Hyperoxaluria is a metabolic disorder responsible for calcium oxalate nephrolithiasis. The study was conducted on glass slides to observe the growth patterns of urinary calcium oxalate monohydrate crystals and their inhibition by 5, 10, 15 and 20 % infusion of Macrotyloma uniflorum seeds. For this purpose, a drop of gel medium (sodium metasilicate of 1.06 specific gravity and 3M acetic acid solution) at pH 5.02 - 5.17 was placed in the middle of a glass slide and converted into a gel. A 1 M oxalic acid drop was dropped to the left, and 1 M calcium chloride and magnesium acetate (1:1) solution was dropped to the right side of the properly formed gel. The glass slide was observed under a microscope till it was completely dried. In the case of the crystal inhibition study, a drop of M. uniflorum infusion was also added on the right side just after adding calcium chloride and magnesium acetate solution. The results without infusion showed detailed morphology and aggregation patterns of observed crystals such as donut, dumbbell, needles, platy, prismatic, rosette, round edges, X-shape crystals, loose and compact aggregates. All infusions of M. uniflorum affected the crystals, forming defective crystals. 5 % infusion inhibited crystals of all morphologies except donuts, X-shaped crystals, donuts, platy crystals and rosettes. Defected rosettes were observed in 10 % infusion, which was reduced gradually in the crowd by 15 and 20 %, respectively. From this study, it can be concluded that M. uniflorum seeds infusion is effective against calcium oxalate nephrolithiasis.

Dr. salman ahmed

The incorporation of lomustine, a hydrophobic anticancer drug into PLGA nanoparticles by interfacial deposition method was optimized. Based on the optimal parameters, it was found that lomustine-PLGA nanoparticles with acceptable properties could be obtained. Optimization of formulation variables to control the size and drug entrapment efficiency of the prepared nanoparticles seems to be based on the same scientific principles as drug-loaded nanoparticles prepared by nanoprecipitation, solvent evaporation method. The process was the most important factor to control the particle size, while both the drug-polymer interaction and the partition of drug in organic and aqueous phases were the crucial factors to govern the drug entrapment efficiency. PLGA concentration at lower level (100 mg), 1:5 organic phase: aqueous ratio, 1%w/v PVA concentration, 3%w/v pluronic F68 achieved smaller particle size. Additionally, L:G ratio of PLGA 75:25, lower volume of organic solvent (1:10 organic phase: aqueous phase), higher initial drug content (10mg) enhanced the drug entrapment efficiency and maintained lomustine concentration in blood for an extended time period, elevated lomustine concentration in lungs and slowed the elimination of lomustine. The biodistribution profiles of prepared nanoparticles in albino mice showed higher plasma drug concentration for longer period of time, elevated drug concentration in lungs and slow elimination from kidney. No toxic effects of prepared nanoparticles were observed in histopathological examination of lungs and kidney. The systematic investigation reported here promises the development of PLGA nanoparticles loaded with lomustine when tested in Lung Cancer cell line L132 and toxicological/ histopathological studies in albino mice.

Archana mehrotra

To improve education quality and governance, the Higher Education Commission of India (HECI) has proposed four regulatory entities, including the National Accreditation Council (NAC). To build up India as a universal knowledge giant over the next ten years, the policy promotes equitable educational opportunities and transformative initiatives. To significantly improve the standards for higher education in India, quality control, accreditation, & ranking systems become crucial. With an emphasis on quality, employability, and lifelong learning, the National Education Policy-2020 (NEP-2020) seeks to create a flexible, value-based educational system that integrates 21st-century capabilities. India's higher education is currently at a critical juncture, requiring transformation to enhance its overall contribution to society and address social injustices. This involves examining how information is produced and how students are taught to promote sustainability and social responsibility. Higher education institutions must comprehend and address student expectations regarding quality because the service sector is expanding quickly due to liberalization, privatization, and globalization. As a result, evaluating service quality becomes crucial for future enhancements and feedback. The Higher Education Commission of India (HECI) legislation, 2018, was introduced by the Ministry of Human Resource Development toward the end of June with the goal of repealing the University Grants Commission (UGC) Act, 1956, which has been in place for seven decades. The HECI will interchange with the University Grants Commission (UGC), which has been the foundation of India's college and university structure. This transition analyzes the proposed bill and examines its shortcomings. This advocates that the current bill be unsuccessful in reporting the flaws of the previous official; instead, it merely reflects those issues and will not resolve the long-standing problems of low autonomy and subpar instruction in the higher education system. As the new regulator, HECI's strategy isn't very revolutionary. Regulators who encourage centralization of duties to reduce autonomy must be disregarded at moments when Indian institutions are striving to rank highly in the world.

Dr. awadhesh singh gautam

Cleome scaposa DC. has long been used in traditional herbal medicine for the treatment of pain and inflammation. The present investigation is an attempt to evaluate the antiemetic, analgesic and anti-inflammatory activities of Cleome scaposa leaves methanolic extract by using the chick emesis model (oral treatment), analgesia meter test (intraperitoneal treatment) in rats and carrageenan-induced rat paw oedema (oral treatment) respectively. The antiemetic activity (150 mg/kg b.w. of extract) was carried out by using chlorpromazine (150mg/kg) as a standard antiemetic drug. The analgesic activity (250 mg/kg b.w., of extract) was performed by using diclofenac sodium (50mg/kg) as a standard analgesic drug whereas, anti-inflammatory activity (500mg/kg b.w., of extract) was done and indomethacin (10mg/kg) was taken as a standard anti-inflammatory drug. The results showed significant antiemetic, analgesic and anti-inflammatory effects.

Dr. salman ahmed

The notable developments in renewable energy facilities and resources help reduce the cost of production and increase production capacity. Therefore, developers in renewable energy evaluate the overall performance of the various equipment, methods, and structure and then determine the optimal variables for the design of energy production systems. Variables include equipment characteristics and quality, geographical location, and climatic variables such as solar irradiance, temperature, humidity, dust, etc. This paper investigated and reviewed the current big data methods and tools in solar energy production. It discusses the comprehensive two-stage design and evaluation for examining the optimal structure for renewable energy systems. In the design stage, technical and economic aspects are discussed based on a robust analysis of all input/output variables for determining the highest performance. Next, assess and evaluate the effectiveness of each method under different circumstances conditions. Then convert each qualitative indicator into a quantitative measure using extensive data analysis methods to determine the overall performance of the various qualitative variables. The paper also provides an in-depth analysis of the mathematical techniques used in measuring the efficiency of the renewable energy production system and discussing future axes of work in the field of specific energy.

Acaa pub

The subjective experience of consciousness, a cornerstone of human existence, is profoundly disrupted in disorders of consciousness (DOC) arising from severe brain injuries, spanning-states from coma to the minimally conscious state. A significant challenge in clinical practice is the phenomenon of covert consciousness, in which individuals may retain awareness despite the absence of overt behavioral responsiveness. Diagnosis based solely on observable behavior is inherently limited by factors such as co-occurring motor impairments, the fluctuating nature of consciousness, and subjective interpretation, potentially leading to misclassification. To overcome these limitations, neuroscientific methodologies have advanced significantly. To address these limitations, neuroscientific methods have advanced considerably. Functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) provide objective evidence of preserved brain activity and cognitive processing, enabling detection of willful modulation and offering prognostic insight. Electrophysiological techniques—including electroencephalography (EEG), event-related potentials (ERPs), transcranial magnetic stimulation combined with EEG (TMS-EEG), and advanced downstate analysis—further reveal dynamic neural patterns indicative of residual awareness. The detection of covert consciousness has profound ethical, clinical, and societal implications. It necessitates a re-examination of patient rights, end-of-life decision-making, the use of brain-computer interfaces, and societal conceptions of personhood. This evolving understanding mandates a shift towards integrating objective neuroscientific assessments with compassionate, person-centered care, aiming to preserve dignity and navigate the complex ethical landscape of severe brain injury.

Mostafa eissa

Subcutaneous emphysema is defined as a trapped air in tissues under the skin. This entity most often occurs in the chest wall and neck but can infrequently happen in other parts of the body like the orbital area [1]. The main mechanism of subcutaneous emphysema is the traumatic damage of the anatomical air-filled cavities or canals. Most of the rare, reported cases of orbital and periorbital emphysema were described in adults as complications of several types of traumas, including direct trauma, recent or previous surgery [2,3], barotrauma secondary to non-invasive ventilation, such as continuous positive airway pressure therapy [4], and even post forceful noseblowing [5]. In this report, we described the first reported case of post-vomiting subcutaneous emphysema surrounding the medial canthus of the right eye in a 10-year-old boy.

Karishma

Research Aim: This study investigates the influence of workload and work environment on employee performance, with work stress serving as the mediator Approach: The study employed a quantitative approach using SEM-PLS analysis. The sample included 75 factory workers selected through census sampling conducted from February to June 2023 at PT PSB, a manufacturing firm in Medan, North Sumatra Findings: Findings reveal that workload and work environment positively impact employee performance, mediated by work stress Theoretical Contribution/Originality: This research contributes to the literature by exploring work stress as a mediator in enhancing the understanding of employee performance within the manufacturing sector Policy Implication: Recommendations include PT PSB and similar companies prioritizing plant workers' stress levels, monitoring workload, and fostering a healthy workplace environment Research Limitation: The scope of the study was limited by the number of respondents and the factors considered in assessing employee productivity

L

भारतीय मध्यकालीन समाज और संस्कृति की समझ रखने और समझने की कोशिश करने वाले हरेक अध्येता की नज़र इस ओर जाती है कि बाज़ार भक्तिकालीन कवियों के बात करने का एक ख़ास बिन्दु रहा है। जहाँ ये कवि बाज़ार को सबसे अधिक जनतांत्रिक जगह के रूप में प्रस्तुत करते रहे हैं, चाहे वे कबीर रहे हो रैदास हो या फिर तुलसी। ये कवि हमें होशियार भी करते हैं कि बाज़ार में सारी भौतिक चीजें बिक रही हैं आप उन्हें खरीद सकते हैं मगर प्रेम आप नहीं खरीद सकते। ये कवि प्रेम की लगातार वक़ालत करते है। इनके पास दुनिया को खूबसूरत बनाने का एक ही रास्ता है -प्रेम। वे बताते हैं कि कैसे ये भौतिक चीजें मनुष्य के प्रेम को ब्रह्म यानी ज्ञान या मानवता के रास्ते में रोड़ा बन जाती हैं। साथ ही कैसे भौतिक चीज़ें आज अपनी पाँव तेजी से पसारती जा रही हैं।

Manish patel

This Document addresses the main trends around healthy eating in the global, Latin American, and Peruvian environment related to the proposed business plan. Analysis shows that with an increase in the population around the world it is important for food producing organizations to introduce new food products in order to be in the race of famous food brands. Based on qualitative and quantitative data from various sources, it is possible to know the opportunities for a plant-based burger business. This assignment aims to recognize if there is a favorable evolution for the proposal of this business plan at the different levels of the environment. The brand focused on this assignment in KFC. A plan for introducing green burgers in Peru and other regions of Latin America was developed in this paper.

Zamzam abdelazim

Plants produce a diverse range of bioactive compounds making them rich source of different types of medicines. The plants are mostly cultivated for decoration and to enhance the appearance of houses, gardens, road sides, and also for commercial purposes such as floral decorations in form of bouquet. They are also source of fragrant oils for perfume making and cosmetic. However only very few of these plant species have found to be used in medicine and little or no literature exit on their chemical and biological activities. Araucaria columnaris is an ornamental plant, commonly known as Christmas tree, belonging to the family Araucariaceae. Plant resin was used for the present study, antibacterial activity and GC-MS analysis of Araucaria columnaris resin was carried out. The resin was subjected to solvent extraction using decreasing polarity solvents (aqueous, methanol, ethyl acetate and benzene). TLC profiling of all the extracts gives an idea about the presence of various phytochemicals and its fractions were checked for antibacterial activity against major clinical pathogens. It was found that fraction 4 (F4) of methanolic extact showed maximum zone of inhibition against Gram positive organisms. This fraction was subjected to GC-MS analysis; the result revealed the presence of a board range of many medicinal compounds and antioxidant activity of resin of Araucaria columnaris were identified.

Dr. saranya devi k

Despite the evolution of modern technology, the users of hearing aids do not realize the persistence of feedback, while wearing the device until the condition becomes worse. The feedback cancellation algorithms, instead of cancelling the acoustic feedback, limits speech intelligibility. The paper presents a novel method for estimation of SNR based adaptive-feedback equalizers (SBAFE) algorithm to develop an optimized hearing aid for the feedback less sound transmission and achieving better speech discrimination. The data gathered for the optimization is visualized and compared with the traditional technology, which provides the subjective and objective quality of the hearing aids.

Jayanthi g

The increasing prevalence of Artificial Intelligence (AI) in creating content signifies a notable change in the digital communication landscape. While the broader effects on widespread media platforms have been extensively discussed, the specific consequences within specialized online communities remain less explored. These communities, frequently founded and established on shared interests, mutual confidence, and perceived genuineness, are particularly susceptible to alterations in the origin and trustworthiness of content. This paper challenges three questions: (1) How AI content affects credibility perceptions, (2) Verification methods used by communities, (3) Consequences for trust dynamics. A hypothetical framework would be used to investigate the potential impact of AI-produced content on the dynamics of trust and credibility within these focused digital environments. By drawing upon existing academic work in media studies, the behavior of online communities, and the concept of source credibility, a theoretical model and outline a potential research strategy were encouraged to examine how the presence, identification, and interpretation of content authored by AI might modify member interactions, processes for verifying information, and the overall unity of the community. The hypothetical outcome suggests that the subtle integration of AI content could diminish perceived authenticity, complicate established indicators of trust, and potentially lead to the fragmentation or decline of communities that depend on authentic human connection and collective expertise. The article concludes by considering the ramifications for those who manage communities, design platforms, and participate as members, stressing the importance of greater openness and digital literacy in navigating the evolving digital media landscape.

Mostafa eissa

In April 2020, Food and Drug Administration (FDA) requested immediate withdrawal of all prescription and over the counter ranitidine products. Ranitidine recalled due to the presence of unacceptable level of carcinogenic substance N-nitosodimethylamine (NDMA). Several pharmaceutical manufacturers have issued ranitidine product recalls including brand and generic ranitidine. FDA alerts patients to stop using ranitidine and advised to talk with their health care professional about alternative treatments. In Libya, limited studies have been conducted to address people awareness and knowledge in this regard. The objective of this study was to assess people's awareness and behavior towards ranitidine recall and related issues. A cross-sectional study was conducted in Zawia city for two months. Online questionnaire was distributed to 300 participants. Descriptive statistics analysis using statistical package for social sciences (SPSS) version 26.0 was used. The study found that more than half of the participants and their family member were likely to utilize ranitidine inappropriately. They seem to consume ranitidine more often without medical consultation. The findings also showed that 82.5% of the participants that were using ranitidine obtained the drug from pharmacies after the date of announcing ranitidine withdrawal from the market by FDA. Furthermore, the vast majority of the participants were poorly informed or even they had no information about ranitidine toxicity and their perception of the dangers of continue use of this drug is limited. The participants argued that pharmacists do not provide slightly information about dispensed ranitidine. In conclusion, all results reported as benefits of the participants in the study whereas the participant's perception and awareness increased when a brief notification regarding the reason of ranitidine toxicity was provided.

Mediterranean journal of pharmacy and pharmaceutical sciences

Introduction: Mental illness is a global issue that affects various population groups, including university students. Gaining insights into students' perspectives on mental illness plays a vital role in fostering mental health awareness and combating stigma in educational environments Purpose: The present study aimed to investigate Vietnamese undergraduate students’ knowledge, perceptions, and attitudes of mental illness by focusing on the dimensions: (i) the level of knowledge students possess about the causes and manifestations of mental illness, and (ii) their attitudes towards individuals experiencing mental health problems. Methodology: Using a descriptive cross-sectional design, this study involved 350 undergraduate students from five universities in Ho Chi Minh City, Vietnam. Data collection was conducted between June and July 2024 and utilized the Perception Towards Persons with Mental Illness (PWMI) Scale adapted from previous studies. Data analysis was performed using the Statistical Package for Social Science software, version 25 (IBM SPSS, Chicago, IL, USA). Results: The results indicated that approximately 80.6% knew about mental illness, and 70.5% perceived mental illness as a common or quite common phenomenon in Vietnam. Regarding the etiology of mental illness, a significant majority identified "bad things happening to you" as a cause (73.3%), followed by substance abuse (51.4%) and brain disease (50.0%). The findings also revealed that, despite some positive perceptions and attitudes, many responses clustered around the neutral option, particularly for controversial or personal items. Conclusions: The findings of this study underscore the need for targeted educational interventions to foster more informed and compassionate attitudes towards individuals with mental illness among undergraduate students.

Le minh tien

Cet article porte sur l’ouvrage Le ventre, le pain ou la cendre de Tchicaya U Tam’si. À partir des approches linguistique, stylistique et sémiotique, nous avons tenté de montrer, dans notre analyse, en quoi l’écriture de ce recueil construit des stratégies discursives propres à retenir l’attention du récepteur. À cet effet, nous avons relevé deux principales figures de rhétoriques à savoir, l’emphase et l’hyperbole. Ces deux procédés de style produisent d’une part un effet d’insistance du procès poétique ; et de l’autre, un effet d’amplification du langage poétique.

Assanvo

Tobacco smoking negatively affects the quality of saliva and affects many biological parameters including salivary α-amylase enzyme activity. Salivary α-amylase enzyme is essential for the catabolism of carbohydrates. Forty- five healthy male volunteers aged between 18 and 69 years (40.0 ± 15.0) were divided into two groups, namely, the control group (n = 21) and the cigarette smoker group (n = 24). The effect of smoking on salivary α-amylase enzyme activity depends on the number of smoked cigarettes per day and the type of cigarettes as well as the period for how long the person smoking tobacco cigarettes was investigated. Different methods were used to analyze the activity of salivary α-amylase enzyme including the dinitrosalicylic acid method (standard colorimetric method). The results showed a significant increase (P < 0.05) in salivary α-amylase activity in Libyan smokers compared to the non-smokers in the morning and night, also, the findings showed a significant decline in salivary α-amylase activity during the increasing smoking period. The activity of salivary α-amylase in the young age smokers group increases in morning and night compared to the non-smokers group. There is no change in the activity of salivary α-amylase in the middle and older adult groups in the morning and night compared to young smokers group. In conclusion, smoking for a long period time more than 20 cigarettes per day decreases the activity of salivary α-amylase in Libyan subjects.

Mediterranean journal of pharmacy and pharmaceutical sciences

Adolescents’ scholastic and social life has become increasingly reliant on the internet and mobile technology in recent years. Problematic Internet Use (PIU) is a growing problem in Indian adolescents. However, in many cases, this use has become obsessive, causing them to neglect other elements of their lives. Adolescents account for over 35% of internet users in India. The purpose of this study was to evaluate the psychosomatic problems related to internet overuse among school going adolescent students. This cross-sectional survey was conducted among 348 students in selected schools of Aspur block in Dungarpur-district, Rajasthan, India in the month of February 2016. Problematic internet use (PIU) was assessed by Young’s twenty question internet addiction test. The Depression, Anxiety, Stress Scale (DASS-42) and self structured questionnaire check list was used to measure psychosomatic problems among adolescents. Approximately 5.17% adolescents showed Problematic internet use (PIU). Adolescents with PIU were associated with age between 14-16 year, males,10th class of study, using internet since more than 3 years, being at home, mobile as a source of internet use, purpose of internet use with online gaming. Compared with normal internet users, there were significant correlation between Problematic Internet Use and Somatic Complaints r=0.3660, p<0.05, Depression r=0.3982, p<0.05. Anxiety r=0.2512, p<0.05 and Stress r=0.2886, p<0.05. Problematic internet use (PIU) is an increasing problem among teenagers and it has been linked to psychosomatic issues. Timely Effective measures are needed to prevent the spread of this problem

Dr k c yadav

The purpose of this study is to look at development trends and patterns of structural change in India's rural and labour markets. The rural labour strength have been moving from agricultural sector to non-agricultural sector for a living, after a long period of change (due to pain and growth-induced motives). Although the manufacturing sector lags, the building industry is a significant growing sector that employs rural people. Some improvements in rural areas have been made since the implementation of the MGNREGA rural employment development programme, but it has its own set of problems that experts are discussing. Furthermore, the rural labour market is plagued by high unemployment as a result of both the agricultural and non-farm sectors' failure to absorb rural employees. Nonetheless, the continuing COVID-19 epidemic has worsened its situation by causing a job-loss catastrophe. The rural labour market's future will become more unclear as a consequence of Covid pandemic-induced opposite migration of city workers to their villages, which has worsened food security and poverty issues in rural regions.

Dr. amarjeet singh

Kidney mass lesions are common and are often discovered accidentally. Renal cell carcinoma (RCC) represents approximately 5% of all cancers. Men have a two-fold higher likelihood of developing the disease and experience a higher mortality rate than females. The differences between the genders are attributed to individual variations, including hereditary factors, underlying medical conditions, genetics, lifestyle, hormonal factors, and others, such as hypertension and obesity. Renal tumors are usually asymptomatic; however, hematuria, dull aching flank pain, and lower abdomen pain can present symptoms. A tissue biopsy is typically unnecessary but may be required in certain cases. Men tend to exhibit larger and more severe tumors. Radiology tools application is helpful for early diagnosis and follow-up. Partial or radial nephrectomy is an effective curative therapy in localized renal masses. Nevertheless, immunotherapy, cryotherapy, and sometimes chemotherapy are used, especially in high-income nations. In this review, epidemiology, pathophysiology, risk factors, presentation, diagnosis, and kidney mass management will be reviewed and updated. Different keywords and phrases, such as kidney malignancy, renal cancer, epidemiology of kidney cancer, nephrectomy in kidney masses, and management of renal cell tumors, were used to search PubMed, EMBASE, Scopus, Google, and Google Scholar for new reviews and original articles and new comments with updates that were published between January 2019 and May 2025.

Karishma