Over the last few years, Libyan scientists and researchers have investigated most of the native wild plants from various regions of Libya. Since tens of years, research groups from Libyan universities, especially at Faculty of Pharmacy and Biotechnology Center, have assessed the native wild plants for their detailed biochemical and pharmacological active composition in order to identify their biologically active compounds with health and therapeutic benefits and economical values. Recent scientific reports stated that several wild Libyan plants carry various bioactive compounds which have a substantial role in treating certain human diseases such as diabetes mellitus, inflammations, microbial infections, cancer, etc

Mediterranean journal of pharmacy and pharmaceutical sciences

Work life balance of employees has become an important issue which discusses mainly about their carrer development and the family care, it is necessary to know how the employees balance the demand for their profession and also their domestic compulsions. Professional life is hat the aim to grow and earn respect in the workplace and the society they live-in. Personal life means taking care of family, spouse, children, health and spending the available leisure time effectively. According to work foundation, the term work-life balance is about individuals having a measure of control over when, where and how they work, leading them to be able to enjoy an optimal quality of life. It is defined as establishing a successful balance between working obligations and personal commitments. Work – life balance for teaching professional has become a challenge in recent years. Teachers work load demands their time both in the institution and also extends to their home. Teaching professionals need to focus on soft skills and life skills so that they should aim at producing good citizens for the country.

Dr.n.s.lissy

The unprecedented global effort to develop and distribute COVID-19 vaccines has highlighted remarkable scientific achievements and persistent inequities in access across populations. Analyzing of regional vaccine deployment patterns reveals critical insights into pandemic response dynamics, shaped by manufacturing capacity, regulatory frameworks, procurement strategies, and regional health priorities. Data from WHO regions (Africa, the Americas, Eastern Mediterranean, Europe, and Western Pacific) demonstrate significant disparities in vaccine types and suppliers, underscoring the complexity of global vaccination efforts. (Figure 1) illustrates this regional vaccine distribution by WHO regions.

Karishma

A 25-year-old male presented with vaguely painful and pruritic vesicles and bullae on the oral cavity, abdomen, and superior limbs with symmetrical dissemination, which appeared over the past 3 weeks. No clinical history of importance. The physical examination showed a pallid and prostrated patient, with arterial hypertension (190/110); with several symmetrical dermal vesicles and bullae located on the abdomen and superior limbs (Fig. 1) and on the oral cavity varying from 1.5mm to 4 cm. No lymphadenopathy and sigs of arthritis were identified. Laboratory tests revealed a complete blood cell count with hemoglobin levels of 10.5 g/dL (12.7–15.7 g/DL), leukocytes of 2956/mm3 (4.3–10.7 × 103), and platelet count of 120,000/mm3 (150–350 × 103). Urinalysis shown proteinuria, hematuria, and leukocyturia. The direct Coombs assay, anti-nuclear antibodies, anti-double-stranded DNA, and anti-histone were positive. Histopathological analysis reported subepidermal discontinuity associated with neutrophilic infiltrate and direct immunofluorescence was positive for IgG, staining the basement membrane. Elisa was positive for antibodies against type VII collagen. The diagnosis was bullous systemic lupus erythematosus (BSLE) and he was treated successful with rituximab due to poor response to steroid use.

Karishma

Pumping fluid is one of the crucial parts of any microfluidic system. Using electric and magnetic fields as a substitute for moving parts can have many advantages. In this study hydrodynamic and heat transfer characteristics of electroosmotic flow under influence of lateral electric and transverse magnetic field, are studied numerically. Results indicate that the dimensionless parameters such as Hartmann number, intensity of the lateral electric field, pressure gradient parameter and aspect ratio have an important role in controlling flow. It can be implied that the enhancement of pressure gradient leads to the decrease of critical Hartmann number, and this dependency can be reduced from 44% to 7% for S=0.5 to S=50 in two pressure gradients of Ω=1 and Ω=20. In addition, the reduction of aspect ratio of microchannel section leads to the increment of critical Hartmann number in a specified lateral electric field. At the end, thermal analysis is being done by consideration of the effects of magnetic and electric fields on the Nusselt number.

Hossein seyedzadeh

This study was aimed to develop lomustine loaded chitosan nanoparticles using a homogenization and spray drying technique. Effect of crosslinking agents (sodium tripolyphosphate (TPP), and sodium hexametaphosphate (HMP)) were studied on the leaching of drug, water uptake of hydrogels, drug release from matrix and its mechanism. Nanoparticles were obtained in the average size range of 111±16.2 to 942±11.7 nm with polydispersity index (PDI) from 0.116±0.039 to 0.517±0.037. Zeta potential of nanoparticles was ranged from 29.0±1.1 to 56.0±1.1 mV. The % encapsulation effi ciency of nanoparticles ranged between 58±0.88% and 96±0.51%.nanoparticles were coated with PEG 6000 to modulate drug release. Swelling index of chitosan-TPP and chitosan-TPP-PEG nanoparticles was about 428% and 350% over the 4 h and it was more (about 465% and 395%) for chitosan-HMP and chitosan-HMP-PEG nanoparticles. Drug release was sustained and diffusion controlled. Optimized formulation was tested for anticancer activity and drug retention study. Cytotoxicity on human lung cancer cell line L132 was studied by trypan blue dye exclusion test. Drug loaded nanoparticles killed L132 cells more effi ciently than the corresponding drug alone (p< 0.05). Due to the increased surface area lomustine loaded TPP and HMP crosslinked chitosan nanoparticles showed better anticancer activity.

Archana mehrotra

Background: Non-syndromic combined pituitary hormone deficiency (CPHD) occurs due to defects in transcription factors that govern early pituitary development and the specification of hormone-producing cells. The most common mutations are in the Prophet of Pit-1 (ProP1) gene. This work aims to (1) report findings of genetic analyses of Tunisian patients with non-syndromic CPHD and (2) describe their phenotype patterns and their evolution through life. Methods: Fifteen patients from twelve unrelated families with variable clinical phenotypes were included after excluding autoimmune and acquired forms of non-syndromic CPHD. Detailed pedigree charts and auxological, hormonal, radiological, and therapeutic details were recorded. Sanger sequencing was performed, and sequences were analyzed with a specific focus on coding and splice site regions of the ProP1 gene. Retained variants were classified using several in silico pathogenicity prediction tools and the VarSome platform. Results: We identified the common p.Arg73Cys mutation in seven patients from four unrelated pedigrees. We found a novel homozygous mutation (c.340C>T) in one sporadic case. This mutation generates a truncated ProP1 protein, predicted to be non-functional, lacking the last 112 codons (p.(Gln114Ter)). We confirmed by polymerase chain reaction (PCR) the absence of large exon deletions or insertions in the remaining sporadic patients (7/8). Conclusions: We report two mutations {one newly identified [p.(Gln114Ter)] and one previously reported (p.Arg73Cys)} in five unrelated Tunisian families with non-syndromic CPHD. This work is of clinical importance as it reports the high frequency of the p.Arg73Cys mutation in Tunisian CPHD families. Our study also illuminated the involvement of novel gene(s) in the emergence of non-syndromic CPHD.

Mariam moalla

WSN is a low-power system and are often used in numerous monitoring uses, such as healthcare, environmental, and systemic health surveillance, in addition to military surveillance. It is important to reduce network resource usage since many of these applications need to be installed in locations that are virtually inaccessible to humans. Many protocols for WSN to extend the presence of the network have been established to solve this problem. In the energy efficiency of WSN networks, routing protocols play an important role since they help minimize power usage and response time and provide sensor networks with high data density and service quality. This study also employed a Hopfield neural network and the findings from this study are presented next to each other to enable comparison. This paper also discusses how to easily and accurately capture and handle WSN collisions. Future experiments that require the usage of neural networks and so many fuzzy structures will be able to prevent a crash in these respects.

Mohd haroon

One of the most important challenges for a company is to manage its supply chain efficiently. One way to do this is to control and minimize its various logistics costs together to achieve an overall optimization of its supply network. One such system that integrates two of the most important logistics activities, namely inventory holding and transportation, is known as the inventory routing problem. Our replenishment network consists of a supplier that uses a single vehicle to distribute a single type of item during each period to a set of customers with independent and deterministic demand. The objectives considered are the management of supplier and customer inventories, the assignment of customers to replenishment periods, the determination of optimal delivery quantities to avoid customer stock-outs, the design and optimization of routes. A genetic algorithm (GA) is developed to solve our IRP. Different crossover structures are proposed and tested in two sets of reference instances. A comparison of the performance of different crossover structures was established. Then, it was used to find the most appropriate crossover structure that provides better results in a minor computation time. The obtained results prove the competitiveness of GAs compared to literature approaches, demonstrate the performance of our approach to best solve large scale instances and provide better solution quality in fast execution time.

Mohamed salim amri sakhri

Therapies highly plays a crucial role for all those children and adults with disabilities. In this article, We aim to research the Special Educators’ Knowledge about Therapies in various special schools in the city of Hyderabad, Telangana, India. A qualitative approach was taken for this purpose. Questionnaires was used to collect the data. It was found that the teachers did not have proper conception on Therapies. The data indicated that the teachers are unaware about the unconventional therapies such as Drama Therapy, Pet Therapy and Laughter Therapy and there benefits when working with CSN. This lack of awareness needs to be addressed for the enhancement of the teacher as well students capabilities.

Husna habib

Rasa shastra is aPharmaco – therapeutic branch of Ayurved, incorporates many of the Herbo– mineral – metallic pharmaceutical preparations prepared out of the Parada namely KhalviyaRasayana, ParpatiRasayana, PottaliRasayanaandKupipakwaRasayana.Rasaushadhis are important for their uniqueness in Ayurvedic therapeutics due to lesser doses. KharaliyaRasayanais used in wide range for therapeutic utility and is easy for preparation. Icchabhedi Rasa is one such kharaliyaherbo-mineral formulation mentioned in various Ayurvedic text. Icchabhedi Rasa is a classical preparation commonly used for Virechana. Icchabhedi Rasa is described in various classical texts with some variation of ingredients. Jayapalais the chief ingredient of the preparation having Katu Rasa, UshnaVirya and KatuVipaka. It is well known for its strong purgative action. Though variation is observed in thedescription of these KharaliyaRasayana and compilation of these will help to study in comparative manner.AYU

Suri abhiram

Mucosal systems such as orally disintegrating films (ODFs) and mucoadhesive buccal films (MBFs) have gained attention and become a potential alternative to the conventional oral drug delivery systems, especially for patients who are geriatric or pediatric or those having difficulty in swallowing or drugs with extensive first-pass metabolism. Such films provide benefits, including a quick onset of action, increased bioavailability, and patient compliance. Successful development entails meticulous optimization of ingredients such as film-forming polymers, plasticizers, surfactants, taste maskers, and material selection for the corresponding manufacturing process, including solvent casting, hot-melt extrusion, 3D printing, and electrospinning. Limitations remain, with challenges including low drug loading capacity, no unified evaluation standard, stability problems, and regulatory vagueness of the liposome carrier. Emerging trends signal the promise of nanocarrier-based films, solid dispersions, and stimuli-responsive systems to circumvent these barriers. Personalization technologies, specifically 3D printing and natural and biodegradable polymers, are expected to broaden the clinical use of oromucosal films. This article provides an overview of the current state of development, along with formulation and manufacturing considerations of ODFs and MBFs, the role of which is significant in addressing translational and regulatory hurdles.

Karishma

Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It is one of the most widely used chemotherapeutic agents for various solid tumors in the clinic due to its high efficacy and broad spectrum. The antineoplastic activity of cisplatin is mainly due to its ability to cross-link with DNA, thus blocking transcription and replication, Subsequently inducing apoptosis in cancer cells. However, because of drug resistance and numerous undesirable side effects such as severe kidney problems, allergic reactions, decreased immunity to infections, gastrointestinal disorders, hemorrhage, and hearing loss especially in younger patients. Other common side effects include ototoxicity, neurotoxicity, gastrointestinal toxicity, hematological toxicity, cardiotoxicity, and hepatotoxicity. These side effects together reduce the life quality of patients and require lowering the dosage of the drug, even stopping administration, thus weakening the treatment effect Therefore, substantial effort has been made to explore the complicated biochemical processes involved in the toxicology of cisplatin, aiming to identify effective ways to reduce or eradicate its toxicity. This review summarizes and reviews the updated advances in the toxicological research of cisplatin.

Nehal

Plants a wealth of secondary metabolites have been used for thousands of years to treat different ailments. A number of these natural products have shown biological and pharmacological activities and serve as the starting point in the development of modern medicines. Screening of crude plant extracts open the door for the way for discovery of novel bioactive compounds and elucidation of their structures leads towards new synthetic preparations, which can be administered in reproducible, accurate doses for particular therapeutic purposes. There is less known information about Samanea saman Merr., and Prosopis cineraria Druce. However, authors in this book present comprehensive information about traditional uses, biological and phytochemical investigation of Samanea saman Merr., and Prosopis cineraria Druce.

Dr. salman ahmed

This study aims at classifing hotels in Jordan into groups based on their Total Quality Management (TQM) implementation. Using a survey methodology, the TQM questionnaire was designed to measure the level of TQM implementation throughout Critical Success Factors (CSFs) which are necessary for TQM implementation. A total of 345 TQM questionnaires were distributed to managers, working in 17 four- and five-star Jordanian hotels. The researcher obtained 227 usable TQM questionnaires. The results classified Jordanian hotels based on the CSFs for TQM implementation. More specifically, using cluster analysis on the CSFs of TQM resulted in two groups of hotels: ‘low TQM adopters’ and ‘high TQM adopters’. These two groups showed significant differences across the TQM CSFs

Mukhles m. al-ababneh

Intensively cultivated rice-wheat cropping system of the Indo Gangetic plain (IGP) is a potential source of greenhouse gas (GHG) emissions.Agriculture sector emits GHGs like methane (CH4) and nitrous oxide (N2O). The total amount of GHGs emitted by a product is known as its carbon footprint (CFP).Quantification of CFP of crops will help in identifying management practices to reduce CFP of crop production. Studies related to assessing of CFP of agricultural products are lacking. The present review paper was aimed to discuss about the studies done on GHG emission from rice-wheat cropping system of the Indo Gangetic plains. The paper elaborates on what is CFP, how to calculate CFP of rice-wheat cropping system with the help of different case studies. The paper provides insights about certain agricultural management practices which can help in reducing CFP of rice-wheat cropping system. Discussion from this paper signifies the importance of carbon footprint assessment in maintaining the sustainability of rice wheat cropping system.

Dr.renu dhupper

The study examined the impact of school enrolment growth on the carrying capacity of universities in Imo State, Nigeria. Three research questions and hypotheses guided the study. The study adopted the descriptive survey design with a population of 2,929 academic staff in the two public universities in Imo State. The sample size was 352 representing 12% of the population drawn using stratified random sampling technique. An instrument titled ‘School Enrolment Growth and Carrying Capacity of Universities Questionnaire (SEGCCUQ)’, structured on the 4 point scale, validated by experts and with reliability index of 0.84 was used for data generation. Mean and standard deviation were used to answer the research questions while z-test was used to test the hypotheses at 0.05 alpha level. Among others, the study revealed that factors such as natural increase of population, influx of migrants, enforcement of compulsory education, raising of school-leaving age, increased enrolment of girls and so on influence school enrolment growth that bear on the carrying capacity of universities. It was recommended among others that the factors should help the governments and institutions to forecast enrollment more effectively likewise permit them to make adjustments to meet current or future enrolment.

Fxintegrity publishing

This study aims to determine the effect of communication, competence and work discipline on job satisfaction at PT. Tribahtera Srikandi. This research was conducted at PT. Tribahtera Srikandi lasted for 6 months, starting from January 2020 to June 2020. Sampling was taken in research using proportional random sampling method. The population in this study are all employees of factory workers in PT. Tribahtera Srikandi 155 people. The number of respondents in this study was established by using the statistics of the population, amounting to 112 people. The instruments used to collect data are questionnaires from communication, competence, work discipline and job satisfaction. The data analysis tool in this study is a multiple linear regression by carrying out a classic assumption test that is continued by testing the partial hypothesis or t test, the simultaneous hypothesis test or the F test, and the calculation of the coefficient of determination. The contribution of communication, competence and work discipline variables explained the variable of job satisfaction as big as 0.765 or 76.5%. The remaining 0.235 or 23.5% was influenced by other independent variables not examined in this study.

L

Pulses are well known richest source of vegetable protein and poor man’s food because of its essential component of diet. The frontline demonstrations of chickpea crop was carried out by Krishi Vigyan Kendra, Nagaur-I, Agriculture University, Jodhpur during rabi seasons from 2011-12 to 2019-20 on 178.5 ha area with 382 demonstrations in different clusters of Nagaur district of Rajasthan. The results shows that demonstrations produced on an average 18.02 q/ha grain yield of chickpea, which was 24.18 per cent higher as compared to prevailing farmers practice (14.51 q/ha). The front line demonstrations fetched more average gross returns (Rs.60161/ha), net return (Rs. 37963/ha) and B:C ratio (2.76) with slightly higher investment on cost of cultivation (Rs.1663/ha) as compared to farmers practice. The increase in gross and net returns was in the tune of Rs.11960 and Rs. 10285 per hectare with incremental benefit: cost ratio of 0.33. The average extension gap, technology gap and technology index was 350kg/ha, 608 kg/ha and 25.2 per cent, respectively. It is also observed that majority of the respondent farmers expressed high (51.83%) to the medium (32.72%) level of satisfaction regarding the performance of chickpea under demonstrations

Dr. babu lal jat

The purpose of the presenting review was to share the medicinal and surgical contribution of Greco-Arabic Muslim scientists in diagnosis, surgery and natural medicines for managing and treating urolithiasis. The contribution of Al-Antaki, Al-Baghdadi, Al-Baitar, Al-Bokhari, Al-Razi, Al-Zahrawi, Ibn Sina, and Ibn Zuhr was highlighted. The data compilation was preliminary, and much more efforts are still needed to restore the missing continuity in the history of medicine.

Dr. salman ahmed