A simple, precise, accurate, sensitive, specific and reliable stability indicating RP-HPLC method was developed for the simultaneous estimation of Miconazole (MIC) and Ornidazole (ORN) in pharmaceutical dosage form. The method was developed with mobile phase containing buffer (0.05M potassium dihydrogen ortho phosphate, ph3.5): Methanol in the ratio of 25:75, C18 (250 x 4.6mm, 5µm) as a stationary phase and flow rate was 1 ml/min. Detection was carried out at 236nm in UV-2000 detector. The selected chromatographic conditions were found effectively to separate Miconazole and Ornidazole at 6.58 and 3.26 min respectively. The proposed method has been validated for precision, accuracy, robustness. Thus, the statistical analysis confirms that developed methods were successfully used for analysis of formulation and thereby can be used for routine analysis of drugs in Quality Control laboratories.

Prachi barbhaiya

Vitamin C causes a significant change in pharmacological effects of some drugs which may lead to unpredictable responses. Vitamin C-haloperidol interaction has not been confirmed in vivo. This study was aimed to investigate the influence of vitamin C on some pharmacological effects of haloperidol (extrapyramidal side effects caused by the antipsychotic haloperidol). Albino male mice (n = 24, body weight of 20 - 40 gm) were divided into four groups and each of consists of six mice. Group I (control): given 1% Tween 80 solution, group II: given vitamin C in a dose of 100 mg/kg, group III: given haloperidol (2 mg/kg), while group IV: given a combination of vitamin C and haloperidol. All the treatments were given by intraperitoneal route of administration. Three sub-acute doses of different treatments were given at 24:0, 5:0, 1:0 hour before scoring. Parameters scored were catalepsy, ptosis, rigidity and akinesia. The experiment was repeated using vitamin C in a dose of 500 mg/kg. Both doses of 100 and 500 mg/kg of vitamin C significantly antagonized the effect of haloperidol by decreasing all the tested parameters. The results indicate that vitamin C decreases extrapyramidal side effects caused by the antipsychotic haloperidol and show that it successfully decreases catalepsy, ptosis, rigidity and akinesia in mice.

Mediterranean journal of pharmacy and pharmaceutical sciences

Is open theological education reducing barriers and increasing access to theological training? Has the use of digital technologies in accessing theological training deviated from or complied with the training criteria? This paper highlights the seminarians’ borderless access to theological education and its benefits. Several persons frowned on open education a few years ago, but from March 2020, the COVID-19 pandemic has seen many institutions adopting elearning. Is it a wake-up call for theological education? The study discovered that theological education without barriers enhances theological training, research writing, scholarship, and academic honesty. The accreditation criteria for open theological learning does not alter contents but ensures that the greater populace can access a high standard of delivery of theological training equal to the on-campus programmes.

Ransford k awuku-gyampoh

In this research study, the mechanical properties of several Polymer matrix composites are investigated. These composites are multi-phase materials in which reinforcing materials are properly mixed with a polymer matrix. More precisely, Nylon 6 reinforced with 5, 15 and 25 wt. % of silicon carbide (SiC) and Nylon 6 reinforced with 5, 15 and 25 wt. % of boron carbide (B4C), prepared by means of an injection moulding process at three different injection pressures are considered. Specific attention is paid to the tensile and impact strength of these composites. The Taguchi technique is used to optimize the process parameters such as reinforcement material, its percentage and the injection pressure. It is observed that the specimens 5% SiC with 80 MPa injection pressure display a better tensile strength and similarly the specimen 5% B4C with 90 MPa injection pressure have a superior impact strength.

Boopathy govindarajan

The Group of Twenty (G20) has emerged as a pivotal forum for international cooperation, bringing together leaders from the world's major economies to address pressing global challenges. In this paper, we analyse the priorities of G20 leadership in fostering consensus and advancing collective action on key issues facing the global community. Drawing upon recent declarations, communiqués, and policy statements, we identify and examine the core areas of focus for G20 members, exploring both common ground and divergent perspectives. Our analysis reveals several recurring themes that underscore the G20's commitment to promoting economic stability, sustainable development, and inclusive growth. Addressing climate change and environmental sustainability emerges as a top priority, reflecting growing recognition of the urgent need for concerted action to mitigate the impacts of climate change and transition to a low-carbon economy. Additionally, enhancing global health resilience and strengthening pandemic preparedness feature prominently on the agenda, as demonstrated by recent efforts to coordinate responses to the COVID-19 crisis and bolster health systems worldwide. Furthermore, the G20 remains committed to advancing trade and investment liberalization, promoting financial regulatory reform, and fostering innovation and digital transformation to drive economic recovery and prosperity. However, divergent views on issues such as trade imbalances, protectionism, and technology governance persist, posing challenges to consensus building and cooperation among member states.

Dr gedam kamalakar

Background:Calcium, the very important mineralhelps in growth and development ofinfants.Calcium helps in building strong bones, teeth,proper functioning of nerves and muscle, blood clot and in activating the enzymes that convert food into energy. Infants and Children are growing new bone all the time, they need continuous supply of calcium to support the healthy growth.Milk is the only food for infants which is richest source of calcium. Some infants are sensitive to lactose in milk because they have Lactose Intolerance. The present study aimsto develop an alternate milk forlactose intolerance infants with finger millet and pearl millet.Method:Traditional methods were used to process the milletswhich help in retaining and increasing the nutritional content in millets.The millet milk was analyzed for calcium content using the ICPMS.The millet milk was supplemented for 6 weeks to albino rats in comparison with cow milk. The tibia weight and length were measured and calcium content in tibia was analyzed. Result:The calcium content of the millet milk was 80mg/100mlwhere as in cow milk it was 120mg/100ml.The mean calcium content of the tibia inalbino rats was15.35±3.50mg/dl fed with millet milkand20.40±3.74mg/dl in rats fed with cow milk.Conclusion: The developed millet milk contain good amount of calcium on par with cow’s milk, it can be used as substitute milk for lactose intolerant infants.

Kimeera ambati

Numerous initiatives to rely on new renewable energy sources, such solar electricity, have been sparked by the increased interest in global warming. With an increase in home photovoltaic (PV) panels that are available to the public, more precise calculations of energy generation are now possible. Segmenting satellite images offers a straightforward and inexpensive way to categorize solar panels..This work suggests a method for classifying and segmenting solar panels that combines the watershed algorithm with deep learning approaches. First, a Convolutional Neural Network (CNN) architecture with the ResNet, EfficientNet, and Inception architectures is used for classification. Through the fine-tuning of pre-trained networks on a heterogeneous dataset of solar panels, transfer learning improves performance. The categorization model recognizes solar panels in a variety of settings with accuracy, making maintenance and monitoring easier. After classification, the watershed method uses intensity gradients to precisely delineate solar panels from the background. Tasks like defect detection and layout optimization are made easier when deep learning-based classification and watershed segmentation are combined. The outcomes of the experiments show how well the suggested method performs in terms of segmenting and classifying solar panels under various circumstances. A flexible automated solar panel management solution is provided by the combination of deep learning and the watershed algorithm, which promotes increased sustainability and efficiency in solar energy systems.

Bakka arun kumar

Experimental and numerical investigation have been done to evaluate the aluminum agglomerate size in AP/HTPB/Aluminum propellants and compared it with burning rate results. Bimodal AP particle size distribution is considered in the present work. The effect of aluminum size, aluminum content, fine AP size, fine AP/binder ratio and coarse AP size in aluminum ignition, accumulation and agglomerate formation during combustion, typically in their ranges, are focused. The burning rates were found to be higher for the propellants with lower fine AP/binder ratio. The agglomerate sizes for the propellants with 10 % Al was found to be higher than those with 15 and 18 % aluminum. Observing the agglomerate sizes and the burning rate trends, it can be concluded that the agglomerate sizes vary inversely as the burning rates.

Boopathy govindarajan

The scaling of metabolic rates with body mass is one of the best known and most studied characteristics of aquatic animals. We studied here how size is related to oxygen consumption, ammonia excretion and O: N ratio in Freshwater Bivalve Mollusc Lamellidens marginalis species in an attempt to know how size specific changes affect their metabolism. The freshwater bivalve molluscs with specific size i.e. small (77 79 mm in shell length) and large (90 93 mm in shell length) were selected for experimental work from Bhima River at Siddhatek on December and January during winter. The adult bivalve molluscs with small size reported high value in oxygen consumption and O: N ratio but ammonia excretion was low value in small sized bivalves compared to large ones. The results are discussed in the glow of metabolic processes in fresh water bivalve molluscs.

Dr. pritesh ramanlal gugale

The rate of aging is rapidly increasing and the term of geriatric refers to offer a medical care to elderly people. Drug consumption study on geriatric population is a vital issue since this group is totally neglected in Libya. The aim of this study was to assess drug utilization pattern among elderly patients in terms of world health organization core prescribing indicators and to evaluate the treatment cost. A total of 106 prescriptions were randomly collected from different community pharmacies located in Tripoli during the summer 2019, and were evaluated (total number of prescribed drugs is 359) for their clinical efficacy and safety. The findings revealed that 60 drugs acting on GIT (16.7%), 50 antimicrobial drugs (13.9%), 31 antihypertensive drugs (8.6%) and 30 drugs for respiratory diseases (8.4%) were prescribed to patients who are 65 years old or more. With regard to disease pattern in the elderly Libyan patients, 27 drugs were prescribed for diabetes mellitus (7.5%), 24 drugs for cardiovascular drugs (6.7%) and 14 drugs for anti-hyperlipidemia (3.9%). According to the WHO core drug use indicator pattern, the average number of drugs prescribed per encounter was 3.3. Prescription by generic name was low (41.5%). Antibiotics were 36.8% while injections were 26.6%. Thus, this study suggest that geriatric medicine and rational drug use should strongly be implanted in medical schools and teaching hospitals. Besides, a drug pattern use of the Libyan community is urgently required to avoid drug prescribing errors.

Mediterranean journal of pharmacy and pharmaceutical sciences

Stem cells hold great promise for tissue regeneration and have the potential to treat many incurable degenerative diseases. Cancer stem cells (CSCs), or cancer initiating cells, have the ability to self-renew and differentiate into heterogeneous lineages of cancer cells. Current stem cell therapies face limitations, such as limited stem cell sources, time consumption, tumor formation, and immune rejection upon allogeneic transplantation. Allogeneic stem cell treatments simplify stem cell manufacturing and reduce transplant time, but their therapeutic potential is limited by human leukocyte antigen (HLA)-matched donors. CSCs retain characteristics essential for tissue regeneration. However, several limitations hinder cancer stem cell reprogramming with pluripotent factors. The development of 3D culture models for tissue imitating extracellular matrix in cancer cell lines aims to enhance CSC enrichment. This mini-review focuses on a new strategy for treating incurable degenerative diseases involving in vitro and in vivo 3D cancer models and the induced differentiation of CSCs into mature normal cell types. This allows tissue survival without immune rejection and offers a safe alternative to cancer stem cell reprogramming with pluripotent factors. In conclusion, preservation and banking of allogeneic CSCs offer an alternative, readily available, and safe strategy that can be used to facilitate stem cell-based cell therapy.

Josita alloysius

This study ascertained availability of disaster preparedness and digitization in archives preservation in public libraries in Rivers state. Two objectives and its corresponding research questions and hypotheses guided this study. The descriptive survey design was adopted for this study. The target population of this study comprised 514 library staff drawn from Rivers state library board and staff from Jubilee library Port Harcourt. The sample size for this study was 399 library staff comprising of 227 staff from Rivers state library board and 172 library staff from Jubilee library Port Harcourt. The sample size was determined by Taro Yamane sample size determination formula while a two-stage sampling technique of stratified and simple random sampling techniques was used to select the sample size. A self-structured questionnaire titled availability of disaster preparedness and digitization in archives preservation questionnaire was used as the instrument for data collection. Face and content validation was ensured by three experts. The instrument yielded reliability coefficients of 0.79 with the use of Cronbach Alpha reliability method. Meanand Standard Deviation was used in answering research questions while z-test was used for the inferential statistics. The findings revealed that disaster preparedness and digitization in the preservation of archives are supported and available in public libraries in Rivers state, Nigeria. Based on the findings, it can be concluded that there are significant differences in the responses of Rivers state library board staff and Jubilee library Port Harcourt staff on the terms of the availability of the disaster preparedness and digitization in archive preservation in the public libraries. It was therefore recommended that more librarians should be employed by the Rivers state government so as to make the process of archive preservation in the State’s public libraries through disaster preparedness and digitization less rigorous and efficient.

Fxintegrity publishing

Nowadays, the Internet of Things (IoT) has been used widely in our daily day to day life, starting from health care devices, hospital management appliances to a smart city. Most of the IoT devices have limited resources and limited storing capability. All the sensed information must have to be transmitted and to store in the cloud. To make a decision and for making analysis all the data stored in the cloud has to be retrieved. Making certain the credibility and security of the sensed information are much necessary and very important for the use of IoT devices. We tend to examine the proposed technique to be much secure than the existing one. In IoT, if the security is not ensured, then it may result in a variety of unsought issues. This survey resembles the overall safety aspects of IoT and debates the overall issues in the security of IoT.

Jebin bose s

Lakes are characterized by dynamic responses to ecological and limnologic disturbances that occur within a constrained timeframe. Some endorheic lakes in the Kenyan Rift valley are presently regarded as environmental hotspots because of complex changes that are revealed through multiple proxies; changing lake levels and surface area, turbidity and sedimentation, and the proliferation of macrophytes, and loss of aquatic biodiversity. Lake Baringo is characterized by widespread catchment degradation accompanied by high levels of turbidity during erratic and decline of the native fishery based on Oreochromis niloticus baringoensis. A careful analysis implicates potential natural factors such as catchment topography and increasing anthropogenic pressure as the main causes of lake ecosystem degradation. This paper recommends several strategies for restoration of Lake Baringo based on an integrated multi-faceted approach that combines catchment rehabilitation, pollution control, and provision of alternative livelihoods such as agriculture to the riparian communities

Omweno job

The strategy is a means of establishing the organisation's purpose in terms of priorities for resource allocation, action programs and long term objectives (Grant 2005). Chandler (1962) defines strategy as determining the primary long-term goals of an organisation, the adoption of courses of action, and the allocation of necessary resources. Besides, the strategy also focuses on allocating resources in relation to the organisation and its environment (Schendel & Hatten 1972). The strategy also pertains to the top management's decisions pertaining to its scope and the future direction. Such strategy covers an action plan on the organisation's future, commitments to specific products, services, and the markets.

Zamzam abdelazim

The significance of fermentation is gaining more relevance due to the need for better preparation of plants, the desire for better plant constituents, and the aim for the preservation of medicinal plants. Hence, this study sets out to determine and compare the pH, proximate composition, chemical constituents, antioxidant, and antimicrobial effects of 3-day and 7-day fermented seeds of Nigella sativa. The fermentation of the seed was done for 3 and 7 days using 2.5% sugar. The pH of the sample declined from 3.5 to 3.45 during the fermentation. The proximate composition (moisture, ash, lipid, protein, and carbohydrates) was higher for the 3-day fermented sample while fiber was higher for the 7-day sample. The phytochemical constituents (tannins, saponins, phenols, alkaloids, flavonoids, phytates, oxalates, terpenoids, steroids, and glycosides) were higher for the 3-day than the 7-day sample. The Gas Chromatography-Mass spectrometry technique showed peaks that were characterized as 17 and 20 constituents on days 3 and 7 of the sample, respectively. The antioxidant capacity (ranging from 35.50% to 82.69% for the 3-day and from 37.50% to 84.99% for the 7-day sample) varies by the increasing concentration (7.81 mg/mL to 1000 mg/mL) of the sample. The diameter of zones of inhibition tested at different concentrations (25 mg/mL, 50 mg/mL, and 100 mg/mL) showed varying degrees of activity against Proteus vulgaris and Staphylococcus aureus. The zones obtained were higher 8-10 mg/mL against Staphylococcus aureus and 10-12 mg/mL against Proteus vulgaris for the 7-day fermented sample while 8.0 to 9.0 mg/mL was obtained for the 3-day fermented against Staphylococcus aureus and 8.0 to 10.0 mg/mL against Proteus vulgaris. Overall, the results of this study indicated that fermentation contributed to enhancing the bioactive components and antioxidant capacity of the fermented seeds of N. sativa thereby supporting the use of fermentation in the production of value-added functional foods.

Mediterranean journal of pharmacy and pharmaceutical sciences

Distributed Generators (DGs) are incorporated in the power distribution systems to develop green energies in microgrids. Islanding is a challenging task in a microgrid. Different types of islanding methods, e.g. local and remote methods, have been developed for handling this task, with local methods being easier to implement, while remote methods are communication-based and costly. The local methods are classified as passive, active, and hybrid, out of which the passive methods are more simple and economical. In this paper, a passive islanding detection method is proposed to detect single line to ground fault. This fault is considered to represent the 60 to 70% of the total un-intentional faults of this category. The available passive methods cannot detect islanding at lower power mismatches as the variations in voltage and frequency fall within thresholding values. In this method, the voltage signals are first retrieved at the targeted DG output and then the phase angle is estimated. Finally, the phase angle is differentiated to get Rate Of Change Of Voltage Phase Angle (ROCOVPA) to detect islanding, and then it is compared with the Rate Of Change Of Frequency (ROCOF) at zero percent power mismatch. Simulation results depict that the ROCOVPA is more effective than ROCOF. The proposed method not only reduces detection time and NonDetection Zone (NDZ) but is also stable during non-islanding cases like load connection and disconnection to avoid nuisance tripping.

Bangar raju lingampalli

আলোচ্য প্রবন্ধের কালানুক্রমিক উৎস একটি ঔপনিবেশিকতার সীমাবদ্ধতায় থাকা ভূখণ্ড এবং সেই সমাজের মেয়েদের সভা, সমিতি ও আলোচনা সভা গঠন। স্বাধীনতার পূর্বকাল অর্থে, ১৯৪৭ সালের আগে পর্যন্ত সময়কাল। কালের নিরিখে প্রাক – স্বাধীনতা সময়কালের বিস্তার দীর্ঘ হলেও, এর আলোচনার সময়কাল কেবলমাত্র নারী সংগঠনের সূচনা বা উৎসের সময় থেকেই আলোচ্যের। সেই সময়কাল দুভাগে ভাগ করা যায়। এক, এদেশের মেয়েদের সভা – সমিতি গঠনের পূর্বকাল। দুই, এদেশের মেয়েদের সভা – সমিতি গঠনের শুরু। এক্ষেত্রে, আলোচ্য প্রবন্ধের নিরিখে আলোচনা করা যায় দু-প্রকারে। এক, উনিশ শতকের মেয়েদের তৈরি সভা, সমিতি ইত্যাদি। দুই, সমাজ-বহির্ভূত মন্দ মেয়েদের যোগদান করা সভা, সমিতি বা আলোচনা সভা। এক্ষেত্রে ভাষার ব্যবহার সূচিত – সভা হিসেবেই লিখিত ও আলোচিত হবে।

Mou

The most successful and cost effective method for control the COVID-19 pandemic is the vaccination. Currently, there are different COVID-19 vaccine introduced into Libyan market. This study aimed to evaluate and compare the acceptance of COVID-19 vaccine among general population and students in Benghazi city. A cross sectional survey was conducted during March 2021 among 440 respondents (240 general populations and 200 students) using a self-administered questionnaire. The results were considerably similar among the two groups of participants. Only 10.9% said that they infected with COVID-19 during the pandemic period. About two thirds of the respondents agreed to be vaccinated against COVID-19 when available whereas the majority said they would wait some time before taking the vaccine (71.4%). Approximately, one third of the participants preferred the Sputnik vaccine, 24% preferred the Pfizer and BioNTech and 19.2% preferred Oxford (AstraZeneca) vaccine. More than a half (55.9%) of the participants are refused to pay for the vaccine. The majority of the respondents do not think the vaccine alone will be enough in protection against the COVID-19 (79.8%). There was no significant association between general population, students and the COVID-19 vaccine acceptance (p = 0.776). Additionally, there was no significant correlations between socio-demographic data and attitudes of the respondents with the acceptance of COVID-19 vaccine (p > 0.05), except for using hand sanitizers daily was significantly associated among the general population (p = 0.008). In conclusion, although, the general population and students have a good acceptability to the COVID-19 vaccine, more education health programs and promotion are wanted to reduce the vaccine hesitancy by declaring the importance of the vaccine, showing sufficient data stabilize the vaccine safety.

Mediterranean journal of pharmacy and pharmaceutical sciences

This study aims to examine and compare the levels and patterns of aggressive behavior among higher secondary students in rural, semi-urban, and urban areas. Aggression among adolescents is a significant concern, and understanding its variations across different settings can provide valuable insights for intervention and prevention strategies. The study employs a review-based research design, using articles published between 1993 and 2023 to collect data on aggressive behavior of higher secondary students. For this purpose, a review of the literature was performed by using the search words “aggressive behavior”, “higher secondary students”, “rural”, “semi-urban”, “urban” in the databases like Google Scholar, ResearchGate, Academia, Shodhganga, PubMed, JSTOR and Elsevier for articles. The results will shed light on the prevalence, types, and potential factors influencing aggression in these areas, informing the development of targeted interventions and policy recommendations and statistical analyses will be employed to examine the relationships between variables. Importance and Scope of the Topic: Aggressive behavior is a topic that affects us all. From playground bullies to road rage enthusiasts, aggressive behavior has a significant impact on our daily lives. Understanding the causes and consequences of aggression is crucial in finding ways to prevent and manage such behavior. After all, the world would be a much better place if we all knew how to calm down and express our frustrations in healthy ways.

Abdul jaleel kuzhiyengal mambra