Different derivatives of Cinnamaldehydes were prepared by Claisen-Schmidt condensation (by using Strong basic reagent). The prepared Cinnamaldehydes were treated with Hydrazine hydrate in presence of ZnO Nano-catalyst under microwave assisted solvent-free conditions to afford different substituted Pyrazoles. Green chemistry was employed. Comparisons of both microwave & conventional methods were studied & found that the first was more potent than the later. The synthesized compounds were characterized by FT-IR, 1HNMR & elemental analysis. All synthesized compounds were screened for in vitro test against EAC cell lines. Most compounds exhibited good inhibitor potency with IC50 values.

Dr ganesh n yallappa

Although, antibiotics play a fundamental role in control of infectious diseases still the injudicious prescription of antibacterial agents and antibiotic resistance are a global problem. This study aims to assess prescribing pattern of antibiotics and to provide a baseline data about behaviors of physicians prescribing antibiotics during pediatric consultations. In this study, a total of 316 pediatric patients of both genders were receiving different antimicrobial therapy were evaluated during 2021 in pediatric health care services in Bayda, Libya. Data revealed that the average of drugs prescribed was 4.10 per patient while the average of antimicrobials was 2.30 per prescription. Most of the antibiotics were prescribed for the respiratory tract infections (34.0%) and followed by the urinary tract infections (29.0%). Cephalosporins and penicillins were the most common antibiotics prescribed in this study. In conclusion, these findings show the presence of polypharmacy and inappropriate prescribing pattern. To improve and minimize the unnecessary prescribing of antimicrobial agents, a continuous training program for physicians, as well as engaged pharmacists in health care services are needed.

Mediterranean journal of pharmacy and pharmaceutical sciences

The increasing usage of composite materials has immersed simpler techniques for inspecting the integrity of composite structures, as composite materials typically have probability of getting material imperfections. In non-destructive testing, shearography reveals defects in associate object by distinguishing defect-induced deformation anomalies. Non-destructive testing (NDT) methods skit and streamer role in physical characterization of new composite materials and in assessment of their quality and serviceability in structures. Non-destructive testing (NDT), Non-destructive inspection (NDI), and Non-destructive evaluation (NDE) are concerned with the techniques and measurements that provide data on the condition of the materials and structures at the time of manufacturing and in-service.

Boopathy govindarajan

The incorporation of lomustine, a hydrophobic anticancer drug into PLGA nanoparticles by interfacial deposition method was optimized. Based on the optimal parameters, it was found that lomustine-PLGA nanoparticles with acceptable properties could be obtained. Optimization of formulation variables to control the size and drug entrapment efficiency of the prepared nanoparticles seems to be based on the same scientific principles as drug-loaded nanoparticles prepared by nanoprecipitation, solvent evaporation method. The process was the most important factor to control the particle size, while both the drug-polymer interaction and the partition of drug in organic and aqueous phases were the crucial factors to govern the drug entrapment efficiency. PLGA concentration at lower level (100 mg), 1:5 organic phase: aqueous ratio, 1%w/v PVA concentration, 3%w/v pluronic F68 achieved smaller particle size. Additionally, L:G ratio of PLGA 75:25, lower volume of organic solvent (1:10 organic phase: aqueous phase), higher initial drug content (10 mg) enhanced the drug entrapment efficiency and maintained lomustine concentration in blood for an extended time period, elevated lomustine concentration in lungs and slowed the elimination of lomustine. The biodistribution profiles of prepared nanoparticles in albino mice showed higher plasma drug concentration for longer period of time, elevated drug concentration in lungs and slow elimination from kidney. No toxic effects of prepared nanoparticles were observed in histopathological examination of lungs and kidney. The systematic investigation reported here promises the development of PLGA nanoparticles loaded with lomustine when tested in Lung Cancer cell line L132 and toxicological/ histopathological studies in albino mice.

Archana mehrotra

It is virtually impossible to mention the phrase ‘project management’ without introducing the concept of risk management. As Hillson (2016, p.11) states, “risks [are] particularly relevant to projects” suggesting that effective management of risk is an integral ingredient for project success. The close link that exists between projects and risks may be deduced by the definition of the word ‘project’. In simple terms, projects refer to unique endeavours undertaken with the aim of achieving desired outcomes. These endeavours typically specific start and completion dates, and involve resource, time and cost constraints. These characteristics imply that projects are intended to deliver identifiable benefits to the organisation; these benefits, however, are not enjoyed immediately even if the project is completed. On the contrary, projects commonly create capabilities that call for operation or utilisation for the actual gains to be generated (Hillson, 2016 p.11). The interpretation of this is that projects have a risk element in that they contain a potential reward and possibility of loss. For this reason, project managers must be well-versed with risk management.

Mohamed sorogy

his study aims to explain the optimization of the ARCS learning model as an effort to increase the learning motivation of students, especially in thematic learning at MI At-Taqwa Bondowoso. The method used is qualitative with a descriptive qualitative approach, while the type of research used in this research is field research. The data collection techniques used interviews, observation, and documentation. Data analysis used was condensation, data presentation, and verification. And the validity of the data uses triangulation of sources and techniques. The results of this study indicate (1) Thematic Learning Problems at MI At-Taqwa Bondowoso, namely: Teachers are less biased in utilizing learning media, so that the only sources used are textbooks, classroom learning is only centered in the teacher, the students' lack of interest in the learning process, so that students do not pay attention to the teacher who teaches. (2) The application of the ARCS model in thematic learning at MI At-Taqwa Bondowoso, namely: The implementation of the ARCS model was carried out by teachers with several methods and strategies such as modeling the way strategy and also contextual teaching and learning, ARCS Model as an alternative solution in learning for increasing students 'learning motivation is able to stimulate students' enthusiasm in thematic learning.

Educare: journal of primary education

The genus Caesalpinia belongs to the family Caesalpiniaceae and includes 280 species distributed in tropic and subtropical regions of the world. Historically, species of the genus Caesalpinia have been used to treat a wide range of ailments, such as malaria, ascariasis, dysentery, fever, rheumatism, and influenza. Phytochemical works led to the isolation of triterpenoids, diterpenes, flavonoids, steroids and phenolic compounds. Pharmacological studies have shown that the extracts and compounds isolated from this genus exhibited anticancer, anti-inflammatory, anti-malarial, antipyretic, anti-microbial, anti-rheumatic, antiulcer and anti-diabetic activities. Therefore, this review aims to provide a comprehensive overview of the genus Caesalpinia's ethnopharmacology, phytochemistry and pharmacology.

Dr. salman ahmed

Background: The first wave of the COVID-19 pandemic was associated with significant morbidity and mortality among healthcare workers worldwide. The present study aimed to assess the knowledge, attitudes, and practices of healthcare workers toward COVID-19 at Ataq General Hospital, and three other hospitals and health centers in Shabwah Governorate, Yemen. Materials and Methods: From January 1, 2022, to February 28, 2022, a cross-sectional survey of healthcare workers was conducted in the city of Ataq, Shabwah Governorate at the following hospitals: Ataq General Hospital, Al Shefa’a Hospital, Al Aafiah Hospital, and COVID-19 Isolation Center. Results: A total of 107 healthcare workers completed the survey. Their mean age was 28.17 ± 7.73 years, 79 (73.8%) of them were male and 28 (26.2%) were female. The overall knowledge was good, with a score of 19 out of 21; however, most participants were unaware of some of the extra-respiratory symptoms of the disease, such as diarrhea and confusion, and about 57% of them were unaware that eating or interacting with wild animals may contribute to the infection with the COVID-19 virus. Attitude analysis of the participants revealed that about half of those surveyed do not believe that Yemen can contain COVID-19. In general, the practice of the participants was good. Conclusion: Although the overall knowledge score in this study was good, most respondents could not recognize some of the extrapulmonary manifestations of COVID-19 and were unaware of the possibility of transmission of the disease from wild animals. In addition, about half of those surveyed do not believe that Yemen can contain COVID-19

Karishma

Service quality is a key factor for success in any hotel. Many researchers have conducted studies on service quality, but only a few studies have been conducted on internal service quality (ISQ) in general, and in the hotel industry in particular. Since there is no general agreement among researchers on the measurement of ISQ, many studies have used SERVQUAL instrument to measure the employees’ perceptions of ISQ. The purpose of this study is to explore the influence of ISQ on employee’s job satisfaction in five-star hotels in Jordan. The current study was carried out by measuring the data gathered through a seven-point Likert scale. The quantitative survey method was applied, and therefore the SERVQUAL instrument was used to measure ISQ, and the Job Satisfaction Survey (JSS) was used to measure job satisfaction. Data obtained from a sample of 238 respondents drawn from 14 five-star hotels in Jordan were analysed with the SPSS software based on descriptive statistics. The study’s findings indicated that the ISQ of five-star hotels in Jordan has a significantly positive influence on an employee’s job satisfaction. These findings support the hypothesis that there is a positive relationship between ISQ in the hotel industry and industry employees’ job satisfaction.

Mukhles m. al-ababneh

Aging seldom comes alone and it is considered to be the major factor for many diseases and comorbidities and disabilities. The objectives of the study are to examine demographic characteristics and prevalence of comorbidities and polypharmacy of elderly patients who were admitted at Sebha Medical Center according to the selected period. This study is descriptive and retrospective cross-sectional study conducted in Sebha during 2021. From 195 participants of the study, the highest rate of patients was from the age group of 65 - 74 years which accounted for 86 participants (44%) and followed by those age group of 75 - 84 years which was reported by 65 participants (33%). The majority of elderly patients have hypertension, (n = 116, 59%) and over one-third of the patients (n = 73, 37%) have diabetes mellitus while nearly one-quarter of patients have both diseases at the same time (n = 47, 24%). Nearly, three-quarters of patients have electrolytes imbalance (n = 142, 72%). Nearly, two-thirds of the patients had three to five comorbidity diseases (n = 122, 63%). Whereas, over one-third of the patients had just one or two comorbidities (n = 70, 36%). Almost all the participants have polypharmacy (n = 187, 96%). Just above half of the patients have five - ten medications (n = 100, 51%) compared with 45% of the patients from those who have more than ten medications (n = 87). This study showed that there is a strong relationship between the prevalence of polypharmacy and the number of comorbidities. A Spearman correlation test indicated that rate of comorbidities was related to polypharmacy with a significant correlation (P < 0.01). The present study found high prevalence of comorbidities and polypharmacy among elderly inpatients. Based on this high prevalence, practicing pharmaceutical care could play an effective role to reduce the risk of inappropriate polypharmacy among hospitalized elderly patients through encouraging clinical pharmacist to engage in clinical activities in hospitals.

Mediterranean journal of pharmacy and pharmaceutical sciences

в статье анализируются основные причины и критерии иностранных инвестиций, основная роль внедрения инновационных технологий в рыночную экономику. А также роль иностранных инвестиций в модернизацию экономики Узбекистана.

Ikboljon odashev mashrabjonovich

Internet of Things (IoT) enhances the global connectivity to all the remote sensing devices. It enables the connectivity of communication and processing the real-time data that has been collected from an enormous number of connected sensing devices. There is an increase in the IoT technology that leads to various malicious attacks. It is more important to overcome the malicious attacks, mainly to stop attackers or intruders from taking all the control of devices. Ensuring the safety and accuracy of the sensing devices is a serious task. It is very much important to enabling the authenticity and integrity to obtain the safety of the devices. Dynamic tree chaining, Geometric star chaining and Onion encryption are the three solutions that has been proposed in this project for in order to enable authenticity and integrity with information hiding for secure communication. The simulation results are driven displays that the proposed system is very stable and much better than other existing solution in means of security, space and time.

Jebin bose s

Objectives: Improper and inappropriate use of antibiotics is one of the possible factors affecting the transmission of antibiotic resistance is Because Pseudomonas aeruginosa is one of the most serious pathogenic bacteria in hospital environments and resistant It is an antibiotic that causes problems in treatment. This study aims to determine multiple resistances Pseudomonas has been treated with antibiotics, arsenic and metals. Materials and Methods: In this study, 23 strains of Pseudomonas aeruginosa were isolated from clinical specimens. for review Resistance of these bacteria to penicillin antibiotics was used by Kirby-Bauer method. The minimum concentration C.I.M. (and minimum lethal concentrations (C.B.M.) of antibiotics and heavy metals (cadmium, mercury) and arsenate Tubal dilution, agar and growth were performed in agar plate, respectively. Results: In this study, the highest and lowest MIC values obtained in Pseudomonas aeruginosa for metals, respectively. * 8 and 3 cadmiums (0.6 and 4.9 μg / ml), mercury (<0.12 and 4 μg / ml) and arsenate (10 × were 256 μg / ml). Of 23 strains, 84% to the antibiotic carbonicillin, 63% to piperacillin and 100% to 103 Arsenic and cadmium were resistant. Also, 82.6% of the strains were resistant to mercury. Conclusion: The results of this study showed that Pseudomonas aeruginosa strains have multiple resistance to arsenic, metals and the antibiotics are car penicillin and piperacillin.

Amirhossein jahromi

The samples of K1-xNaxNbO3 (X=0.4, 0.2, 0) ceramics (PSN) have been prepared by the conventional solid state reaction method and sintering process. The prepared samples have been characterized by XRD. All the prepared samples show orthorhombic structure at room temperature. Dielectric and Electrical properties of PSN system have been investigated in the temperature range 450C-2450C, and at 1MHz frequency. It is observed that dielectric constant, loss tangent and electrical conductivity increases with increasing temperature. Near the transition temperature dielectric constant, loss tangent and electrical conductivity of these samples show anomalous behaviour with temperature.

Manish uniyal

The aim of the study is to: assess the effectiveness of structured teaching programme on prevention of selected postoperative complications among 300 patients undergoing abdominal surgeries in selected hospitals. A pre-experimental research design and convenient sampling technique was adopted study. Data were collected by using structured interview schedule and structured questionnaire was used to assess the existing knowledge regarding prevention of selected post operative complications. Shows that majority (42.70%) subjects had inadequate knowledge and (18.30%) had moderate knowledge in pre test. In post test majority 44 (73.3%) had adequate knowledge and 16 (26.7) had moderate knowledge. The pre test mean score was 16.15 with the standard deviation of 4.65, whereas in post test the mean score was 30.7 with the standard deviation of 5.387 which indicates that structured teaching programme is statistically significant at P<0.01 level. There was significant difference between the pre test and post test knowledge scores t=20.56, P<0.01 level. There was a significant association between pre test knowledge scores with their education and no association between age, gender, religion, occupation, marital status, type of family, place of domicile, dietary pattern, personal habits and source of health information at P<0.01 level. Author concluded that that post test knowledge scores was improved after structured teaching programme. So structured teaching programme was effective in increasing the knowledge level regarding prevention on selected post operative complications among patients undergoing abdominal surgeries.

Prof.k.c yadav

Vitamin C is associated with history of the cause of the ancient hemorrhagic disease scurvy. Vitamin C is an essential nutrient with important antioxidant properties. It is required by the body for normal physiological function. The body cannot synthesize vitamin C, it is present in nature through foods and other natural sources and it exists as a nutritional food supplement. The antioxidant activity of vitamin C protects the body from free radical damage. Vitamin C is essential for the development and maintenance of connective tissues. It is used as therapeutic agent in many diseases and disorders. Vitamin C plays an important role in several metabolic functions, as the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin, and the conversion of cholesterol to bile acids. Vitamin C supplementation resulted in a significant increase in vitamin C levels in populations; its high intake is associated with positive effects on cardiovascular risk factors. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight infections. It has an important role in bone formation, wound healing and the maintenance of healthy gums. There is profound beneficial effect of vitamin C in respect to human diseases as cancer, atherosclerosis, diabetes, neurodegenerative disease and many metal toxicities. Several vitamin C analogs have been produced as anticancer and antioxidant activity. Vitamin C is useful if it is used as adjuvant therapy for several chronic diseases. Thus, this review summarizes the importance of vitamin C in the body’s physiology and biochemistry, in addition, the different mechanisms that vitamin C is implicated to treat different acute and chronic diseases. Future exploration should pay attention to chronic disease management by vitamin C.

Mediterranean journal of pharmacy and pharmaceutical sciences

Analgesic activity on two Cleome scaposa and Cleome brachycarpa by applying pressure-induced pain model

Dr. salman ahmed

Salinity is a major environmental stress which has been studied extensively and has its impact on agriculture in the past, present and future. The global importance of salt affected soils can be explained by their wide distribution on all continents covering about 10% of the total land surface. At present, there are nearly 954 million ha of saline soils on earth’s surface. It is extremely difficult to quantify the social and economic costs of salt prone land and water resources. Plant Growth Promoting Rhizobacteria (PGPR) is a group of bacteria that actively colonize plant roots and increase plant growth and yield. They play an important role within the interaction between soil and plant. As plants grow on marginal soils such as saline soils, the importance of the rhizobacteria increases as they mobilize nutrients and provide tolerance ability to the plants. In the present study, an attempt was made and isolated 51 PGPR isolates (Phosphate Solubilizing Bacteria–18; Azotobacter spp.-16 and Azospirillum spp.-17) from different salt affected areas in Tamil Nadu and Puducherry. All the isolates were screened for their efficacy against different sodium salts namely sodium chloride, sodium citrate and sodium sulphate. It was observed that the absorbance of the culture broth grown in salt stress to sodium chloride decreased with increasing concentration of the salt. Similarly decrease in growth pattern in terms of the absorbance was also observed in salt stress to sodium citrate and sodium sulphate.

Dr. saranya devi k

Adolescents’ scholastic and social life has become increasingly reliant on the internet and mobile technology in recent years. Problematic Internet Use (PIU) is a growing problem in Indian adolescents. However, in many cases, this use has become obsessive, causing them to neglect other elements of their lives. Adolescents account for over 35% of internet users in India. The purpose of this study was to evaluate the psychosomatic problems related to internet overuse among school going adolescent students. This cross-sectional survey was conducted among 348 students in selected schools of Aspur block in Dungarpur-district, Rajasthan, India in the month of February 2016. Problematic internet use (PIU) was assessed by Young’s twenty question internet addiction test. The Depression, Anxiety, Stress Scale (DASS-42) and self structured questionnaire check list was used to measure psychosomatic problems among adolescents. Approximately 5.17% adolescents showed Problematic internet use (PIU). Adolescents with PIU were associated with age between 14-16 year, males,10th class of study, using internet since more than 3 years, being at home, mobile as a source of internet use, purpose of internet use with online gaming. Compared with normal internet users, there were significant correlation between Problematic Internet Use and Somatic Complaints r=0.3660, p<0.05, Depression r=0.3982, p<0.05. Anxiety r=0.2512, p<0.05 and Stress r=0.2886, p<0.05. Problematic internet use (PIU) is an increasing problem among teenagers and it has been linked to psychosomatic issues. Timely Effective measures are needed to prevent the spread of this problem

Dr k c yadav

Living with epilepsy, its unpredictable seizures, and its comorbid conditions present many challenges over the time. Continued educational efforts can play a key role in helping people learn to live with epilepsy and understand epileptic medications over the life span. The aim of this study is to assess the impact of pharmacist-initiated education on patients with epilepsy. Prospective and observational pilot study to evaluate the impact of educational interventions during February and March, 2019 was conducted. A total of seven patients with epilepsy was included in this study. They received ordinary consultation care in National Centre of Epilepsy at Ali Omar Askar Hospital in Tripoli, Libya. Knowledge assessment questionnaire was assessed initially and patients were subjected to pharmacist-initiated education and they have given follow up reporting card. A follow up for one month has continuously been done and final evaluation included: knowledge assessment questionnaire, adverse drug reactions and epileptic attacks reporting. All the patients completed the pre and post education questionnaire. There was no significant difference between the patients’ knowledge before and after interventional questionnaire except for only two patients which is statistically significant (P=0.03) and (P=0.02) whose knowledge was significantly enhanced by post education. Thus, there are a lot of opportunities and challenges for pharmacists to play a role in epileptic care and education as patients with epilepsy are not knowledgeable about their illness regardless of age, educational background or duration of epilepsy. This role must be highly enforced and implemented in patients with epilepsy.

Mediterranean journal of pharmacy and pharmaceutical sciences