A 33-year-old young male patient with a history of uncontrolled hypertension was referred to my clinic due to a 2-week fever, generalized body aches, shortness of breath, and easy fatigue. Clinical examination showed a toxic dyspneic patient, but conscious and well-oriented. His blood pressure was 170/100 mm Hg, pulse 90 beat/min, respiratory rate 15/min, and the temperature was 38.6°C. Cardiac examination showed a harsh systolic murmur at the mitral area radiating to the axilla. Abdomen examination revealed moderate splenomegaly and mild hepatomegaly. The rest of the examination was unremarkable.

Karishma

A Novel route one-pot three-component reaction was developed for the synthesis of 2,3-Dihydro-2-phenyl-1- H-Naphtho-[1,2-e] [1,3] Oxazine by using Substituted Aniline, Formalin & β-Naphthol in the presence of Tannic acid (10 Mol %) as catalyst. The reaction is observed by using TLC, after completion of reaction product is characterized by 1H, NMR, 13C NMR, IR and Mass Spectra.

Dr.prashant kumdale

Anthropogenic and climatic factors influence soil’s physical, chemical, and biological properties, setting the stage for agriculture’s sustainability. Soil is a primary carbon sink crucial for reducing greenhouse gas emissions, making soil health essential for mitigating climate change. Healthy soil enhances climate resilience by maintaining or increasing carbon content and lowering emissions. The overuse of fertilisers pollutes the environment and inadequate application damages soil fertility and microbial activity. The conversion of forests and pastures to agricultural land has resulted in significant carbon losses from the soil. Additionally, soil sealing, air pollution, and industrial contamination all contribute to climate change. Harmful practices such as heavy tillage, land neglect, monoculture cultivation, and excessive chemical use, driven by the pressure to meet growing food demand, have led to soil compaction, degradation, pollution, and nutrient imbalances. Current mismanaged crop and soil techniques deteriorate soil quality; however, by increasing carbon storage in mineral soils and removing emissions from organic soils, sustainable management can contribute to climate neutrality. Climate change can be exacerbated by the release of carbon dioxide into the atmosphere from unsustainable farming practices and poorly managed soils. The purpose of this study is to investigate the detrimental impacts of anthropogenic (Anthropocene) effects on the environment and soil health from a comprehensive perspective and to formulate potential recommendations. The European Union’s Green Deal, Bioeconomy, and Farm to Fork initiatives aim to sustainably transform agriculture in response to climate challenges. These strategies aim to reduce chemical pesticide use by 50%, fertilizer use by 20%, and nutrient losses by 50% by 2030 to preserve soil fertility. These management practices include efficient fertilizer use to maintain soil health and mitigate climate change effects. Restoring degraded soils and implementing conservation measures can reduce greenhouse gas emissions and increase carbon storage capacity. Sustainable soil and crop management, including crop rotation, minimizing post-harvest ploughing, preserving vegetation cover, boosting organic matter, and using fertilizers sensibly, is urgently needed to minimize greenhouse gas emissions and store atmospheric carbon dioxide in soil.

International journal of agricultural and applied sciences (ijaas)

Around the world, several oral health measures have been implemented. The most popular method is to use a toothpaste. However, chewing sticks are still used in many cultures around the world in a conventional manner. Chewing sticks have a mechanical cleansing action similar to a toothbrush in addition to their antimicrobial effect. The purpose of this study is to evaluate the effect of Miswak on the growth of Candida species and to compare it to that of toothpaste. A cross-sectional study was carried out on 120 selected randomly volunteers from January to April, 2022. Two groups of participants were used for two weeks. The participants were separated into a group used Miswak and a group use ordinary toothpaste. Samples were collected before and after two weeks in these two groups. Samples were immediately processed for microbiological phenotypic conventional methods and in vitro susceptibility testing of the microbial isolates to antimicrobial. The findings show that a significant effect of Miswak against an oral cavity candida species. Total candida count was 27.5 ± 18.48, P = 0.001 (Mean ± SD) from Miswak group and 247.0 ± 90.14, P = 0.979 (Mean ± SD) in toothpaste group. The most frequent Candida isolates organisms were C. albicans: 22 (36.67%) in the Miswak group and 24 (40.0%) in the toothpaste group, the second isolate was C. dubliniensis: 04 (6.69%) in the Miswak group and 12 (20.0%) in toothpaste group followed by C. glabrata: 02 (3.33%) in Miswak group. In conclusion, Miswak has a considerable antifungal impact immediately and after two weeks of use.

Mediterranean journal of pharmacy and pharmaceutical sciences

Fungsi pendidikan adalah untuk mengembangkan karakter peserta didik. Oleh karenanya, guru dituntut agar dapat mengembangkan karakter melalui proses pembelajaran diantaranya melalui pembelajaran tematik. Salah satu sikap yang dapat dikembangkan melalui pembelajaran tematik adalah karakter mandiri. Penelitian ini bertujuan untuk mendeskripsikan perencanaan, pelaksanaan serta faktor-faktor yang mempengaruhi pengembangan karakter mandiri melalui pembelajaran tematik pada kelas III di Madrasah Ibtidaiyah Negeri 5 Jember. Penelitian ini menggunakan pendekatan kualitatif dengan jenis fenomenologis. Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Hasil penelitian ini adalah: 1) perencanaan pembelajaran tematik dalam pengembangan karakter mandiri di Madrasah Ibtidaiyah Negeri 5 Jember diwujudkan dalam RPP yang disusun secara sitematis dan berbasis karakter dengan memasukkan karakter mandiri pada komponen kompetensi inti, kompetensi dasar, indikator, kegiatan pembelajaran, dan penilaian; 2) pelaksanaan pengembangan karakter mandiri pada pembelajaran tematik dilakukan melalui kegiatan pembelajaran mulai dari kegiatan pendahuluan, inti dan penutup. Namun kegiatan inti lebih dimaksimalkan dengan menggunakan model learning by doing dengan melakukan lima aktivitas belajar yaitu menanya, mengamati, mengumpulkan informasi, mengasosiasi, dan mengkomunikasikan; dan 3) faktor-faktor yang mempengaruhi pengembangan karakter mandiri yaitu lingkungan keluarga, lingkungan sekolah dan lingkungan masyarakat.

Educare: journal of primary education

Background Urban legends and myths are prevalent in drug-use environments. However, the distinction between myth and fact is not always clear. We found contradictory claims regarding the emergence of cold cook methods for producing methamphetamine when contrasting user-generated reports with official reports repudiating such methods as myths. Our aim is to open the topic for more academic discussion. Methods We examine cold cook methods of methamphetamine production revealed in our ethnographic study and interviews with former (n = 50) and current (n = 48) methamphetamine users. Data were collected in the suburbs of a large southeastern city in the United States. We compare the data with reports from law enforcement professionals and public health officials. Results Official reports claim the cold cook method described by users in our study is a myth and does not produce methamphetamine. Small-scale producers sell it as methamphetamine and users claim it has the same effect as methamphetamine. They are charged for possession and distribution of methamphetamine when caught with this drug. It appears the unintended consequences of recent policy aimed to reduce production and use of methamphetamine may be a user-friendly production method. We do not know the health implications at this time. Conclusion We do not make any definitive conclusions on the legitimacy of the stories or myths discussed here but instead suggest that labelling drug stories as myths might lead to dismissing facts that hold partial truth. The subsequent dismissal of cold cook methods among policy and public health officials risks a range of unintended consequences among vulnerable populations. We present our case for more research attention on the myths of methamphetamine production. Keywords: Cold Cook Methods, Cold Cook Methods step by step, Cold Cook Methods steps, Methamphetamine, Cold Cook Methods list

Kamal singh

PHYSICO-CHEMICAL ANALYSIS OF RHIZOSPHERIC SOIL OF MAIZE (Zea mays L.) AND ITS EFFECTS ON MAIZE DISEASE INCIDENCE (IN VIVO) IN KARNATAKA

Veerabhadraswamy al

The seeds of Cleome viscosa are used in traditional systems of medicine for the treatment of many diseases in Asia. This study evaluated fixed oil from the seeds of Cleome viscosa for analgesic and antiemetic activity by using the acetic acid induced writhing test in mice (intraperitoneally) and chick emetic model (oral treatment) respectively. The results showed significant analgesic and antiemetic activities of Cleome viscosa fixed oil.

Dr. salman ahmed

Background: This study was conducted to determine the level of the public knowledge, attitudes and practices related to common eye diseases in the southern Indian population. Methods: A cross sectional population-based survey used a semi structured questionnaire on awareness, knowledge, attitude and practices related to eye diseases. Stratified multistage cluster random sampling method was used with a sample size of 867 adults >16 years based on, estimated awareness of cataract 70%, assuming an expected rate of 85%, design effect of 1.5, margin of error 4% with 95% confidence interval with 25% from urban areas and 75% from rural areas. A pilot study was conducted to validate the questions used in the main study. SPSS (version 19) used for analysis. Results: A total of 782/867 (90.1%) subjects participated in the survey, with females 47.4%. Awareness of major eye diseases for cataract 81.5%, glaucoma 47.8%, refractive error 74.3%, squint 89.0%, diabetic retinopathy 65.0% and age-related macular degeneration 36.7% respectively. 41.8% subjects reported wearing glasses either for distance, near or for both. Of the 777 subjects only 294 people underwent an eye examination by an ophthalmologist in the last two years (37.8%). 57.5% subjects had knowledge of the nearest eye care facility within five kilometers of their residence. Electronic media were the major source of information on eye health. Conclusions: Though the awareness levels of common eye diseases were quite high, the knowledge of cataract (10.4%) was poor. There is a need to increase the level of awareness for eye diseases like glaucoma and age-related macular degeneration.

Srinivasa reddy pallerla

Industry 5.0 is still a developing concept, but it is expected to leverage a range of advanced technologies to facilitate human-machine collaboration and enable more customized and sustainable manufacturing.This research paper tried to discuss the opportunities and challenges in the implementation of Industry 5.0. It primarily explored the need to transform from Industry 4.0 to Industry 5.0. The research paper further studied the technologies needed for the implementation on Industry 5.0 and also the principles of Industry 5.0.

Dr. kishor bholane

Objective: The present study was conducted to determine the level of attachment of fathers in Karabuk province and the factors affecting them. Materials and Methods: The sample of this descriptive study consisted of 200 fathers who brought their children Karabuk University Education Research Hospital Pediatric Outpatient Clinic and were selected by random sampling method. The socio-demographic data form prepared by the researchers by scanning the literature and the Paternal-Infant attachment Scale, which was validated by Gulec in Turkish, were used. Data forms were applied to the fathers who agreed to participate in the study by face to face interview method. The data were calculated by applying descriptive statistics, percentage calculation and nonparametric tests used in independent variables. Results: It was found that 22.5% of the fathers defined attachment as “happiness”, 5.5% “sacrifice”, 17% “unconditional love” and 55% “I do not know”. The mean score of attachment scores of the fathers was 80.3±8.23. Conclusion: Significant differences were found between the age of the children, duration of marriage, father's age, family type, number of children, and type of delivery. There was no significant difference between defining attachment, infant gender and working status.

Reyhan aydin doğan

Identifying the targets for improving antimicrobial prescription and development of antimicrobial stewardship interventions can better serve to combat the situation of antimicrobial resistance. The primary objective was to determine the prevalence of antimicrobial use at tertiary care teaching hospital with both acute and long-term care patients. A periodical point prevalence survey was done in a tertiary care hospital of South India during 2019 using manual and webbased GLOBAL-PPS tool. Of 945 patients eligible for the study, 645 (69.5 %) received at least one antibiotic, with highest rates in the adult surgical ward and pediatrics. Of 645 therapeutic antibiotic prescriptions, 58.6% prescriptions have an infectious indication of them, 62.6% are community-acquired infections. Third-generation cephalosporins were the most prescribed antibiotics. The prevalence of antibiotic use is very high, and our study evidence that the country needs a robust antimicrobial stewardship intervention program.

Vineela chadalavada

Finance is a key component for entrepreneurial survival , growth and sustainability. Adequacy and consistency in finance is important for healthy entrepreneurial status . The participation of women, SC, ST, OBCs in the financial facilities provided by the govt through Swavalamban Scheme will invite social inclusion in the state .

Md. abdur rahman choudhury

Higher education is leadership education. The values and virtues practiced in universities heavily influence the future leaders. Many institutions of higher education simultaneously show excellence in academic subjects, are green campuses with manifold ethics curricula, are active members in community engagement, and also are adept in providing value orientation to all stakeholders. It is universally felt that the status of teaching profession requires to be raised to ensure its dignity and integrity. Accordingly, it is considered necessary that there should be a code of ethics which may be evolved by the teaching community itself for its guidance. There are five major areas of professional activities which encompass the work of a teacher. For each of these areas certain principles have been identified to serve as guidelines for teacher’s conduct. HUMAN VALUES Basic human values refer to those values which are at the core of being human. The values which are considered basic inherent values in humans include truth, honesty, loyalty, love, peace, etc. because they bring out the fundamental goodness of human beings and society at large.

Kamal singh

Aging seldom comes alone and it is considered to be the major factor for many diseases and comorbidities and disabilities. The objectives of the study are to examine demographic characteristics and prevalence of comorbidities and polypharmacy of elderly patients who were admitted at Sebha Medical Center according to the selected period. This study is descriptive and retrospective cross-sectional study conducted in Sebha during 2021. From 195 participants of the study, the highest rate of patients was from the age group of 65 - 74 years which accounted for 86 participants (44%) and followed by those age group of 75 - 84 years which was reported by 65 participants (33%). The majority of elderly patients have hypertension, (n = 116, 59%) and over one-third of the patients (n = 73, 37%) have diabetes mellitus while nearly one-quarter of patients have both diseases at the same time (n = 47, 24%). Nearly, three-quarters of patients have electrolytes imbalance (n = 142, 72%). Nearly, two-thirds of the patients had three to five comorbidity diseases (n = 122, 63%). Whereas, over one-third of the patients had just one or two comorbidities (n = 70, 36%). Almost all the participants have polypharmacy (n = 187, 96%). Just above half of the patients have five - ten medications (n = 100, 51%) compared with 45% of the patients from those who have more than ten medications (n = 87). This study showed that there is a strong relationship between the prevalence of polypharmacy and the number of comorbidities. A Spearman correlation test indicated that rate of comorbidities was related to polypharmacy with a significant correlation (P < 0.01). The present study found high prevalence of comorbidities and polypharmacy among elderly inpatients. Based on this high prevalence, practicing pharmaceutical care could play an effective role to reduce the risk of inappropriate polypharmacy among hospitalized elderly patients through encouraging clinical pharmacist to engage in clinical activities in hospitals.

Mediterranean journal of pharmacy and pharmaceutical sciences

It is virtually impossible to mention the phrase ‘project management’ without introducing the concept of risk management. As Hillson (2016, p.11) states, “risks [are] particularly relevant to projects” suggesting that effective management of risk is an integral ingredient for project success. The close link that exists between projects and risks may be deduced by the definition of the word ‘project’. In simple terms, projects refer to unique endeavours undertaken with the aim of achieving desired outcomes. These endeavours typically specific start and completion dates, and involve resource, time and cost constraints. These characteristics imply that projects are intended to deliver identifiable benefits to the organisation; these benefits, however, are not enjoyed immediately even if the project is completed. On the contrary, projects commonly create capabilities that call for operation or utilisation for the actual gains to be generated (Hillson, 2016 p.11). The interpretation of this is that projects have a risk element in that they contain a potential reward and possibility of loss. For this reason, project managers must be well-versed with risk management.

Mohamed sorogy

CoronaVirus’ is a hard hit on both Millennial consumers and marketers. It forced consumers and marketers to do the usual activities of buying and selling differently. Panic buying and herd mentality was widely noticed among millennials. Their unusual buying behavior which reflects behavior during a crisis is highly influenced by environmental stimuli. From this study, it is found that there has been a significant buying behavioral shift of global millennials in emerging markets (BRIC – Brazil, Russia, India, China; CIVETS – Columbia, Indonesia, Vietnam, Egypt, Turkey, South Africa). It is evident that the initial marketing attempts of marketers failed during COVID-19 due to the lack of understanding of the significance of environmental and marketing stimuli in consumers’ purchase decisions. This study brings out the various positive substantial changes brought about through internetization in marketing goods and services to millennial customers during the pandemic. The pandemic enabled a rapid digital revolution in buying and selling using digital/online platforms. The study suggests the application of the Black Box Model by marketers in marketing and selling decisions. The Internet has been the most important tool used by customers and sellers to access what they need. This study is useful to marketers and upcoming entrepreneurs to understand that it is the consumer’s buying behavior that triggers and pushes marketers to sell differently.

Sridevi

Self-medication of antibiotics is an irrational use of drugs, contributing to microbial resistance, increasing health care cost and higher mortality and morbidity. This study was aimed to assess self-medication with antibiotics without a medical prescription in the community of Libya. This is a cross-sectional study conducted from June to December, 2022 and the total number of participants was 200. The design of the study and sample size were modified according to the proficiency of pharmacists and the medical and non-medical population of Libya. The questionnaire was developed in English and Arabic language and was distributed through social media platforms. The questions were used after a thorough literature search and assessing the validity and reliability. The significant signs regarding reasons for the treatment by self-medication drugs of antibiotics, because of its various drugs of antibiotic by pharmacist (n = 80, 40.0%) and family (n = 90, 45.0%) compare with experience and physicians by used prescription was 13 (06.50%) and significant sings regarding by nasal congestion self-medication of various antibiotics (n = 100, 50.0%). This sign must be practiced based on a previous physician’s prescription. The antibiotics are often self-administered as patient feel that they will save money and time but this can lead to substantial adverse drug reaction, antibiotic resistance, treatment failure and drug-related toxicity. This study respondent's medical and non-medical public of Libya who should be relatively informed and educated about the risk of treatment by self-medication of antibiotics with the development of resistance.

Mediterranean journal of pharmacy and pharmaceutical sciences

Background: Avicenna, as the Persian physician, made a significant contribution to the field of medical sciences, especially surgery, in the 10th and 11th centuries AD. Methods: In the present paper, Avicenna's translated quoted words were shared about his surgical practice. Indexing databases of PubMed and Google Scholar were searched using keywords like Avicenna, surgery, and anesthesiology to find related papers and documents. Results: The first portion comprises some of the most commonly used simple and compound herbal preparations to produce general and local anaesthetics before the surgery and as dental anaesthetic agents. In the second portion, practices regarding surgical management for skull fractures, spinal trauma, bone fractures, cataracts, incurable urinary retention, bladder calculi, haemorrhoids, cancer, as well as endotracheal intubation and tracheostomy, have also been incorporated. Finally, it ends up with practices regarding the use of natural products as postoperative dressing for traumatic and surgical wounds and after cataract surgery. Conclusion: Based on the recent investigations, the findings of this review study will provide a brief insight into Avicenna’s Canon of Medicine and the sciences of anesthesiology and surgery.

Dr. salman ahmed

Background: As Bangladesh has gained the reputation of improving the health sectors, much health related sites still require improvements. Community clinic services (CCS) may contribute to this sector with its foremost importance. So this study was conducted to investigate the utilization and health services provision by community clinics (CCs) in rural area. Methods: A descriptive longitudinal study was conducted among three community clinics of Jashore and a structured questionnaire was developed on which most of the questions were developed to find out the contributions of these community clinics. Here for data analysis we used SPSS version 25.0 software. Results: Here we analyzed health service related data from three randomly selected community clinics (CCs). We found an average of 15 patients got antenatal care every month by the Komlapur CC throughout the year. About 140 patients received health services per month from Dogachiya CC. About 634 children were benefited by Saziyali CC throughout the year. By this study we came to know that average 67-75 patients were provided iron supplementations each month by Saziyali CC. All of the CCs had active referral system and online reporting system. Conclusion: From our study we came to know that majority % of rural people are now dependent on community health care services. But most of the community clinics have many limitations regarding infrastructure, training, medicines, financial etc. So the government should take necessary steps regarding this.

Arafat hassan razon