Antioxidant assays in phytonutrient research: translating laboratory innovations into practical applications

Background: There is great promise for improving nutrition and health thanks to phytonutrients' antioxidant qualities and health advantages. Their capacity to combat oxidative stress and associated illnesses emphasizes the importance of precisely evaluating their antioxidant characteristics. Objective: This study concludes by providing a comprehensive and critical critique of the current approaches to measure the antioxidant activity of phytonutrients. It dives into the fundamentals, benefits, drawbacks, and most recent developments of commonly used antioxidant assays, giving the reader a comprehensive grasp of the topic. This recapitulation of the review's goal in the end reinforces the reader's primary takeaway. Methods: Research on several antioxidant tests, such as FRAP, ORAC, DPPH, and ABTS, is consolidated in this review. It looks at each assay's performance traits, technological advances, and techniques. The review also assesses the incorporation of many assays to thoroughly examine phytonutrient potency and its uses in the food industry and nutritional science. Results: The review shows how antioxidant tests have advanced significantly, improving sensitivity, accuracy, and physiological relevance. It demonstrates how these tests can be used practically to guarantee food quality, create supplements, and offer nutritional advice. The paper also lists the difficulties today, including the intricacy of antioxidant mechanisms, test variability, and the requirement for assay standardization. The practical value of the research is emphasized by highlighting the significance of antioxidant tests for quality assurance, adulteration detection, and shelf life extension in the food business. Discussion: Scientists, doctors, and business experts interested in evaluating and applying phytonutrients will find this review helpful. It emphasizes how crucial it is to improve antioxidant testing to ascertain the possible health advantages and therapeutic uses of phytonutrients. The review highlights the need for increased test sensitivity, accuracy, and relevance while discussing the benefits and drawbacks of the available techniques. It draws attention to the importance of strong and trustworthy antioxidant tests to maximize the use of phytonutrients in food quality control and pharmaceutical research. Prospects: Future directions seek to address the challenges discovered through the development of multidisciplinary research and testing technologies. Novel approaches will advance our knowledge of phytonutrient potency and aid in developing medicines and nutraceuticals. This study highlights the significance of trustworthy assays for understanding and utilizing phytonutrients, providing academics and professionals in the business with vital insights.

Dr. Salman Ahmed Dr. salman ahmed

A comparative financial study on selected companies in automobile industry in india

India’s automobile industry is the fourth largest automobile industry in the world. The researcher selected the automobile companies of 2 and 3 wheelers based on group A companies listed in the Bombay Stock Exchange. The selected automobile companies are Bajaj Auto ltd, Eicher Motors ltd, Hero MotoCorp ltd and TVS Motor Company ltd. The main target of this analysis is to compare the financial positions of the selected automobile companies for the time of a long time from 2016-2020. This study proved that financial position of Eicher Motors ltd financial position is superior to other selected automobile companies. Current ratio, quick ratio, debt-equity ratio, net profit ratio, return on assets ratio of Eicher Motors ltd is better than other selected automobile companies.

Dr. Jeyalakshmi P Dr. jeyalakshmi p

Essential employee knowledge management and re-skilling within the 4ir in the south african automotive industry towards

The Fourth Industrial Revolution (4IR), internet definition is considered as growing out of the third industrial revolution, but is considered a new era rather than a continuation because of the explosiveness of its development and the disruptiveness of its technologies. It is not a new phenomenon that many South African manufacturers are facing important talent challenges when organising their business. Diverse IT skill sets, improved skills blend and a rearrangement of skills are necessary. It is undisputed that 4IR requires a highly skilled workforce, and one which South Africa, regrettably, has been struggling to produce. It was the purpose of the study to gain an understanding of what Essential Employee Knowledge Management and Re-Skilling is needed in the South African Automotive Industry towards 2030 with regards to the Fourth Industrial Revolution (4IR). Methodology: Firstly, an environmental scanning was performed, examining pertinent literature, thereafter a case study approach was used was used to describe the true experiences of assembly workers and their immediate supervisors in a South African automotive plant. Results: The automotive industry is extremely robust and skilled employees are essential. From the study, the major solution to remedy low competence was continuous skills transfer through highly structured cross-functional skill development programmes. Conclusion: The study results cannot be generalised but do give an insight into what the current situation is in an automotive industry in South Africa.

Luyolo Mahlangabeza Luyolo mahlangabeza

Breast cancer knowledge and practice of breast self-examination among palestinian female, west bank: a cross-sectional study

Background Worldwide, breast cancer (BC) is the most frequently discovered tumor in women. Breast self-examination (BSE) is a helpful screening method that gives women more control over their bodies by educating them about the structures of their breasts and assisting in the early detection of any developing breast abnormalities. The purpose of this research was to assess Palestinian girls' degree of BSE awareness and practice. Method A self-administered questionnaire was used to gauge participants' knowledge about BC and associated topics. Through an online survey, all girls above the age of 20 are encouraged to take part in the study. Female university students at academic levels I, II, III, and IV in Palestine were also invited to participate in the study by way of an online survey. Results The study included 467 female participants, with 69% of the individuals being single. The majority of females (68.7%) scored poorly on knowledge of BC disease (possible risk, methods of detection, methods of diagnosis, methods of treatment, signs and symptoms, information about mammography, and other knowledge questions), whereas only 31.7% scored well. Conclusion BC, which is thought to be the most common malignant development among them and the second leading cause of cancer mortality, is one of the issues that women in the West Bank face. Screening methods are crucial for the early detection of BC and for lowering disease-related morbidity and mortality. It has been advised that starting at age 20, every woman should take the BSE.

Mohamad  Banat Mohamad banat

Analysis of risk factors on hemoglobin level in libyan women

Anemia is a common health problem among Libyan women. Age, heavy menstruation, and pregnancy are vital risk factors for this problem. In this study, we prospectively examined 60 Libyan women all of which were diagnosed with iron deficiency anemia, their hemoglobin levels were less than 10.0 g/dl. The level of hemoglobin is also analyzed for vegetarian and charcoal-eating women. We found that during pregnancy charcoal-eating women exhibit lower hemoglobin levels than non-eating women. Pregnant young women in the age of 17-27 years have the lowest hemoglobin levels than the other age groups. In addition, vegetarians, heavy coffee and tea drinking, and heavy menstruation in non-pregnant women, as well as breastfeeding, strongly lower hemoglobin levels as measured by their complete blood count.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

Dignity therapy for individuals with severe mental illness: a holistic approach to care –a narrative review

Dignity therapy (DT) is an evidence-based psychotherapeutic approach originally designed to alleviate emotional and existential distress in patients with terminal illnesses. While dignity therapy has been well documented in palliative care, emerging perspectives suggest that its principles such as promoting autonomy, meaning, and self-worth can be beneficial for persons with severe mental illness (SMI) who often experience stigma, identity loss, and existential suffering. Although severe mental illness and terminal illness are distinct conditions both may involve the profound psychological and existential challenges that affect personal dignity. This paper explores the philosophical foundations and therapeutic benefits of dignity therapy, with a particular focus on its potential application in mental health settings. It highlights the significance of preserving dignity in psychiatric care and emphasizes the need for compassionate, personcentered mental health support tailored to the lived experiences of the person with severe mental illness.

Karishma Karishma

In vitro antagonistic activity of some actinomycetes and fungal spp. isolated from rhizosphere of maize against fusarium sp. by bio-control dual inoculation method

Rhizosphere actinomycetes are promising biocontrol agents for use in agriculture and have been isolated from various plant species. In the present investigation, actinomycetes were isolated from rhizospheric soil of maize to test antagonistic activity against Fusarium verticillioides and fungal strain (T. viride) were procured from National fungal culture collection of India (NFCCI), T. harzianum and A. niger were isolated from soil to test their antagonistic effects against Fusarium verticillioides. In the present study bio-control dual inoculum method were followed to evaluate the bacterial and fungal strains against the pathogen and reveals that Single Bacterial Inoculum (SBI) of S. cinereus shows more effective in controlling the growth of Fusarium verticillioides (28 mm in treated plate) compare to control (45 mm fungal growth). But in Dual Bacterial Inoculum (DBI), the combination of S. albosporous and S. cinereus shows more effective (08 mm fungal growth in treated plate) compare to control (52 mm fungal growth). Similarly, in Single Fungal Inoculum (SFI), T. harzianum were more effective (18.8 mm fungal growth) and in Dual Fungal Inoculum (DFI), T. viridae and T. harzianum act as a more effective (2.5 mm fungal growth) against Fusarium verticillioides compare to controls (60 mm and 52 mm fungal growth respectively). Overall interpretation of the present work reveals that DBI and DFI were more effective than SBI and SFI against Fusarium verticillioides.

Veerabhadraswamy AL Veerabhadraswamy al

The effect of phaseolus vulgaris l. fixed oil on the behavioural activity of swiss albino mice

Background: Phaseolus vulgaris, commonly known as kidney bean, has been studied previously for pharmacological properties such as antidiabetic, antioxidant, analgesic, anti-inflammatory, antifungal, and antibacterial properties. Various extracts of the seeds have been researched except fixed oils. Objective: Therefore, the present study aims to investigate the behavioral activity of fixed oil extracted from Phaseolus vulgaris seeds. Methodology: Hole board, light and dark, stationary rod and open field tests were used for behavioral evaluation. Four groups were made with seven mice in each : (1) Control = Normal saline 2ml/kg (2) Phaseolus vulgaris fixed oil = PVFO 2ml/kg (3) PVFO 4ml/kg (4) Diazepam (1mg/kg) as standard. All treatments were given orally 30 minutes before the performance of tests. In the hole board test, PVFO 4ml/kg decreased the number of head poking (p≤0.01). Results: In light and dark tests, PVFO in both doses reduced the time spent in the light compartment (p≤0.01). In the open field test, the number of peripheral lines crossed was decreased (p≤0.05), whereas in the stationary rod test, no effect was observed by any dose of PVFO. Conclusion: Results indicate that Phaseolus vulgaris fixed oil does not affect memory or learning in mice and may possess a dose-dependent sedative hypnotic effect.

Dr. Salman Ahmed Dr. salman ahmed

Bank liquidity risk and bank credit risk: implication on bank stability in ghana

Bank sector crisis across the globe is largely blamed on the joint effort of bank liquidity and bank credit risks. And so, the twin concepts of liquidity and credit risks have come under keen academic scrutiny, especially in investment finance. Contributing to the extant literature on these developments, secondary data were obtained from the websites of nine banks in Ghana, spanning 2008 to 2018, to determine how liquidity and credit risks separately and interactively impact bank stability in Ghana. Analysis of data was done using a panel regression through the fixed effects model after running the Hausman Test. The study confirms an inverse liquidity risk-bank stability relationship, emphasising the need to channel idle funds into interest-earning securities to consolidate bank profits. Although a further revelation suggests an insignificant negative relationship between credit risk and bank stability, it re-echoes the need to implement policy recommendations made by the Banks and Specialised Deposit-Taking Institutions’ ACT 2016 (ACT 930), section 62 of Ghana, on the threshold to lend funds to clients. The bank-size-stability relationship was positive. Increasing bank size through establishing more branches nationwide is encouraged but to a precautionary level since banks tend to suffer diseconomies of large scale operations due to unregulated expansion. There is the need to observe the Basel III provisions on maintenance of a 30-day optimum liquidity threshold of up to 100% and above. Besides, banks should tighten up their credit requirements and also ensure loan repayments history is monitored to benefit clients who are in good standing.

Juabin matey

Molecular changes in invasive front of oral cancer

Treatment planning for oral squamous cell carcinoma (OSCC) is based on the clinical TNM (Tumor, Node and Metastasis) classification. This system operates on the assumption that small tumours without clinical spread have a better prognosis than larger tumours with metastases. However, it is a well-known fact that some tumours with the same clinical staging show different growth patterns and clinical behaviour. This makes the prognosis for patients with OSCC difficult to predict on the basis of clinical staging alone. Although many histopathological characteristics of OSCC have been identified as prognostic factors, none is believed to be completely infallible. Therefore, a great need exists for more reliable prognostic markers, which will assist in treatment decisions. It is now well documented that several molecular events of significance for tumour spread, such as gain and loss of adhesion molecules, secretion of proteolytic enzymes, increased cell proliferation and initiation of angiogenesis occur at the tumour–host interface or invasive front, where the deepest and presumably most aggressive cells reside. This review describes the various molecular events and interactions, which take place in the invasive front of the OSCC, and elucidates their role as prognostic markers.

Mohit Sharma Mohit sharma

Phytochemical evaluation and pharmacological screening of antiparkinson’s activity of allium sativum in swiss/albino mice

Abstract: Objective: To evaluate the Antiparkinson activity of Allium sativum in Haloperidol induced Parkinson‟s disease in mice. Method: Parkinson‟s disease was induced by administering haloperidol (2.0 mg/kg i.p.) Daily for a week. The mice were divided into 5 group (n=6). Group II received haloperidol (2mg/kg body weight).Group III received combination of levodopa and carbidopa (100mg+ 10mg/kg by i.p along with haloperidol) and Group IV and V received Allium sativum extract (200 and 400mg/kg by p.o), respectively for 7 days along with haloperidol. To evaluate the antiparkinson effect of Allium sativum, catalepsy bar test, rotarod test, hang test and horizontal bar test were used. One way ANOVA was used to test statistical significance followed by Bonferroni multiple comparison tests .Results: Allium sativum extract (200 and 400mg/kg by p.o) was found to decrease the duration of catalepsy significantly (P<0.001) in catalepsy bar test as compared to haloperidol group, and significantly increases (P<0.001) fall off time in, rotarod test, hang test and horizontal bar test respectively as compared to haloperidol group. Conclusion: The result of the present study conclusively shows the Antiparkinson‟s activity of Allium sativum in haloperidol induced Parkinson‟s disease in mice.

Zeenath Banu Zeenath banu

The implementation of total quality management (tqm) in the hotel industry

This study sets out to explore the Critical Success Factors (CSFs) necessary for Total Quality Management (TQM) implementation in hotels. It also aims to classify participating hotels into groups based on their TQM adoption by using cluster analysis. A quantitative survey method was applied. Data were collected from a sample of managers from four- and five-star hotels in Jordan, 170 questionnaires were distributed to managers and 104 usable questionnaires were returned. The findings revealed that TQM is existed and implemented in the hotel industry. The researcher then confirmed that four- and five-star hotels can be classified into two groups, namely, “high TQM adopters” and “low TQM adopters”.

Mukhles m. al-ababneh

Declining clinical skills in medical education: a perspective on its causes and potential solutions0

Medical science has grown tremendously at a rapid rate over the recent past. This is especially true in the fields of diagnostics and therapeutics encompassing various diseases of all the systems of the human body including psychosomatic disorders. During the past three to four decades, precision in diagnostics has enormously improved due to invention of multiple imaging modalities such as computerized tomography (CT) scan, magnetic resonance imaging (MRI) scan, positron emission tomography scan, ultrasound scanguided studies, CT-guided diagnostic procedures, Doppler studies, arteriography, CT angiography, advanced needle biopsy procedures, histochemistry studies, tumor marker studies, as well as in the ongoing improvements in all diagnostic and therapeutic branches. The surgical advancements due to increasing use of key-hole surgery using scopes such as arthroscope, laparoscope, colonoscope, and bronchoscope have revolutionized the surgical treatments and made surgery safer, less time-consuming, less costly, and less risky with reduced post-operative morbidity. Cardiac catheterization, percutaneous cardiac angiography, angioplasty, and vascular surgery have made the procedures/ surgeries related to the heart and major vessels, much simpler, faster, and safer minimizing the need for big infrastructures or large operative teams.

Karishma Karishma

Fesability of international trading

With the projected growth of the global electric vehicle market that is estimated to double in the next decade, the expansion of the battery manufacturing capacity will primarily depend on the auto market’s electrification. Moreover, the market growth puts new requirements on the end-of-life phase and the recycling components. Therefore, the report provides a feasibility research study aimed at investigating the international initiative. It identifies the production and exportation of Lithium-Ion Batteries to the Chinese electric vehicle manufacturers and consumers as a business opportunity and discusses the gaps in the current market. The research also includes a look at the cost estimates that are bound to affect the company. Additionally, the report also includes recommendations for the company to ensure that it understands the policy frameworks and market systems for electric cars adoption. By doing so, the report discusses several aspects of the entire Lithium-Ion Battery business, justifying the business idea.

Mohamed Sorogy Mohamed sorogy

Evaluation of adverse effects of astrazeneca covid-19 vaccine after the first dose in libyan adults: a cross-sectional study

On January 2021, cases affected by coronavirus epidemic are constantly increasing, Libyan Ministry of Health provides the vaccine to the people those who are most at risk. The purpose of this study was to assess and verify the adverse effects of the first dose of the AstraZeneca COVID-19 vaccine. The study conducted at the Aljmail city, west region of Libya. The study was cross-sectional study during the period of August 31st and November 5th, 2021. The method involved 133 adult Libyan participants of both gender ageing more than 18 years old. The preliminary data were 54.0% who developed post-vaccination symptoms. The participant's aged 60 years and more with chronic diseases were more likely to have adverse effects after receiving the first dose of vaccine. In conclusion, AstraZeneca vaccine was good and effective but this study indicates a need for a large and long period study to confirm the safety of the vaccine use in the adult people.

Mediterranean Journal of Pharmacy and Pharmaceutical Sciences Mediterranean journal of pharmacy and pharmaceutical sciences

A systematic review on self-reported questionnaires to assess medication adherence in diabetic patients

Adherence to pharmacological therapies are keys to effective treatments in diabetic patients. Previous reviews found that most adherence measurement studies on chronic diseases used a self-reported scale. However, there is no consensus on the best scale to measure adherence in diabetic patients. The purpose of this systematic review was to identify the potential self-reported scale that could be considered for measuring medication adherence in diabetic patients and to provide recommendations for researchers or clinicians to determine appropriate adherence self-reported scales in diabetic patients. This review follows general guidelines in the implementation of systematic reviews. After further review, it was found that 33 studies met all inclusion criteria from 4 databases (Wiley, Science Direct, Scopus, and PubMed). The articles were done by the PRISMA, while the keywords were determined by the PICO method. Most research was conducted in Asia (69.7%) and America (18.2%) on patients with type 2 diabetes (81.3%), patients in hospitals (54.5%), suffering for 1–6 months (54.5%), and using a cross-sectional study design (78.8%). HbA1c clinic data (57.6%) were used in most studies as biological markers of adherence. The measurement scales of medication adherence in diabetic patients are MMAS-8 (57,.5%), MMAS-4 (12.1%), BMQ (9%), MCQ (6%), ARMS (3%), ARMS-D (3%), GMAS (3%), LMAS-14 (3%), and MARS-5 (3%). This review provides information on the different self-reported scales most widely used in diabetic medication adherence research. Various aspects need to be considered before choosing the scale of adherence.

Much Ilham Novalisa Aji Wibowo Much ilham novalisa aji wibowo

Association of vitamin d deficiency with dyslipidemia, glycemic control, and microalbuminuria in patients with type 2 diabetes mellitus in qatar

Background: Emerging data found that Type 2 diabetes mellitus (T2DM) is associated with Vitamin D deficiency at various frequencies. This study aims to estimate the prevalence of Vitamin D deficiency in T2DM patients in Qatar and the correlation between Vitamin D deficiency and other variables such as dyslipidemia, glycemic control, and microalbuminuria. Methods: This retrospective cross-sectional analytical study was conducted in the medical outpatient clinic at Hamad General Hospital. The study involved adult patients (≥18 years) with T2DM. The study covered patients admitted between January 1, 2018, and July 31, 2018. Ethical approval was obtained from the Medical Research Committee. Results: We recruited 400 subjects with T2DM. Their mean age was 58.97±10.32 years, and the majority were women (52.0%) and Arabs (69.5%). The mean duration of Type 2 diabetes diagnosis was 14.94±8.99 years. The prevalence of Vitamin D deficiency was 29.5%. A comparison between Vitamin D deficiency and non-vitamin D deficiency groups showed a statistically significant difference in terms of fasting blood (FB) sugar (p<0.001), random blood (RB) sugar (p<0.001), hemoglobin A1c (HBA1c) (p<0.001), total cholesterol (P = 0.001), low-density lipoprotein cholesterol (LDL [C]) (p=0.004), high-density lipoprotein cholesterol (HDL [C]) (p<0.001), triglyceride (p<0.001), and urinary albumin excretion rate (UAER) (p=0.007). Data analysis showed that a significant negative correlation was found between Vitamin D level and FB sugar (r=−0.208, p<0.001), RB sugar (r=−0.20, p<0.001), HBA1c (r=−0.260, p<0.001), total cholesterol (r=−0.218, p<0.001), LDL (C) (r=−0.176, p=0.004), triglyceride (r=−0.342, p<0.001), and UAER (r=−0.184, p=0.007). Conclusion: Our study showed a significant correlation between Vitamin D deficiency and the poor control of T2DM, dyslipidemia, and microalbuminuria. The results emphasize the importance of monitoring Vitamin D status in high-risk populations.

Karishma Karishma

Bioassay of new chemistry insecticides against pod borer, helicoverpa armigera on chickpea

Toxicity of different insecticides was evaluated against 2nd and 3rd instar larvae of Helicoverpa armigera under laboratory conditions by leaf dipping method. The insecticides viz., thiodicarb 75WP, novaluron 10EC, spinetroam 11.7EC, indoxacarb 15.8EC, quinalphos 25EC, rynaxypyr 18.5SC, emamectin benzoate 5SG and cypermethrin 25EC were tested. Spinetoram was found most effective in managing the 2nd instar larvae of H. armigera and it was followed by novaluron 10EC and indoxacarb 15.8EC as compared to cypermethrin 25EC. Emamectin benzoate 5SG @ 1 x 10-7 to 1 x 10-9 per cent concentrations recorded 100% mortality against 2nd instar larvae and LC50 values for 3rd instar larvae was 0.00000000045%. Insecticides novaluron 10EC, spinetoram 11.7EC and cypermethrin 25EC did not show promising and consistent results against 3rd instar larvae of H. armigera at 24 hrs. The LT50 of novaluron 10EC at 0.00005% concentration was 19.861 hrs and it was 28.144 hrs at 0.000001% against 2nd instar larvae of H. armigera

DR. BABU LAL JAT Dr. babu lal jat

Renal mass: epidemiology, clinical presentation, diagnostic strategies, management, and outcomes: a comprehensive update

Kidney mass lesions are common and are often discovered accidentally. Renal cell carcinoma (RCC) represents approximately 5% of all cancers. Men have a two-fold higher likelihood of developing the disease and experience a higher mortality rate than females. The differences between the genders are attributed to individual variations, including hereditary factors, underlying medical conditions, genetics, lifestyle, hormonal factors, and others, such as hypertension and obesity. Renal tumors are usually asymptomatic; however, hematuria, dull aching flank pain, and lower abdomen pain can present symptoms. A tissue biopsy is typically unnecessary but may be required in certain cases. Men tend to exhibit larger and more severe tumors. Radiology tools application is helpful for early diagnosis and follow-up. Partial or radial nephrectomy is an effective curative therapy in localized renal masses. Nevertheless, immunotherapy, cryotherapy, and sometimes chemotherapy are used, especially in high-income nations. In this review, epidemiology, pathophysiology, risk factors, presentation, diagnosis, and kidney mass management will be reviewed and updated. Different keywords and phrases, such as kidney malignancy, renal cancer, epidemiology of kidney cancer, nephrectomy in kidney masses, and management of renal cell tumors, were used to search PubMed, EMBASE, Scopus, Google, and Google Scholar for new reviews and original articles and new comments with updates that were published between January 2019 and May 2025.

Karishma Karishma

Effectiveness of the alternative learning system informal education project and the transfer of life skills among als teachers: a case study

Alternative Learning System (ALS) has been adopted in Philippine basic education, yet there is no academic institution in the region prepares ALS teachers in teaching life skills. ALS teachers graduated from different programs of teacher education for formal education. In response, an extension project was conceptualized and implemented to enhance the teaching capacity and effectiveness of ALS teachers. Case study was conducted to evaluate the effectiveness of the project. It explored the transfer of life skills among ALS teachers. Data were collected from multiple sources. Interview and written responses, and feedback were analyzed using thematic narrative analysis. Other data were analyzed using document and descriptive analyses. The project had achieved its objectives and rated best by participants. These indicate that the project was implemented effectively and successfully. ALS teachers have acquired life skills and transferred them to others. Thus, the project has made a difference in the lives of these teachers.

Manuel Caingcoy Manuel caingcoy

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