Background: This manuscript presents an audit focused on assessing the extent of drug wastage and associated costs linked to the disposal of unused intravenous agents within the operating theatres of a tertiary care hospital. The study aims to carefully look at drug wastage, figure out why it happens, and propose strategies for optimizing resource utilization and cost-efficiency in clinical settings. Materials and Methods: This audit is a prospective observational study carried out in a tertiary care hospital. The amount of drug loaded preoperatively, the amount of drug utilized, the amount of drug unutilized and discarded, the total quantity of drug wasted, and the cost related to the wastage were calculated in percentage. Results: The maximum wastage of loaded drugs was seen with atropine (100%), followed by ephedrine (93.6%), propofol (52.5%), phenylephrine (35.2%), atracurium (28.6%), dexmedetomidine (27.8%), fentanyl (16.8%), vecuronium (16.2%) and morphine (6.4%). The cost analysis revealed that 36.3% of the total loaded drugs were wasted amounting to Rs.46903.54. The cost of wastage of propofol was maximum with Rs.14006 which is 29.8% of total cost wastage followed by atracurium 21%(Rs.9856), dexmedetomidine 18.4%(Rs.8687.5), ephedrine 14.7%(Rs.6919), phenylephrine 10.4%(Rs.4910), fentanyl 3.7%(Rs.1780), atropine 1.9% (Rs.906), vecuronium 1.2% (Rs.563.76), Morphine 0.18% (Rs.85.28). Conclusion: In our audit, the maximum drug wastage was observed with atropine (100%) amounting to Rs.906, and the cost of wastage was maximum with propofol amounting to Rs.14006 which was 29.8% of the total cost of wastage. Our audit underscores the importance of proactive management of drug wastage and disposal costs in healthcare settings, particularly within operating theatres where intravenous agents play a crucial role in patient treatment. By conducting a comprehensive audit and proposing targeted interventions, healthcare institutions can optimize resource utilization, enhance sustainability, and ultimately improve patient outcomes.

Kamal singh

This research was carried out at SDS Harapan Jakarta. This research aims to unravel the implementation of character education’s values through thematic subject, specifically on Indonesian Language Content. This research uses qualitative descriptive approach to gather research data deeply and thoroughly regarding character education’s value. Data collection was done using interviews, observation, and documentation. Miles and Huberman method was used to analyze data collected with the process of data collection, condensation, data display, and data verification. Triangulation was used to verify the validity of the data. The result of this study revealed that 1) The implementation of character education values in the content of Indonesian Language learning in Class 3 is implemented through reading and writing activities that prioritize the five main values in education according to the Minister of Education and Culture. 2) There are still less-effective efforts to achieve learning objectives. 3) There is still a lack of learning innovations carried out to achieve learning goals. 4) No lesson plans that are not made routinely as a means of evaluating learning. 5) There is still a need for improvement in the application of character education in Indonesian content that is linked to students' real experiences, both through online and offline learning.

Educare: journal of primary education

The general meaning of a word is the representation of the type from it, in linguistic contexts and certain grammatical forms and this meaning is opposed to the individualized meaning, the separation of a unique item of the type, distinguishable from others. The general meaning seems like a grammatical meaning that is not formally sufficiently marked, but the indefinite articles and the suffixes, in addition to other grammatical meanings, can also express a general meaning in certain contexts. A definite meaning of the noun is generally considered the meaning of the noun in the definite form and indefinite meaning the one of the indefinite noun. But how does the general meaning relate to them? Nouns with general meaning, whether in the indefinite form or in the definite form are meaningfully definite. Both the speaker and the listener know the class that the general noun marks. Despite the formal indefiniteness / definiteness, nouns with a general meaning are semantically definite.

Anglisticum

The identification of isomorphism in epicyclic gear trains has been found a lot of attention by researchers for the last few years. Various methods have been suggested by different authors for the detection of isomorphism in planer kinematic chains and epicyclic gear trains (EGTs), but everyone has found some difficulties to address new issues. In this paper, a modified path matrix approach was presented in order to compare all the distinct geared kinematic mechanisms. A new method based on the matrix approach and corresponding train values is required to identify isomorphism among epicyclic gear trains and their mechanisms. The proposed method was examined on the basis of various examples from four-link, five-link, six links, and eight-link one-degree-of-freedom EGTs and six links two-degree-of-freedom EGTs. All the examples have been found satisfactory results with existing literature.

Jiyaul mustafa

The presented study initially attempted to discover bergenin as an antiemetic compound isolated from Peltophorum roxburghii L. leaves. It is the extension of antiemetic activity from the methanol extract of Peltophorum roxburghii L. leaves. The antiemetic activity was assessed using copper sulfate-induced emesis in the chick’s model. Bergenin (25 mg/kg, p.o.) exhibited significant antiemetic activity compared to the standard drug, chlorpromazine. This is the first time that bergenin has declared antiemetic activity. Bergenin has already been evaluated positively for its anti-inflammatory activity, and this paper will report its antiemetic activity. Both the activities of the same compound may be beneficial for drug design against the disease, as they have anti-inflammatory and antiemetic symptoms like migraines. The preliminary antiemetic evaluation of bergenin was conducted on a single dose due to the low yield of Bergenin. However, the result was significant in terms of the standard used. Further, the isolation and purification of Bergenin are in the process of establishing detailed data on different doses of Bergenin.

Dr. salman ahmed

Adverse drug reactions have increased significantly in people as many new drugs have come to the market in the last two decades. This has not only economic consequences but also causes morbidity and mortality. In Bangladesh, some incidents happened related to drug problems and it took several lives. Spontaneous reporting of adverse drug reactions can primarily control this situation and healthcare professionals can play an immeasurable role. Therefore, this study was aimed to be conducted at seven different hospitals and diagnostic centers to find out the actual scenario of adverse drug reactions among the healthcare professionals in Bangladesh to make them aware of adverse drug reactions and the reporting system, and to know about their opinion towards adverse drug reactions. However, after evaluation of the questionnaires it was found that a large number of healthcare professionals were not aware of adverse drug reactions and pharmacovigilance, especially the nurses. It was found that 13.3% of nurses did not know about adverse drug reactions and 93.3% of them had not reported any reactions. Furthermore, many healthcare professionals did not show a positive attitude towards pharmacovigilance. If proper pharmacovigilance practice cannot be started, the nation will face serious economic and health-related problems.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background: In a Benghazi medical center, this observational study assessed the role of laparoscopic cholecystectomy (LC) in the early stages of acute gallbladder illness. Materials and Methods: From January 2022 to December 2022, all emergency and urgent admissions for acute gallbladder disease were identified, and additionally, data from hospital medical records were then evaluated retrospectively. Results: Out of a total of 334 patients with gallstone diseases, we found 321 individuals (206 with acute biliary colic, 115 with acute calculous cholecystitis), and 13 with acalculous cholecystitis. Early laparoscopic surgery for acute calculous cholecystitis had a greater conversion rate than procedures for acute biliary discomfort (19% vs. 4%; p=0.002). When surgery was performed 72 h from the onset of the symptoms for patients with acute calculous cholecystitis, the conversion rate was considerably lower (one out of 25) than when surgery was postponed past 72 h (14 out of 53) or later performed electively (seven out of 23) (p=0.014). In comparison to elective surgery for acute biliary colic (three of 66), elective surgery for prior acute cholecystitis was linked to a higher conversion rate (seven of 22 patients) (p=0.002). Conclusion: LC for acute calculous cholecystitis needs to be done within 72 h of the onset of symptoms, and it is worthwhile.

Karishma

Menstruation is a normal physiological impact on each girl’s life. Menstruation is monthly uterine bleeding for 3-5 days after every 28 days from puberty till menopause. A change in mood, behaviour, appearance of some abnormal vague symptoms is often noticed in the second half of the cycle. Symptoms are severe enough to disturb the life cycle of a woman called premenstrual syndrome (PMS). The study aimed to assess the premenstrual symptoms and coping strategies among adolescent girls. The majority of the students suffered from premenstrual syndrome. Objective: to assess the premenstrual symptoms and coping strategies among adolescent girls. Methodology: A nonexperimental descriptive research design was adopted in this study. Non probability convenient sampling technique was used to select the sample size of 30 adolescent girls. The assessment of premenstrual symptoms and coping strategies was carried out using a self-reported Likert’s rating scale. Data was analyzed by using descriptive and inferential statistics. Result: Majority (93.3%) of the samples sometimes had physiological and psychological problems, 90% of them had behavioural symptoms. Majority (43.3%) of the samples always followed coping strategies and 16.7% of the samples sometimes followed coping strategies and 40% never followed any coping strategies. Conclusion: PMS was common among students at 18-24 years. The most common physical symptoms experienced by adolescent girls were headache, backache and lower abdominal pain. Adolescent girls used coping strategies as taking hot / cold drinks, do not express anger to others, and turn to study and forget things, hearing music and taking medications. Keywords: Premenstrual Symptoms, physiological, psychological & behavioural symptoms, Coping Strategies, Adolescent Girls.

Elsi queen

Learning is a process of interaction that occurs between teachers and students. The learning process requires a way or method so that interaction occurs reciprocally and can achieve the desired learning goals. This research uses a descriptive qualitative approach, and the type of research is a case study. Data collection techniques using observation, interviews, and documentation. While the data analysis with an interactive analysis model (interactive analysis)—the validity of this research data uses the triangulation technique. The results of this study indicate (1) Planning for STAD Type Cooperative Learning Methods in Fiqh Subjects at MIMA 42 Wuluhan, namely: The teacher makes a Learning Implementation Plan (RPP), makes observation sheets and score assessment sheets, choose learning media, makes materials and questions. group and individual assignments, and designing study groups. (2) Implementation of STAD Type Cooperative Learning Method in Fiqh Subjects at MIMA 42 Wuluhan: Initial activity: the teacher explains the material that will be given to students. The core activities are: The teacher explains the method to be used, divides students into several groups, plays videos as material, asks students to observe pictures/videos of people, and discusses the material in the video. And all groups present the results of their discussions. Closing activities, namely: providing reinforcement to the material presented by students, the teacher and students reciting prayers, and the teacher planning follow-up learning. (3) Evaluation of STAD Type Cooperative Learning Method in Class Fiqh Subjects at MIMA 42 Wuluhan Jember, namely: Evaluation of observation and performance (demonstration) on group performance. Meanwhile, individual evaluation is in the form of homework (PR).

Educare: journal of primary education

In the article first assesses the potential distribution in Eurasia of Neodiprion abietis (Harris, 1841) first time assessed. The species id a widely distributed in North America fir and spruce defoliator, intercepted in 2016 in the Netherlands. Analysis of the literature data on the known distribution and host plants of the species is given. Insufficient data for ecological modeling is shown, which causes a high degree of uncertainty in assessment of potential range. The results of modeling the potential range of the species using several algorithms are presented. The reliability of the obtained models and the importance of bio-climatic environmental variables for species distribution are assessed.

Svedbergopen

It is with more sorrow and tremendous sadness we remember the death of our colleague the Libyan pharmacist, professor Mokhtar Ramadan Haman, at his home in Tripoli, Libya after long-suffering from brain cancer. He died on 02, February 2017 and his immaculate corpse was buried on the following day at the Souk-Al-Ahad cemetery, Bin Ghashir Palace. Professor Haman, was born in Tripoli, Libya, on January 1, 1957. He obtained his Bachelor of Pharmaceutical Sciences in 1981 at the University of Tripoli and his Ph.D. in Pharmacognosy in 1989 at Cardiff University, UK.

Mediterranean journal of pharmacy and pharmaceutical sciences

This Experiment was conducted on 120 day old unsexed Ross broiler chicks to study the effect of added methionine to soybean meal as substitute for protein concentrate in the starter ration on some productive traits . The chicks were raised on floor were distributed to three treatments with four replicates each ( 10 birds) . The three experimental starter rations (1-28) day contained 2800 kcal/kg ME and 22% cp . The first supplemented with 5% protein concentrate , while the second and third were with out protein concentrate but supplemented with 0.1 and 0.2% methionine respectively . The Finisher ration (29-49) day contained 3047 kcal/kg ME and 19.19% cp. At 49 day of age 2 birds from each replicate were slaughtered for carcass traits . Statistic analysis of data showed a significant increase (P ≤ 0.05) in body weight , weight gain , feed and protein efficiency ratio for third treatment during (1-28) day , No significant difference in all studied traits during (29-49)day, and the third treatment showed best economic efficiency .

Rafea mohammedtaher khulel

Cloud computing is used to achieve sustainability in terms of computing. It reduces energy and resource consumption. Most of the companies have been moving their applications to the cloud to reduce power, energy re-source, and carbon emission. Today's computing landscape is rapidly shifting toward creating applications to leverage Cloud platforms to have necessary features such as elasticity, virtualization, low cost, and pay-per-use. Cloud computing's rising demand and versatility are achieving acceptance in the research community as a means of implementing large-scale electronic systems in the format of workflows (set of tasks). One of the most important objectives of this effort is to trim down makespan which is the total period taken by the resources to complete all workflow activities. Another foremost objective of this work is to satiate all the user-delineated time constraints while scheduling workflow activities.

Mohd haroon

Cerebrospinal fluid (CSF) is critical in maintaining brain interstitial fluid balance and providing hydromechanical protection. Lumbar puncture (LP) is a common invasive procedure for obtaining CSF samples to evaluate central nervous system infections and cancers and measure intracranial pressure. While LP is generally considered safe, it is associated with both minor and major complications. Post-LP meningitis occurs in approximately 50% of spinal anesthesia cases and 9% of diagnostic LPs. Additionally, over 70% of diagnostic LPs result in minor bleeding, which can lead to serious outcomes such as spinal epidural hematoma, nerve damage, or paralysis. Significant consequences of LP include headaches and hearing loss; however, other rare complications, such as cerebral herniation and CSF leak syndrome, must be considered carefully. This review synthesizes findings from multiple studies published in PubMed, Google Scholar, and Scopus, highlighting the need for further research on the complications and interventions related to this commonly performed procedure.

Karishma

Kegiatan belajar mengajar siswa disekolah yang berpusat pada guru mengakibatkan siswa hanya menerima mata pelajaran secara pasif pembelajaran yang seperti ini mengakibatkan siswa kurang berminat dalam mengikuti pembelajaran tematik,proses pembelajaran yaitukurang maksimal pelaksanaan proses pembelajaran yang diterapkan sehingga peserta didik kurang menarik dengan pembelajaran dan metode yang sebelumnya, Sehingga berpengaruh kepada pemahaman siswa. Berdasarkan latar belakang Fokus dalam penelitian ini adalah 1)Bagaimana Perencanaan metode Rol Playing pada pembelajaran tematik di Madrasah IbidaiyahDarul Ulum Sukorambi Jember tahun pelajaran 2018/2019? 2)Bagaimana Pelaksanaanmetode Rol Playing pada pembelajaran tematik di Madrasah Ibidaiyah Darul Ulum Sukorambi Jember tahun pelajaran 2018/2019? 3) Bagaimna evalusai Metode Role Playingpada pembelajaran tematik di Madrasah Ibidaiyah Darul Ulum Sukorambi Jember tahun pelajaran 2018/2019? Hasil dari penelitian ini adalah: Perencanaan metode Role Playing pada pembelajaran tematik di kelas IV yaitu: dengan menyusun Program tahunan, program semester, silabus dan RPP(Rencana Pelaksanaan Pembelajaran) dan dikembangkan dalam RPP dengan menggunakan metode Role Playing sehingga setiap siswa dapat memahami materi yang telah dipelajarinya.

Educare: journal of primary education

Several diseases affect maize plants and one among them is black bundle disease, causal organism of which is yet to be confirmed with conflicting reports appearing in literature. In the present work, an effort was made to record the disease incidence by carry out filed surveys in Southern most district of Karnataka state, India and also to isolate and identify the causal organism. The surface sterilized pith tissue from the infected plants was cultured on PDA medium to identify the organism in the affected vascular tissue. The isolated tissue produce Cephalosporium acremonium which was confirmed based on morphological characters. In addition, Simplicillium sp. and Macrophomina phaseolina were also isolated from the same infected plant material and suspected to have participated in the disease development. In accordance with several reports in literature, Cephalosporium acremonium was tested and confirmed as the causal organism of disease in green house experiments by following the Koch’s postulates. This is in contrast with some earlier reports, wherein the exact symptoms of black bundle disease were reported as barren stalks in corn caused by Fusarium sp. The simplicillium sp. which had morphological similarity with C. acremonium and had an ambiguous taxonomic status in literature was confirmed as a distinct species through PCR based diagnosis.

Veerabhadraswamy al

This paper proposes EPyNet, a deep learning architecture designed for energy reduced audio emotion recognition.In the domain of audio based emotion recognition, where discerning emotional cues from audio input is crucial, the integration of artificial intelligence techniques has sparked a transformative shift in accuracy and performance.Deep learning , renowned for its ability to decipher intricate patterns, spearheads this evolution. However, the energy efficiency of deep learning models, particularly in resource-constrained environments, remains a pressing concern. Convolutional operations serve as the cornerstone of deep learning systems. However, their extensive computational demands leading to energy-inefficient computations render them as not ideal for deployment in scenarios with limited resources. Addressing these challenges, researchers came up with one-dimensional convolutional neural network (1D CNN) array convolutions, offering an alternative to traditional two-dimensional CNNs, with reduced resource requirements. However , this array-based operation reduced the resource requirement, but the energy-consumption impact was not studied. To bridge this gap, we introduce EPyNet, a deep learning architecture crafted for energy efficiency with a particular emphasis on neuron reduction. Focusing on the task of audio emotion recognition, We evaluate EPyNet on five public audio corpora-RAVDESS, TESS, EMO DB, CREMA D, and SAVEE.We propose three versions of EPyNet, a lightweight neural network designed for efficient emotion recognition, each optimized for different trade-offs between accuracy and energy efficiency. Experimental results demonstrated that the 0.06M EPyNet reduced energy consumed by 76.5% while improving accuracy by 5% on RAVDESS, 25% on TESS, and 9.75% on SAVEE. The 0.2M and 0.9M models reduced energy consumed by 64.9% and 70.3%, respectively. Additionally, we compared our Proposed 0.06M system with the MobileNet models on the CIFAR-10 dataset and achieved significant improvements. The 1035 proposed system reduces energy by 86.2% and memory by 95.7% compared to MobileNet, with a slightly lower accuracy of 0.8%. Compared to MobileNetV2, it improves accuracy by 99.2% and reduces memory by 93.8%. When compared to MobileNetV3, it achieves 57.2% energy reduction, 85.1% memory reduction, and a 24.9% accuracy improvement. We further test the scalability and robustness of the proposed solution on different data dimensions and frameworks.

Jiby mariya jose

The maximum H. armigera and M. vitrata infestation was recorded in Pusa-992 (3.72% and 7.90%) and in D2 (1st week of July) sown crop with infestation of 4.54 and 13.08 per cent, respectively. Whereas, the infestation of pod fly, M. obtusa was maximum in Manak (2.72%) and 2.58 per cent pod infestation in D2 (1st week of July) sown crop. The infestation of pod borer complex was negatively associated with pod wall thickness (-0.909**, - 0.739*, -0.870*, -0.834*, -0.840*, -0.705* and -0.745*) and non-glandular type A (-0.730*, -0.945**, -0.768*, -0.766*, -0.923** and -0.728*) and (-0.751*, -0.759*, 0.766*, -0.852*, -0.802*, -0.895** and -0.832*) glandular type B (-0.864*, -0.734*, -0.871* and -0.858*) and (-0.729*, -0.705*, -0.730* and -0.845*) density of pod trichomes of top and middle canopy of the plant. Fat (-0.884**, -0.754*, -0.743*, -0.871* and -0.750*) phenol (-0.900** and -0.806*) and tannin (-0.792*, -0.812* and -0.763*) content showed negative correlation with the pod infestation, whereas, crude protein (0.740*, 0.881**, 0.734*, 0.810*, 0.823*, 0.856*, 0.844* and 0.711*) and total soluble sugar (0.738*, 0.792*, 0.793*, 0.898**, 0.714*, 0.816*, 0.888** and 0.819*) showed positive association. Based on the results, it can be concluded that the variety Pusa-992 and Manak was most susceptible to the pod borers.

Dr. babu lal jat

Inflammation is said to be a healthy component of the body immune system's reaction. Inflammation is characterised by four key symptoms: pain, redness, heat or warmth and swelling. As secondary metabolites, plants may produce a wide range of phytochemical compounds, which possess anti-inflammatory characteristics. Herbal remedies are important therapies for a wide range of ailments all over the world. There are around 7 500 species of medicinal plants, including representatives from over 17 000 flowering plant species. Even when synthetic chemistry has developed out their expectations, the use of natural ingredients in the manufacture of drugs used in contemporary medicine is unparalleled. By interfering with the biology of inflammation, anti-inflammatory medications may assist to minimise tissue damaging and increase patient’s comfort. Because of the bulky figure of species reachable for study, the effective development of novel naturally taking place anti-inflammatory drugs is mostly dependent on a multidisciplinary approach to discovering new chemicals. Despite the statistic that many review papers have been produced in this field, the conventional of them simply examined the issue from an area perspective. Several non-steroidal anti-inflammatory drugs have been shown to reduce inflammation and pain by decreasing the isoform of the cyclooxygenase enzyme's digestion of arachidonic acid, hence lowering prostaglandin production. Non-steroidal anti-inflammatory drugs have a host of harmful effects. There are, however, medicinal herbs with anti-inflammatory pharmacological properties that have few or no negative effects.

Mediterranean journal of pharmacy and pharmaceutical sciences

Brucellosis is a zoonotic infection often linked to direct or indirect exposure to animals or unpasteurized dairy products. Atypical presentations in patients without classical risk factors pose significant diagnostic and management challenges. A 68-year-old woman presented with a 2-month history of burning pain involving cervical and lumbar regions, associated with weight loss, decreased appetite, and subjective fever. Examination revealed paravertebral tenderness and left knee swelling with effusion. Previous MRI showed multifocal marrow edema and soft tissue thickening in the lumbar spine, suggesting infection or inflammation. The patient denies exposure to unpasteurized dairy products, raw meat, or animals. Brucella serology revealed positive IgG with Brucella melitensis titer 1:160, later confirmed by blood cultures. PET imaging demonstrated multifocal metabolically active arthritic changes involving the spine, shoulders, and knees. Arthrocentesis confirmed inflammatory arthritis due to brucellosis. The patient was started on doxycycline, rifampin, and a 14-day course of intravenous gentamicin. During hospitalization, management was complicated by persistent knee pain and swelling requiring multimodal analgesia. Spinal brucellosis in the absence of classical risk factors is an odd presentation, emphasizing the importance of maintaining a high index of suspicion in endemic regions. Advanced imaging and microbiological confirmation are pivotal procedures in diagnosis. Early recognition of atypical brucellosis is critical to prevent complications and improve outcomes.

Karishma