A novel, simple, accurate, sensitive, reproducible, economical and less time consuming spectroscopic method was developed and validated for determination of cefixime. The solvent used was 0.1 N HCL and the absorbance maxima or the λmax was found to be 283.0 nm and 303nm for zero order and first order derivative respectively. This method obeyes Beer’s Law for the concentration range of 8–16 µg/ml for cefixime. The proposed method was been validated statistically as per the ICH guidelines for linearity, accuracy, precision, specificity, LOD and LOQ. The method developed and validated successfully for the quantitative analysis of cefixime in bulk and dosage form.

Prasanna pradhan

Conservation of Biodiversity is an activity must carry out by all individuals in the world to share the benefits derived from biodiversity. It is a critical task to conduct the biodiversity census and conservation (Biodiversity C & C or Biodiversity C2). Throughout the world several Governament and Non-Governamental organizations work together as a unit to maintain our biodiversity in safe mode. India is a mega diverse country with rich biodiversity. The development of modern science and technologies have increased the value of biodiversity and associated traditional knowledge. To save valuable biodiversity and traditional knowledge of our country, National biodiversity board and State biodiversity board constantly involved in this approach and biodiversity law's support to conserve the living diversity.

Veerabhadraswamy al

Araucaria columnaris is one of the ornamental plants of all over the world. It is commonly known as Christmas tree. In the present study tree exudates – resin from the bark of the Araucaria columnaris belonging to the family Araucariaceae were investigated for phytochemical and antibacterial activity. The resin was separately extracted with different solvents based on its polarity, water, methanol, ethyl acetate and benzene. The extracts were screened for phyto-chemical analysis, the result shows that methanolic extract involved in extraction of large number of phytochemicals when compared with other extracts and subjected to antibacterial assay against major human pathogens. Methanolic extract act as good inhibitory agent against major microorganisms. This finding revealed that methanolic resin extract of Araucaria columnaris had significant potential for the control of dreadful diseases causing human pathogens.

Dr. saranya devi k

Furosemide is a widely potent diuretic drug used in the management of edema and hypertension. Various brands of furosemide are available in the Libyan market and should be subjected to different quality control tests to assess their pharmaceutical equivalence. This study aimed to assess and compare the quality and the pharmaceutical equivalence of some generic brands of furosemide 40 mg tablets marketed in Libya. The pharmaceutical quality of four brands of furosemide tablets was investigated using official and unofficial compendia standards including uniformity of weight, friability, thickness, hardness, drug content and dissolution rate. The results obtained showed acceptable external features as well as the thickness, diameter and uniformity of weight for all the furosemide tablets. The tested brands complied with the official specifications of friability, hardness and drug content. In conclusion, all four brands can be considered as bioequivalence and thus can be pharmaceutically substituted in clinical practice.

Mediterranean journal of pharmacy and pharmaceutical sciences

A simple method for the synthesis of pyrazoles derivatives carried out by cyclization of cyanide with hydrazine hydrate by using sonication method. All the prepared compounds were characterized by 1H,13C NMR and IR Spectroscopy.

Dr.prashant kumdale

Our research is a contribution to the analysis of emergent practices in the mediatization of the Gospel. It mobilizes an intercultural approach of the appropriation of the TIC by social actors at ends of proselytism and propaganda. The mobilized problem is that of the seduction in the media revival of the neo-pentecostal leaders. By supporting us on an observation of the practices of the TVevangelism in Cameroon, we analyze the emergent social uses of the audio-usual mediums at ends of proselytism and propaganda. Our research reveals the interest to go beyond the deterministic analyses of the development of the TIC to propose an intercultural analysis which underlines the sociocultural contingency of the movement of emergence and development of the TIC. The aim is to propose an intercultural analysis which underlines the sociocultural contingency of the movement of emergence and development of the TIC in Africa.

Tedongmo teko

Phaseolus vulgaris Linn commonly known as red kidney bean, is enriched in protein, carbohydrates and dietary fibres. Beans have nutritional and health benefits and possess antimicrobial, antihyperglycemic, antioxidant and anticancer activity due to bio-active chemical constituents. The following study was carried out to evaluate the anti-depressant activity of Phaseolus vulgaris fixed oil (PVFO) using a forced swim test and tail suspension test in mice. In this study, animals were assigned into four groups (n=7). Group I: Control normal saline (2 mL/Kg), Group II: PVFO I (2 mL/Kg), Group III: PVFO II (4 mL/Kg) and Group IV: standard amitriptyline (10 mg/Kg). The significant results indicated the possible anti-depressant role of Phaseolus vulgaris fixed oil.

Dr. salman ahmed

One must accept the complexity of modern society as a multifaceted influence which will direct the future of all social organizations. Technology has brought the people of the world into almost instant communication. Biomedical science has conquered most infectious, acute diseases and has provided several medicines for a successful maintenance therapy of chronic diseases. The life style of some people as smoking and drug addiction remain a strong factor to their achievement of health goals of the good life. Universally, economic inflation and international business have created an economic interdependence among nations and dealing of the economic problems of one country must take into account this interdependence. When one views the future within this technologic-social-economic framework, he has difficulty sorting out certain directing influences that may shape the future of pharmacy practice in Libya. Currently, the duties, functions and roles undertaken by pharmacists in Libya range from those limited to traditional dispensing duties to highly clinically oriented roles [1]. In this regard, the Libyan health service providers request for the expanded roles of pharmacists in the society. Many of them ask for a number of clinical and patient-oriented functions as oncology, patient counseling, chronic care, hypertension, pediatric, diabetes, psychiatric, cardiology and others. They also question for protocols, standing orders and procedures for pharmacist management of drug therapy and provide information to use as a basis for initiation of clinically oriented services. The treatment of chronic diseases will be refined and drug therapy in many instances will be improved through the application of pharmacokinetic principles and improved methods of monitoring. There is no doubt that pharmacy practice has made clear steps in its own professionalization in hospitals during the past years. With an increase in the number of pharmacists practicing in hospitals and drug stores has come other changes in pharmacy manpower. Technicians and assistant pharmacists now perform many of the routine tasks in drug distribution under pharmacist's supervision. The latter, therefore, is available to participate in clinical programs in inpatient areas and in outpatient clinics. The practice of technicians and assistant pharmacists both in and out of hospitals remains a controversial issue in Libya (absence of a clear national medical policy). Many pharmacists in Libya who provide services hold Bachelor degree in Pharmacy or Pharmaceutical Sciences or Doctor of Pharmacy (Pharm D) or have completed a short or long term diploma training in teaching hospitals or postgraduate academics. Some hold appointments in other health professions institutions. Libyan Association for Pharmacists (LAP) and Libyan Medical Board are currently planning for a program in clinical pharmacy in different clinical branches. Nevertheless, professional pharmacy personnel must be upgraded in the future in both educational background and competence if continued professionalization is to be achieved [2]. The future will see continued stratification of professional personnel according to specialized functions in management and clinical and other professional; services particularly in large hospitals. The scope of the educational function of pharmacy will expand and become an increasingly important activity in the future in Libya. Some hospitals will maintain health education facilities as part of their physical plant. Others will participate in the program of area health education centers. Pharmacy's responsibility in this effort will require not only an increased commitment, but likewise, increased capability and capacity to provide educational services.

Mediterranean journal of pharmacy and pharmaceutical sciences

Thrombocytopenia is a recurrent hematological disturbance in pregnancy. In pregnant women with thrombocytopenia, the risk of excessive bleeding during or after child-birth is high, particularly when they require a cesarean section, other surgery during pregnancy, labor or in the puerperium period. The objective of this study was to assess the prevalence of thrombocytopenia among pregnant women attending antenatal care service at Tripoli University Hospital, Libya. A cross-sectional analysis was used to determine the prevalence thrombocytopenia in pregnant women attending prenatal care services from July to December, 2020 at Tripoli University Hospital. A structured pretested questionnaire was used to obtain socio-demographic data, nutritional factors, obstetrics and gynecological factors, history and clinical conditions. Venous blood samples were collected for platelet count and other platelet parameters, which determined by using Sysmex automation. A total of 72 participated women; about 40%, 35% and 259% of the participants were in the third, second and first trimester, respectively. The mean number of children that women have was 2, with 2.7% having just one child and 47% having three or more children. This study concluded that the prevalence of thrombocytopenia and mostly with mild form is 8.3% and as being greater among pregnant women living in rural areas. Health care providers should do thrombocytopenia test regularly for every pregnant woman in order to prevent excessive bleeding during pregnancy, especially whom living in rural areas.

Mediterranean journal of pharmacy and pharmaceutical sciences

Scholars who apply artificial intelligence to political questions seek, most generally, to expand the scope and relevance of political model analysis. By incorporating the effects of variable human notions, traditions, and meanings, they seek to humanize political models. Most early applications of artificial intelligence in political science research address substantive issues pertaining to political decision making. Most of these works apply production-system technology to construct choice models in for eign-policy decision contexts. In recent years, political applications have begun to diver sify. Today, lively research efforts flourish in widely varied application areas, such as computational text analysis, logic programming, computer learning, and conflict sim ulation. The works reviewed here constitute the early steps of a nascent program of study. Much remains to be accomplished. Nevertheless, the efforts conducted thus far suggest many potentially fruitful research avenues. Youth are the most essential and promising segment of every country’s population. India has a larger advantage over other countries in terms of becoming a global leader because we effectively tap into the youth’s potential. Quality education is the only way to achieve this. With artificial intelligence’s potential growth in India, now is the ideal time to incorporate AI in education to reap its benefits and prepare India’s young for the future. Artificial intelligence has great potential in India. India’s AI technology has the potential to make it a world leader in artificial intelligence. In India, AI technology is used effectively in nearly every area, including agriculture, healthcare, education, infrastructure, transportation, retail, manufacturing, and

Dr gedam kamalakar

The problem of chemical fertilizers and pesticides can be solved by the action of plant growth promoting fungi (PGPF). The indigenous fungal isolates obtained from the rhizosphere soil can be used as they are said to solubilize the insoluble zinc, phosphorous, potassium etc. They are known to control the different fungal pathogens and thus promoting the plant growth and health. In the present study, attempt was made to isolate soil beneficial fungi from the rhizosphere soil samples of important medicinal plants such as Aegle marmelos, Azardirachta indica and Citrus limon. A total of 22 fungal isolates was isolated and screened for their efficacy on phosphate and zinc solubilization and antagonistic potential against selected plant pathogenic fungi under in vitro condition and the isolates were identified up to species level.

Dr. saranya devi k

In today's globalized world, the role of foreign direct investment (FDI) in shaping higher education cannot be overstated. This paper explores the multifaceted impact of FDI on higher education institutions worldwide, delving into its influence on academic programs, research endeavors, institutional infrastructure, and student experiences. Drawing upon a comprehensive review of scholarly literature, policy documents, and case studies, this paper elucidates the ways in which FDI contributes to the expansion and transformation of higher education systems across the globe. The analysis begins by examining the motivations driving foreign investors to engage with higher education, including economic imperatives, strategic partnerships, and knowledge transfer objectives. It then explores the diverse forms that FDI takes in the higher education sector, ranging from institutional partnerships and joint ventures to the establishment of branch campuses and research collaborations. By analyzing specific examples from different regions, this paper illustrates how FDI shapes the academic landscape, fosters innovation, and enhances internationalization efforts within higher education institutions.

Dr gedam kamalakar

The incorporation of lomustine, a hydrophobic anticancer drug into PLGA nanoparticles by interfacial deposition method was optimized. Based on the optimal parameters, it was found that lomustine-PLGA nanoparticles with acceptable properties could be obtained. Optimization of formulation variables to control the size and drug entrapment efficiency of the prepared nanoparticles seems to be based on the same scientific principles as drug-loaded nanoparticles prepared by nanoprecipitation, solvent evaporation method. The process was the most important factor to control the particle size, while both the drug-polymer interaction and the partition of drug in organic and aqueous phases were the crucial factors to govern the drug entrapment efficiency. PLGA concentration at lower level (100 mg), 1:5 organic phase: aqueous ratio, 1%w/v PVA concentration, 3%w/v pluronic F68 achieved smaller particle size. Additionally, L:G ratio of PLGA 75:25, lower volume of organic solvent (1:10 organic phase: aqueous phase), higher initial drug content (10mg) enhanced the drug entrapment efficiency and maintained lomustine concentration in blood for an extended time period, elevated lomustine concentration in lungs and slowed the elimination of lomustine. The biodistribution profiles of prepared nanoparticles in albino mice showed higher plasma drug concentration for longer period of time, elevated drug concentration in lungs and slow elimination from kidney. No toxic effects of prepared nanoparticles were observed in histopathological examination of lungs and kidney. The systematic investigation reported here promises the development of PLGA nanoparticles loaded with lomustine when tested in Lung Cancer cell line L132 and toxicological/ histopathological studies in albino mice.

Archana mehrotra

The current study seeks to develop and validate a high-performance liquid chromatography method for atorvastatin diastereomer separation and analysis. In particular, we wish to identify the many diastereomers in atorvastatin, which can help us to better understand their pharmacological properties and provide significant information for pharmaceutical applications. Atorvastatin was chromatographed on a Chiralcel® OD-RH column and n-hexan-2-propanol (95:05 v/v) as the mobile phase, with an injection volume of 10 µL. The solution was pumped at a continuous flow rate of 1 mL/min, with a detection wavelength of 260 nm. The investigation found two peaks with retention times of 3.23 and 3.85 min, respectively. The resolution, capacity, and selectivity factors obtained were Rs = 1.2, k′1 = 3.50, k′2 = 4.37, and α = 1.24.

Mediterranean journal of pharmacy and pharmaceutical sciences

Introduction/aims: Maturity-Onset Diabetes of the Young (MODY) is a monogenic non-autoimmune diabetes with 14 different genetic forms. MODY-related mutations are rarely found in the Tunisian population. Here, we explored MODY related genes sequences among seventeen unrelated Tunisian probands qualifying the MODY clinical criteria. Materials and methods: The GCK and HNF1A genes were systematically analyzed by direct sequencing in all probands. Then, clinical exome sequencing of 4,813 genes was performed on three unrelated patients. Among them, 130 genes have been reported to be involved in the regulation of glucose metabolism, β-cell development, differentiation and function. All identified variants were analyzed according to their frequencies in the GnomAD database and validated by direct sequencing. Results: We identified the previously reported GCK mutation (rs1085307455) in one patient. The clinical features of the MODY2 proband were similar to previous reports. In this study, we revealed rare and novel alterations in GCK (rs780806456) and ABCC8 (rs201499958) genes with uncertain significance. We also found two likely benign alterations in HNF1A (rs1800574) and KLF11 (rs35927125) genes with minor allele frequencies similar to those depicted in public databases. No pathogenic variants have been identified through clinical exome analysis. Conclusions: The most appropriate patients were selected, following a strict clinical screening approach, for genetic testing. However, the known MODY1-13 genes could not explain most of the Tunisian MODY cases, suggesting the involvement of unidentified genes in the majority of Tunisian affected families.

Mariam moalla

The advancement of the information technology and web technology have brought changes to existing information storage and retrieval system such as Digital library, online database, digital repository, virtual library, etc. Libraries have witnessed tremendous changes in recent years in terms of their collection and services. Information explosion and user's demand of the users required the development of a more comprehensive library collection. Publishers have now started publishing on-line version/electronic versions of their printed journals. Owing to the cost of journals, many colleges and universities are unable to procure these journals. Ministry of HRD and UGC has started procuring the e-resources from the 25 world-class publishers under consortia mode at a much reduced price for all university libraries. BHU library is one of the beneficiaries of this UGC-INFONET Digital Library Consortium. The present study is the part of Ph.D. research work of one of the authors. To ascertain the usage of the e-resources available to the BHU library by the teachers and scholars, this survey was conducted. The present investigation discusses the use of electronic resources (e-journals, e-books, online/ offline databases, web resources) which are made available by the INFLIBNET Centre in eresource consortium like UGC-INFONET Digital Library Consortium by the teachers and scholars of BHU. The present study was conducted as a part of doctoral research work from January 2015 to July 2015.

Dr. awadhesh singh gautam

The study identified the pragmatic competence level of the second language (L2) learners through Written Discourse Completion Test (WDCT) administered to purposively selected 40 first-year education students. A modified questionnaire based on Survey for Academic English Language Exposure (SAELE) was used to determine the effectiveness of academic English language exposure on the pragmatic competence development of the respondents. The study employed the descriptive-correlational method, while various statistical tools were utilized to analyze and interpret the data. Weighted mean was used to determine the respondents’ pragmatic competence level and the effectiveness of academic English language exposure on the pragmatic competence development of the respondents. Moreover, Pearson Product Moment Correlation (PPMC) was employed to determine the significant relationship between the two variables. Results in WDCT showed that the average scores in the pre-test and post-test results fall under the competent level. Meanwhile, the effectiveness of academic English language exposure on the pragmatic competence development of the respondents was 0.207, which is ineffective. Lastly, the statistical correlation of the two variables showed no significant relationship between them (r=0.046, p>0.05). Based on the study’s results, pedagogical implications for pragmatic and L2 teaching and learning were conceptualized.

Darrel ocampo

In some countries, a high percentage of the population relies on traditional plants for treating certain diseases. The aim of this study was to investigate the effect of G. alypum extract (GAE) and Alhagj marorum extract (AME) on lipid profiles in experimentally induced hypercholesteremic rats and on the blood pressure of experimentally induced hypertensive rats. Male Wistar rats weighing 200 - 300 g were divided into five groups: group 1 received a normal diet (negative control), group 2 received a high lipid diet containing coconut oil (10 g/kg/day), cholesterol (4 g/kg/day) and cholic acid (0.20 g/kg/day) (positive control), group 3 received a high lipid diet together with clofibrate (50 mg/kg/day), group 4 received a high lipid diet together with AME (200 mg/kg/day) and group 5 received GAE (200 mg/kg/day). The experiment continued for two weeks, then the rats were sacrificed and blood samples were collected for estimation of cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein. To induce hypertension, rats were divided into two groups (n = 8 in each group). Group 1 received normal saline (control) and Group 2 received dexamethasone (0.40 mg/kg, i.p.) for seven consecutive days. Later, the rats were anesthetized using thiopental and the carotid artery was cannulated for recording blood pressure. AME (40 mg/kg) or GAE (40 mg/kg) were injected through a cannula placed into the internal jugular vein at a dose volume of 0.1 ml. Systolic and diastolic blood pressure were measured before and after plant extract administration. The results showed that clofibrate GAE extract and ANE extract significantly decreased cholesterol, triglycerides, low-density lipoprotein and high-density lipoprotein as compared to high-lipid diet-treated rats. Data also indicated that administration of GAE or AME extract significantly decreased systolic and diastolic blood pressure in experimentally induced hypertensive rats. In conclusion, GAE and AME have antihyperlipidemic and antihypertensive activities and further investigation is needed to clarify the mechanism of these effects.

Mediterranean journal of pharmacy and pharmaceutical sciences

Since the WHO declared COVID-19 a pandemic on March 11, 2020, all countries worldwide have taken precautions to combat this pandemic, except for Yemen. The civil war and resulting humanitarian crises have diverted the attention of the Yemeni people and authorities away from COVID-19, potentially leading to the escalation of the pandemic. Following the initial denial, the internationally recognized government and the de facto authority of the Houthis acknowledged the first COVID-19 cases on March 11, 2020 and May 13, 2020, respectively. With only half of the Yemeni hospitals and medical facilities being fully operational, the authorities and humanitarian groups are working together to end the crisis. Due to paucity of information on the real number of cases in the country attributed to various reasons, no one can predict the future in this country, which will be most likely worse unless the civil war stops, and the humanitarian groups with the authorities need to work hard to strengthen the health system to prepare it for the current and all upcoming health crisis and pandemics.

Karishma

Background: Poverty and malnutrition are associated with the risk of developing tuberculosis (TB). Nutritional reintegration with anti-TB therapy may improve treatment success rate. Aim: To investigate the nutritional status of low-income pulmonary TB patients in relation to the different anti-TB treatment phases. Methods: Forty five pulmonary TB patients and 40 controls aged 19-54 years, receiving treatment at Infectious Disease Hospital, Calabar, Nigeria, between September 2018 and July 2019 were studied. Serum total protein, albumin, iron and vitamin A were determined by colorimetric and HPLC methods respectively. Height and weight were measured and BMI computed, and data analysed using Student’s t-test, ANOVA, and Pearson’s correlation at P<0 P=0.001).>0.05) respectively. Albumin and iron were significantly lower in CPAT-HIV compared with CPAT patients. Albumin correlated positively and significantly with iron (r=0.405, p=0.006) in TB patients. Conclusion: Tuberculosis is associated with decreased BMI, albumin, iron and vitamin A, and higher total protein, and globulin, suggesting that malnutrition may be associated with TB risk, poor treatment compliance and outcomes

Eworo raymond