Shell and tube heat exchanger is the most common type of heat exchanger, widely used in oil refinery and other large chemical process. The energy present in the exit stream of many energy conversion devices such as I. C engines, Gas turbines etc. goes as waste, if not utilized properly. For example, the heat energy stored in the engine coolant can be utilized in a better way by recovering the heat for heating purposes inside the cabin. It is comparatively economical than the existing heating arrangements, which employ conventional heating coils. So, the present work has been carried out with a view to predicting the performance of a shell and tube heat exchanger in the field of waste heat recovery application. The objective of this project is to design a shell and tube heat exchanger and study the flow and temperature field inside the shell and tubes using ANSYS Fluent R14.5. An attempt has been made to calculate the performance of the above heat exchanger with and without baffles for parallel flow configurations, and the results so obtained have been compared.

Boopathy govindarajan

Higher education institutions are expected to produce quality and competitive graduates for the job market and nation-building. In realizing this role, the Bukidnon State University needs to ensure that graduates may land a job-relevant and aligned with their education and training. With this, a tracer study was conducted to verify whether the three batches of graduates are employed and are employable. It ascertained their employability based on their work experience from graduation to the present job. It employed a cross-sectional method and data mining for the information of 326 graduates. The results revealed that the majority of graduates had jobs relevant to their education and training; yet, there was a significant difference in the employability of graduates across batches, except in terms of gender. Biological Science, Social Studies, and Math graduates were employable within the first six and twelve months compared to graduates from other curricula. It was claimed that the BukSU had prepared BSE graduates for employment. These results have implications for the strategic options in improving the programs. The study made some recommendations for future tracer initiatives.

Manuel caingcoy

Improving the agricultural productivity is an imminent need to meet the food requirement of constantly growing population rate. It can be gracefully satisfied if the farming process is integrated through technologies such as big data and IoT. The integration of agricultural processes with modern technologies has emerged as the smart agriculture technology. This research work is focused on proving the suitability of the big data analytics for smart agricultural processes in terms of increasing production and quality of yields with less resources and overhead. This research paper expounds the extensive review carried out on the related works in smart agricultural farming, challenges in implementing the smart farming technologies at large scale, followed by the conceptual framework model for the effective implementation of big data together with IoT devices in smart farming.

Dr h shaheen

ABSTRACT Background: One of the many functions of the liver is the synthesis of carrier proteins and hormone metabolism, and liver diseases have been linked to a variety of endocrine disorders. Aim:The study's goal was to look at the spectrum of chronic liver disease and the relationship between thyroid profile and severity of liver damage in a tertiary hospital. Methods and materials: The current study was a single-center, tertiary care hospital-based,case-control study that included 50 cases of liver cirrhosis/chronic liver disease and 50 age/sex matched healthy controls (chosen at random from relatives attending OPD with patients). Thyroid function tests were performed and results were compared between cases and controls.Result : This study included 50 cases of liver cirrhosis/chronic liver disease and 50 healthy controls.The mean age and gender of cases and controls were comparable, and the difference was not statistically significant. The majority of cases (76%) had alcoholic liver cirrhosis, with the remainder having non-alcoholic liver cirrhosis (16%) and chronic viral hepatitis (8%). As per Child-Pugh Score, the majority of cases (40%), followed by Child-Pugh C (32%) and Child-Pugh A (28%). In the current study, free T3, free T4, and TSH levels were compared between cases and controls, and abnormal values were found in cases, indicating a statistically significant difference. Serum thyroid profile abnormalities were observed as Child-Pugh Score Classes advanced, and the difference was statistically significant for free T3 and free T4. Conclusion: As compared to healthy subjects, patients with liver cirrhosis had abnormally high levels of circulating thyroid hormone, and severe abnormalitieswere linked to an advanced Child Pugh score. Derangement in thyroid profile is common in patients with cirrhosis of liver. Low free T3 and T4 levels are associated with more severe liver injury and may be used for prognostication in patients with cirrhosis of liver. Keywords: chronic liver disease; NAFLD, cirrhosis, Liver function tests; Free T3 and T4; TSH;

Tapas tripathi

Oecophylla longinoda has some reported medicinal uses, including antimicrobial, analgesic, and anti-inflammatory activities. This study was designed to investigate the Oecophylla longinoda methanol extract to evaluate the toxicity profiles of its acute and sub-acute effects. The experiments were conducted to determine the oral median lethal dose (LD50) and other gross toxicological manifestations on an acute basis. In the first phase of the acute toxicity study, three per group were administered Oecophylla longinoda at single oral doses of 10, 100, and 1000 mg/kg body weight, and 1600, 2900, and 5000 mg/kg of Oecophylla longinoda in the second phase. In the sub-acute studies, the mice were orally administered 2.5 g/kg Oecophylla longinoda per day for 14 consecutive days. Rat body weight and fluid intake were recorded during the 14 days. The rat kidney, heart, liver, and blood sera were obtained for weight, histological, and biochemical markers including glucose, cholesterol, proteins, triglycerides, enzymes including ALT, AST, and ALP, as well as electrolytes (sodium and potassium) examinations. Results show that the methanol extract of Oecophylla longinoda is safe, and no significant changes in the biochemical markers that indicate harmful effects on the kidney and liver were observed in mice. However, the liver showed slight changes while the kidneys and heart remained healthy in mice exposed to Oecophylla longinoda. The no-observed-adverse-effect limit was 5000 mg/Kg body weight/day.

Mediterranean journal of pharmacy and pharmaceutical sciences

Ecbalium elaterium has a very violent effect on the body and has little use in modern herbalism. Little is known about the acute and chronic toxicities of ecbalium elaterium in human. This study aims to determine the acute toxicity (LD50) of fruit extract and another aerial part extract of the ecballium elaterium in experimental animals. Thus, male albino mice were divided into different groups each group consists of six mice receiving 40, 46, 52, 61, and 69 mg/kg of fruit extract of ecballium elaterium, respectively. Other groups were given 1000, 1412, 1995, 2818, and 3981 mg/kg of the areal part of ecballium elaterium extract, respectively. The LD50 in both treatments was determined by using the Spearman-Karber method. The LD50 of the fruit and aerial parts of ecballium were 55 mg/kg and 2112.5 mg/kg, respectively. The present findings showed significant weight loss after one month of treatment with 1400 mg/kg and 40 mg/Kg of fruit and aerial part extracts, respectively. The results indicated that the fruit extract is highly toxic as compared to the extract of the aerial parts.

Mediterranean journal of pharmacy and pharmaceutical sciences

This research paper focused on the role of FDI in Indian automobile sector& dramatic changes in automobile sector after 1991’s open economy policy of Govt. This paper also attempt to splash light on some important aspects such as the journey of Indian Automobile sector from scratch to spectacular progress with combination of foreign technology & Indian talents, growth in direct & indirect employment, economic development of some important aspect in country like GDP as well technology transfer, improvement in R&D through the automobile clusters in country, focusing on potential of Indian automobile sector which is attracting Foreign investment.As well the policy support (Automobile mission plans 2006-16, 2016-2026, NATRiPS, Make in India Mission) by the Central & State Government for establishment of production facilities attracted automakers worldwide. As FDI is key driver not only in terms of inflow of FOREX but changes in the attitude of Government, Customers, &Automakers itself.

Anshuman vijay magar

Background: Parkinson’s disease (PD) is one of the most common, disabling neuro-degenerative disorders. The disease has a significant clinical impact on patients, families, and caregivers through its progressive degenerative effects on mobility and muscle control. Available treatments for PD have varied results. Although there are anecdotal reports of improvement with Homoeopathy, there is a dearth of literature concerning usefulness in management of PD Objectives: To assess the usefulness of ultrahigh dilution of Zinc in the management of PD. Methods: A case of PD under standard care and refractory to treatment visited Out- Patient Department and was assessed with and Unified Parkinson’s Disease Rating Scale (UPDRS). As per the classical Homoeopathic guidelines Zincum metallicum 200 was prescribed after Repertorization. Results: UPDRS total score of 112 at baseline turned to 40 at the end of 1 year and 7 at the end of two years, in spite of reduction in the conventional medicines. Patient was on Stage 3 of Modified Hoehn and Yahr staging at the baseline and turned to Stage O in duration of 21 months. SEADL score has turned from 40% to 100%. Conclusion: Homoeopathic medicine Zincum met. is a valuable adjuvant in the management of Parkinson’s disease.

Dr deepthi gilla

The scaling of metabolic rates with body mass is one of the best known and most studied characteristics of aquatic animals. We studied here how size is related to oxygen consumption, ammonia excretion and O: N ratio in Freshwater Bivalve Mollusc Lamellidens marginalis species in an attempt to know how size specific changes affect their metabolism. The freshwater bivalve molluscs with specific size i.e. small (77 79 mm in shell length) and large (90 93 mm in shell length) were selected for experimental work from Bhima River at Siddhatek on December and January during winter. The adult bivalve molluscs with small size reported high value in oxygen consumption and O: N ratio but ammonia excretion was low value in small sized bivalves compared to large ones. The results are discussed in the glow of metabolic processes in fresh water bivalve molluscs.

Dr. pritesh ramanlal gugale

This study was carried out to evaluate the effects of thermal processing techniques on the nutrient and antinutrient contents of pigeon pea (Cajanus cajan) flours. The pigeon pea seeds were sorted, cleaned and divided into five equal lots of 0.5kg each. Four lots of pigeon pea seeds were processed into blanched, boiled, roasted, and autoclaved pigeon pea flours, while the fifth lot was processed raw and used as control. The raw and thermally processed samples obtained were analysed for nutrient and antinutrient composition using standard methods. The proximate composition of the samples showed that the flours had a range of 8.61 - 11.46 % moisture, 21.13 - 23.94 % crude protein, 1.26 - 1.68 % fat, 5.12 – 6.10 % crude fibre, 1.74 – 2.97 % ash, 55.56 – 60.41 % carbohydrate and 333.45 - 342.75 kJ/100g energy, respectively. The mineral composition showed that the flours contained 86.24 – 144.72 mg/100g calcium, 137.80 – 170.33 mg/100g magnesium, 125.86 - 156.76 mg/100g potassium, 66.66 – 95.62 mg/100g sodium, 4.38 – 6.64 mg/100g iron and 130.27 – 178.29 mg/100g phosphorus, respectively. The vitamin content of the flours were 3.09 - 4.33 mg/100g ascorbic acid, 0.05 - 0.17 mg/100g thiamine, 0.03 - 0.21 mg/100g riboflavin, 0.13 - 0.28 mg/100g niacin, 3.21 - 6.25 mg/100g vitamin A and 1.10 - 2.70 mg/100g vitamin E, respectively. The antinutrient composition of the flours also showed that the levels of trypsin inhibitor, tannin, phytate, oxalate, saponin and haemagglutinin ranged from, 2.30 – 5.61 Tiu/mg, 0.81 – 1.5mg/100g, 1.12 - 4.18mg/100g, 0.48-4.01 mg/100g, 1.28 – 3.66 mg/100g and 1.30 – 7.44 Hiu/g, respectively. Therefore, the study showed that thermally processed pigeon pea flours could be used as nutrient dense ingredients in the preparation of a wide range of foods for children, adolescents and aged adults especially in developing countries where the problems of protein-energy malnutrition and micronutrients deficiencies are prevalent than the raw sample.

Okechukwu obed chukwuemeka

This study examined the spatial distribution pattern of public lower basic schools for the implementation of lower basic education in Rivers State. One research question guided the study. The descriptive survey design was used. The population for the study was the 942 public lower basic schools in Rivers State. Stratified random sampling technique was used to draw the sample size of 289 schools. A handheld Global Positioning System receiver was the instrument used for the study. Nearest neighbour analysis was used to answer the research question. Findings revealed that the overall pattern of distribution of existing public lower basic schools in Rivers State is clustered. Specifically the distribution of schools in Degema and Akuku-Toru Local Government Areas is dispersed with Rn of 1.72 and 1.36 respectively. The pattern of distribution of Bonny, Opobo/Nkoro, Abua/Odual, Port Harcourt, Obio/Akpor and Ikwerre indicates a clustered pattern with Rn of 0.91, 0.83 0.84, 0.74, 0.72 and 0.24 respectively. The study therefore recommended among other things that the state governments should make policies that guide school mapping and ensure their strict compliance. Since school mapping is an integral aspect of micro-planning, every local government should be statutorily required to have a comprehensive school map of its area that should be updated at least every decade. The services of professional planners should be utilized by the Ministry of Education and should also ensure that modern mapping equipment are deployed for this very important exercise.

Fxintegrity publishing

Gingivitis, a reversible inflammation of the gums leads to an advancement to periodontitis, a more severe and often irreversible stage characterized by the destruction of connective tissue and bone, potentially leading to tooth loss. This study was designed to develop and evaluate muco-adhesive buccal films containing metronidazole for localized treatment of periodontal disease, aiming to reduce systemic side effects and improve therapeutic efficacy. Thin films were prepared using chitosan as the primary polymer, combined with various copolymers (HPMC, MC, EC, PVP, HPC, and Carbopol) via the solvent casting technique. Thirteen formulations (F1-F13) were investigated for their ability to control the in vitro drug release, surface pH, folding endurance, drug content uniformity, and muco-adhesion, in addition to studying drug release kinetics. Formulations F12 (60.0% HPMC, 20.0% chitosan) and F13 (20.0% HPMC, 60.0% chitosan) showed optimal surface pH (≈6.7-7.0) with high muco-adhesion characteristics (49-51 Mn/m). Sustaining or expediting the drug release rate was manipulated by tailoring the polymer composition within the studied formulations. Examining drug release data has shown that the release kinetics followed the Korsmeyer-Peppas model, indicating diffusion and polymer relaxation mechanisms. The study demonstrates that polymer selection, in addition to the chosen ratio allows customization of release kinetics, Formulation F9 (20.0% HPC, 60.0% Chitosan) was proven to have the ability to provide the most sustained release characteristics. These findings support the potential of chitosan-based muco-adhesive films as effective localized delivery systems for metronidazole in periodontal therapy.

Mediterranean journal of pharmacy and pharmaceutical sciences

The share of renewable energy share in India's energy mix of India has been increasing recently owing to the promotion and implementation of various government policies that promote the use of renewable sources of energy, depleting fossil fuel levels, increasing fuel prices, and stringent laws for emission reduction worldwide. The increase in the use of solar-evacuated-tube-collector-based domestic water heating is the result of this transition from conventional to nonconventional sources of energy. The recent urban agglomeration is challenging to install these solar water heaters in every household because the roof space is limited. Space reduction can be achieved by reducing the collector area by varying the diameter of the evacuated tubes. This study used a single tube and tank arrangement model with a fixed inclination to achieve a thermosyphon effect in a solar water heating system with three different diameter configurations of 48 mm, 54 mm, and 72 mm, with a tube measuring 1800 mm in length. Thermal assessment of the thermosyphon-based evacuated tube-solar water heater using the ANSYS CFD simulation software involves measuring the temperature at three different positions in the tank to study the thermosyphon initialization. This study signifies that the 72-mm-diameter evacuated tube is more capable of initializing the thermosyphon effect in the system. Nevertheless, the final temperature of the system is better achieved in the 48-mm-diameter evacuated tube

Swapnil ratnakar mane

Diabetes mellitus (DM) is considered as ”the mother of all diseases" because it causes many complications. Knowing and measuring medication adherence may have a greater effect on DM patients. Several studies in Indonesia used a questionnaire scale to measure adherence, however they do not validate the study population, so it could still be found anomalous correlation analysis between adherence and clinical data even though it measured in the same country and scale. This study measure the adherence level of type 2 diabetes patients, evaluates the validity of the medication adherence scale, and analyze the correlation with the clinical outcome of type 2 diabetes patients in four health centers in Banyumas district. The study uses a cross-sectional design in Prolanis type 2 DM patients of January -April 2020. The adherence is measured by MARS-10, backward-forward translation method followed by content and internal validation. Clinical outcome is evaluated based on fasting blood glucose measurement. The results of the MARS-10 Gregory index analysis showed content validity in the high category (IG ≥ 0.8). The content validity showed the results of 9 questions with the value of r count> r table (n = 30, r table = 0.361). Reliability analysis showed Cronbach's Alpha 0.747> 0.6. The measurement showed 80.3% were adherent patients and 19.3% were non-adherent patients. Correlation analysis showed that there was no significant relationship (p> 0.05) between patient adherence and clinical outcome. Those results showed that type 2 diabetes mellitus patients in 4 health centers were categorized as adherent but not correlated with the clinical outcome. This was enabled due to the clinical outcome was simultaneously influenced by several factors: general factors, individual factors, and unpredictable factors.

Much ilham novalisa aji wibowo

Over the years, pharmacy has developed from a simple floor stock system to a complex unit dose, I.V. additive, and clinical pharmacy program. This development would have never been possible without the support of the nursing, medical, and administrative staff. The support of obtained slowly by developing services that increase the pharmacist's credibility as a team member concerned with the pediatric and neonate patients. These services include a unit dose program, I.V. additive program, drug information services, and pharmacy medication program. One area in which pharmacist does not obtain a background from generalized training is the area of pediatric dosing. Pediatric pharmacists must learn in clinical practice the proper dosing of the pediatric patient and neonate patient. The dose must be checked periodically. In the premature or newborn infant, the pharmacist must consider the immature renal and hepatic function so that he/she does not overdose initially and then underdose as the infant grows and matures. Neonates are a special group of children, they are less than 30 days, and within this group preterm babies (that means less than 37 weeks). Determining the correct dose for drugs used to treat neonates is a critically vital factor. Prematurity affects kidney and liver function and the proper adjustment of drug doses is crucial [1]. The absence of drug level necessitates the adjustment of drug doses and the presence of qualified oriented dependable pharmacists. Drug doses are not numbers, or decimals used within the therapeutic range. Neonatal Intensive Care Unit (NICU) needs a system for the calculation and preparation of drugs [2].

Mediterranean journal of pharmacy and pharmaceutical sciences

Prevalence of hypovitaminosis D is not restricted to the elderly and hospitalized population. Worldwide, the rate of prevalence of vitamin D deficiency has grown up rapidly in adults over the past decades. Among Libyan population including young students may has a high risk of vitamin D deficiency. The aims of this study were to examine vitamin D status among pharmacy students of Sebha University and to study the hematological profile as well as correlation of vitamin D deficiency with incidence of anemia among the students. This study was carried out on Pharmacy students from 13th January to 12th March, 2020. This is a cross-sectional study designed to determine vitamin D status among healthy young pharmacy students studying at the Sebha University. The blood samples were collected randomly from 62 pharmacy students to analysis complete blood count and 25-hydroxyvitamin D. The concentration of hemoglobin on total student was 12.5 ± 1.9 g/dl which was normal according to the WHO level (12.0 g/dl). Out of total, 36 students (59.1%) were found to have normal hemoglobin concentration (13.7 ± 1.4 g/dl) and 26 students (40.9 %) were found to have low hemoglobin concentration (10.8 ± 1.1 g/dl). Other blood profile as HCT, MCV, MHC and MCHC where statistically significant lower but the counts of RBCs, WBC and platelets were not on anemic group comparing to normal group. The present study reported that majority of pharmacy students in male and female blood donors have low vitamin D levels which represent (87.0%). Out of the total participants (n = 54) who have low vitamin D (n = 49, 79.0%) were classified under vitamin D deficiency category while (n = 05, 08.0%) of students had vitamin D insufficiency. In conclusion, prevalence of hypovitaminosis D (low 25-hydroxyvitamin D) among the pharmacy students at Sebha University was highly occurrence with concomitant a high rate of prevalence of anemia. Thus, vitamin D deficiency at this age represents a public health problem that should be addressed.

Mediterranean journal of pharmacy and pharmaceutical sciences

Hemodialysis patients suffer from poor health-related quality of life which results in a higher risk of hospitalization and mortality. This study investigates the importance of pharmaceutical care and role of pharmacist for hemodialysis patients to optimize drug therapy, minimize drug related problems and thereby improving their health-related quality of life. The study was conducted to evaluate the impact of pharmaceutical care interventions on health-related quality of life of hemodialysis patients in Benghazi, Libya. Randomized control study was carried out after getting an ethical approval from the committee of the hospital. Health-related quality of life was assessed using SF-36 instrument for all the patients (n = 80). Among them, 40 patients were received the normal care along with brief medication review and counselled by pharmacists for two months. Then, health-related quality of life was assessed again for those 40 patients who received the pharmaceutical care. Data was analyzed using an appropriate methods. The results showed that the quality of life for hemodialysis patients was poor in both physical and emotional aspects. After implementation of appropriate pharmaceutical care to the patients, their quality of life improved significantly. Health-related quality of life is an important determinant of treatment effectiveness in dialysis patients

Mediterranean journal of pharmacy and pharmaceutical sciences

Tonsil stones, also known as tonsilloliths or tonsiliths, are usually tiny white or yellowish mineralized structures packed with organic debris and bacteria that develop in the enlarged palatine tonsillar crypt. Tiny tonsillitis is commonly detected in diagnostic imaging such as computed tomography (CT) and less so in panoramic radiography, with the prevalence increasing with age. Giant tonsilloliths are rare and most reported cases have been in adults, with only a few cases reported in the pediatric population. In this report, we described a 9-year-old girl who had suffered from halitosis for 6 months and odynophagia with oropharyngeal foreign body sensation for 2 weeks and was later diagnosed with a tonsil stone.

Karishma

Parkinson’s disease, first described by James Parkinson in 1817, is a neurodegenerative ailment resulting from the damage of nerve cells in the brain. It is a chronic, progressive, neurodegenerative disorder with an estimated prevalence of 31 to 328 per 100,000 people worldwide. It is estimated that more than 1 percent of the population over age 65 are afflicted with Parkinson’s disease; incidence and prevalence increase with age. There are numerous unanswered questions regarding the diagnosis and management of Parkinson’s disease. Worsening mobility, causing problems with activities of daily living, pain and communication problems due to rigidity of facial muscles, are the main reasons of their decreasing quality of life. This study is focused on the role of psychological variables, which could be associated with quality of life in PD patients. After their identification a discussion about opportunities of improvement patient’s quality of life can be opened. Current drug therapies for human PD with Levodopa or various dopamine receptor agonists offer symptomatic relief and appear to have little effect on the neurodegenerative process. More than 50% of patients with PD treated over 5 years with Levodopa will develop complications such as motor fluctuations and dyskinesia’s. In this scenario, slowing the progression of PD through neuroprotective or restorative therapy is a major focus of research. From a pharmacologic standpoint, current strategies involve interrupting the cascade of biochemical events that leads to death of dopaminergic cells. The significance of many indigenous medicinal plants and their phytoconstitutents in the management of Parkinsonism with minimal side effect profile arise in this context

Zeenath banu

Blister beetle, Mylabris pustulata (Thunb.) is a polyphagous pest attacking flowers of pigeonpea (Cajanus cajan), cotton (Gossypium sp), lady’s finger (Abelmoschus esculentus), mungbean (Vigna radiata), urdbean (Vigna mungo), ricebean (Vigna umbellata) etc. throughout the country. Because of its polyphagous feeding nature and hard protective adaptation against insecticides, long term management of this pest with a single molecule is difficult. Therefore, field cum laboratory experiments were carried out for three consecutive cropping seasons during kharif 2008-09, 2009-10 and 2010-11 to find out the persistence and efficacy of different insecticides. It was found that decamethrin 2.8EC was 3334 times toxic with lowest LC50 value (0.0000563) followed by monocrotophos 36SL as compared with endosulfan which was the least toxic with LC50 value (0.1877). Insecticides evaluated for their persistent toxicity during 2009-10 revealed that decamethrin and thiodicarb caused cent per cent mortality of adult blister beetle immediately after spray. At 8th days after spraying, decamethrin caused 60 per cent mortality. Insecticides evaluated for their efficacy during the year 2010-11 revealed that the plants were found free from adult blister beetle population in treatments involving decamethrin and cypermethrin even at ten days after spray. Among all the treatments, spraying of thiodicarb 75WP @ 625 g ha-1 provided the highest grain yield (18.87 q ha-1). Maximum cost-benefit ratio was observed in monocrotophos 36SL, cypermethrin 25EC and decamethrin 2.8EC

Dr. babu lal jat