In the modern world, Tuberculosis (TB) is regarded as a serious health issue with a high rate of mortality. TB can be cured completely by early diagnosis. For achieving this, one tool utilized is CXR (Chest X-rays) which is used to screen active TB. An enhanced deep learning (DL) model is implemented for automatic Tuberculosis detection. This work undergoes the phases like preprocessing, segmentation, feature extraction, and optimized classification. Initially, the CXR image is preprocessed and segmented using AFCM (Adaptive Fuzzy C means) clustering. Then, feature extraction and several features are extracted. Finally, these features are given to the DL classifier Deep Belief Network (DBN). To improve the classification accuracy and to optimize the DBN, a metaheuristic optimization Adaptive Monarch butterfly optimization (AMBO) algorithm is used. Here, the Deep Belief Network with Adaptive Monarch butterfly optimization (DBN-AMBO) is used for enhancing the accuracy, reducing the error function, and optimizing weighting parameters. The overall implementation is carried out on the Python platform. The overall performance evaluations of the DBN-AMBO were carried out on MC and SC datasets and compared over the other approaches on the basis of certain metrics.

Dr h shaheen

Crude methanol extracts of the leaves of Adenanthera pavonina L., Peltoforum roxburghii L, Prosopis cineraria L., and Prosopis juliflora DC., were evaluated for anti-emetic activity. Emesis was induced by the oral administration of copper sulphate 50mg/kg body weight to male chicks of four days age. The anti-emetic activity was determined by calculating the mean decrease in number of retching in contrast with those of control. All extracts (150 mg / kg body weight orally) showed anti-emetic activity when compared with standard drug Chlorpromazine at the same dose. Among all the extracts, Prosopis juliflora showed the highest (73.64%) and Adenanthera pavonina showed the lowest (50.17%) anti-emetic activity

Dr. salman ahmed

The aim of the study was to explore the inhibition and modulation of calcium oxalate monohydrate crystals into calcium oxalate dihydrate by phytic acid. The study was carried out on glass slides using phytic acid (1 - 5%) solutions. All tested solutions inhibited the growth and modulated calcium oxalate monohydrate crystals. Donuts, rosettes and X-shape crystals of calcium oxalate monohydrate along with their defected forms were observed. The presence of calcium oxalate dihydrate crystals as elongated rods and tetragonal bipyramidal crystals revealed the modulated forms of calcium oxalate monohydrate. Smaller zones of nucleation are declared as general patterns of growth inhibition. This study gives valuable information about calcium oxalate crystals' inhibition and modulation patterns. Further studies are required to confirm the results of the present study.

Dr. salman ahmed

WSN is a low-power system and are often used in numerous monitoring uses, such as healthcare, environmental, and systemic health surveillance, in addition to military surveillance. It is important to reduce network resource usage since many of these applications need to be installed in locations that are virtually inaccessible to humans. Many protocols for WSN to extend the presence of the network have been established to solve this problem. In the energy efficiency of WSN networks, routing protocols play an important role since they help minimize power usage and response time and provide sensor networks with high data density and service quality. This study also employed a Hopfield neural network and the findings from this study are presented next to each other to enable comparison. This paper also discusses how to easily and accurately capture and handle WSN collisions. Future experiments that require the usage of neural networks and so many fuzzy structures will be able to prevent a crash in these respects.

Mohd haroon

This study was aimed at investigating the extent to which signage and ICT facilities correlate to the utilisation of information resources in federal university libraries in South-South zone of Nigeria. The correlational research design was adopted for the study. Three research questions were answered while three hypotheses were tested. The population of the study comprised 32,190 registered library users for the 2017/2018 academic session and 776 library staff from six federal university libraries in south-south zones of Nigeria. The sample size for the study was 3,219 registered library users and 310 library staff representing 10% and 40% of the population respectively. A two-stage sampling technique of stratified and simple sampling techniques was used to select the sample size. Two Sets of instruments titled; “Signage and Information and Communication Technology Facilities Questionnaire (SICTFQ)” for the students and “Utilization of Information Resources Questionnaire (UIRQ)”were used for data collection. Face and content validity was ensured by three experts. The two instruments yielded reliability coefficients of 0.81 and 0.87 respectively with the use of Cronbach Alpha. Mean was used in answering research questions while Regression was used in testing the null hypotheses at 0.05 alpha level. It was found that to a great extent signage relates to the utilisation of information resources while information and communication technology facilities is the vice versa. Based on the findings, it was concluded that jointly, signage and ICT facilities are significant correlate to the utilisation of information resources in federal university libraries in South–South zone of Nigeria. It was therefore recommended among others that library management should improve on the provision of signage by ensuring that well-designed signage suitable for the 21st century is placed at strategic location to guide library users on the utilisation of information resources in federal universities libraries in South-South zone of Nigeria.

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Garcinia cambogia, commonly known as Asam Gelugur, has entrenched itself as a traditional herbal medicine, renowned for its applications in treating obesity and its integration into global nutraceutical formulations. The bioactive compounds within, particularly hydroxy citric acid, mediate various effects. This study aims to assess the in vitro cytotoxicity of Taxol, a cytotoxic drug used as a control, and the aqueous extract from Garcinia cambogia against the Vero cell line - a kidney-like cell. Cytotoxicity was evaluated using the 3-(4,5-dimetyl-2-2thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide (MTT) assay. The assay relies on mitochondrial succinate dehydrogenase's potential to reduce MTT, providing a colorimetric indication of cell viability. The results revealed an IC50 value exceeding 500 µg/mL for the aqueous extract from Garcinia cambogia significantly higher than Taxol's 0.0581 µg/mL. This higher IC50 value implies lower toxicity, positioning the Garcinia cambogia extract as a safe component in nutraceuticals and herbal supplements. The aqueous extract of Garcinia cambogia demonstrates low cytotoxicity, reinforcing its safety profile for use in nutraceuticals, which contributes valuable insights into the safety considerations of incorporating Garcinia cambogia into herbal supplements.

Mediterranean journal of pharmacy and pharmaceutical sciences

Viral hepatitis is one of the main public health concerns around the world. Even though infection management techniques have been implemented over the last few decades, eradication or significant reduction has remained a mystery. The purpose of this study is to look into the prevalence of acute infectious hepatitis in the East of Libya and how the type of virus, age, gender, clinical manifestations, and outcome are related. This is a hospital-based retrospective study. The data on the frequency and distribution of viral hepatitis based on age, gender, seasonal, clinical, and ultrasound findings, and the outcomes during a period of two years from January 2020 to December 2021 were collected and analyzed. Of the 0.39% (72 cases) of total hospital admissions (18340) under the age of 15 years old for acute infectious hepatitis patients, the most common age group was 5-12 years (79.6%). Winter accounted for 41.6% of all the cases. Females made up 65.3% of the cases. Jaundice was the most prevalent presentation (87.5%). Hepatomegaly was seen in 83.3% of the patients. Most of the cases have mild hyperbilirubinemia (5-9 mg/dL, 75.0%). Approximately 1/5th of the patients' serum glutamic-oxaloacetic transaminase (SGPT), and nearly 1/3rd of the patients' SGPT levels were in the range of 1000-2000. One patient's hepatitis C was positive, one patient's hepatitis B was positive, and 97.2% were positive for hepatitis A. 88.8% of the individuals recovered without complications, whereas 11.1% showed symptoms of hepatic failure but recovered. The present study indicates that acute hepatitis A is more prevalent, especially in the winter. Those who are females and 5-12 years of age were more affected by acute viral hepatitis in Libya.

Mediterranean journal of pharmacy and pharmaceutical sciences

In the present study nanoparticles of lomustine were fabricated using chitosan polymer crosslinked with different crosslinking agents like sodium tripolyphosphate and sodium hexametaphosphate. Different formulations of nanoparticles were prepared using different concentrations of crosslinking agents and polyethylene glycol 6000. The average particle size ranged between 112 nm to 942 nm. Zeta potential of nanoparticles ranged between 29.0 mV up to 56.0 mV. Encapsulation efficiency was variable from 58%-96%. The nanoparticles were solid spherical. In vitro drug release study was carried out in phosphate buffered saline solution pH 7.4 for 10 h. The analysis of regression values of Higuchi plot suggested diffusional mechanism and follows Fick's law of diffusion. Drug polymer interaction was absent as evidenced by FT-IR spectra and DSC thermograms. With polyethylene glycol inclusion shows interaction between lomustine and PEG. Cell viability assay (MTT Assay) showed that the lomustine nanoparticles were able to reduce the tumour cell proliferation and increased cell viability significantly (p< 0.05) as compared to pure drug in L 132 human lung cancer cell line

Archana mehrotra

Aerva lanata species belonging to Amaranthaceae family (a.k.a mountain knot grass/Gorakha Ganga is a perennial shrub. It is self-pollinating, bisexual plant having globose like structure has various phytochemical constituents. Among the 28 species of Aerva, medicinal properties are likely to be present in Aerva lanata, Javanica and Persica varieties. Traditionally it was used in treating cough, dysuria, hemiplegic migraine and kidney related disorders. Flavonoid glycosides such as Kaempferol, Isorhamnetin, quercetin, flavanone are major phytoconstituents and minor constituents are apigenin, narcissin, ferulic acid, syringic acid and vanillic acid. Alkaloid glycoside includes Ervine, aervine etc. Aerva lanata has much more beneficial activities like demulcent, diuretic, ulcer wounds, rheumatism, Anti-malarial. Pharmacological studies included that aerva species has beneficial properties of antimicrobial, anti-urolithiasis, antiulcer, anti-asthmatic, acute kidney injury, anti-diarrheal activity, antioxidant, antihyperglycemic, hypolipidemic and antiulcer. Aerva lanata has promising role in the treatment of various diseases and metabolic disorders due to its higher antioxidant effect and other such constituents thereby providing better healthcare. Various such constituents are to be analyzed properly and to ensure that it was suffice to exhibit the pharmacological activity. Analytical methods are to be used promptly to find various concentration of substances present in the alcoholic extract of Aerva lanata plant.

Ankul singh

Industrial waste is one of the most essential sources of contamination in the environment. Chromium (Cr) is a toxic heavy metal, a major contaminant in tannery wastes and its accumulation in soil and water is a major environmental concern today. In the present study, an attempt was made and investigated the status of different beneficial microbes particularly plant growth promoting rhizobacteria (PGPR) from tannery sludge samples collected from tannery effluent treatment plant at Dindugal, Tamil Nadu, India. Experiments were conducted and evaluated their chromium heavy metal tolerance abilities and plant growth promoting activities under in-vitro. Based on molecular analysis, the PGPRs were identified as Achromobacter xylosoxidans (LK391696), Azotobacter vinelandii (LK391702) and. The production of IAA was found to be high by Achromobacter xylosoxidans (46μg/ml) followed by Azospirillum lipoferum (30μg/ml). Phosphate solublization activity was also found to be positive in all these PGPR isolates. Significance of these results revealed that there is a possibility of using these potential PGPRs for bioremediation of chromium contaminated sites and also as good plant growth promoter.

Dr. saranya devi k

The COVID-19 crisis has impacted all dimensions of our lives say it as the public health, the labour system, the social interaction, the political debate, the use of public spaces, the economy, the environment, and last but not the least it has proved to be a major contributor to the cultural value system of the individual living in society. This research paper is to analyse and understand the changes enforced by this pandemic on Indian culture and individual of the society. It also analyses the context of COVID-19 scenario with special reference to Indian culture and Hofstede’s theory of cultural dimension. This research paper is an attempt to emphasize the changes in culture and value system during the COVID-19 pandemic faced by India. India is enriched enough in cultural dimensions to combat COVID-19. The Hofstede’s model analysed in depth also leads to this finding that it also fits well in the present context. Thus, it is hereby summed up that as India is enriched in its cultural values it has posed itself as a fighter for this pandemic

Mamta gaur

Background Type 2 diabetes and obesity are serious public health concerns globally and a growing burden in Africa. Both conditions have serious repercussions on health when they co-occur, yet the extent of their co-occurrence in Africa remains unknown. Therefore, this review aimed to identify the prevalence and associated factors of overweight and obesity among persons with type 2 diabetes in Africa. Method A systematic search was conducted on PubMed, MEDLINE, Embase, African Index Medicus (AIM), and African Journals Online (AJOL) for observational studies that reported the prevalence of overweight and/or obesity among type 2 diabetes patients in Africa. The prevalence data from individual studies were aggregated through a random-effects meta-analysis. The I2 statistic was used to evaluate between-studies heterogeneity, while subgroup analysis and mixed-effects meta-regression were performed to identify sources of heterogeneity. We assessed publication bias using funnel plots and Egger’s test. This review adhered to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Results Of 1753 records retrieved, 80 articles were eligible for this review, with 74 cross-sectional studies included in the meta-analysis. The pooled prevalence of overweight and obesity was 35.6% and 25.6% respectively, while the overall prevalence of both overweight and obesity was 61.4%. Also, the pooled prevalence of both overweight and obesity across the five geographical areas in Africa ranged from 56.9% in East Africa to 88.5% in Southern Africa. Nineteen factors were significantly associated with overweight and obesity among patients with type 2 diabetes. Conclusion The high prevalence of overweight and obesity among patients with type 2 diabetes is a significant public health concern that transcends geographical boundaries within Africa. The findings from this review highlight the need for innovative weight management interventions that are tailored to the cultural context of the African setting

Emmanuel ekpor

The current study explores creative cultural tourism as a new model of the relationship between cultural heritage and tourism. Cultural heritage with its tangible and intangible components represents an essential part of culture tourism. Many changes have been happened in tourism due to new forms of consumption patterns, tourism activities, and tourism products. These changes require shifting from traditional culture tourism to creative cultural tourism as a new concept of cultural heritage. Tourists face many problems in the traditional culture tourism which is a form of mass tourism, thus, creative cultural tourism came to solve these problems. In addition, this study explains the transformation from traditional culture tourism to creative culture tourism.

Mukhles m. al-ababneh

Background: This manuscript presents an audit focused on assessing the extent of drug wastage and associated costs linked to the disposal of unused intravenous agents within the operating theatres of a tertiary care hospital. The study aims to carefully look at drug wastage, figure out why it happens, and propose strategies for optimizing resource utilization and cost-efficiency in clinical settings. Materials and Methods: This audit is a prospective observational study carried out in a tertiary care hospital. The amount of drug loaded preoperatively, the amount of drug utilized, the amount of drug unutilized and discarded, the total quantity of drug wasted, and the cost related to the wastage were calculated in percentage. Results: The maximum wastage of loaded drugs was seen with atropine (100%), followed by ephedrine (93.6%), propofol (52.5%), phenylephrine (35.2%), atracurium (28.6%), dexmedetomidine (27.8%), fentanyl (16.8%), vecuronium (16.2%) and morphine (6.4%). The cost analysis revealed that 36.3% of the total loaded drugs were wasted amounting to Rs.46903.54. The cost of wastage of propofol was maximum with Rs.14006 which is 29.8% of total cost wastage followed by atracurium 21%(Rs.9856), dexmedetomidine 18.4%(Rs.8687.5), ephedrine 14.7%(Rs.6919), phenylephrine 10.4%(Rs.4910), fentanyl 3.7%(Rs.1780), atropine 1.9% (Rs.906), vecuronium 1.2% (Rs.563.76), Morphine 0.18% (Rs.85.28). Conclusion: In our audit, the maximum drug wastage was observed with atropine (100%) amounting to Rs.906, and the cost of wastage was maximum with propofol amounting to Rs.14006 which was 29.8% of the total cost of wastage. Our audit underscores the importance of proactive management of drug wastage and disposal costs in healthcare settings, particularly within operating theatres where intravenous agents play a crucial role in patient treatment. By conducting a comprehensive audit and proposing targeted interventions, healthcare institutions can optimize resource utilization, enhance sustainability, and ultimately improve patient outcomes.

Kamal singh

The maximum H. armigera and M. vitrata infestation was recorded in Pusa-992 (3.72% and 7.90%) and in D2 (1st week of July) sown crop with infestation of 4.54 and 13.08 per cent, respectively. Whereas, the infestation of pod fly, M. obtusa was maximum in Manak (2.72%) and 2.58 per cent pod infestation in D2 (1st week of July) sown crop. The infestation of pod borer complex was negatively associated with pod wall thickness (-0.909**, - 0.739*, -0.870*, -0.834*, -0.840*, -0.705* and -0.745*) and non-glandular type A (-0.730*, -0.945**, -0.768*, -0.766*, -0.923** and -0.728*) and (-0.751*, -0.759*, 0.766*, -0.852*, -0.802*, -0.895** and -0.832*) glandular type B (-0.864*, -0.734*, -0.871* and -0.858*) and (-0.729*, -0.705*, -0.730* and -0.845*) density of pod trichomes of top and middle canopy of the plant. Fat (-0.884**, -0.754*, -0.743*, -0.871* and -0.750*) phenol (-0.900** and -0.806*) and tannin (-0.792*, -0.812* and -0.763*) content showed negative correlation with the pod infestation, whereas, crude protein (0.740*, 0.881**, 0.734*, 0.810*, 0.823*, 0.856*, 0.844* and 0.711*) and total soluble sugar (0.738*, 0.792*, 0.793*, 0.898**, 0.714*, 0.816*, 0.888** and 0.819*) showed positive association. Based on the results, it can be concluded that the variety Pusa-992 and Manak was most susceptible to the pod borers.

Dr. babu lal jat

The purpose of this paper is to offer insights that can help researchers to link ontology, epistemology and research methodology. This paper outlines the links among ontology, epistemology and research methodology by exploring ontological, epistemological and methodological perspectives in the research. It discusses how ontological and epistemological issues influence research methodology by providing a clear understanding of different research methodologies based on ontology and epistemology. Furthermore, attention is given to research aspects such as the elements of the research process, research philosophy, research approach, research strategy, the choice of method, and research design

Mukhles m. al-ababneh

All the people who need loan may turn to their local banks, credit unions or peer to peer lenders. Every lending institution has its own advantages and drawbacks. In this scenario credit risk management becomes increasingly important element as the same is concerned with managing the financial debts and safeguarding the interest of the banks. The purpose of credits given by banks is to earn interest and make profits. The important function of credit management is to decide how much credit should be given to the borrower and ensuring compliances with the credit terms of repayment and avoid Non-Performing Assets (NPA) to the banks. Credit risk is the biggest risk the bank faces by the virtue of nature of business, inherits. The ability of commercial banks to formulate and adhere to policies and procedures that promote credit quality and curtail non-performing loans is the means to survive in the stiff competition. Inability to create and build up quality loans and credit worthy customers leads to default risk and bankruptcy as well as hamper the economic growth of the country

Shaila kamath

Mosquitoes conveying Plasmodium store parasites into the skin of the mammalian host. Parasites make a trip through the circulation system to the liver, where they cross a few hepatocytes prior to building up a disease. Inside the last hepatocyte the parasite goes through morphogenesis and afterward abiogenetically partitions to become more than 20,000 blood-infective parasites, called merozoites. On account of P. vivax, P. ovale, and P. cynomolgi, the parasites can stay lethargic in the liver in structures called hypnozoites. The merozoites are delivered once again into the circulation system, where they start the repetitive blood stage. Inside erythrocytes, a little division of parasites separate into male or female gametocytes. These gametocytes are ingested by the mosquito during blood taking care of, where they will duplicate explicitly, in the long run prompting the arrangement of sporozoites

Rukshi naaz

Over the years, pharmacy has developed from a simple floor stock system to a complex unit dose, I.V. additive, and clinical pharmacy program. This development would have never been possible without the support of the nursing, medical, and administrative staff. The support of obtained slowly by developing services that increase the pharmacist's credibility as a team member concerned with the pediatric and neonate patients. These services include a unit dose program, I.V. additive program, drug information services, and pharmacy medication program. One area in which pharmacist does not obtain a background from generalized training is the area of pediatric dosing. Pediatric pharmacists must learn in clinical practice the proper dosing of the pediatric patient and neonate patient. The dose must be checked periodically. In the premature or newborn infant, the pharmacist must consider the immature renal and hepatic function so that he/she does not overdose initially and then underdose as the infant grows and matures. Neonates are a special group of children, they are less than 30 days, and within this group preterm babies (that means less than 37 weeks). Determining the correct dose for drugs used to treat neonates is a critically vital factor. Prematurity affects kidney and liver function and the proper adjustment of drug doses is crucial [1]. The absence of drug level necessitates the adjustment of drug doses and the presence of qualified oriented dependable pharmacists. Drug doses are not numbers, or decimals used within the therapeutic range. Neonatal Intensive Care Unit (NICU) needs a system for the calculation and preparation of drugs [2].

Mediterranean journal of pharmacy and pharmaceutical sciences

The study examined the impact of school enrolment growth on the carrying capacity of universities in Imo State, Nigeria. Three research questions and hypotheses guided the study. The study adopted the descriptive survey design with a population of 2,929 academic staff in the two public universities in Imo State. The sample size was 352 representing 12% of the population drawn using stratified random sampling technique. An instrument titled ‘School Enrolment Growth and Carrying Capacity of Universities Questionnaire (SEGCCUQ)’, structured on the 4 point scale, validated by experts and with reliability index of 0.84 was used for data generation. Mean and standard deviation were used to answer the research questions while z-test was used to test the hypotheses at 0.05 alpha level. Among others, the study revealed that factors such as natural increase of population, influx of migrants, enforcement of compulsory education, raising of school-leaving age, increased enrolment of girls and so on influence school enrolment growth that bear on the carrying capacity of universities. It was recommended among others that the factors should help the governments and institutions to forecast enrollment more effectively likewise permit them to make adjustments to meet current or future enrolment.

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