Fresh water crab was exposed in fluoride water at 96h the rate of oxygen uptake was higher in gills followed by hepatopancreas and muscle. On exposure to fluoride water, tissue respiratory rates decreased, effect on gill tissue appeared to be more pronounced than other tissues under the study. The rate of oxygen uptake in male was higher tha control animal. Rate of oxygen consumption showed a significant decrease in both sexes with increase in duration of exposure to fluoride.

.vijay digambar suryawanshi

Diabetes mellitus (DM) is a complex and chronic illness requiring continuous medical care. Type 2 diabetes (T2D) is commonly associated with obesity, hypertension, and a tendency to develop thrombosis, and an increase risk of cardiovascular diseases (CVD). Diabesity is a term used to indicate the coexistence of obesity and DM. Diabesity increases as obesity is an emerging epidemic in modern societies, the co-incidence with DM is also rising, so a joint plan of anti-obesity and anti-hyperglycemia for the management approaches. Therefore, this study aimed to identify the impact of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on body weight and glycemic response in obese Libyan patients with T2D at the National Diabetes Centre in Tripoli, between July 2013 and May 2022. This prospective study included obese adults with T2D who were newly prescribed GLP-1RA therapy for six months with dulaglutide once weekly or liraglutide once daily. The study included 170 diabetic patients who were started on GLP1-RA as add on therapy to their treatment, with a regular follow-up with dietitian and their physicians to adjust their glucose-lowering medications, then comparing the effect of these agents on body weight and the level of glycated hemoglobin before and after 24 weeks of treatment. Most of the patients (n = 99, 58.23%) were in the age period from 54 to 74 years old and 101 of whom were female subjects (59.4%), with a mean duration of DM equal to 8.8 ± 7.3 years. The patients were divided randomly into two groups, the first group included 110 patients who received liraglutide pens showed a significant reduction in HbA1c from 9.6% (± 1.54) to 7.4% (± 1.03) by p < 0.001 and a significant weight loss from 88.3 kg (± 10.68) to 80.8 kg (± 11.83) by p < 0.001. The reported adverse events were in 23 cases of minor hypoglycemia due to gastrointestinal upset. The other group included 60 patients for dulaglutide pens and showed significant decrease in HbA1c = 9.6% (± 1.54) to 7.1% (± 1.2) by p < 0.05 and a significant reduction of bodyweight from 88.3 kg (± 10.68) to 83.8 kg (± 16.3) by p < 0.05. The reported adverse events were mild transient gastrointestinal distress for the initial week of a start and then subside with regular intake. Whereas, 115 patients (67.6%) with HbA1c above 10.0% before starting therapy, no patient with HbA1c above 10.0% after six months of both GLP-RA agents therapy. Thus, the uses of GLP-RA as add-on therapy for obese patients with T2D significantly improved glycaemic control with less hypoglycaemia, accordingly, reduce insulin requirement for blood glucose control and loss in body weight. It can thus be concluded that GLP-1RA therapy is an effective treatment option when used in obese patients with DM.

Mediterranean journal of pharmacy and pharmaceutical sciences

In addition to the ordinary pharmacists’ role in dispensing and ensuring safety and efficacy of drugs, pharmacy profession is also concerning with clinical services towards community through multidisciplinary approach. In this regard, the clinical pharmacy is an area of pharmacy that concerned with the science and practice of rational drug use in which clinical pharmacist provides patient care that optimizes medication therapy and promotes health, wellness and prevention of diseases. During the recent crises of COVID-19 pandemic, the health systems appeared to be weak worldwide. Health care professionals seem to have nothing to present to their COVID-19 infected patients as no effective medications are approved by the World Health Organization (WHO) yet. Moreover, physicians are worried about the secondary infection for COVID-19 patients, therefore, treatment protocols were designed and mostly applied for critical COVID-19 patients who have been hospitalized in Libya. WHO does not recommend antibiotic therapy or prophylaxis for patients with mild COVID-19 unless symptoms of a bacterial infection exist. This monograph will highlight the widespread use of antibiotics and anticoagulants for COVID-19 patients at Maetiga Hopital in Tripoli, Libya

Mediterranean journal of pharmacy and pharmaceutical sciences

Assessment of convergent validity of latent variables is one of the steps in conducting structural equation modeling via partial least squares (PLS-SEM). In this paper, we illustrate such an assessment using a loadings-driven approach. The analysis employs WarpPLS, a leading PLSSEM software tool.

Johnny amora

Gender Bias is an ambivalent issue all over the world. Understanding the values of being a man on women by one another may solve many consequences in future. Gender Bias will be dismissed by empowering women in the society. Because of the Gender Bias particularly women are in despaired state. UNO and many organizations have taken many decisions and efforts to empower women which will reduce the impacts of Gender Bias. Even though women are empowered we didn’t get remarkable result yet. Even our society is ridicule get ride from traditional customs but women themselves are opponent for accepting new rules and liberations. Empowering women is a mandated one; it is not implemented properly empower must bring the equal rights to women.

Priya darshini

Research on treatment for diabetes and co-occurring eating disorders is sparse. We examined outcomes from multidisciplinary residential treatment for women with type 1 diabetes and eating disorders and the impact of treatment duration on outcomes. Participants were 29 women with type 1 diabetes and eating disorders receiving residential treatment. Repeated measures analyses of variance examined changes in blood glucose and psychological symptoms over treatment. Analyses were repeated to include treatment by duration interactions. Treatment produced significant reductions in blood glucose, eating disorder symptoms, and psychological concerns. Longer treatment duration was associated with greater improvements in psychological symptoms. Disordered eating is alarmingly common among individuals with type 1 diabetes mellitus, with rates of co-occurring diabetes and eating disorders estimated as high as 40% (Young etal., 2012; Young-Hyman & Davis, 2012). The most commonly noted link between type 1 diabetes and eating disorders is in the form of purging through insulin omission for weight loss purposes (Darbar & Mokha, 2008), which has been noted for individuals with diabetes co- occurring with anorexia nervosa (AN), bulimia nervosa (BN), and eating disorder not otherwise specified (EDNOS; Nielsen, 2002; Peveler & Fairburn, 1989). However, even among individuals with diabetes who do not omit insulin, eating disorder symptoms are elevated (Jones, Lawson, Daneman, Olmsted, & Rodin, 2000).

John dolores

India is in the midst of a severe second wave of Covid-19. As per the Global Commission for Post-Pandemic Policy by mid-April of 2021, India had manufactured nearly 17 percent of all Covid-19 vaccine doses globally. It was the world’s fourth-largest producer, after China (about 36 percent), the United States (about 22 percent) and the European Union (more than 17 percent). Even so, following a shortage of vaccines and with insufficient local production, Government of India decided to import more foreign vaccines with quicker approval process for vaccines accepted in US/EU markets. India is currently using made-in-India vaccines, namely, Covishield manufactured by Serum Institute India and Covaxin of Bharat Biotech in its COVID-19 immunisation programme. The shortcoming in the production of vaccines and its dissemination within the country urges one to understand who the local producers are and how the market is playing out. This paper looks at the evolving market structure of vaccine production in India in the textbook framework of an oligopoly market. We use secondary data sources and daily newspaper briefs.

Nandini

It is not possible to imagine the modern world without the product of innovation and the new evolutionary development that they bring. Many researchers believe that innovation is now the driving force behind economic and social development. In this regard, the main objective of this research is to identify the factors based on the use of the international experience that shapes the economic model of innovative development and make recommendations for the economy of Uzbekistan, to ensure the timely and high-quality performance of certain types of human society, and also study of the affective impact of high technologies as a solution and consumption on management decisions, to critically assess existing problems, to make scientific predictions for prospects. This is because the macroeconomic indicators of many leading countries in the field of innovation development, the effective functioning of financial networks, the quality and level of living of the population are inextricably linked to innovative decisions.

Ikboljon odashev mashrabjonovich

Purpose: To assess incidence of demodex species, correlate ocular symptomatology, evaluate efficacy of coconut oil as treatment method in all types of blepharitis. Materials and Methods: 30 patients with anterior & mixed blepharitis, meibomian gland dysfunction & non-specific irritation were enrolled for study. History taken & examined clinically. 2 lashes/lid were sampled & mounted on slides with normal saline & observed under light microscope. Number of mites counted. Patients positive for demodex were treated with coconut oil application over lid margins & reviewed after 3 weeks. Results: Incidence of demodex was 40% & it increased with age. Demodex was commonly associated with meibomian gland dysfunction, non-specific irritation, madarosis, cloudy & toothpaste like meibum quality. Burning sensation and itching were common complaints. At 3rd week, all patients were symptom-free. Mite count dropped by 52.8% but were not eliminated. Conclusion: Demodex infestation is often overlooked but it is associated with about half of blepharitis cases. Hence further evaluation should be considered. Coconut oil is an easily available mode of treatment & helps reduce symptoms and mite counts.

Kamal singh

Developmental venous anomalies (DVAs) are congenital vascular malformations often found incidentally on neuroimaging. This case report describes a 37-year-old female with chronic headaches and an incidentally discovered DVA in the left frontal lobe. Magnetic resonance imaging (MRI) revealed a classic "caput medusae" pattern without hemorrhage or associated cavernous malformation. This case highlights the importance of recognizing DVAs as incidental findings, differentiating them from other causes of chronic headaches, and understanding the significance of associated imaging findings.

Karishma

Urolithiasis has been a common problem for centuries and has a high recurrence. This review covers the forty-nine (49) antiurolithiatic plants of the family Lamiaceae used in 11 countries. Hopefully, this review will be helpful for the general public and attract the scientific world for antiurolithiatic drug discovery.

Dr. salman ahmed

This study sets out to explore the Critical Success Factors (CSFs) necessary for Total Quality Management (TQM) implementation in hotels. It also aims to classify participating hotels into groups based on their TQM adoption by using cluster analysis. A quantitative survey method was applied. Data were collected from a sample of managers from four- and five-star hotels in Jordan, 170 questionnaires were distributed to managers and 104 usable questionnaires were returned. The findings revealed that TQM is existed and implemented in the hotel industry. The researcher then confirmed that four- and five-star hotels can be classified into two groups, namely, “high TQM adopters” and “low TQM adopters”.

Mukhles m. al-ababneh

The primary cause of many fatalities is hypertension (high blood pressure). Many hypertensive patients are not even aware that they have the condition. As a result, hypertension is sometimes referred to as a silent killer. Until the harmful effects of high blood pressure, such as myocardial infarction, stroke, renal abnormalities, and vision problems, are identified, hypertension is typically asymptomatic. Without the use of herbs and dietary control, conventional medication therapy could not be enough to treat hypertension. The growing number of persons with high blood pressure can be effectively treated using alternative medicine. Numerous alternative therapies, such as diet, exercise, stress management, vitamins, and herbs, have been proven to be effective in lowering high blood pressure. There are several medications available to treat this disorder however popular antihypertensive medications typically have a long list of adverse effects. Numerous active ingredients with pharmacological and preventative qualities found in medicinal plants can be used to treat hypertension. This review discusses an overview of important medicinal plants and phytochemicals with hypotensive or antihypertensive effects.

Mediterranean journal of pharmacy and pharmaceutical sciences

During this research work, a theoretical study was done to compare the boiler efficiency by using two different fuels, i.e. commercial sawdust briquette and biomass briquette prepared using 850 μ coconut leaves, with sawdust as the binder. For preparing the biomass briquettes to leave of coconut were gathered, dried, milled, and sieved and sizes of 850μ were selected. The sized coconut leaves were then mixed in the company of sawdust that worked as a binder in 1:2 ratios, and compressed by means of a piston-type briquette machine, which was fabricated for the same. Ultimate and proximate analyses were carried out on the biomass briquette to determine their various compositions. Results from analysis were used to calculate the boiler efficiency by the indirect method using Indian Standard Boiler Efficiency IS 8753. Results from the analysis showed that boiler efficiency by indirect method for commercial sawdust briquette is 68.80% and boiler efficiency by indirect method for coconut leaves of 850μ, with sawdust as a binder is 61.17%. The reason for higher boiler efficiency for commercial sawdust briquette is due to its higher calorific value (4451.37KCal/gm) when compared to that coconut leaves briquette made from 850μ size with sawdust as a binder (3672.45KCal/gm). From proximate and ultimate analysis, the results showed a reduction in ash content percentage, moisture content, and rise in volatile matter percentage, when the comparison was along with the marketable sawdust briquette, which is of considerable significance. Additional properties akin to the percentage of hydrogen, fixed carbon, sulfur, nitrogen, and oxygen were roughly the same as that of the commercially available sawdust briquettes. After calculating the boiler efficiency of the two biomass briquettes, coconut leaves with sawdust as binder exhibited the most optimistic trait and as it is more easily and readily available, thus making it more economically viable.

Dr.deepak kb

WhatsApp is mobile application which allows exchange of messages, videos, audio’s and images via Smartphone. The increased use of IM on phones has turned to be goldmine for mobile and computer age. This paper focuses on understanding experimental viewpoint about the intensity, usage of whatsapp messenger and its impact on the academic performance of students in institutions. Instead of fast communication and enhancing effective flow of information and idea sharing among students, whatsapp has actually impacted in some pessimistic performance of students. For instance it takes up much of the students study time resulting in procrastination related issues , destroys students’ linguistic skills, leads to lack of concentration during lectures, results in difficulty in balancing online activities (whatsapp) and intellectual preparation and distracts learner from completing their assignments and adhering to their private studies time table. It is very userfriendly and easy to get initiated. Simply enter the telephone number of the device into the app. It then sorts through the contacts (with your permission) on the phone to figure out who else also has the app already installed. Users can then invite more contacts or go ahead and start sending messages to the ones that the app discovered. Brian Acton and Jan Koum (2009) invented Whatsapp messenger for easy and fast communication and distribution of multimedia messaging. Whatsapp is one of the trend and fashion in technology that is commonly used on specific mobile phones and computers. Since the Smartphones became popular, many messaging services were launched but Whatsapp has become widespread among them. The service is available free for one year and later user has to pay very less annual amount. Besides all, this Application is highly fanatic and can create a great impact on regular users, and apart from that it can leave a trace that becomes difficult to control and cure. With whatsapp messenger, communication through mobile phones has become easier, faster and cheaper. It is less expensive as compared to the normal phone messaging. An individual can chat with friends and family overseas through whatsapp without having to incur global SMS charges.

Sunita singh

The construct of Leadership entails the process of influencing other people to accomplish specific objectives. However, like love, the construct of Leadership is a universal desire that is virtually difficult to define explicitly (Klingborg, Moore and Varea-Hammond, 2006, p.280). It is characterised by the idea of an individual charisma capable of recruiting followers towards his or her path, promoting team-based problem-solving. Conversely, the concept of Leadership is based on many factors such as; "leaders are made not born", "he was a leader since he was a kid" and "if you have the will power, you can become an effective leader" (Klingborg, Moore and Varea-Hammond, 2006, p.280). However, scholars and organisations tend to focus on Leadership and how leaders impact an organisation. The leadership process entails how an individual influences other(s) to achieve a common goal or mission.

Zamzam abdelazim

Abstract- The injection of the PV Grid power into an electric grid affects the power quality. The influence of the PV Grid in the grid system concerning the power quality measurements and the norms followed according to the guidelines specified in the International Electro technical Commission standard, are the active and reactive power variations, variation of voltages, flicker, harmonics and electrical behavior of switching operations. The work study demonstrates has overall good functional characteristics, better performance and faster response than existing systems. The proposed system of having STATCOM is smaller in size and less costly when compared to the existing system. In this proposed system static compensator (STATCOM) is connected at a point with a battery energy storage system to reduce the power quality issues. The effectiveness of the proposed scheme gives the reactive power demand of load and the induction generator. Simulation is done by using MATLAB / SIMULINK-Sim power system software.

Deepak patel

The present study focused on analysing the impact of ‘Make in India’ campaign on FDI inflows in country. The research period is divided in two parts one is pre ‘MII’ & another is post ‘MII’ period. The analysis of ‘Make in India’ campaign is done to identify the scope of the campaign & methodology of working of various allied departments monitoring campaign. The present research work also attempted to take overview of various policy reforms initiated by Government of India to promote the FDI as well domestic investment in 25 sectors shortlisted under MII. The FDI inflows statistics reveals that, the post MII period is showing the highest growth in FDI equity inflows as compare to same period i.e. 2009- 2014. The MII initiative is one of the reason for the jump in FDI inflows. The overview of policy reforms shows that GOI through DIPP attempted to open almost all sectors for 100% FDI through automatic route. Government has provided multiple incentives for Foreign Investors to establish their manufacturing facilities in country but very negligible response has been seen in the nature of FDI equity inflows in the same period. Further results of study reveals that multiple ‘MOU’s have been signed by States & Central Governments, but they yet not converted in actual investments. The major reasons behind the same is lack of SWOT analysis through Governments before inviting the foreign investors. As well lack of basic infrastructure, land, lack of skilled manpower, cheap & un interrupted power supply to MIDC’s & SEZ’s is yet not successfully provided, lower rankings in Ease Of Doing Business (EODB), Global Manufacturing Competitiveness Index (GMCI) is also cause of concern & tumbling block in the success of MII mission..

Anshuman vijay magar

Objectives: Improper and inappropriate use of antibiotics is one of the possible factors affecting the transmission of antibiotic resistance is Because Pseudomonas aeruginosa is one of the most serious pathogenic bacteria in hospital environments and resistant It is an antibiotic that causes problems in treatment. This study aims to determine multiple resistances Pseudomonas has been treated with antibiotics, arsenic and metals. Materials and Methods: In this study, 23 strains of Pseudomonas aeruginosa were isolated from clinical specimens. for review Resistance of these bacteria to penicillin antibiotics was used by Kirby-Bauer method. The minimum concentration C.I.M. (and minimum lethal concentrations (C.B.M.) of antibiotics and heavy metals (cadmium, mercury) and arsenate Tubal dilution, agar and growth were performed in agar plate, respectively. Results: In this study, the highest and lowest MIC values obtained in Pseudomonas aeruginosa for metals, respectively. * 8 and 3 cadmiums (0.6 and 4.9 μg / ml), mercury (<0.12 and 4 μg / ml) and arsenate (10 × were 256 μg / ml). Of 23 strains, 84% to the antibiotic carbonicillin, 63% to piperacillin and 100% to 103 Arsenic and cadmium were resistant. Also, 82.6% of the strains were resistant to mercury. Conclusion: The results of this study showed that Pseudomonas aeruginosa strains have multiple resistance to arsenic, metals and the antibiotics are car penicillin and piperacillin.

Amirhossein jahromi

This study's objective was to determine the distribution of allele frequencies of CYP2C9 and CYP2C19 gene polymorphisms among the Papuan population, known as the second-largest ethnic group in Indonesia. According to recent research, there is a decrease in CYP2C9 and CYP2C19 produced by humans globally, including in Indonesia. These gene polymorphisms aid in the transmission of various endogenous and exogenous drugs in the human body. Material and Methods: A sum of 99 subjects, comprising 73 male and 26 female subjects aged 20-30 years, were used for this research. PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) analysis using AvaII, NsiI, and SfaNI enzymes tested for the genotypes CYP2C9 and CYP2C19 administered. The distribution of genotypes was calculated in the population (P<0.05) using the Hardy-Weinberg equilibrium. The Faculty of Medicine Gadjah Mada University's Medical and Health Research Ethics Committee (MHREC) accepted this research with written consent. The results revealed that in Papua subjects, CYP2C9*2 (rs1799853) and CYP2C19*17 (rs12248560) alleles were absent while in 17 percent of the population CYP2C9*3 (rs1057910) allele frequency was. In conclusion, CYP2C9*3 has the highest polymorphism rate in Indonesia, with the absence of CYP2C9*2 and CYP2C19*17. Therefore, genetic drift can occur within this ethnic group.

Syahrul tuba