The coexistence of Moyamoya syndrome (MMS) and Graves’ disease (GD) is uncommon. Here, we report a case of a 41-year-old Filipino female, who presented with thyrotoxicosis and acute ischemic stroke. Based on her clinical presentation, cerebral computed tomography angiography, and thyroid function tests, she was diagnosed with MMS and GD. Her Burch-Wartofsky point scale score was 30, suggesting an impending thyroid storm. Antithyroid therapy was started with her neurological status deterioration initially, but after controlling the thyroid storm, the patient’s neurological status stabilized. She remained stable till she travelled to her country. We hypothesized that MMS in a patient with GD is mediated through anti-dsDNA antibodies, by altering key biological mechanisms, that is, inflammation, neutrophil extracellular traps, and apoptosis that drive a distinctive and coordinated immune and vascular activation. To the best of our knowledge, this is the first case of MMS associated with GD reported in Qatar.

Karishma

Patients’ knowledge of hypertension and treatment has been found to affect health outcomes of hypertension. This study aimed to assess the impact of therapeutic patients’ education on knowledge of hypertension and lifestyle/dietary modification among hypertensive patients in Nigeria. The study was conducted among 317 hypertensive patients randomized into controlled and intervention groups (158 vs 159, respectively) between March 2021 and February 2022. Baseline knowledge of the patients was assessed and intervention was provided for the intervention group with a structured educational program at a baseline and six months. Descriptive data were presented with a frequency table in percentage while the chi-square test and univariate logistic regression were used to determine the association between categorical variables. Out of the total number of 318 patients, 275 completed the study (response rate: 86.8%) with 136 in the control group and 139 in the intervention group. The mean age of the patients was 59.5 (±12.5) and patients > 60 years (49.5%) were the most frequent age category. The baseline knowledge score of hypertension was 9.8 (±2.6) and 9.3 (±2.6) on a scale of 16 points in the control group and intervention group, respectively (P = 0.060) while at six months 11.9 (±2.3) vs 10.8 (±2.4) (P < 0.001) and 12 months 12.6 (±2.5) vs 9.5 (±2.0) (P < 0.001), respectively. Knowledge of lifestyle/dietary modification in the control group and intervention group at baseline was 7.0 (±2.1) and 6.6 (±2.0), respectively, while at six months 7.5 (±1.5) vs 9.9 (±1.3) (P < 0.001) and at 12 months 7.2 (±1.5) vs 10.4 (±1.2), respectively. Marital status, body mass index, and family history of hypertension were associated with knowledge of hypertension and lifestyle/dietary modification (P < 0.001). The educational intervention provided was found to be associated with a significant improvement in knowledge of hypertension and lifestyle/dietary modification. The marital status of the patients, body mass index and family history of hypertension influenced patients’ level of knowledge.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background: Pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, has demonstrated potential in managing Alzheimer’s disease (AD); however, its oral administration is limited by systemic side effects such as cardiovascular risks and hepatotoxicity. This study aimed to formulate and evaluate a thermo-adhesive intranasal gel containing pioglitazone, utilizing Poloxamer 407 and Carbomer, as a targeted drug delivery system for AD. Methods: A series of gel formulations was prepared and assessed for gelling capacity, homogeneity, pH, and stability. The solubility of pioglitazone in various solvents was tested, and the optimal thermo-adhesive gel was selected based on gelation at physiological temperature (37°C–39°C). Results: The formulation containing 3 g Poloxamer 407 and 0.8 mg Carbomer successfully transitioned into a gel at body temperature and maintained physical stability over 2 months under accelerated conditions. The pH remained within the acceptable intranasal range (5.7–6.0), and no visual or olfactory changes were observed. Conclusions: The developed thermo-adhesive intranasal gel offers a promising alternative to oral pioglitazone delivery for AD, with the potential for enhanced Central Nervous System (CNS) targeting and reduced systemic side effects. Further toxicity and in vivo efficacy studies are warranted to confirm safety and therapeutic value.

Karishma

Internet of things describes the network of physical objects such as sensors, receivers, transmitters and other technologies which are used in VCN. In Vehicular communication network two or more vehicles are communicate with each other. VCN use advanced technologies to solve transportation related problems like long traffic delays, road accidents and air pollution. IOT based technologies make vehicular network smart. In this chapter we reviewed about network resource allocation security techniques, challenges and also discuss how we can make vehicular communication network smarter. We reviewed about different models and schemes for V2V communication. These schemes were developed to ensure a fair, efficient and transparent allocation of resource in an intelligent transportation system.

Vartika agarwal

To improve education quality and governance, the Higher Education Commission of India (HECI) has proposed four regulatory entities, including the National Accreditation Council (NAC). To build up India as a universal knowledge giant over the next ten years, the policy promotes equitable educational opportunities and transformative initiatives. To significantly improve the standards for higher education in India, quality control, accreditation, & ranking systems become crucial. With an emphasis on quality, employability, and lifelong learning, the National Education Policy-2020 (NEP-2020) seeks to create a flexible, value-based educational system that integrates 21st-century capabilities. India's higher education is currently at a critical juncture, requiring transformation to enhance its overall contribution to society and address social injustices. This involves examining how information is produced and how students are taught to promote sustainability and social responsibility. Higher education institutions must comprehend and address student expectations regarding quality because the service sector is expanding quickly due to liberalization, privatization, and globalization. As a result, evaluating service quality becomes crucial for future enhancements and feedback. The Higher Education Commission of India (HECI) legislation, 2018, was introduced by the Ministry of Human Resource Development toward the end of June with the goal of repealing the University Grants Commission (UGC) Act, 1956, which has been in place for seven decades. The HECI will interchange with the University Grants Commission (UGC), which has been the foundation of India's college and university structure. This transition analyzes the proposed bill and examines its shortcomings. This advocates that the current bill be unsuccessful in reporting the flaws of the previous official; instead, it merely reflects those issues and will not resolve the long-standing problems of low autonomy and subpar instruction in the higher education system. As the new regulator, HECI's strategy isn't very revolutionary. Regulators who encourage centralization of duties to reduce autonomy must be disregarded at moments when Indian institutions are striving to rank highly in the world.

Dr. awadhesh singh gautam

The choice of the study design is a major determinant of scientific quality and clinical value of a research study. To select an appropriate study design is a perplex task for novice as well as veterans in research. AYUSH systems of medicines have evidence database showing the effectiveness in a wide range of clinical conditions, yet improving the quality of trials by well- designed studies is indispensable to demonstrate widespread utility on more scientific grounds. This article describes the structured classification of research designs done on the basis of a selective literature search concerning medical research. The study design and type that can best answer the particular research question at hand must be determined not only on a scientific basis, but also in view of the available resources, ethical issues and practical feasibility of study.

Dr deepthi gilla

Background: The first wave of the COVID-19 pandemic was associated with significant morbidity and mortality among healthcare workers worldwide. The present study aimed to assess the knowledge, attitudes, and practices of healthcare workers toward COVID-19 at Ataq General Hospital, and three other hospitals and health centers in Shabwah Governorate, Yemen. Materials and Methods: From January 1, 2022, to February 28, 2022, a cross-sectional survey of healthcare workers was conducted in the city of Ataq, Shabwah Governorate at the following hospitals: Ataq General Hospital, Al Shefa’a Hospital, Al Aafiah Hospital, and COVID-19 Isolation Center. Results: A total of 107 healthcare workers completed the survey. Their mean age was 28.17 ± 7.73 years, 79 (73.8%) of them were male and 28 (26.2%) were female. The overall knowledge was good, with a score of 19 out of 21; however, most participants were unaware of some of the extra-respiratory symptoms of the disease, such as diarrhea and confusion, and about 57% of them were unaware that eating or interacting with wild animals may contribute to the infection with the COVID-19 virus. Attitude analysis of the participants revealed that about half of those surveyed do not believe that Yemen can contain COVID-19. In general, the practice of the participants was good. Conclusion: Although the overall knowledge score in this study was good, most respondents could not recognize some of the extrapulmonary manifestations of COVID-19 and were unaware of the possibility of transmission of the disease from wild animals. In addition, about half of those surveyed do not believe that Yemen can contain COVID-19

Karishma

Colon cancer is the second most common cause of cancer death in women and the third most common cause of cancer death in men. Therefore, early detection of this cancer can lead to lower infection and death rates. In this research, we propose a new lightweight deep learning approach based on a Convolutional Neural Network (CNN) for efficient colon cancer detection. In our method, the input histopathological images are normalized before feeding them into our CNN model, and then colon cancer detection is performed. The efficiency of the proposed system is analyzed with publicly available histopathological images database and compared with the state-of-the-art existing methods for colon cancer detection. The result analysis demonstrates that the proposed deep model for colon cancer detection provides a higher accuracy of 99.50%, which is considered the best accuracy compared with the majority of other deep learning approaches. Because of this high result, the proposed approach is computationally efficient.

Mehdhar s. a. m. al-gaashani

La socialisation en Afrique de l’Ouest se fait par des canaux normatifs dont le mariage. Ce lien sacré, scellé par les Hommes et béni par Dieu, est une nécessité humaine et reste un goulot social pour plusieurs femmes. Sur cette entité géographique patriarcale, la condition féminine relève très souvent d’’un chemin de croix’ pour un épanouissement multiforme. Issoufi DICKO et Safiatou BA se saisissent de cette facette de la thématique du genre pour questionner les vies et les règles traditionnelles en contexte de modernité. Les deux jeunes écrivains maliens portent, entre condition féminine et inversion sexuelle, un regard sans complaisance sur leur société en profonde mutation. Trame nourricière de leurs ouvrages respectifs, ces thèmes leur permettent de mettre en scène des personnages hauts en couleur et en courage. Contrariées en partie par leurs quotidiens et la vie, le système patriarcal et l’embrigadement socioreligieux, leurs héroïnes s’indignent et se révoltent contre les sorts qui leur sont imposés. Défiant les règles de la vie en couple et celles socio-culturelles, elles s’érigent en rempart des dérives sociales perpétrées contre les femmes. Parallèlement à la condition féminine et les conflictualités de la vie en couple, le lesbianisme balbutiant au Mali est convoqué. Issoufi DICKO et Safiatou BA décrivent méticuleusement les arcanes de son enracinement progressif. Cette contribution aborde, avec la méthode qualitative, la condition féminine et l’homosexualité au Mali, entre fiction et réalité sociale. L’objectif de cette contribution est d’analyser la condition féminine et l’homosexualité à travers les deux romans.

Assanvo

It is the goal of every company to gain the most from investment in advertising. Contrary to conventional wisdom that sustained spending in advertising is needed to maintain high levels of sales, the concept of marketing persistence suggests that short term advertising campaigns can have long-lasting impacts on sales. This study offers impact of TV advertising on choice of consumer durable goods in Coimbatore District through the use of a marketing. Significant marketing persistence was found in sales of consumer durables. Based on the findings, implications for long-term marketing resource deployment are suggested.

Dr.n.s.lissy

n India, the education sector has been always attentive to adopt innovations and techniques in the teaching-learning process due to various challenges. But nowadays, academic institutions are becoming flexible in accepting the new teaching and learning techniques to satisfy the student sector which as cited as the most vital entity in the educational sector. New technologies, tools, and techniques are proving as a boom for innovative teaching and learning practices. One of the emerging teaching technique is Blended learning which is a process refers to “mixing of the different learning environment for educational transfer”. It combines the traditional face to face classroom method with online learning method supported by advanced technology and tools. Blended learning should be viewed not only as a temporal construct but also as a fundamental redesign model. Through this content, delivery becomes digital and online. Truly blended learning requires teachers should adopt the approach as guides and mentors and learning should go beyond the classroom walls. Blended learning is also known as Hybrid learning. Although, Indian Government is taking initiatives to implement a blending learning approach yet there is a need to access the behavioral aspect of the students to use this blending learning approach. Adopting a blended learning approach must start with a re-examination of the intended learning outcomes.The deployment of cloud in the blended learning process makes its existence more strong. This study is the review of literature selected to identify the need for blended learning deploy with cloud in the teaching-learning process in the Higher Education Sector.

Inderbir kaur

The Cellular Manufacturing is adopted in batch type manufacturing industries nowadays for their production with increased productivity, less cost and time with effective control. The proposed optimization model is used to determine the cost of machine cells, i.e., machine duplication, part subcontract, inter intra cellular movements cost and cost of production associated with machine cell, such as machine reconfiguration and part inventory considering machine flexibility for various time periods. Initially, a mathematical model is proposed to calculate machine cell cost with and without considering machine flexibility, and then another lpp integer model is proposed to calculate the machine cell production and associated cost for the changes in the time period, part type, and volume considering machine flexibility. The manufacturing data in the incidence matrix and machine cell, and part family data in the block diagonal form are given as input to the optimization programming language Cplex and the output is given for the two mathematical models. The data relating to machine duplication, part subcontract, inter intracellular movement; machine reconfiguration, and part inventory are given. Two-dimensional shop floor layouts are presented in rectilinear coordinates for all the problems for easy analysis of material movement length and shop floor area

S ramesh

Cleome scaposa DC. has long been used in traditional herbal medicine for the treatment of pain and inflammation. The present investigation is an attempt to evaluate the antiemetic, analgesic and anti-inflammatory activities of Cleome scaposa leaves methanolic extract by using the chick emesis model (oral treatment), analgesia meter test (intraperitoneal treatment) in rats and carrageenan-induced rat paw oedema (oral treatment) respectively. The antiemetic activity (150 mg/kg b.w. of extract) was carried out by using chlorpromazine (150mg/kg) as a standard antiemetic drug. The analgesic activity (250 mg/kg b.w., of extract) was performed by using diclofenac sodium (50mg/kg) as a standard analgesic drug whereas, anti-inflammatory activity (500mg/kg b.w., of extract) was done and indomethacin (10mg/kg) was taken as a standard anti-inflammatory drug. The results showed significant antiemetic, analgesic and anti-inflammatory effects.

Dr. salman ahmed

Background: The rising global DM epidemic is driving the problem of TB control. This research determined glycemic control in TB only infected and DM-TB comorbidity and the consequence of the double burden on treatment outcome. Methods: fifty M. TB infected subjects and fifty control subjects were enrolled into the study, all the participants gave consents. FPG and HbA1c were determined by Colorimetry. Data were analyzed using SPSS version 20.0 statistical package, differences between groups and variation among groups were determined by Student’s t-test and ANOVA respectively while the association between variables by Pearson’s correlation. Differences were considered statistically significant at p<0.05. Results: The mean FPG and HbA1c levels of TB subjects were significantly (P<0.05) higher than those of the control. The mean BMI of the TB infected subjects was significantly lower (p=0.001) than that of the controls. The mean age, FPG and HbA1c of TB subjects at the beginning phase of treatment were significantly lower (p<0.05) than those of subjects at the continuation phase of treatment. The mean age, FPG and HbA1c of subjects with DM-M.TB coexistence were significantly (p<0.05) higher than those of the M.TB only infected subjects. BMI of the DM-M.TB comorbidity subjects was lower than that of the M.TB only infected subjects (p=0.109). A significant positive correlation was obtained between HbA1C and FPG in M.tb infected subjects. (r=0.910, p=0.001). A negative correlation obtained between HbA1C and BMI in M.tb infected subjects. (r=0.267, p=0.061). Conclusion: Infection with mycobacterium tuberculosis poses a risk to DM and vice versa, which may adversely affect treatment outcome and control of both diseases. Firm efforts to control DM may likely have a significant valuable effect on TB treatment outcome.

Eworo raymond

Human being has some basic needs which include Food, Clothing & Shelter, in addition to above Healthcare, Education, Sanitation are also core part of basic necessities in modern society. In above mention basic necessities Healthcare facility was near to unavailable till independence for majority of citizens in country but this picture change dramatically with help of FDI allowed by Govt. of India. Foreign Direct Investment as a strategic element of funding is required in every develop & developing country. FDI inflows are long term in nature which causes source of non-debt finance, as well as bring modern & innovative technology in country by creating international network. In this paper, author attempted to discover how FDI is crucially impact on Indian Pharmaceutical Sectors progress by stimulating domestic investment & new employment opportunities, improving healthcare facilities to citizens in India. With the help of available relevant secondary data, a qualitative approach was followed for the study. It was found in study that the major factors responsible for attracting FDI in pharmaceutical sector are rise in outsourcing activities, demand in the generics market, demand from emerging segments, increase in domestic demand, large numbers of forthcoming patent expires. On the other hand Indian pharmaceutical industry is facing some challenges such as, low government expenditure on healthcare, poor healthcare infrastructure in rural areas, lack of proper Govt. policy to attract larger FDI in healthcare sector.

Anshuman vijay magar

The Nano-bio fusion is a booming area with high expectations that major steps in health treatment, body repair and body improvement can be made. It is regarded as the most innovative domain of this moment. Developments are in the field of: Nanomedicine: targeted drug delivery by medically functionalized nanoparticles, for rapid cure without side effects or human stimulation. Regenerative medicine: DNA programmed tissue engineering for quick and efficient wound healing, rebuilt of organs and other body parts. Smart implants: biocompatible implants that can sense and actuate in order to repair or enhance a body function. Nanotechnology idea has as of late gone into the exercises of day by day living. Nanotechnology in games solution cals be characterized as the adjustment of a wide range of improvements in nanoscale into therapeutic applications related with games wounds. The adjusted advancements can be either specifically related with the restorative mediations, for example, recovery of a tissue, implantation, and drug treatments or supporting components like imaging, strappings, and tapings. In this section, the impression of recently developed nanoscale advancements in regards to games wounds will be talked about with recent researches.

Yatendra sharma

Learning is a conscious effort made by individuals to acquire various kinds of abilities (competencies), skills (skills), and attitudes (attitudes) through a series of learning processes that will ultimately result in behavioral changes in the individual. The learning process in schools tends to emphasize the achievement of changes in cognitive (intellectual) aspects which are carried out through various forms of approaches, strategies, and certain learning models. Learning systems that specifically develop affective abilities have received less attention, affective abilities are only used as a nurturing effect. This study aims to (1) find out whether online learning is able to bring out the affective abilities of prospective study program teachers (2) analyze the affective abilities of prospective teachers in online learning. The data used in this study is qualitative data. The technique used is a questionnaire. This questionnaire was given to respondents, namely students of PGSD teacher candidates at Muhammadiyah University of Pringsewu. The results of the study indicate that affective abilities can appear in online learning as evidenced by the results of the questionnaire that has been given to respondents. The indicators of affective ability in this study include attitudes, interests, self-concept, values, and morals, all of which are in the good range. This means that the results of students' affective abilities can be said to be valid or appear in online learning

Educare: journal of primary education

Financial Inclusion is emerging as a new paradigm of economic growth that plays major role in driving away the poverty from the country. It refers to delivery of banking services to masses including privileged and disadvantaged people at an affordable terms and conditions. Financial inclusion is important priority of the country in terms of economic growth and advances of society. It enables to reduce the gap between rich and poor population. In the current scenario financial institutions are the robust pillars of progress, economic growth and development of the economy. When and where all citizens are participated in financial system, the economy and system will become very strong. In this regard the research article was focuses on customer perceptions towards inclusive banking practices.

Dr tatayya bommali

Vehicular adhoc structures (VANETs) handle the Public Key Infrastructure (PKI) and Certificate Revocation Lists (CRLs) for their security. In any PKI structure, the check of a got message is performed by checking if the check of the sender is joined into the current CRL, Verifying the reliability of the certification and standard for the sender. In this paper, it has been propose a Vehicular Digital Hash Gen show up (VDHG) for VANETs, which replaces the dull CRL checking process by a profitable revoking checking process. The renouncing check process in VDHG uses a Private Key Infrastructure (PKI), where the key used in finding the VDHG is shared particularly between On-Board Units (OBUs). In like manner, VDHG uses a novel probabilistic key stream, which extras with OBUs to trade and revive an issue key. VDHG can on a very basic level lessen the data torment in light of the message declaration deferral pulled back and the standard assistance structures using CRL

Dr h shaheen

In this summary, the ideas used by the sales management to enhance the effective Selling of items to clients are addressed in detail. Overall, the report focuses on sales management, describing how the Marks and Spencer organisation's sales can be enhanced through the adoption of appropriate strategies and approaches that would aid in improving sales in the face of increasing market competition. The company modifies ongoing sales management techniques as well as sales organisation factors in an order to promote and retain competitiveness, highlight the significance of the sales organisation, and the necessity of such modifications appears to be stronger in the contemporary business environment.

Zamzam abdelazim