hence, every State Government geared up to make the mid-day meal scheme successful in their respective States. The Karnataka government also participated and named this programme as ‘Akshara Dashoha’. Government of Karnataka took the pioneering step to involve NGOs like Akshaya Patra as an important partner of the government to run this innovative mid-day meal scheme under the Public Private Partnership (PPP) Model. Presently, Indian mid-day meal scheme considered as one of the largest mid-day meal programme in the world has a target to reach out nearly 120 million children in the country.

Nitin mali

Background: Quality of life (QOL) is an important determinant in assessing the health status. It includes physical, psychological, and social well being. The aim of this research was to identify the intrinsic and extrinsic factors of QOL; and the association of QOL with socio-demographic, anthropometric variables and lifestyle variables. Methods: This cross sectional study was conducted in Tamil Nadu among 327 adults during July 2020 through online using standardized WHOQOL-BREF tool to assess the quality of life along with socio-demographic variables, anthropometric variables and lifestyle variables. Principal component analysis method was used to identify the factors which influence the QOL of adults. The association between socio-demographic variables, anthropometric variables and lifestyle variables with quality of life was also assessed. Among the selected samples 165 were female and 162 were male. The structured questionnaire included Section A- socio-demographic variables such as age, gender, occupation, educational qualification, place of residence, marital status; Section B - anthropometric variables such as height, weight and BMI; Section C lifestyle variables such as type of diet and physical activity pattern; and Section D -consisted of Standardized WHO-BREF tool to assess the quality of life. Results: The identified intrinsic factors include Life style approach, Emotional stability and Health status; Safety & accomplishment, Financial support with societal information were identified as extrinsic factors. These factors played an influential role in QOL of the adults during pandemic crisis. The association between the type of residence (p=0.001), occupation (p=0.000) and marital status (p=0.022) with QOL was highly significant at 1 % and 5 % respectively. Conclusion: The identified factors during covid-19 pandemic had influenced the quality of life domains namely physical health, psychological, social relationship and environment. Intrinsic factors were dependent on individual’s perception towards accepting the new normal during the pandemic. Whereas, extrinsic factors were greatly influenced by the environment and society in which the study participants were exposed. One of the identified extrinsic factors (residence), showed high significant association with QOL.

Athina deepa prasanna

Konsep edutainment mencoba memadukan antara pendidikan dan hiburan, yang didalam konsep edutainment tersebut terdapat beberapa pendekatan yang lebih kita kenal sebagai SAVI (Somatik, Auditori, Visual dan Intelektual). Metode penelitian ini menggunakan jenis penelitian Library research, yaitu jenis penelitian yang dilakukan dan difokuskan pada penelaahan, pengkajian dan pembahasan literature-literatur, baik klasik maupun modern. Literature berbahsa arab, inggris, Indonesia dan sebagainya yang ada kaitannya dengan persoalan ini. Penelitian ini bersifat analisis deskriptif. Sumber data penelitian ini yaitu: Sumber primer dari pemikiran Beby De Poter. Sumber skunder meliputi: buku, artikel atau esai yang membahas konsep edutainment, dan buku yang berkenaan dengan konsep psikologi belajar anak, serta buku pendidikan karakter, terutama karakter cinta tanah air. Hasil penelitian ini menunjukkan: (1) Pembelajaran Edutainment Dalam Penanaman Karakter Cinta Tanah Air Bagi Anak Usia Dini Di Sekolah Dasar, yaitu: menumbuhkan karakter cinta tanah air, memunculkan emosi minat anak seperti rasa senang dan gembira dalam pembelajaran, guru dalam menyampaikan pembelajaran di kelas harus menunjukkan sikap kepedulian terhadap peserta didik. (2) Proses Penanaman Karakter Cinta Tanah Air Bagi Anak Usia Dini Di Sekolah Dasar, yaitu: proses pembelajaran interaksi antara siswa dan guru terbangun suasana menyenangkan, fleksibiltas guru dalam menyampaikan materi menyesuaikan dengan emosi peserta didik, hubungan keakraban dan persahabatan sebagaimana teman sendiri, dan guru memberikan kebabasan berexspresi kepada perserta didik pada saat proses pembelajaran.

Educare: journal of primary education

Human resource practices are strategic in nature. They represent a vital guidance system that coordinates with executive business plan. HR practices form the foundation supporting the way of bank’s human capital will operate effectively. This research has estimated the impact of HR practices among the employees working in private sector banks on their productivity in Coimbatore district of Tamilnadu. In this research, the researcher has taken randomly around 125 banking employees working in private sector banks in Coimbatore district. A structured questionnaire has framed and collected their opinion about the HR practices which were practiced in their banks. Their opinion were subdued into tables by using percentage analysis, mean score analysis, correlation analysis and regression analysis. The results showed that PG qualified employee whose age between 41 to 50 years have more impact of HR practices and their productivity also high

Dr.n.s.lissy

Background: Perforation is the most serious surgical complication of peptic ulcer disease due to its attendant high morbidity and mortality. Hypovolemia, a consequence of gastro-duodenal perforation, is considered to be a cause of renal hypo perfusion with accompanied decreased clearance of urea and creatinine. The aim of this study was to determine the preoperative baseline serum urea and creatinine profile among patients with perforated peptic ulcer disease and the relationship of serum urea and creatinine with the outcome of care. Methods: A retrospective study of patients who had operation for perforated peptic ulcer disease over a 5-year period at Dalhatu Araf Specialist Hospital, lafia, North-central Nigeria was conducted. Results: Sixty-four patients were studied with a mean age of 36.6 ± 12.3 years. Majority of the patients were males, 59 (92.2%). While 38 (59.3%) patients had elevated preoperative baseline urea levels, 37 (57.8%) patients had elevated creatinine levels. Out of 29 patients who had surgical site infection, 16 (55.2%) had elevated serum urea (p = 0.535) while 19 (65.2 %) had elevated serum creatinine (p = 0.579). An overall in-hospital mortality rate of 14.1% was recorded. There was statistically significant relationship between elevated serum urea and inhospital mortality (p = 0.007). Conclusion: This result showed that preoperative baseline serum urea and creatinine levels were elevated in majority of the patients. In addition, the result of this study suggests that elevated baseline serum urea level has considerable relationship with in-hospital mortality

Karishma

L’émergence des territoires et l’épuisement des saltus stimulent des questions foncières longtemps restées en veilleuse. Au T ogo en général et spécifiquement dans l’Ouest de la Région des Savanes, la terre est une propriété privée des lignages. Le droit foncier y repose sur la prééminence du droit du premier occupant et matérialisé par une divinité appelée Tingban. L’insuffisance des preuves de prééminence et l’authenticité des fétiches, source de droit, opposent souvent les collectivités. La présente étude décrit l’épuisement des ressources foncières et analyse les conflits fonciers qui opposent les collectivités dans l’Ouest de la Région des Savanes. La méthodologie adoptée repose sur l’observation participante, la recherche documentaire et les entretiens. Les résultats révèlent de nombreuses disputes socio-foncières qui opposent les lignages, les villages et les cantons. Les collectivités contestent entre elles, les droits de paternité sur les terres dans 74% des cas alors que 26% des querelles foncières sont dus aux remises en cause des limites des propriétés collectives. Ces contestations plongent leurs racines dans la complexité du droit foncier coutumier fondé sur la prééminence du droit du premier occupant. Elles sont aussi liées à la non maîtrise des limites des domaines fonciers lignagers et des territoires cantonaux respectivement par les descendants, les chefs de villages et les chefs de cantons.

Assanvo

The rate of oxygen consumption was measured in mercury chloride treated freshwater fish, cyprinus carpio for 96h and compared to control group. The present investigation showed that average oxygen rate was decreased in all treated animal as compared to controlled group. Behavioural changes was also recorded in both concentration. The behavioural alterations observed like surfacing, erratic movement, increased mucous secretion, decreased opercular movement and loss of balance. The present study revealed that, mortality rate increased with increases in concentration.

.vijay digambar suryawanshi

Background: Hospital acquired infections (HAIs) are infections that patients acquire while receiving treatments for other conditions. Studies have shown that stethoscopes and sphygmomanometers can act as potential sources of these infections in patients accessing treatment in healthcare facilities. This study aimed to increase awareness among health workers in Nigeria of the potentials of stethoscopes and sphygmomanometers to transmit HAIs. Methods: Moist swab sticks were used to collect samples from 38 randomly selected stethoscopes and sphygmomanometers from some departments of four district hospitals. Collected samples were cultured using standard microbiological techniques. In addition, self-designed questionnaire was used to assess the knowledge and practice of doctors and nurses on the roles of stethoscopes and sphygmomanometers in HAIs. Results: About 83.8% of the health workers demonstrated some awareness of the roles of stethoscopes and sphygmomanometers in HAIs. 42.5% cleaned their stethoscopes, while 5% their sphygmomanometers. Staphylococcus aureus, (65.9% of stethoscopes), proteus mirabilis, Pseudomonas aeruginosa (67.6% of sphygmomanometers), Streptococcus and Coliform species were isolated. There was no significant difference between the contamination of stethoscopes and sphygmomanometers by the isolates, except for Pseudomonas aeruginosa (t=3.49, p=0.04). Conclusions: Awareness did not match practice in cleaning the stethoscopes and sphygmomanometers in the four facilities. Staphylococcus aureus and Pseudomonas aeruginosa were the two most common organisms isolated with a significant difference (t=3.49, p=0.04) between stethoscopes and sphygmomanometers in isolation of Pseudomonas aeruginosa. To curb HAIs, health workers need to improve on their practice of cleaning stethoscopes and sphygmomanometers.

Emmanuel umegbolu

Diabetes mellitus is a common and chronic metabolic disorder. Uncontrolled diabetes mellitus leads to body organ damage if not treated properly. Educational intervention is necessary from health-care providers such as pharmacists to prevent or reduce organ damage and complications among the diabetic patients. Several studies have demonstrated the contribution of pharmacists in achieving a better control of diabetes mellitus. Thus, this study intended to assess the knowledge and practice regarding foot care among Libyan diabetic patients in Al-Bayda city. In addition, to determine the association between knowledge and practice regarding diabetic foot care with selected demographic variables. This is a cross sectional study conducted at Diabetes Center Aljabal Al akhdar in Al-Bayda between April and August, 2022. A total of 400 participants with diabetes were enrolled and interviewed by using a self-design questionnaire for knowledge and practice of foot care after taking verbal agreement. Data was analyzed by using SPSS software version 26.0. In this study, 191 subjects were male (47.8%) and 209 subjects (52.3%) were female. On the topic of foot care, 51.8% of the participants stated they did know how to perform correct foot hygiene and 33.5% stated that drying should consist of passing a towel between their toes. Female subjects statistically had more knowledge than male subjects on the right footwear and correct way of nail cutting (p < 0.01 and p < 0.001, respectively). In relation to practice, the frequency of patients with a good practice was 126 (31.5%) and with poor practice was 274 (68.5%). Evaluating the parameters dry, moisturize and nail cutting, women showed a significant difference in relation to men, with a high significance level in the three parameters. In conclusion, the knowledge and practice of foot care in Libyan patients with diabetes were poor. So, an educational program is recommended to improve the awareness of foot care. Diabetic patients should be provided information about self-care of their feet by health care providers such as pharmacists to prevent and delay onset of foot complications and improve the quality of life.

Mediterranean journal of pharmacy and pharmaceutical sciences

Epilepsy is a chronic neurologic disease that comes third after cerebrovascular and Alzheimer’s disease. Anti-epileptic drugs may affect certain hematological parameters of epileptic patients. Few researches investigated hematological adverse effects of antiepileptic drugs in Libya. Thus, the aim was to evaluate hematological parameters in epileptic children who are on antiepileptic drugs. This retrospective study included 83 pediatric patients with epilepsy recruited from Benghazi Children Hospital, Department of Neurology, from December 2017 to April 2018. Data collected included demographic characteristics, types of epilepsy, anti-epileptic drugs and serum hematological parameters. Hematological parameters recorded included: hemoglobin, hematocrit, platelet, mean cell volume, mean cell hemoglobin, mean cell hemoglobin concentration and white blood cell count. In all treated patients, regardless of the number of antiepileptic drugs therapy used, the average levels of hematological parameters were significantly lower in treated group compared to control group (11.64 gm per dl, 34.53%, 27.74 pg and 33.13 gm per dl, respectively). A significant increase (12.12109 per l) in white blood cell counts in treated group was found. Average hemoglobin, hematocrit and mean cell hemoglobin concentration levels were significantly lower in patients on poly-therapy compared to mono-therapy and control groups. Average white blood cell counts were significantly increased in patients on anti-epileptic drugs. In sodium valproate users, levels of hematological parameters were significantly decreased but significantly increased in white blood cell counts. In diazepam users, significant increases in white blood cells and platelet but no difference in other parameters observed. There were no differences in all hematological parameters among patients using carbamazepine except for platelet counts (significantly decreased). In conclusion, there is substantial effect of the anti-epileptic drugs, especially sodium valproate, on hematological parameters of children despite the effects were not critical as the changes were still in the normal range.

Mediterranean journal of pharmacy and pharmaceutical sciences

This study aims to see and determine the effect of transformational leadership and competence of PT Waruna Shipyard Indonesia on employee performance through job satisfaction as intervening variable. This research was conducted at PT. Waruna Shipyard Indonesia, located on Bagan Deli Street, Medan Belawan District, North Sumatra. This research was conducted of the month of August 2019-January 2020. The data analysis tool by structural equation modeling (SEM) with smartpls program. The population is employees at PT. Waruna Shipyard Indonesia in 2019, namely as many as 134 employees. This study used slovin formula for the sampling, calculations sample were respondents is 100 permanent employees of PT. Waruna Shipyard Indonesia. Thus taken 30 respondents outside of the sample to validity and reliability test instrument for testing questionnaires. Based on structural equation modeling (SEM) analysis, transformational leadership and competence have positive and significant effect on employee performance with job satisfaction as intervening variable at PT. Waruna Shipyard Indonesia. The contribution of transformational leadership, competence, and job satisfaction explains the employee performance variable of 0.724 or 72.40%. The remaining 0.276 or 27.60% is effect by other independent variables not examined in this study.

L

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in humans. It is characterized by excessive cell growth, accelerated intrusion of normal brain tissue, and a poor prognosis. The current standard of treatment, including surgical removal, radiation therapy, and chemotherapy, is largely ineffective, with high mortality and recurrence rates. As a result, traditional approaches have evolved to include new alternative remedies, such as natural compounds. Aquatic species provide a rich supply of possible drugs. The physiological effects of marine peptides in glioblastoma are mediated by a range of pathways, including apoptosis, microtubule balance disturbances, suppression of angiogenesis, cell migration/invasion, and cell viability; autophagy and metabolic enzymes downregulation. Herein, we address the efficacy of marine peptides as putative safe therapeutic agents for glioblastoma coupled with detailed molecular mechanisms.

Dr. salman ahmed

Now a day’s contribution of Electronic banking towards economic development plays a crucial role in developing countries like India. Banks are no longer restricted to traditional banking rather it is shifted to the virtual banking system. Customers are experiences more feasible in banking operations because of Information technology. The banks are adopting IT-enabled tools and techniques for banking operations which improve in offering quality service to the customers. In traditional banking customers has to visit bank branches to avail banking services. Now with the ATMs, Internet banking, Mobile banking and Information Technology-enabled services are replacing the traditional method of service. In the recent days banks are concentrating on value-based service through E-banking. The present study throws a light on the growth of Electronic banking and its product which are used in the banking sector.

Kamal singh

Objective: Pyrazolopyrimidines are heterocyclic molecules containing nitrogen as the main composition, and hence, they exhibit pharmacological efficacy. They are analogs of purines so that possessing wide applications in the field of medicinal chemistry. The main objective of this study is to synthesize different derivatives of pyrazole-pyrimidine classes by adopting simple methodology as well as by employing green chemistry. The purpose of the synthesis of these molecules is to study the antitumor activity against Ehrlich ascites carcinoma (EAC) cell lines. Methods: After literature studies, it makes us to involve in the research of synthetic organic chemistry, especially to synthesize new compounds of pyrazolopyrimidines. We are reported solvent-free synthesis of pyrazolo [3,4-d]-pyrimidine-thiones through ethyl acetoacetate, hydrazine hydrate, thiourea, and different benzaldehydes. An ionic liquid 2-methyl-imidazolium-oxalate catalyzed the reactions under ultrasonication bath. Both conventional and ultrasonic methods were employed and comparison studies have been made. It was found that ultrasonic method completed the reaction quicker than the conventional method. All the synthesized compounds were confirmed their structures by 1 HNMR, Fourier transform infrared, 13C-NMR, and elemental analysis spectra. The compounds were tested for in vitro anticancer activity against EAC cell lines. Most compounds revealed significant anticancer activity relative to doxorubicin as a positive control with inhibitory concentration (IC50) values. Results: Ultrasonication method is a simple method under which all the reactions were completed at faster time (<7 min) compared to the convention method. Among eight molecules, 8a and 8d completed the reactions at a faster rate. We reported IC50 values of all the molecules, in which 8e and 8g were exhibited excellent potency against EAC cell lines at different concentrations .

Dr ganesh n yallappa