Identity-based encryption (IBE) is a public key cryptosystem and eliminates the demands of public key infrastructure (PKI) and certificate administration in conventional public key settings. Because of the absence of PKI, the revocation drawback could be a crucial issue in IBE settings. Many rescindable IBE schemes are planned relating to this issue. Quite recently, by embedding associate outsourcing computation technique into IBE, Li et al. planned a rescindable IBE theme with a key-update cloud service supplier (KU-CSP). However, their theme has 2 shortcomings. One is that the computation and communication prices are above previous rescindable IBE schemes. The opposite disadvantage is lack of measurability within the sense that the KU-CSP should keep a secret worth for every user. Within the article, we have a tendency to propose a replacement rescindable IBE theme with a cloud revocation authority (CRA) to resolve the 2 shortcomings, namely, the performance is significantly improved and the CRA holds only a system secret for all the users. For security analysis, we demonstrate that the proposed scheme is semantically secure under the Decisional Bilinear Diffie-Hellman (DBDH) assumption. Finally, we have a tendency to extend the planned rescindable IBE theme to gift a CRA-aided authentication theme with period-limited privileges for managing an outsized range of varied cloud services.
Vitamin C is associated with history of the cause of the ancient hemorrhagic disease scurvy. Vitamin C is an essential nutrient with important antioxidant properties. It is required by the body for normal physiological function. The body cannot synthesize vitamin C, it is present in nature through foods and other natural sources and it exists as a nutritional food supplement. The antioxidant activity of vitamin C protects the body from free radical damage. Vitamin C is essential for the development and maintenance of connective tissues. It is used as therapeutic agent in many diseases and disorders. Vitamin C plays an important role in several metabolic functions, as the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin, and the conversion of cholesterol to bile acids. Vitamin C supplementation resulted in a significant increase in vitamin C levels in populations; its high intake is associated with positive effects on cardiovascular risk factors. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight infections. It has an important role in bone formation, wound healing and the maintenance of healthy gums. There is profound beneficial effect of vitamin C in respect to human diseases as cancer, atherosclerosis, diabetes, neurodegenerative disease and many metal toxicities. Several vitamin C analogs have been produced as anticancer and antioxidant activity. Vitamin C is useful if it is used as adjuvant therapy for several chronic diseases. Thus, this review summarizes the importance of vitamin C in the body’s physiology and biochemistry, in addition, the different mechanisms that vitamin C is implicated to treat different acute and chronic diseases. Future exploration should pay attention to chronic disease management by vitamin C.
Mediterranean journal of pharmacy and pharmaceutical sciences
Antimicrobial resistance poses a critical threat to global health, exacerbated by inappropriate antibiotic usage. This study evaluates antibiotic consumption at Hospital 199, a public security hospital in Vietnam, using the defined daily dose per 100 bed-days and the World Health Organization AWaRe classification framework. Data were collected retrospectively from inpatient departments over 2022, analyzing prescribing trends to assess stewardship effectiveness and identify areas for improvement. The findings reveal a total antibiotic usage rate of 60.8 defined daily dose per 100 bed-days, predominantly driven by watch antibiotics (63.8%), followed by access antibiotics (36.2%), and minimal use of reserve antibiotics (0.0003%). Critical care departments, such as anesthesiology and intensive care, reported the highest consumption (190.54 DDD/100 bed-days), which may reflect the complexity of care provided and potential empirical prescribing practices, or an elevated infectious burden. β-lactam antibiotics accounted for 59.4% of total use, with third-generation cephalosporins representing the largest subgroup at 40.2% of defined daily doses. While adherence to stewardship principles was evident in the limited use of reserve antibiotics, the reliance on broad-spectrum agents highlighted systemic challenges, including empirical prescribing practices and limited diagnostic capacity. This study highlights the need for targeted interventions to promote access to antibiotics, reduce over-reliance on watch agents, and enhance diagnostic support. By aligning local practices with World Health Organization guidelines, Hospital 199 demonstrates its potential to combat antimicrobial resistance effectively. These findings offer insights for similar low- and middle-income settings, contributing to global efforts to mitigate resistance and optimize antibiotic stewardship.
Mediterranean journal of pharmacy and pharmaceutical sciences
Background Predisposing factors for chronic obstructive pulmonary disease (COPD) comprise endogenous genetic factors and exogenous factors such as positive and negative smoking, air pollution, inhalation of dust, and work-related chemicals. Because only a small percentage of smokers develop COPD, it is thought to arise as an outcome of environmental harm and a host’s response system, which boosts the tendency of the disease to arise. Objective To clarify the effect of smoking on the level of oxidant–antioxidant in patients with COPD. Patients and methods Thirty patients with COPD (20 smokers and 10 nonsmokers) and 40 healthy individuals (18 smokers and 22 nonsmokers) participated in this study. The investigations included measurement of malondialdehyde (MDA), superoxide dismutase (SOD) activity, catalase (CAT) activity, glutathione peroxidase (GPx), glutathione reductase (GR), vitamin C, and glutathione (GSH) content. Results SOD, CAT, GPx, GSH, GR, and vitamin C were significant lower (P<0.0001) among patients with COPD (smokers and nonsmokers) than in the control group, whereas the MDA levels were elevated (P<0.0001) in patients with COPD (smokers and nonsmokers) when compared with the control group. Moreover, the values of SOD, GSH, and GPx were significantly lower (P<0.001) in smokers with COPD as compared with nonsmokers with COPD. Finally, there was no significant difference in the level of MDA between patients with COPD (smokers and nonsmokers). Conclusion There is a significant reduction in the level of some antioxidants (SOD, GSH, and GPx) in smokers with COPD compared with nonsmokers with COPD, but other antioxidants (CAT, GR, and vitamin C) did not change significantly, whereas the oxidant levels (i.e., MDA) were relatively convergent in patients with COPD (smokers and nonsmokers). This, in turn, points to the modest role of smoking in the causation of oxidant–antioxidant imbalance in this diseas
The current study explores creative cultural tourism as a new model of the relationship between cultural heritage and tourism. Cultural heritage with its tangible and intangible components represents an essential part of culture tourism. Many changes have been happened in tourism due to new forms of consumption patterns, tourism activities, and tourism products. These changes require shifting from traditional culture tourism to creative cultural tourism as a new concept of cultural heritage. Tourists face many problems in the traditional culture tourism which is a form of mass tourism, thus, creative cultural tourism came to solve these problems. In addition, this study explains the transformation from traditional culture tourism to creative culture tourism.
Despite the evolution of modern technology, the users of hearing aids do not realize the persistence of feedback, while wearing the device until the condition becomes worse. The feedback cancellation algorithms, instead of cancelling the acoustic feedback, limits speech intelligibility. The paper presents a novel method for estimation of SNR based adaptive-feedback equalizers (SBAFE) algorithm to develop an optimized hearing aid for the feedback less sound transmission and achieving better speech discrimination. The data gathered for the optimization is visualized and compared with the traditional technology, which provides the subjective and objective quality of the hearing aids.
Simply put, advertising is an important marketing strategy that works in conjunction with information and persuasion channels. Every single person is exposed to commercials on a daily basis. They've become an inseparable part of the print medium, whether it's newspapers or magazines, over time. This is also true in the case of broadcast media, where ad-commercials predominate. The Indian advertising industry has grown tremendously from a small business to a full-fledged industry. The purpose of this study is to determine the advertising attractions and the influence they have on Indian culture. Advertisements in India are not only used to sell products. It sells dreams, visions, and the ideal way of life, while also reinforcing stereotyped values. The longer an individual is exposed to an advertisement, the more likely it is that it will effect them. The appeals' goal is to change how people think about themselves and how they decide whether or not to buy certain things will benefit them. Because India has such a large population and cultural diversity, the advertising industry has created a wide range of advertisements to capture people's attention and persuade them to buy products. The appeals are written in such a way that they have an impact on people's purchasing decisions.
Background: The first wave of the COVID-19 pandemic was associated with significant morbidity and mortality among healthcare workers worldwide. The present study aimed to assess the knowledge, attitudes, and practices of healthcare workers toward COVID-19 at Ataq General Hospital, and three other hospitals and health centers in Shabwah Governorate, Yemen. Materials and Methods: From January 1, 2022, to February 28, 2022, a cross-sectional survey of healthcare workers was conducted in the city of Ataq, Shabwah Governorate at the following hospitals: Ataq General Hospital, Al Shefa’a Hospital, Al Aafiah Hospital, and COVID-19 Isolation Center. Results: A total of 107 healthcare workers completed the survey. Their mean age was 28.17 ± 7.73 years, 79 (73.8%) of them were male and 28 (26.2%) were female. The overall knowledge was good, with a score of 19 out of 21; however, most participants were unaware of some of the extra-respiratory symptoms of the disease, such as diarrhea and confusion, and about 57% of them were unaware that eating or interacting with wild animals may contribute to the infection with the COVID-19 virus. Attitude analysis of the participants revealed that about half of those surveyed do not believe that Yemen can contain COVID-19. In general, the practice of the participants was good. Conclusion: Although the overall knowledge score in this study was good, most respondents could not recognize some of the extrapulmonary manifestations of COVID-19 and were unaware of the possibility of transmission of the disease from wild animals. In addition, about half of those surveyed do not believe that Yemen can contain COVID-19
Among the consequences of armed conflict, the effect on the mental health of the civilian population is one of the most significant aspect of psychiatric disorders. Studies of the general population show a positive increase in the incidence and prevalence of mental disorders. This study is aimed to determine the relationship of the national crisis on the mental health conditions of university students and their academic performance. Specifically, this study was aimed to evaluate the national crisis effects on the mental health and the academic performance as well as the association of the national crisis, mental health and academic performance. 40 sample size of pharmacy students at the academic year 2019-2020 at Attahadi University, Tripoli, Libya were used in this study and a survey of validated questionare for mental health was considered. The findings revealed that the effects of national crisis on the mental health of the students disclosed the verbal interpretation of rarely grade. Indeed it can be found that mental health of the students was not of greatly affected in this sample. The academic performance of the students disclosed that academic year levels one and three have verbal interpretation of good and academic year level two has fair. Though the academic performance of the students did not show a verbal interpretation of weak or very weak. It is still worthwhile to note that none of them has reached the very good and the excellent performance. It can be concluded that a need for the students coping strategies be enhanced for them to reach their maximum potential with their academic performance. This study shows also that a weak positive relationship among the variables. Though it’s not that high, indeed, the mental health of the students can be a predictor to their academic performance.
Mediterranean journal of pharmacy and pharmaceutical sciences
The city that never sleeps, a vibrant tapestry of dense neighborhoods and relentless energy, has long grappled with the pervasive challenge of air pollution. The very dynamism that defines the city – its traffic, buildings, and industry – contributes to ambient concentrations of fine particulate matter (PM2.5) and ground-level ozone (O3), pollutants known to exact a heavy toll on public health. [1-3] An extended analysis of environmental health data from 2005 to 2019, meticulously compiled by the town Department of Health and Mental Hygiene (DOHMH), offers a crucial lens through which to view the city's journey: a narrative marked by significant public health victories interwoven with stark, persistent environmental injustices. [4] This fifteen-year period reveals not just the efficacy of targeted interventions but also the deeply entrenched disparities that continue to leave vulnerable communities uneasy. Thus, the aforementioned challenge provides a very important lesson to address similar problems around the globe, especially in the crowded urban areas.
This article explores the intersection of Artificial Intelligence (AI) and personalized healthcare, focusing on how AI-driven technologies are revolutionizing the delivery of individualized medical care. Through an in-depth examination of recent advancements, practical implementations, and ethical considerations, this paper elucidates the transformative role of AI in tailoring treatments, improving diagnostic precision, and enhancing overall patient outcomes.
In the United States, prisoner reentry programs are a necessity to re-integrate back into society and are of two types: Faith and Non-Faith. With increased emphasis placed on reforming the criminal justice system policies due to Black Lives Matter and other non-profits actively working to change the system from the outside, reentry programs are having a resurgence of interest for effective public policy. There are significant barriers for major policies at the state, local, and federal to be alleviated, nevertheless, our research wanted to consider the effectiveness of five faith-based, male-only reentry programs in central Florida. Small focus groups were utilized to better understand the concerns and issues returning inmates faced in the program as well as when returning to society. Reentry participants were found to have high confidence in the success of their participation in their faith-based program’s efforts on their personal and family growth.
International journal of business and social science research
Newborn or neonate denotes to an infant in the first few days after birth. They are not small children when it comes to medicinal use and formulation development. Neonates include term, post-term and preterm babies. The neonatal period for preterm newborn infants is defined as the day of birth through to the expected date of delivery plus 27 days. The majority of drugs used in sick newborns receiving intensive care are unlicensed and off-label, exposing infants to a greater risk of adverse drug reactions (ADRs). This study is extremely important due to the presence of a variety of drug information sources if used together lead to medication errors. From this point of view, this approach is suggested to eliminate or minimize these varieties. Where the most important challenges in neonatal intensive care unit (NICU) is proper and correct calculations and administration. Drug-related events in a hospital setting are the highest cause of recorded errors such as in the USA and UK
Mediterranean journal of pharmacy and pharmaceutical sciences
The methanol extract of the whole alga Hypnea pannosa J. Agardh was subjected to antifungal screening. It showed low activity against Aspergillus flavus Link ex Gray 1821.
This paper examines the influence of empowerment on job satisfaction in five-star hotels in Jordan. The influence of empowerment on job satisfaction remains a relatively unexplored area. A 52-item questionnaire, measuring empowerment and job satisfaction, was distributed to 332 employees in 12 five-star hotels in Jordan with a 56% response rate. Principal components analysis determined the factor structure and regression analysis determined the influence of empowerment on job satisfaction. The results revealed both structural and psychological empowerment have significant individual influences on job satisfaction, but more significant when structural and psychological empowerment are combined. Most of previous studies were conducted in western economies and little in the Middle East generally and Jordan in particular. This research contributes to the literature by including both dimensions of empowerment where previous scholars used only one.
The chosen organisation for this research work is Primark. Primark is a renowned fashion retailer operating in the global markets today. The organisation is known for its latest fashion products (Azad, 2018). Primark has been selected because it is a famous brand in the global market and has an okay -developed marketing department. Marketing is one of the most critical areas of an organisation. This is mainly because this area helps plan and implement strategies that can enhance an organisation’s sales, profits, and market share. Moreover, marketing can also ensure that customer satisfaction is high, and the positive relationships are maintained with all individuals and parties that are directly or indirectly associated with an organisation. The marketing mix of an organisation comprises of several strategies that can enhance the value to its customers. Following tasks will further elaborate about marketing and its core concepts -
This study aims to investigate the relationship between green marketing elements and customer purchase intention. To conceptualize green marketing, the researcher has researched the literature and identified the green marketing elements which include Green products, Green price, Green place, Green promotion, and Green Distribution. By using the snowball sampling technique, questionnaires from the respondents were collected as part of the study's survey methodology. According to the study's findings, there is a clear, substantial correlation between customer purchase intention and Green marketing.
Patients who are on regular hemodialysis and who have advanced renal failure but have not yet started on renal replacement therapy have a high risk of tendon rupture, although this is a rare situation. We reported a case of 55-year-old male patient who had been on regular hemodialysis for the past 10 years. He presented with a sudden onset of pain and swelling in the left posterior ankle while climbing stairs. Ultrasonography revealed a complete disruption of the Achilles tendon, which was surgically repaired. His medical history was remarkable for the right Achilles tendon rupture a year ago. Investigations revealed tertiary hyperparathyroidism with chronic metabolic acidosis and high β-2 macroglobulin. With surgical repair, physiotherapy, and parathyroidectomy, the patient regained full active mobility. This case emphasized the importance of high parathyroid hormone level, metabolic acidosis, and high β-2 macroglobulin in the pathogenesis of tendons ruptures.
Background: COVID-19-positive patients are at increased risk of adverse clinical outcomes, with type 2 diabetes cohorts at substantially higher risk compared to the general population. The additional role of diabetic and non-diabetic polypharmacy in these patients' clinical course has remained unexamined. In this study we have comprehensively examined the role of polypharmacy in the determination of mortality outcomes in patients with COVID-19 clinical syndrome. Methods: We retrospectively examined case notes and electronic records of N = 497 patients with type 2 diabetes and COVID-19 infection. We ascertained the number of medications each patient was taking and used this to categorize the study cohort into diabetic [n = 246] (5 or more diabetic medications), and non-diabetic polypharmacy [n = 251] (5 or more non-diabetic medications). The primary outcome was the need for intensive care admission between the two groups. Results: In patients with “non-diabetic polypharmacy” (>5 medications), advancing age, and higher HBA1c levels, were associated with increased risk of Intensive care admission (OR 1.06 [CI 1.03-1.07], P = <0001), (OR 1.01 [CI 1.01- 1.20], P 0.017), respectively. Patients taking 5 or more non-diabetic medications had an increased likelihood of admission into the intensive care unit compared to those on lower medication thresholds (OR = 1.7; CI = 1.1 to 1.3; p-value = <0.0006). Conclusion: In an inpatient cohort of type 2 diabetic patients with COVID-19, non-diabetic polypharmacy was associated with a multiplicative risk of intensive care admissions. This will necessitate the need for periodic medication reviews in these cohorts of patients to mitigate these potential risks and improve clinical outcomes.
One of the most important challenges for a company is to manage its supply chain efficiently. One way to do this is to control and minimize its various logistics costs together to achieve an overall optimization of its supply network. One such system that integrates two of the most important logistics activities, namely inventory holding and transportation, is known as the inventory routing problem. Our replenishment network consists of a supplier that uses a single vehicle to distribute a single type of item during each period to a set of customers with independent and deterministic demand. The objectives considered are the management of supplier and customer inventories, the assignment of customers to replenishment periods, the determination of optimal delivery quantities to avoid customer stock-outs, the design and optimization of routes. A genetic algorithm (GA) is developed to solve our IRP. Different crossover structures are proposed and tested in two sets of reference instances. A comparison of the performance of different crossover structures was established. Then, it was used to find the most appropriate crossover structure that provides better results in a minor computation time. The obtained results prove the competitiveness of GAs compared to literature approaches, demonstrate the performance of our approach to best solve large scale instances and provide better solution quality in fast execution time.