Background: Phaseolus vulgaris, commonly known as kidney bean, has been studied previously for pharmacological properties such as antidiabetic, antioxidant, analgesic, anti-inflammatory, antifungal, and antibacterial properties. Various extracts of the seeds have been researched except fixed oils. Objective: Therefore, the present study aims to investigate the behavioral activity of fixed oil extracted from Phaseolus vulgaris seeds. Methodology: Hole board, light and dark, stationary rod and open field tests were used for behavioral evaluation. Four groups were made with seven mice in each : (1) Control = Normal saline 2ml/kg (2) Phaseolus vulgaris fixed oil = PVFO 2ml/kg (3) PVFO 4ml/kg (4) Diazepam (1mg/kg) as standard. All treatments were given orally 30 minutes before the performance of tests. In the hole board test, PVFO 4ml/kg decreased the number of head poking (p≤0.01). Results: In light and dark tests, PVFO in both doses reduced the time spent in the light compartment (p≤0.01). In the open field test, the number of peripheral lines crossed was decreased (p≤0.05), whereas in the stationary rod test, no effect was observed by any dose of PVFO. Conclusion: Results indicate that Phaseolus vulgaris fixed oil does not affect memory or learning in mice and may possess a dose-dependent sedative hypnotic effect.

Dr. salman ahmed

Monitoring and controlling of clean area environment is of paramount importance to ensure product safety and quality. This comprehensive analysis evaluates environmental monitoring (EM) data from Class C and Class D controlled environments in pharmaceutical manufacturing, utilizing Active Air (AA), Passive Air (PA), and Contact Plate (CP) or Replicate Organism Detection And Counting (RODAC) surface samples. The study aims to identify contamination trends, anomalies, and compliance with ISO 14644-1 and EU GMP Annex 1 standards. Results reveal unexpected findings: Class C Active Air (43 CFU/m³) and RODAC (3 CFU/plate) overall averages are higher than Class D Active Air (34 CFU/m³) and RODAC (2 CFU/plate), respectively, deviating from expected cleanroom classification. Class D Passive Air (22 CFU/plate) is higher than Class C (17 CFU/plate), aligning with expectations. Persistent hotspots were identified in Class C (e.g., location labelled “AA C 12 NG0”AA averages± Standard Deviation (SD): 67.33±17 CFU/m³), indicating localized control failures, while Class D showed extreme individual spikes (e.g., AA D 99 Ac: Max 171 CFU/m³). Sporadic contamination events in Class C suggest transient breaches, necessitating root-cause investigations. The study also highlights limitations of Class D monitoring, which obscures temporal trends and risks missing critical excursions due to long intervals between samples. Recommendations include targeted engineering assessments for high-load zones, enhanced Standard Operating Procedures (SOPs) for cleaning and gowning, adoption of real-time biofluorescent particle counters to replace manual sampling, and increased monitoring frequency in Class D hotspots.

Mostafa eissa

Neurological sicknesses are severe, multifactorial, debilitating disorders that may cause neurodegeneration. Neuroprotection protects the structure and capacity of neurons from affronts emerging from cell injuries instigated by an assortment of specialists or neurodegenerative diseases. Various neurodegenerative diseases, including Alzheimer's, Parkinson's, and epilepsy, afflict many people worldwide, with increasing age representing the leading risk factor. Crocin is a natural carotenoid compound with therapeutic potential in managing neurological disease. In this review, we focused on the therapeutic capabilities of Crocin as a neuroprotective agent. The general neuroprotective impact and the various conceivable essential components identified with Crocin have been examined. In light of the substantial proof indicating the neuro-pharmacological viability of Crocin to different exploratory standards, it is concluded that Crocin exerts direct antioxidant, antiapoptotic and anti-inflammatory activities by multiple signalling pathways. Besides, Crocin was found to elevate dopamine levels in the brain during the experimental model of Parkinson's disease. Thus, this compound has been demonstrated to be a promising option for treating neurodegenerative diseases with few adverse effects. It should be further considered as a potential contender for neuro-therapeutics, concentrating on the mechanistic and clinical evidence for its effects.

Dr. salman ahmed

Physically unclonable function (PUF) is a hardware security module preferred for hardware feature based random number and secret key generation. Security of a cryptographic system relies on the quality of the challenge-response pair, it is necessary that the key generation mechanism must unpredictable and its response should constant under different operating condition. Metastable state in CMOS latch is undesirable since it response becomes unpredictable, this feature used in this work to generate a unique response. A feedback mechanism is developed which forces the latch into the metastable region; after metastable state, latch settle to high or state depends on circuit internal condition and noise which cannot be predicted. Obtained inter hamming variation for 8 PUF is 51% and average intra hamming distance is 99.76% with supply voltage variation and 96.22% with temperature variation.

Abhishek kumar

Objectives: Improper and inappropriate use of antibiotics is one of the possible factors affecting the transmission of antibiotic resistance is Because Pseudomonas aeruginosa is one of the most serious pathogenic bacteria in hospital environments and resistant It is an antibiotic that causes problems in treatment. This study aims to determine multiple resistances Pseudomonas has been treated with antibiotics, arsenic and metals. Materials and Methods: In this study, 23 strains of Pseudomonas aeruginosa were isolated from clinical specimens. for review Resistance of these bacteria to penicillin antibiotics was used by Kirby-Bauer method. The minimum concentration C.I.M. (and minimum lethal concentrations (C.B.M.) of antibiotics and heavy metals (cadmium, mercury) and arsenate Tubal dilution, agar and growth were performed in agar plate, respectively. Results: In this study, the highest and lowest MIC values obtained in Pseudomonas aeruginosa for metals, respectively. * 8 and 3 cadmiums (0.6 and 4.9 μg / ml), mercury (<0.12 and 4 μg / ml) and arsenate (10 × were 256 μg / ml). Of 23 strains, 84% to the antibiotic carbonicillin, 63% to piperacillin and 100% to 103 Arsenic and cadmium were resistant. Also, 82.6% of the strains were resistant to mercury. Conclusion: The results of this study showed that Pseudomonas aeruginosa strains have multiple resistance to arsenic, metals and the antibiotics are car penicillin and piperacillin.

Amirhossein jahromi

When we tested various industrial wastewater samples collected from different industries they shown high amount of toxic chemical components, and the samples are unfit for irrigation or for any kind of activity. Irrigation of untreated wastewater for long time leads to soil pollution by accumulating toxic salts in the soil. The regular growth of plant get effected by this water like improper growth, low chlorophyll content, low carotenoids content, low yield, etc. Three different types of oil yielding plants (Mustard, Ground nut and Sunflower) and three different types of vegetable crops (Tomato, Chilly and Brinjal) has grown by using different industrial wastewater samples. The primitive parameters of vegetative growth (imbibition, seed germination and vigour index) and nutritional components (chlorophyll a, b and carotenoids) have been observed in all the samples after growing for a particular time period. The imbibition test of seed samples in industrial wastewater samples have not shown significant variation compared to imbibition in distilled water sample. All the seeds in all wastewater samples absorbed almost negligible difference but in the percentage of germination there is significant difference. The tests for nutritional compositions have also shown significant decrease in chlorophyll a, b and carotenoids in all varieties.

Veerabhadraswamy al

A P2P network can be an ad hoc connection- a couple of computers connected via a Universal Serial Bus to transfer files. And these networks are vulnerable to peers. The traditional security techniques are insufficient for P2P networks as they are insecure by their very nature. There’s no centralized server controlling access to shared resources in a P2P network which have unique challenges including identity management of the peers, secure reputation data management, Sybil attacks, and above all, availability of reputation data. The future actions are predicted where peers are encapsulated in its digital reputation, based on the past behaviour of the peer.Thus a peer’s reputation allows it to cooperate and prevent from malicious activities. The cryptographic protocol is coupled with selfcertification and cryptographic mechanisms for identity management and countering Sybil attack.

Dr h shaheen

The prevalence of PMS (prevalence of pre most common disorder among the women’s. It has high impact on women’s health, emotions and behaviours during certain days of menstrual cycle. Aim: To determine the symptoms of PMS. Material and methods: PMS.The sampling frame is comprised individual aged 18 was used. Then respondents were given information regarding benefits of jaggery tea consumption to over PMS. Preparation of jaggery tea: add the one cup of water for boiling, and then add the requirement amount jaggery. Add filter to discard the solids. Study subjects were asked to consume jaggery tea five days prior and after the date of menstrual cycle continuously for 3 months. Study subjects were ask premenstrual syndrome screening toll before and after jaggery tea consumption. The data was analysed using descriptive statistics and effect of jaggery tea was evaluated using paired t Result: from PMS, 120(61.5%) of them had mild PMS, 55(28.2%) had moderate PMS and only few 20(10.3%) of then had sever PMS. Conclusion: role in curing PMS

Shwetha hitnal

Abstract The main objective of this paper is to examine the nexus between the reforms that have been carried out in Nigeria concerning the power sector, and the implications of the reforms on the transformation of agro-allied industries. The power sector, no doubt, can be said to have the potential that can propel national development considering the overall importance of energy to the survival of the nation in terms of job creation, industrial development and sustenance as well increase in revenue generation and Foreign Direct Investment opportunities, among others. The unfortunate situation, however, is that in spite of a number of policies enunciated by successive governments aimed at improving on the power sector, not much has been achieved. The multiplier effect of this kind of development has been seen in the widespread epileptic power shortages, downward spiral of efforts towards industrial development drive; unemployment, shortage of national revenue accruing to government coffers, bourgeoning and rising poverty levels, to mention but a few. All of these have further contributed to the growing army of problems currently being witnessed in the country at the moment. This study is a theoretical exposition of the existing works of scholars and experts in the broader field of power sector reforms. The paper is exploratory in structure and method of its investigation. The study concludes and recommends that in view of the prevailing socio-economic circumstances in Nigeria, genuine reforms in the energy sector devoid of political rhetorics will go a long way in mitigating some of the challenges of contemporary times in the power sector

Canice erunke

Avian influenza has impacted negatively on poultry production in Nigeria. The aim of this study was to determine the status of avian influenza virus (AIV) antibodies in wild birds to provide early warning of an outbreak. One hundred and forty-six sera from five different species of wild birds were tested for antibodies to avian influenza A viruses (H5 and H9) using enzyme linked immunosorbent assay and haemagglutination inhibition (HI) tests. An overall seroprevalence of 3.4% (5/146) was recorded in the study area. Seroprevalence of 6.67% (2/30) was recorded in speckled pigeons (Columba guinea) and Village weavers (Ploceus cucullatus) respectively and 3.33% (1/30) in Cattle egrets (Bubulcus ibis). No antibodies were detected in laughing doves (Spilolepia senegalensis) and African silver bill (Euodice cantans). The serological detection of AIV subtypes H5 and H9 by HI showed the exposure of these birds to the two subtypes. The result from this study indicates evidence of the presence of H5 and H9 AI viruses in wild birds in Zaria, Kaduna State. Therefore, comprehensive surveillance of influenza A involving wild birds’ population and H5 as well as H9 subtype is recommended. This is necessary in order to know the actual status of these strains in the poultry population in Nigeria in view of their zoonotic and economic importance.

Bitrus inuwa

ABSTRACT- Objective- The principal objective of the present investigation was the preparation of several analogs to further evaluate the binding site hypothesis. Aryl semicarbazides have also been reported to display excellent anticonvulsant activity in mice and rats. Method- In this project, the synthesis of semicarbazone derivatives was carried out. All molecules were synthesized using the common starting material –aniline. In all compounds, an intermediate was first formed by substituted phenyl urea using substituted aniline and potassium cyanate, and then it was hydrolyzed to get substituted phenyl semicarbazide, which was directly coupled with ketones. All the synthesized compounds were biologically screened for their anticonvulsant activity by the MES method. Result- Standard error mean was calculated concerning standard and control drug, Phenytoin sodium (25mg/kg.) and DMSO. The synthesized semicarbazone was characterized by using IR Spectroscopy. One another representative molecule compound was characterized using 1H NMR Spectroscopy. Conclusion- It can be concluded that designed semicarbazones were synthesized and characterized successfully. After synthesis of designed semicarbazones compounds were evaluated for anticonvulsant activity. Finally, two compounds have shown better activity in comparison to the other molecules.

Ajay garg

Over the recent years, cloud computing has emerged as a powerful means for providing automated healthcare facilities. Cloud helps in massive sharing of information between doctors and hospitals using Electronic Health Records. This major transformation has changed the way doctors and hospitals deliver quality and effective service to their patients. Using Cloud storage inhealthcare services has revolution- ized health industry, making it more efficient. Apart from the primary driving factors of cloud like flexibil- ity in cost of maintenance, infrastructure and development, on-demand scalability of storage centers and pay on use schemes are proven to be most effective. More and more digitalization of data causes breech of security and privacy.Because healthcare information is a highly sensitive data which cannot be com- promised,the future of healthcare relies in providing secure and trustworthy sharing of data by safe- guarding privacy and trust. This paper gives an extensive review of the existing security mechanisms for Cloud based healthcare systems.

Dr.c.priya

In addition to predatory journals and publishers, researchers now need to be wary of predatory conferences as well with the checklist given here to really check yourself.Because the predatory journals and publishers make target to the new researchers there must be need of that type of articles

Dr.ved nath jha

formulation and evaluation of herbal face pace pack

Sumaira taj

Background: The goal of nursing profession is to prepare the nurses to meet diverse needs of the patients, delivering holistic care to the patients. It is the need of the hour for the Nursing students to utilize their knowledge, skills, and technologies to practice independently and collaboratively with all health professionals. Any type of negligence in their work may result in dire consequences. Method: Descriptive Survey Research design was adopted for a study to assess the Academic Procrastination factors for General Nursing students at selected Schools of Nursing, Bhopal, with Sample size of 50 General Nursing students. Result: Result revealed that majority, 35 nursing students were male whereas 15 were females, majority of students (18) were in age group of 22-23 years, 32 students were in GNM 3rd year, mostly (43) resided in Urban area, majority (44) belongs to nuclear family, and 28 mothers as compared to 41 fathers of students were educated. Out of 50 respondents who were the subjects of research on the causes of academic procrastination, namely: 12 respondents (24%) said that it was caused by habit, 15 respondents (30%) answered Poor time management, 23 respondents (46%) said it was due to Tiredness, 28 respondents (56%) said it was due to peer pressure, 22 respondents (44%) due to Low motivation, 14 respondents (28%) answered unclear tasks, and 36 (72 %) said it was due to Deadlines for submission. Majority of nursing students 38 (76%) were moderately affected by Personal factors, and by Environmental factors only 26 (52%) students were moderately affected as compared to academic factors at 12 (24%) students who were moderately affected. Conclusion: The study concluded that personal and environmental factors have more effects on academic procrastination as compared to academic factors

Dr k c yadav

Oecophylla longinoda has some reported medicinal uses, including antimicrobial, analgesic, and anti-inflammatory activities. This study was designed to investigate the Oecophylla longinoda methanol extract to evaluate the toxicity profiles of its acute and sub-acute effects. The experiments were conducted to determine the oral median lethal dose (LD50) and other gross toxicological manifestations on an acute basis. In the first phase of the acute toxicity study, three per group were administered Oecophylla longinoda at single oral doses of 10, 100, and 1000 mg/kg body weight, and 1600, 2900, and 5000 mg/kg of Oecophylla longinoda in the second phase. In the sub-acute studies, the mice were orally administered 2.5 g/kg Oecophylla longinoda per day for 14 consecutive days. Rat body weight and fluid intake were recorded during the 14 days. The rat kidney, heart, liver, and blood sera were obtained for weight, histological, and biochemical markers including glucose, cholesterol, proteins, triglycerides, enzymes including ALT, AST, and ALP, as well as electrolytes (sodium and potassium) examinations. Results show that the methanol extract of Oecophylla longinoda is safe, and no significant changes in the biochemical markers that indicate harmful effects on the kidney and liver were observed in mice. However, the liver showed slight changes while the kidneys and heart remained healthy in mice exposed to Oecophylla longinoda. The no-observed-adverse-effect limit was 5000 mg/Kg body weight/day.

Mediterranean journal of pharmacy and pharmaceutical sciences

HIV/AIDS cases in Indonesia continue to increase and have spread to all provinces in Indonesia. Bandung is one of the cities with a high number of people living with HIV/AIDS in Indonesia. As one of the areas with the highest number of reported HIV cases, the Bandung city government seeks prevention and treatment through the role of existing stakeholders. However, stigma and discrimination against people living with HIV & AIDS, now referred to as PLHIV, are still found and are difficult to eliminate. People diagnosed as contaminated with the HIV & AIDS virus often get a negative stigma. This study aims to analyze how to remove the stigma and discrimination of people with HIV/AIDS through the role of civil society. The research results show that stigma against HIV is often directed at certain minority groups and is often associated with morals and religion. Meanwhile, discrimination against people with HIV is manifested in violations of individual rights in the economic, social, and cultural spheres. The issue of stigma and discrimination against PLWHA has not received serious attention. Therefore, the role of civil society is very important because it can open a dialogue with the community regarding HIV/AIDS to dispel myths that tend to discriminate against PLHIV.

Syahrul tuba

The present study focused on analysing the impact of ‘Make in India’ campaign on FDI inflows in country. The research period is divided in two parts one is pre ‘MII’ & another is post ‘MII’ period. The analysis of ‘Make in India’ campaign is done to identify the scope of the campaign & methodology of working of various allied departments monitoring campaign. The present research work also attempted to take overview of various policy reforms initiated by Government of India to promote the FDI as well domestic investment in 25 sectors shortlisted under MII. The FDI inflows statistics reveals that, the post MII period is showing the highest growth in FDI equity inflows as compare to same period i.e. 2009- 2014. The MII initiative is one of the reason for the jump in FDI inflows. The overview of policy reforms shows that GOI through DIPP attempted to open almost all sectors for 100% FDI through automatic route. Government has provided multiple incentives for Foreign Investors to establish their manufacturing facilities in country but very negligible response has been seen in the nature of FDI equity inflows in the same period. Further results of study reveals that multiple ‘MOU’s have been signed by States & Central Governments, but they yet not converted in actual investments. The major reasons behind the same is lack of SWOT analysis through Governments before inviting the foreign investors. As well lack of basic infrastructure, land, lack of skilled manpower, cheap & un interrupted power supply to MIDC’s & SEZ’s is yet not successfully provided, lower rankings in Ease Of Doing Business (EODB), Global Manufacturing Competitiveness Index (GMCI) is also cause of concern & tumbling block in the success of MII mission..

Anshuman vijay magar

Fungal infection of the nails (onychomycosis) is a common condition that is hard to cure. The fungus hidden in the nail is difficult to treat with antifungal medications, and infected nails take months to heal. Antifungal nail polish can occasionally be used to treat mild cases, but blood-stream-permeable medications are required to treat more serious infections. We need something better because even these are not always successful and can have negative side effects like skin rash or liver issues. Additionally, onycholysis (the separation of the nail plate) creates a moist environment that can encourage the growth of fungi. Moreover, immunosuppressive medication use may worsen onychomycosis. In this example, the diseased entity's clinical presentation in an adult patient was described.

Mediterranean journal of pharmacy and pharmaceutical sciences

Vigna trilobata (L.) VERDC. belongs to the family Papilionaceae, which is found throughout the tropical and warm temperate regions of the world. In folk medicine, it is used for arthritis, fever, cough, dysentery, and urinogenital disorders. Different secondary metabolites, such as alkaloids, glycosides, terpenoids, and flavonoids, have been reported in Vigna trilobata. It has antioxidant, antidiabetic, and anti-inflammatory activities.

Dr. salman ahmed