Here is presented a short review on the medical potency of the most toxic plant of Europe. In many countries it isn't concerned any more as therapeutic agent in medicine due to frequent intoxications. However, in the homeopathy, preparations and patent medicines still contain aconitine and other alkaloids (abundant levels). There exists even a US Patent "ACONITINE COMPOUNDS, COMPOSITIONS, USES, AND PREPARATION THEREOF" (No. US 9,085,536 B2 by du Bois et al. 2015).

Stefan dahl

In the present study, the bacterium Achromobacter xylosoxidans was isolated from tannery effluent sludge sample in Dindugal, Tamil Nadu, India and screened for its bio-control efficacy against selected plant pathogens viz., Alternaria solani, Curvularia lunata and Fusarium oxysporum under in vitro. It was observed that maximum percent inhibition of mycelial growth of C. lunata (95%), followed by A. solani (85%) and F. oxysporum (80%). An attempt was also made for testing its plant growth promoting traits such as production of Indole acetic acid (IAA), phosphate solubilization efficacy, Hydrogen cyanide (HCN), ammonia and catalase production. Significant amount of plant growth promoting traits were noticed. Further studies on mechanism of bio-control against plant pathogens and plant growth promoting activities of Achromobacter xylosoxidans need to be conformed under in-vivo condition.

Dr. saranya devi k

Treatment adherence is a critical component of epilepsy management. Antiepileptic drug side effects affect adherence and may result in the discontinuation of medication. This study aimed to investigate the association between antiepileptic drug side effects and medication adherence among Libyan patients with epilepsy while identifying predictors of adherence. A cross-sectional study was conducted at Tripoli University Hospital involving 200 adult epilepsy patients. Adherence was assessed via a self-report tool dichotomized as adherent/ non-adherent if patients stopped medication due to side effects. Side effects were evaluated using the Side Effects of Antiepileptic Drugs questionnaire. Logistic regression analyzed predictors of adherence, including antiepileptic drug use, therapy regimen, and side-effect profiles, with p<0.05 declared association. The overall adherence rate was 87.0%. Higher adherence was observed in older age groups, 95.8% in patients aged 51-60, 89.4% in married patients, and 91.0% in university-educated patients. Patients on monotherapy and those seizure-free in the preceding month demonstrated better adherence (88.4% and 93.0%, respectively). Valproate users had notably low adherence (52.6%) while carbamazepine and phenytoin users showed higher adherence (89.7% and 91.7%, respectively). Cognitive complaints significantly reduced adherence (76.1% vs. 79.6%), as did aggressive behavior (58.3% adherence). Logistic regression identified two independent predictors: patients on old-generation antiepileptic drugs had 2.7 times higher adherence (AOR=2.702, 95% CI: 1.168-6.249; p=0.02) while cognitive side effects reduced adherence by 86.4% (AOR=0.136, 95% CI: 0.031-0.596; p=0.008). Cognitive side effects predict non-adherence, necessitating routine monitoring. Paradoxically, older antiepileptic drugs correlated with better adherence. Integrating patient-reported metrics and addressing cognitive impacts could optimize epilepsy care, highlighting gaps in side-effect management and advocating personalized strategies in clinical settings.

Mediterranean journal of pharmacy and pharmaceutical sciences

This review was aimed to describe a new approach of healthcare performance strategy based on individual genetic variants. Personalized medicine is a model for health care which is a combination of preventive, personalized, participatory and predictive measures. It is an approach for a better treatment by identifying the disease causing genomics makeup of an individual. This work features key advancements in the improvement of empowering advances that further the objective of customized and precision medication and the remaining difficulties that, when tended to, may produce phenomenal abilities in acknowledging genuinely individualized patient consideration. Customized treatment for patients determined to have strong tumors has brought about a few advances as of late. To improve a multi-drug approach ready to coordinate DNA and RNA adjustment, proteomics and metabolomics will be essential. The execution of translational examinations dependent on fluid biopsy and organoids or xenografts to assess molecular changes because of clonal weight produced because of the utilization of target specialists or tumor heterogeneity would help in the recognition of systems of opposition, proposing opportunities for novel mixes. The investigation of massive data in oncology can profit altogether from being engaged by artificial intelligence and machine learning strategies.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background: Malnutrition is a deficiency of nutrients due to inadequate energy intake. Picky eating behavior in children could be a cause of malnutrition, but previous studies’ results were still inconsistent. This study aimed to determine the relationship between picky eating behavior and malnutrition among children aged 2-5 years. Methods: This case-control study involved 70 children aged 2-5 years in Kutukan Village, Randublatung District, Blora Regency. Malnutrition was defined as a weight-for-age Z score <-2.0 SD based on the WHO classification. Child eating behavior was evaluated using the Child’s Eating Behavior Questionnaire (CEBQ), identifying picky eaters if the food avoidance score surpassed the food approach score. Data analysis employed the Chi-Square test. Results: Boys experienced more malnutrition, with 20 (57.1%) affected, and the most affected age group was 24-35 months, with 19 (54.3%). Questionnaire processing revealed that the number of picky-eater children in the malnutrition group was 33 (94.3%), while in the non-malnutrition group, there were 31 (88.6%). Bivariate analysis showed no relationship between picky eating behavior and malnutrition in children aged 2-5 years (p=0.673; CI 95%=0.364-12.459). Conclusion: This study found no significant relationship between picky eating and malnutrition in children aged 2-5 years.

Minidian fasitasari

Objective As technology continues to improve, it plays an increasingly vital role in the practice of medicine. This study aimed to assess the feasibility of the implementation of virtual reality (VR) in a rheumatology clinic as a platform to administer guided meditation and biofeedback as a means of reducing chronic pain. Methods Twenty participants were recruited from a rheumatology clinic. These participants included adults with physician-diagnosed autoimmune disorders who were on a stable regimen of medication and had a score of at least 5 on the pain Visual Analog Scale (VAS) for a minimum of 4 days during the prior 30 days. VAS, part of most composite outcome measurements in rheumatology, is an instrument used to assess pain that consists of a straight line with the endpoints ranging from “no pain at all” and “pain as bad as it could be.” Patients were randomized into two groups that differed in the order in which they experienced the two VR modules. One module consisted of a guided meditation (GM) environment, whereas the other module consisted of a respiratory biofeedback (BFD) environment. Data on pain and anxiety levels were gathered before, during, and after the two modules. Results The three most common diagnoses among participants were rheumatoid arthiritis (RA), lupus, and fibromyalgia. There was a significant reduction in VAS scores after BFD and GM (P values = 0.01 and 0.04, respectively). There was a significant reduction in Facial Anxiety Scale after the GM compared with the BFD (P values = 0.02 and 0.08, respectively). Conclusion This novel study demonstrated that VR could be a feasible solution for the management of pain and anxiety in rheumatology patients. Further trials with varying treatment exposures and durations are required to solidify the viability of VR as a treatment option in rheumatology clinics

Ben spielberg

The quality of software systems may be seriously impacted by specific types of source code anomalies. For example, poor programming practices result in Code Smells (CSs), which are a specific type of source code anomalies. They lead to architectural problems that consequently impact some significant software quality attributes, such as maintainability, portability, and reuse. To reduce the risk of introducing CSs and alleviate their consequences, the knowledge and skills of developers and architects is essential. On the other hand, ontologies, which are an artificial intelligence technique, have been used as a solution to deal with different software engineering challenges. Hence, the aim of this paper is to describe an ontological approach to representing and analyzing code smells. Since ontologies are a formal language based on description logics, this approach may contribute to formally analyzing the information about code smells, for example, to detect inconsistencies or infer new knowledge with the support of a reasoner. In addition, this proposal may support the training of software developers by providing the most relevant information on code smells. This ontology can also be a means of representing the knowledge on CSs from different sources (documents in natural language, relational databases, HTML documents, etc.). Therefore, it could be a valuable knowledge base to support the struggle of software developers and architects either to avoid CSs or to detect and remove them. The ontology was developed following a sound methodology. The well-known tool Protégé was used to manage the ontology and it was validated by using different techniques. An experiment was conducted to demonstrate the applicability of the ontology and evaluate its impact on speeding up the analysis of CSs.

Mehdhar s. a. m. al-gaashani

Hemolytic uremic syndrome (HUS) is a microangiopathic thrombotic disease, which is classified into atypical, typical, and secondary types. Thrombocytopenia, acute kidney failure, and hemolysis are the main features of HUS regardless of its type. Infection with Shiga toxin-producing Escherichia coli causes typical HUS, and gene mutations trigger atypical HUS, while secondary HUS is associated with bone marrow transplantation, autoimmunity, cancer, and other diseases. New insights into the pathogenesis of HUS have emerged over the past decades, suggesting an important role of the complement system in disease pathogenesis, which has been reinforced by the efficacy of plasma exchange and monoclonal antibodies in its treatment. In this review, we performed an updated review of HUS with a focus on understanding its pathogenesis.

Karishma

Nilai-nilai Nasionalisme yang diterapkan peserta didik dalam kegiatan pembelajaran di Madrasah Ibtidaiyah Maarif Condro Jember seringkali terkesan dikesampingkan. Hal ini dilihat dari kurangnya kesadaran peserta didik terhadap nilai moral dan Nasionalisme, seperti tidak mentaati peraturan sekolah, tidak menghargai teman, membolos, tidak mampu menghafal sila pancasila serta lagu Indonesia raya. Masih dijumpai peserta didik berperilaku dan bersikap belum baik atau masih rendah terhadap nilai-nilai nasionalisme. Penelitian ini bertujuan untuk mendeskripsikan: 1) Strategi internalisasi nilai nasionalisme pada pembelajaran PPKN di Madrasah Ibtidaiyah Maarif Condro Jember. 2) Penerapan nilai karakter nasionalisme yang dilakukan pada pembelajaran PPKN di Madrasah Ibtidaiyah Maarif Condro Jember. Hasil penelitian menunjukkan bahwa: 1) Strategi internalisasi nilai-nilai nasionalisme dalam pembelajaran PPKN ini adalah mamasukkan nilai-nilai nasionalisme dalam pembelajaran PPKN melalui pendekatan-pendekatan yang mampu diterima oleh peserta didik agar peserta didik bisa menjadi warga negara yang baik dan bisa memberikan kontribusi dalam memajukan bangsanya dimasa depan. 2) Penerapan nilai karakter nasionalisme dalam pembelajaran PPKN melalui mediator keteladanan guru dan kegiatan praktik langsung melalui pengalaman belajar seperti model pembelajaran, metode pembelajaran, bahan ajar, dan evaluasi pembelajaran. Perilaku berkarakter nasionalis yang diaktualisasikan dalam kehidupan sehari-hari di sekolah oleh siswa yaitu disiplin, cinta tanah air, semangat kebangsaan, cinta damai, peduli lingkungan, menghargai prestasi, dan toleransi.

Educare: journal of primary education

The exploration encompasses the diverse dimensions of the Verbesina genus, a cluster of flowering plants within the Asteraceae family, comprising 340 species with varied growth patterns and floral attributes. Traditional medicinal practices associated with Verbesina species across different cultures are scrutinized, emphasizing the necessity for scientific validation of these ethnomedicinal traditions. Through chemical and pharmacological profiling, Verbesina plants reveal a plethora of bioactive compounds and therapeutic potentials, propelling drug discovery and development opportunities. Safety considerations, conservation challenges, and sustainable harvesting practices emerge as pivotal factors in maximizing the benefits of Verbesina species while minimizing environmental impacts. Finally, we underscore the significance of collaborative research efforts, recognizing the invaluable contributions of our professional colleagues and researchers in related fields in fully harnessing Verbesina plants' medicinal, healthcare and conservation potentials, promising groundbreaking discoveries and applications with profound implications for human well-being.

Dr. salman ahmed

To prevent the spread of COVID-19, the government has issued a learning policy to be carried out online (online). As implemented at Baiturrohman Elementary School, online learning is applied. This research uses a qualitative approach, and the type is a case study. Data collection techniques used participatory observation, structured interviews, and documentation—data analysis using data condensation, data presentation, and concluding. The validity of the data is source triangulation and technical triangulation. The results of this study indicate: (1) Planning the Recitation Method for Arabic Language Subjects in Online Learning at Baiturrohman Elementary School, namely: The teacher determines the goals according to the lesson plans, gives assignments according to the student's abilities, determines the types of assignments such as reading, writing, and practice. Provide instructions/resources in student books and several applications. The teacher provides time for the deadline for submitting assignments from 07.30 to 18.00 in Google Classroom. (2) Implementation of the Recitation Method on Arabic Language Subjects in Online Learning at Baiturrohman Elementary School, namely: Teachers provide guidance if they have difficulties, provide motivation to study at home, and support parents for children's learning at home; students do assignments at home independently. independent. (3) Evaluation of the Recitation Method on Arabic Subjects in Online Learning at Baiturrohman Elementary School, namely: Student assignments are written in spoken/written packages, sent in the form of photos/videos via Google Classroom, Teacher assessments via Google Classroom, Result assessment PH is done via a google form.

Educare: journal of primary education

Introduction: Apophyseal avulsion fractures of the pelvis predominantly occur in adolescent athletes due to skeletal immaturity. The anterior inferior iliac spine (AIIS) is a rare but characteristic site of injury. Case Presentation: We report the case of a 15-year-old male football player who sustained a traumatic avulsion of the right AIIS. The diagnosis was confirmed radiologically, and the patient was managed conservatively. Results: The clinical course was favorable, with a return to sports at three months. Conclusion: Early diagnosis and conservative management typically allow full recovery in most cases.

Mohamed mokhtar jmal

Ketorolac tromethamine, the non-steroidal anti-inflammatory drug, was formulated into mucoadhesive films to overcome the limitations in the currently available dosage and routes of administration which in sequence will increase patients’ compliance. Films were cast from organic and aqueous solvents using various bioadhesive polymers namely: HPMC E-15, Eudragit RLPO, Eudragit RSPO, Carbopol 934P. The prepared films were subjected to investigation for their physical and mechanical properties, swelling behaviors, in vitro bioadhesion, drug permeation via bovine buccal mucosa, and in vitro drug release. These properties were found to vary significantly depending on the preparation methods, the type of the polymers, and the ratio of addition of both plasticizers (i.e. polyethylene glycol and film forming agent. Formulation F4 is selected for best formulation because it shows the 98.85% drug release at time 6 hr. In addition, this film was subjected to in vitro and in vivo release. The obtained results indicate that the concentration of ketorolac in the oral cavity was maintained above 4.0 µg/ml for a period of at least 6 h. This film shows promising results for using the ketorolac mucoadhesive route of administration topically and systemically, and thus it will be subjected to clinical evaluation in future work.

Kuldeep vinchurkar

Provision of clean water is one of the United Nations Sustainable Development Goals. Water quality assessment as an ongoing exercise, in view of the threat of contamination from natural sources and human activities, plays a pivotal role in the sustainable management of water resources. Potable water samples were collected from Enugu Metropolis for water quality assessment. The physicochemical parameters were determined using APHA (1995 - 1998) protocols, and the presence of 7 heavy metals (Chromium, Zinc, Manganese, Silver, Cadmium, Iron and Lead) in the waters were determined using Atomic Absorption Spectrophotometer (AAS). The results of the physicochemical analysis of the four samples show a pH range of 8.60 - 8.95mg/l; this result showed that pH of the water samples were slightly alkaline and above the WHO stipulated range of 6.50 - 8.50. Acidity ranged from 5.00 - 6.88mg/l, while alkalinity values were between 7.52 - 13.00mg/l. The total dissolved solid (TDS) and total solids (TS) was present in very minute quantities and below their permissible limit of 0.45mg/l; while total suspended solid (TSS) was not present at all. The heavy metal analysis showed that all but 2 heavy metals (Cadmium and Lead) were below the permissible standard set by the WHO in all four samples. Cadmium was present in samples A and C with values 0.021mg/l and 0.006mg/l respectively, which is above its WHO limit of 0.005mg/l; while Lead was present in samples A, B and C with values of 0.021mg/l, 0.011mg/l and 0.015 mg/l respectively, which were above the WHO limit of 0.010mg/l. Given the well-documented toxicity of certain metals, there is a need for safety checks to be carried out in potable water companies to address the source of this contamination and ensure production of safer drinking water.

Okechukwu obed chukwuemeka

This paper investigated the variation in the multidimensional competencies and professional development needs of kindergarten teachers using a cross-sectional research design. It involved 54 purposively selected kindergarten teachers and collected the data using the self-assessment tool adopted by the Department of Education from the National Research Center for Teacher Quality in the Philippines. These data were analyzed using both descriptive and inferential statistics. As found, kindergarten teachers have a high level of competencies across dimensions. Also, they have a very high extent of professional development needs in content knowledge and pedagogy and the learning environment and diversity of learners. Moreover, they have a high extent of professional needs in two dimensions. The reported high priorities for training imply more emphasis on providing them professional development activities. Results found no significant difference in the competencies of kindergarten teachers in terms of age, position, civil status, degree, and years of teaching. On the contrary, significant differences revealed in their competencies in content knowledge and pedagogy, learning environment and learners’ diversity, and curriculum and planning between those with masters and without a master’s degree. Lastly, results show no significant difference in their professional development needs. These results have implications for future research and planning for a more responsive and cost-effective professional development initiatives in the locale.

Manuel caingcoy

Is open theological education reducing barriers and increasing access to theological training? Has the use of digital technologies in accessing theological training deviated from or complied with the training criteria? This paper highlights the seminarians’ borderless access to theological education and its benefits. Several persons frowned on open education a few years ago, but from March 2020, the COVID-19 pandemic has seen many institutions adopting elearning. Is it a wake-up call for theological education? The study discovered that theological education without barriers enhances theological training, research writing, scholarship, and academic honesty. The accreditation criteria for open theological learning does not alter contents but ensures that the greater populace can access a high standard of delivery of theological training equal to the on-campus programmes.

Ransford k awuku-gyampoh

In an era of rapid technological advancement, the digital divide between rural and urban communities has become increasingly apparent. This study aims to investigate consumer awareness towards cyber security in both rural and urban settings, recognizing its critical importance in safeguarding personal and sensitive information. The study underscores the urgent need for targeted interventions to bridge the digital divide in cyber security awareness. Policymakers, educators, and community leaders must collaborate to implement initiatives tailored to the unique needs of rural populations, including improving access to technology, enhancing digital literacy programs, and fostering a culture of cyber security consciousness. By addressing these disparities, we can strive towards a more inclusive and resilient digital society where all individuals, regardless of their geographic location, are empowered to navigate the digital landscape securely. This research paper delves into the awareness and attitudes of consumers regarding cyber security in both rural and urban settings. With the increasing prevalence of online activities, particularly e-commerce, understanding the level of awareness and concerns about cyber security is crucial. The study analyzes data collected from 100 respondents, examining demographics, online shopping behavior, encounters with security issues, familiarity with safety measures, and sources of information about cyber security. The findings provide insights into the digital divide between rural and urban communities and offer recommendations for enhancing cyber security awareness and education.

Dr. kishor bholane

Background: Pulses are well known richest source of vegetable protein and is known as poor man’s food because of its essential component in diet. The frontline demonstrations of pulses were carried out on 311.8 ha area with 694 demonstrations in different clusters of Nagaur district of Rajasthan. Methods: Front line demonstrations on chickpea, mung bean and moth bean crop were conducted by Krishi Vigyan Kendra, Nagaur-I, Agriculture University, Jodhpur during rabi and Kharif season of 2011-12 to 2019-20. Result: In demonstrations up to 29.43%, 30.29% and 35.22% yield increase of chickpea, mungbean and moth bean crop was observed over the farmer’s practices in the year 2011-12, 2017 and 2016. The yield gap between improved technology and conventional farmer’s practices was ranging from 1.98 to 4.54 q/ha, 0.61 to 2.55 q/ha and 0.6 to 1.68 q/ha, respectively. Whereas, the highest net returns of ` 71,881 ha-1 , ` 45,884 ha-1 and ` 14,315 ha-1 was observed in the year 2019-20, 2014 and 2016, respectively with the highest incremental cost benefit ratio of 1:3.71, 1:3.95 and 1:1.97 under demonstrations practices.

Dr. babu lal jat

This article addresses the implementation of the new generalized (G'∕G)-expansion method to the Caudrey–Dodd–Gibbon (CDG) equation and the Lax equation which are associated with the fifth-order KdV (fKdV) equation. The method works well to derive a variety of standard and functional closed-form wave solutions with distinct physical structures, such as, soliton, kink, periodic soliton, and bell-shaped soliton solutions. The solutions obtained using this method are useful and adequate than other methods. In order to understand the physical aspects and importance of the method, the attained solutions have been simulated graphically. The extracted results definitely establish that the new generalized(G'∕G)-expansion method is an effective mathematical tool to work out new solutions to different types of local nonlinear evolution equations emerging in applied science and engineering, but this method is not effective in solving nonlocal equations.

Md khorshed alam

In this report, Tesco PLC's operation and project management have been fully elaborated on. Tesco PLC is a retail organization that deals with retailing and other related activities in insurance service and retail banking (REUTERS, 2020). Tesco is multinational general merchandise and groceries with headquarters at Welwyn Garden City in England. Based on gross revenue rating, Tesco is the third-largest retailer in the world. Tesco was created by Jack Cohen in 1919 in Hackney, London as a set of markets stalls. Tesco developed and expanded very fast in the whole world and above 100 Tesco shops in the entire Facebook. Tesco has segments in ROI and the UK that is; central Europe (Hungary, Slovakia, and the Czech Republic), the Republic of Ireland, and the United Kingdom which do similar activities to those done in Tesco bank in the United Kingdom (Bedford, 2022). Tesco avails different personal banking packages (services and products) that include personal loans, personal current accounts, and credit card receivables. Tesco's businesses are therefore Tesco Hungary, Tesco UK, Tesco Czech Republic, Tesco Slovakia, Tesco Ireland, Dunnhumby, and Tesco Bank.

Zamzam abdelazim