Self-medication of antibiotics is an irrational use of drugs, contributing to microbial resistance, increasing health care cost and higher mortality and morbidity. This study was aimed to assess self-medication with antibiotics without a medical prescription in the community of Libya. This is a cross-sectional study conducted from June to December, 2022 and the total number of participants was 200. The design of the study and sample size were modified according to the proficiency of pharmacists and the medical and non-medical population of Libya. The questionnaire was developed in English and Arabic language and was distributed through social media platforms. The questions were used after a thorough literature search and assessing the validity and reliability. The significant signs regarding reasons for the treatment by self-medication drugs of antibiotics, because of its various drugs of antibiotic by pharmacist (n = 80, 40.0%) and family (n = 90, 45.0%) compare with experience and physicians by used prescription was 13 (06.50%) and significant sings regarding by nasal congestion self-medication of various antibiotics (n = 100, 50.0%). This sign must be practiced based on a previous physician’s prescription. The antibiotics are often self-administered as patient feel that they will save money and time but this can lead to substantial adverse drug reaction, antibiotic resistance, treatment failure and drug-related toxicity. This study respondent's medical and non-medical public of Libya who should be relatively informed and educated about the risk of treatment by self-medication of antibiotics with the development of resistance.

Mediterranean journal of pharmacy and pharmaceutical sciences

A Man-Machine System means an activity occurring/occurred with the involvement of a human being with the help of some tools used to interact with the material. In small foundries, the moulding process is manual & labours have to work in different psychological moods, stress, and strain, without training on ergonomic posture, in different environmental factors such as temperature, vibrations, noise dust which affects productivity and also the amount of human energy input to produce the component. This paper makes an attempt to develop a mathematical model to relate productivity with various parameters and identify the most sensitive parameter to control productivity.

Rahul bachute

This work was focused on identification and evaluation of process parameters of modified nanoprecipitation method, for fabrication of lomustine nanoparticles, with the aim of reducing cancer cell viability at low concentration of lomustine. The parameters controlling particle size, mostly in nanosize, were solvent/nonsolvent composition and emulsification speed of homogenizer along with aqueous phase volume. This controlled particle size is below 250 nm. The stabilizer concentration controlled particle size is within 68 nm ± 0.89 to 137 ± 0.94 nm with PDI 0.06 ± 0.008 to 0.25 ± 0.001. But, the stabilizer addition mode showed more uniform size distribution with PDI 0.085 ± 0.004. Entrapment efficiency was maintained well above 47 ± 0.23%. The drug release pattern was monophasic with controlled release over 24 hrs. In the method used, drug content was affected by ratio of polymer to drug to organic solvent, as well as homogenization speed and time. Percentage viable cells of L132 human lung cancer cell line remained, were only 5% at 100 μg/ml lomustine equivalent PLA nanoparticles.

Archana mehrotra

Numerous initiatives to rely on new renewable energy sources, such solar electricity, have been sparked by the increased interest in global warming. With an increase in home photovoltaic (PV) panels that are available to the public, more precise calculations of energy generation are now possible. Segmenting satellite images offers a straightforward and inexpensive way to categorize solar panels..This work suggests a method for classifying and segmenting solar panels that combines the watershed algorithm with deep learning approaches. First, a Convolutional Neural Network (CNN) architecture with the ResNet, EfficientNet, and Inception architectures is used for classification. Through the fine-tuning of pre-trained networks on a heterogeneous dataset of solar panels, transfer learning improves performance. The categorization model recognizes solar panels in a variety of settings with accuracy, making maintenance and monitoring easier. After classification, the watershed method uses intensity gradients to precisely delineate solar panels from the background. Tasks like defect detection and layout optimization are made easier when deep learning-based classification and watershed segmentation are combined. The outcomes of the experiments show how well the suggested method performs in terms of segmenting and classifying solar panels under various circumstances. A flexible automated solar panel management solution is provided by the combination of deep learning and the watershed algorithm, which promotes increased sustainability and efficiency in solar energy systems.

Bakka arun kumar

To the editor, Hepatitis B virus (HBV) infection remains a global public health concern, with over 296 million chronic carriers worldwide and an estimated 820,000 deaths annually due to HBV-related complications such as cirrhosis and hepatocellular carcinoma (HCC). [1] While serological markers like hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) have long been used in diagnosis and monitoring, emerging research has revealed the value of novel biomarkers in assessing disease progression, predicting treatment response, and guiding personalized care strategies.

Karishma

Contact between pharmaceutical company representatives (PCRs) and medical practitioners is viewed by drug companies as a vital part of their marketing strategy. Studies show that PCRs employ persuasion disguised as information. Because PCRs are keenly involved in competitive marketing, they are more likely to use persuasion than information during their promotional visits. Information increases customer awareness of a particular product without influencing the preferences. Persuasive marketing directly influences a consumer’s brand preference. Positively influencing a prescriber’s attitude towards a product is essential for effective marketing since there is an association between attitude, intention and behaviour. Numerous studies find that pharmaceutical promotional interactions have an impact on physician’s perceptions and their prescribing practices. Yet, many of today's health professionals do not acknowledge their vulnerability to being misled by pharmaceutical marketing. This study demonstrate that Pharmaceutical promotion strategies do not differ greatly from those of other types of marketing, PCRs more likely to use persuasion to highlight the perceived difference of their particular brand. Persuasion often has a subtle influence that is not easy to detect and physicians should receive education regarding the drug promotion techniques used by pharmaceutical companies. Persuasion often has a subtle influence that is not easy to detect. Overconfidence is a major risk factor for being misled. This analysis highlights some critical aspects of persuasive communication by PCRs in promotional visits. It will help prescribers to interpret, evaluate and respond appropriately to manipulative behaviour by PCRs.

Mediterranean journal of pharmacy and pharmaceutical sciences

Regression modeling analyses the relationship between two or more variables and can be used to predict the response variable from one or more independent variables. The present study uses linear regression analysis to evaluate the growth in the two fish species of genus Oreochromis, Nile tilapia and Jipe tilapia, under aquaculture conditions. The models were fitted using a collection of functions in the R-software library. The final models were selected using the goodness of fit criteria based on the coefficient of differentiation, the model p- values and Akaike information criteria. The significance of the linear relationship between predictor variables and the mean response was tested by comparing the computed standardized parameter estimates, whereas the confidence intervals were constructed to assess the uncertainty of predicting the response variable and determine outliers in the model. Generally, both species exhibited good condition during growth and all the measured water quality variables significantly afffected growth (p<0.05). However, only temperature and dissolved oxygen produced the most important linear relationship with fish weight. The study recommends that data from a controlled experiment should be used the determine the interactions between the two growth variables.

Omweno job

The Nano-bio fusion is a booming area with high expectations that major steps in health treatment, body repair and body improvement can be made. It is regarded as the most innovative domain of this moment. Developments are in the field of: Nanomedicine: targeted drug delivery by medically functionalized nanoparticles, for rapid cure without side effects or human stimulation. Regenerative medicine: DNA programmed tissue engineering for quick and efficient wound healing, rebuilt of organs and other body parts. Smart implants: biocompatible implants that can sense and actuate in order to repair or enhance a body function. Nanotechnology idea has as of late gone into the exercises of day by day living. Nanotechnology in games solution cals be characterized as the adjustment of a wide range of improvements in nanoscale into therapeutic applications related with games wounds. The adjusted advancements can be either specifically related with the restorative mediations, for example, recovery of a tissue, implantation, and drug treatments or supporting components like imaging, strappings, and tapings. In this section, the impression of recently developed nanoscale advancements in regards to games wounds will be talked about with recent researches.

Yatendra sharma

Natural products have played an essential role in treating human diseases for thousands of years. According to WHO, 80% of the world’s population relies on traditional medicines to cure and prevent ailments. Numerous plants have been reported to have antitussive activity. Our present study aimed to evaluate the antitussive effect of aerial parts of ethanolic extract of Caesalpinia pulcherrima (Caesalpiniaceae) at 200 and 400 mg/kg doses in healthy albino rats. Caesalpinia pulcherrima is an ornamental plant, usually 3.7-4.3 m in height, known as Peacock flower and is used traditionally to treat cough, bronchitis and asthma. Cough significantly affects human health and is the most common reason to visit physicians. Cough may be produced due to disease, allergens, pollutants and respiratory infections. Any mechanical or inflammatory change provokes the afferent or sensory nerves in the larynx and tracheobronchial, resulting in a cough. In this study, cough was induced by using the sulphur dioxide induction method. Animals were divided into four groups of 7 animals each, and all the drugs were administered orally. Group I was a control group, while group II was a standard taking Prospane. The extract showed highly significant results at 200 and 400 mg/kg doses compared to the control. So, it proves and supports the traditional use of Caesalpinia pulcherrima to relieve cough.

Dr. salman ahmed

Indian Banking industry has witnessed a tremendous developments due to sweeping changes that are taking place in the information technology. Electroic banking has emerged from such an innovative development. Many developments in Tele-communication technology and electronic data processing in recent years have contributed to remarkable changes in the banking sectors. The application of modern information technology has radically altered the traditional way of doing banking business. Availability of ATMs and plastic money (i.e., credit and debit cards) has helped customers avoid going to bank premises for cash. Bank customers can view their bank accounts; get statements of accounts, purchase drafts and transfer funds through their personal computers. Another development viz., Electronic Data Interchange (EDI) has contributed to effective working of banks. The computer networks have helped to automate the funds transfer, contributing to more effeicient systems of payments. All these developments in banking sectors in recent years have given birth to a new concept called E-Banking. Hence this study is undertaken in order to know the customer preference towards E-banking services with special reference to private sector banks.

Dr.n.s.lissy

To the editor, Breast cancer remains one of the leading causes of cancer-related mortality worldwide, necessitating innovative and multifaceted therapeutic strategies. [1] We propose a promising combination approach that synergizes Artificial Intelligence (AI), oncolytic virotherapy, probiotic therapy, stem cell therapy, and immunotherapy to target breast cancer more effectively.

Karishma

Chronic kidney disease is a public health problem affecting people worldwide. This study was aimed to examine the characteristics of patients with chronic kidney disease and to identify prevalence of drug-related problems among Libyan patients. This is a descriptive retrospective study carried out in Southern-west part of Libya, Sebha City. Information abstraction forms were used for collection of data. The investigators reviewed the medications, medical records and laboratory data to identify drug-related problems.1 000 patients' files during 2019-2020 were examined and only 120 files were selected for this study. The majority of the participants were male (73, 61.0%) and the mean age was 56.1 years. 576 comorbidities among the selected patients were identified (73.61%) and the average number per patients was 4.8 concurrent diseases. There were 1 350 medications prescribed and the average of prescribed drugs per patient was 11.25. The majority of patients use more than 10 drugs (64, 53.3%) and the average length of staying in the hospital was 5.58 days. 502 drug-related problems were identified with an average of 4.18 per patient. Untreated conditions such as Hyponatremia and anemia were the highest rate of drug-related problems identified (199, 39.6%) followed by improper drug selection (82, 16.3%) such as cefotaxime, vancomycin and aminoglycoside for chronic kidney disease and drug use without indications such as antibiotics (68, 13.5%) and over-therapeutic dose such as metoclopramide(63, 12.5%). In conclusion, all the patients have polypharmacy and the majority have comorbid conditions and chronic kidney disease with frequent drug-related problems, thus, to lower the incidence rate of drug-related problems, therapeutic interventions are needed. Subsequently, it is a crucial to involve clinical pharmacist in hospital to improve the care of patient with chronic kidney disease.

Mediterranean journal of pharmacy and pharmaceutical sciences

Experimental trials were conducted on the compatibility of urea 2% with insecticides of different groups viz., monocrotophos 36SL @ 500 ml/ha, cypermethrin 25EC @ 125 ml/ha, quinalphos 25EC @ 1000 ml/ha and novaluron 10EC @ 375 ml/ha against larval population of Helicoverpa armigera in the field conditions on chickpea cultivar “HC-1” during Rabi season 2011-12 and 2012-13 at CCS Haryana Agricultural University, Hisar (Haryana). These insecticides were found compatible with urea. Minimum larval population of H. armigera was recorded in novaluron 10EC @ 375 ml/ha at 3, 7 and 10 days after spraying. Monocrotophos 36SL @ 500 ml/ha, quinalphos 25EC @ 1000 ml/ha and cypermethrin 25EC @ 125 ml/ha could not provide consistent results against H. armigera. The larval population, pod damage and incidence were statistically at par with insecticides and their combination. No phytotoxicity effect was observed on the leaves with urea application in combination with insecticides. Minimum per cent pod damage (7.3%), maximum grain yield (14.6 q/ha) and monetary returns (` 6265/ha) was realized from novaluron 10EC @ 375 ml/ha plus 2% urea as compared to other treatments.

Dr. babu lal jat

An online travel agent is one of the platforms that has evolved throughout this digital era, including Tiket.com. Unfortunately, when the Covid-19 pandemic hit, online travel agents were affected the most. Now it is time for Tiket.com to evaluate its marketing strategies to increase the customers' purchase decisions. This research aims to analyze which strategies among Perceived Trust, E-Service Quality, Online Rating, and Online Review have the biggest influence on customer’s Purchase Decision on Tiket.com. This study is conducted from September to December 2022, using a quantitative method with purposive sampling by distributing an online questionnaire to 50 customers of Tiket.com. The data is analyzed for multiple regression analysis to find the influence of each independent variable on the dependent variable. Results show that E-Service Quality, Online Rating, and Online Review have a positive and significant influence on Purchase Decision while Perceived Trust has a positive but insignificant influence on Purchase Decision. Further, Online Rating is found to have the biggest influence on Purchase Decision. Thus, it is important for Tiket.com to pay attention to its Online Rating and Review, E-service Quality, and Perceived Trust.

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Higher Education has an important role in the task of rebuilding a nation and it paves the way for overall development of a nation. The twentieth century has witnessed several revolutions like Green revolution, White revolution, I.T revolution etc; transforming human civilization in to new heights. At the start of 21st century, there is a lot of importance given to higher education. Every country realizes the value of higher education and the benefits accrue from it. There is a greater importance attached to higher education. “The social demands for higher education continue to increase. Indian higher education has a rich and complex history that spans millennia. This abstract provides an overview of the key developments in Indian higher education, highlighting its evolution from ancient times to the modern era. The history of Indian higher education is marked by the establishment of ancient centers of learning, the influence of various empires and dynasties, colonialism, and post-independence reforms. This abstract also touches upon the challenges and opportunities that have shaped the landscape of higher education in India.The history of Indian higher education can be divided into several distinct periods. In ancient India, centers of learning such as Takshashila and Nalanda emerged as renowned seats of knowledge, attracting students and scholars from across the world. These institutions laid the foundation for a tradition of rigorous intellectual inquiry

Dr gedam kamalakar

The mechanical heart valve prosthesis with a caged ball has been around for 60 years. It has since experienced changes and adjustments. The Starr–Edwards (SE) valve was a pioneer and was taken out of clinical use in the late 2000s. SE is reportedly close to or has reached the age of 50, according to numerous sources from around the globe. The author’s observations and review of the literature about thrombogenicity, pannus formation, left ventricular outflow tract obstructions, and infective endocarditis in the SE valves, which were reportedly higher before its clinical ending, were only an overestimation and were not supported by scientific data. However, it was less discussed in the article, along with potential benefits. The main reasons for its demise were its obtrusive size and unattractive shape. There have been several successful implantations of these valves in Asian nations and reports of fewer primary failures and unexpected cardiac fatalities. Therefore, there is a need for extensive data gathering, documentation, and more recent studies on these valves to prepare for a prospective revival of use with newer research, mainly when long-term durability is considered.

Karishma

Prostate cancer (PCa) is the leading cause of cancer death in men, and its treatment is commonly associated with severe adverse effects. So, new treatment modalities are needed. In this context, natural compounds have been widely explored for their anti-PCa properties. Aquatic organisms contain numerous potential medications. Anticancer peptides are less toxic to normal cells and provide a productive treatment approach via multiple mechanisms, including altered cell viability, apoptosis, cell migration/invasion, suppression of angiogenesis and microtubule balance disturbances. This review sheds light on marine peptides as efficacious and safe therapeutic agents for PCa.

Dr. salman ahmed

Background: The rising global DM epidemic is driving the problem of TB control. This research determined glycemic control in TB only infected and DM-TB comorbidity and the consequence of the double burden on treatment outcome. Methods: fifty M. TB infected subjects and fifty control subjects were enrolled into the study, all the participants gave consents. FPG and HbA1c were determined by Colorimetry. Data were analyzed using SPSS version 20.0 statistical package, differences between groups and variation among groups were determined by Student’s t-test and ANOVA respectively while the association between variables by Pearson’s correlation. Differences were considered statistically significant at p<0.05. Results: The mean FPG and HbA1c levels of TB subjects were significantly (P<0.05) higher than those of the control. The mean BMI of the TB infected subjects was significantly lower (p=0.001) than that of the controls. The mean age, FPG and HbA1c of TB subjects at the beginning phase of treatment were significantly lower (p<0.05) than those of subjects at the continuation phase of treatment. The mean age, FPG and HbA1c of subjects with DM-M.TB coexistence were significantly (p<0.05) higher than those of the M.TB only infected subjects. BMI of the DM-M.TB comorbidity subjects was lower than that of the M.TB only infected subjects (p=0.109). A significant positive correlation was obtained between HbA1C and FPG in M.tb infected subjects. (r=0.910, p=0.001). A negative correlation obtained between HbA1C and BMI in M.tb infected subjects. (r=0.267, p=0.061). Conclusion: Infection with mycobacterium tuberculosis poses a risk to DM and vice versa, which may adversely affect treatment outcome and control of both diseases. Firm efforts to control DM may likely have a significant valuable effect on TB treatment outcome.

Eworo raymond

Menstruation is a normal physiological impact on each girl’s life. Menstruation is monthly uterine bleeding for 3-5 days after every 28 days from puberty till menopause. A change in mood, behaviour, appearance of some abnormal vague symptoms is often noticed in the second half of the cycle. Symptoms are severe enough to disturb the life cycle of a woman called premenstrual syndrome (PMS). The study aimed to assess the premenstrual symptoms and coping strategies among adolescent girls. The majority of the students suffered from premenstrual syndrome. Objective: to assess the premenstrual symptoms and coping strategies among adolescent girls. Methodology: A nonexperimental descriptive research design was adopted in this study. Non probability convenient sampling technique was used to select the sample size of 30 adolescent girls. The assessment of premenstrual symptoms and coping strategies was carried out using a self-reported Likert’s rating scale. Data was analyzed by using descriptive and inferential statistics. Result: Majority (93.3%) of the samples sometimes had physiological and psychological problems, 90% of them had behavioural symptoms. Majority (43.3%) of the samples always followed coping strategies and 16.7% of the samples sometimes followed coping strategies and 40% never followed any coping strategies. Conclusion: PMS was common among students at 18-24 years. The most common physical symptoms experienced by adolescent girls were headache, backache and lower abdominal pain. Adolescent girls used coping strategies as taking hot / cold drinks, do not express anger to others, and turn to study and forget things, hearing music and taking medications. Keywords: Premenstrual Symptoms, physiological, psychological & behavioural symptoms, Coping Strategies, Adolescent Girls.

Elsi queen

Customers shopping behaviors have altered because of technological advancement and widespread of internet access. The rise in online sales presents both opportunities and challenges for many e-commerce companies. To successfully increase the customers’ purchase intention, it is important to implement persuasion marketing strategies especially in the online environment, together with other traditional marketing techniques available. The goal of this study is to determine which technique, between Scarcity Tactics and Liking Tactics, has more impact on customers’ Purchase Intention. Zalora Indonesia, as one of the leaders in fashion, beauty, home and lifestyle e-commerce, is chosen to be the research object. Scarcity Tactics and Liking Tactics are the independent variables used in this study, with customers’ Purchase Intention as the dependent variable. Quantitative method using a causal strategy, with an online questionnaire has been delivered to 120 Zalora Indonesia buyers. According to the findings of this research, customers who buy online have the tendency to do purchases when Zalora Indonesia uses Scarcity Tactics and Liking Tactics in its marketing approach. Scarcity Tactics, however, has more influence on online Purchase Intention, whereas Liking Tactics has a promising but insignificant impact. Both Scarcity Tactics and Liking Tactics show influences in customers’ Purchase Intention as much as 60.2%.

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