Purpose: To assess incidence of demodex species, correlate ocular symptomatology, evaluate efficacy of coconut oil as treatment method in all types of blepharitis. Materials and Methods: 30 patients with anterior & mixed blepharitis, meibomian gland dysfunction & non-specific irritation were enrolled for study. History taken & examined clinically. 2 lashes/lid were sampled & mounted on slides with normal saline & observed under light microscope. Number of mites counted. Patients positive for demodex were treated with coconut oil application over lid margins & reviewed after 3 weeks. Results: Incidence of demodex was 40% & it increased with age. Demodex was commonly associated with meibomian gland dysfunction, non-specific irritation, madarosis, cloudy & toothpaste like meibum quality. Burning sensation and itching were common complaints. At 3rd week, all patients were symptom-free. Mite count dropped by 52.8% but were not eliminated. Conclusion: Demodex infestation is often overlooked but it is associated with about half of blepharitis cases. Hence further evaluation should be considered. Coconut oil is an easily available mode of treatment & helps reduce symptoms and mite counts.

Kamal singh

On January 2021, cases affected by coronavirus epidemic are constantly increasing, Libyan Ministry of Health provides the vaccine to the people those who are most at risk. The purpose of this study was to assess and verify the adverse effects of the first dose of the AstraZeneca COVID-19 vaccine. The study conducted at the Aljmail city, west region of Libya. The study was cross-sectional study during the period of August 31st and November 5th, 2021. The method involved 133 adult Libyan participants of both gender ageing more than 18 years old. The preliminary data were 54.0% who developed post-vaccination symptoms. The participant's aged 60 years and more with chronic diseases were more likely to have adverse effects after receiving the first dose of vaccine. In conclusion, AstraZeneca vaccine was good and effective but this study indicates a need for a large and long period study to confirm the safety of the vaccine use in the adult people.

Mediterranean journal of pharmacy and pharmaceutical sciences

In this article, we form the exact wave solutions of the Jimbo-Miwa equation and the Calogero-Bogoyavlenskii-Schiff equation by applying the new generalized (G'/G)-expansion method. We explained the new generalized (G'/G)-expansion method to look for more general traveling wave solutions of the above mentioned equations. The traveling wave solutions attained by this method are in terms of hyperbolic, trigonometric and rational functions. The graphical representation of the obtained solutions is kink soliton, singular kink soliton, singular soliton and singular periodic solution. This method is very significant for extracting exact solutions of NLEEs which habitually occur in mathematical physics, engineering sciences and applied mathematics.

Md khorshed alam

The present study aims to shed some light on the gains from consolidation exercise in terms of profitability of banks. Through the application of paired t-test, we arrived at the result that the consolidation of banks did improve the profitability of banks in India. The increase in profitability of banks under study is due to an increase in employee turnover and the subsequent reduction in operating expenses. Merger and acquisition programmes in Indian banks cannot be regarded as a false step if the benefits of it accrue to all stakeholders.

Akhil antony

Smartphones are constantly changing in today's world, and as a result, security has become a major concern. Security is a vital aspect of human life, and in a world where security is lacking, it becomes a concern for mobile users' safety. Malware is one of the most serious security risks to smartphones. Mobile malware attacks are becoming more sophisticated and widespread. Malware authors consider the open-source Android platform to be their preferred target as it came to lead the market. State-of-the-art mobile malware detection solutions in the literature use a variety of metrics and models, making cross-comparison difficult. In this paper various existing methods are compared and a significant effort is made to briefly address android malwares, various methods for detecting android malwares and to give a clear image of the progress of the android platform and various malware detection classifiers.

Jebin bose s

Tuberculosis (TB) is an infectious disease caused by bacteria called Mycobacterium tuberculosis. The disease mainly affects lungs and causes pulmonary tuberculosis. It can also affect intestine, meninges, skin, bones and other tissues of the body. Although the drugs alone can cure TB, it still remains a major public health problem worldwide. The aim of the study was to assess the quality of life and medication adherence in TB patients. The Quality of life was assessed using SF-36 in patients receiving DOTS treatment in initial or continuous phase while the medication adherence was analyzed using Morisky Green Levine Scale. Subjects were also counselled about their disease during their first visit and a follow up was done after a month. A total of 152 subjects were enrolled in the study of which majority of the subjects had Pulmonary TB (55.26%). Diabetes was found to be the most common comorbidity followed by HTN. The average Physical Component Summary (PCS) and Mental component summary (MCS) were found to be 44.34 and 39.60 respectively. Females had a better quality of life scores compared to males. High adherence was seen in 32.24% of patients while 28.29% had low adherence. Follow up was done for 135 subjects. 15 subjects defaulted and 2 of them died. There was a significant increase in the QoL scores and medication adherence after one month. A significant association was found between the Physical functioning (p=0.001) and emotional wellbeing (p=0.01) with Duration of treatment indicating that subjects who had completed more than one month of their treatment had marked improvement in Physical functioning and emotional well-being scores

Dr mahendrakumar r

Objective As technology continues to improve, it plays an increasingly vital role in the practice of medicine. This study aimed to assess the feasibility of the implementation of virtual reality (VR) in a rheumatology clinic as a platform to administer guided meditation and biofeedback as a means of reducing chronic pain. Methods Twenty participants were recruited from a rheumatology clinic. These participants included adults with physician-diagnosed autoimmune disorders who were on a stable regimen of medication and had a score of at least 5 on the pain Visual Analog Scale (VAS) for a minimum of 4 days during the prior 30 days. VAS, part of most composite outcome measurements in rheumatology, is an instrument used to assess pain that consists of a straight line with the endpoints ranging from “no pain at all” and “pain as bad as it could be.” Patients were randomized into two groups that differed in the order in which they experienced the two VR modules. One module consisted of a guided meditation (GM) environment, whereas the other module consisted of a respiratory biofeedback (BFD) environment. Data on pain and anxiety levels were gathered before, during, and after the two modules. Results The three most common diagnoses among participants were rheumatoid arthiritis (RA), lupus, and fibromyalgia. There was a significant reduction in VAS scores after BFD and GM (P values = 0.01 and 0.04, respectively). There was a significant reduction in Facial Anxiety Scale after the GM compared with the BFD (P values = 0.02 and 0.08, respectively). Conclusion This novel study demonstrated that VR could be a feasible solution for the management of pain and anxiety in rheumatology patients. Further trials with varying treatment exposures and durations are required to solidify the viability of VR as a treatment option in rheumatology clinics

Ben spielberg

Abstract In the existing investigation, experiments were carried out to assess the F2 population’s resultant of crosses between improved Basmati 370 and MAS25 for various agronomical and root traits cultivated under aerobic water conditions. Large variations for grain yield, root length, root dry biomass, root thickness and length/breadth ratio of grain have been displayed in segregating F2 populations. A close examination of phenotypic correlation exhibited that in the F2 population, root length was certainly matched up (r = 0.496) with root thickness. A DNA fingerprinting catalog for the currently studied F2 generation was arranged using 61 polymorphic SSR markers. Composite Interval Mapping (CIM) inspection with WinQTL cartographer version 2.5 disclosed 13 putative QTL (Quantitative Trait Loci), out of which 6 QTL were for root characters 7 QTL for agronomical characters situated on 1, 2, 3, 8 and 10 chromosomes. The QTL documented in the above-said generation, some promising F2 plants were also scrutinized and found in the homozygous or heterozygous state with high repetitions.

Rajesh yogi

The past few decades have witnessed several attempts to establish renowned medical journals in the Republic of Yemen. Some of these initiatives were successful but fell short of the researchers’ expectations, because they failed to meet international standards of scholarly writing in the medical field. Recently, the civil war has dashed any hopes of launching such a journal from within the country. We believe that this is the right time to establish a new peer-reviewed medical journal of high standards which meet the expectations of all Yemeni researchers across the board, from both within and outside the country. As a result of enormous efforts, discussions, and extensive collaboration, we have now been able to finalize the structure and content of the Yemen Journal of Medicine (YJM). Files

Karishma

Introduction/aims: Maturity-Onset Diabetes of the Young (MODY) is a monogenic non-autoimmune diabetes with 14 different genetic forms. MODY-related mutations are rarely found in the Tunisian population. Here, we explored MODY related genes sequences among seventeen unrelated Tunisian probands qualifying the MODY clinical criteria. Materials and methods: The GCK and HNF1A genes were systematically analyzed by direct sequencing in all probands. Then, clinical exome sequencing of 4,813 genes was performed on three unrelated patients. Among them, 130 genes have been reported to be involved in the regulation of glucose metabolism, β-cell development, differentiation and function. All identified variants were analyzed according to their frequencies in the GnomAD database and validated by direct sequencing. Results: We identified the previously reported GCK mutation (rs1085307455) in one patient. The clinical features of the MODY2 proband were similar to previous reports. In this study, we revealed rare and novel alterations in GCK (rs780806456) and ABCC8 (rs201499958) genes with uncertain significance. We also found two likely benign alterations in HNF1A (rs1800574) and KLF11 (rs35927125) genes with minor allele frequencies similar to those depicted in public databases. No pathogenic variants have been identified through clinical exome analysis. Conclusions: The most appropriate patients were selected, following a strict clinical screening approach, for genetic testing. However, the known MODY1-13 genes could not explain most of the Tunisian MODY cases, suggesting the involvement of unidentified genes in the majority of Tunisian affected families.

Mariam moalla

Objective: Pyrazolopyrimidines are heterocyclic molecules containing nitrogen as the main composition, and hence, they exhibit pharmacological efficacy. They are analogs of purines so that possessing wide applications in the field of medicinal chemistry. The main objective of this study is to synthesize different derivatives of pyrazole-pyrimidine classes by adopting simple methodology as well as by employing green chemistry. The purpose of the synthesis of these molecules is to study the antitumor activity against Ehrlich ascites carcinoma (EAC) cell lines. Methods: After literature studies, it makes us to involve in the research of synthetic organic chemistry, especially to synthesize new compounds of pyrazolopyrimidines. We are reported solvent-free synthesis of pyrazolo [3,4-d]-pyrimidine-thiones through ethyl acetoacetate, hydrazine hydrate, thiourea, and different benzaldehydes. An ionic liquid 2-methyl-imidazolium-oxalate catalyzed the reactions under ultrasonication bath. Both conventional and ultrasonic methods were employed and comparison studies have been made. It was found that ultrasonic method completed the reaction quicker than the conventional method. All the synthesized compounds were confirmed their structures by 1 HNMR, Fourier transform infrared, 13C-NMR, and elemental analysis spectra. The compounds were tested for in vitro anticancer activity against EAC cell lines. Most compounds revealed significant anticancer activity relative to doxorubicin as a positive control with inhibitory concentration (IC50) values. Results: Ultrasonication method is a simple method under which all the reactions were completed at faster time (<7 min) compared to the convention method. Among eight molecules, 8a and 8d completed the reactions at a faster rate. We reported IC50 values of all the molecules, in which 8e and 8g were exhibited excellent potency against EAC cell lines at different concentrations .

Dr ganesh n yallappa

Dietary intake of contaminated food with heavy metals may cause severe risk for the human health. Heavy metals affect adversely a human health. The current study assessed the concentrations of heavy metals including Cu, Zn, Pb and Ni in eggplant (Solanum melongena L.) of urban and rural areas in Bangladesh. The experimental samples of fresh eggplant fruits were collected from six local markets in Jashore, Bangladesh, and the tissues were extracted with nitric acid and hydrogen peroxide. Trace elements in eggplant fruits were estimated with atomic absorption spectrophotometer. Obtained result show that Heavy metal concentrations were high in the urban areas compared to rural areas. Heavy metals in the eggplant fruits of rural and urban areas were: Pb (2.74-18.64), Cu (10.20-67.16), Ni (46.63-148.46), and Zn (86.65-148.73) mg.kg-1 respectively. The concentrations of Pb, Ni and Zn in eggplant were at an excess of safe limits according to the Food and Agriculture and World Health Organizations. While, Cu was lower than the maximum safe limit. The present study concluded that growing eggplants in Jashore areas are heavily contaminated with Pb, Ni and Zn that would be hazardous for consumer’s health. The result of this study will be beneficial for the agricultural policy makers in Bangladesh to take appropriate action and reduce the heavy metal toxicity among fresh food products.

Arafat hassan razon

The study aims to explore the possible morphological features of monosodium urate monohydrate crystals. The study was carried out on a glass slide under a microscope to observe the growth patterns. As a result, three types of spherical ring-banded, dumbbell, and composite spherulites were observed. This study gives detailed information about the morphology and aggregation patterns of mono sodium urate monohydrate crystals.

Dr. salman ahmed

Though the anatomy and physiology of the adult caprine (Capra hircus L.) stomach have been investigated extensively, the early development of the abomasum has not yet been fully elucidated. The glandular part of abomasum plays an important role in digestion of ingested food by action of gastric juices. Very few studies have been conducted so far regarding histogenesis of goat foetal abomasum in India. In the present study, we have investigated the embryonic and early foetal development of the goat, Capra hircus L. fundic abomasum. We collected 36 developing abomasum of healthy and normal embryos/foeti of goat and assigned them into three group viz. Gr. I (0-50 days of gestation), Gr. II (51-100 days of gestation) and Gr. III (101-150 days of gestation). Small pieces of tissues were processed by routine paraffin. The wall of glandular stomach, the fundic part, was composed of epithelium, pleuripotent blastemic tissue and serosa up to 44 days of gestation. Tunica muscularis became separable at 46 days of gestation. The epithelium was stratified type up to 50 days and gradually changed to pseudo-stratified columnar to simple columnar type from 76 days of gestation. Primary and secondary abomasal folds were observed at 51 and 76 days of gestation, respectively. Gastric pit, the fore runner of gastric gland was reported first at 70 days. The gland became branched tubular type at 145 days. The cells found in the mucosa of the abomasum were surface epithelial cells, chief cells, parietal cells, mucous neck cells and undifferentiated cells. Chief and parietal cell were observed at 76 days and mucous neck cells at 82 days of gestation. Reticular, collagen and elastic fibers came into sight at 38, 76 and 100 days of gestation, respectively. The present study is expected to supplement known data and knowledge regarding histogenesis of goat fetal abomasum and help in diagnosis and treatment of related congenital anomalies.

Varsha gupta

The primary objective of this study is to conduct a comprehensive analysis of the relationships between liquid- ity (LIQ), capital structure (LEV), and fnancial performance (FIP). Additionally, we seek to investigate the indirect efect of liquidity (LIQ) on fnancial performance (FIP) by examining the intermediary role of the capital structure (LEV) of non-fnancial-listed companies in the Vietnamese stock market. This study utilizes PLS-SEM with a robust sample of 644 non-fnancial-listed companies in the Vietnamese stock market. The fndings suggest that liquidity positively infuences fnancial performance but negatively impacts capital structure. Conversely, capital structure negatively afects fnancial performance. Thus, liquidity indirectly enhances fnancial performance through capital structure mediation. This research result can provide suggestions for non-fnancial enterprises in making fnancial decisions to increase fnancial efciency by increasing the holdings of highly liquid assets to prevent risks and take advantage of new investment opportunities in the future. In addition, increasing the holding of highly liquid assets also reduces debt pressure and reduces interest costs, thereby increasing fnancial efciency. Our research shows that the relationship between economic factors is extremely complex; specifcally, our research shows the true nature of the positive impact of liquidity on fnancial performance, including direct positive efects and indirect positive efects through capital structure. In addition, our research results also show that non-fnancial enterprises that want to increase fnancial efciency need to pay attention to revenue growth, and non-fnancial companies with larger total assets (size) will have more advantages in increasing fnancial performance.

Nam nguyen hoang phi

Autophagy is a self-digesting mechanism responsible for removal of damaged organelles, malformed proteins during biosynthesis, and nonfunctional long-lived proteins by lysosome. Autophagy has been divided into three general types depending on the mechanism by which intracellular materials are delivered into lysosome for degradation that is, microautophagy, chaperone-mediated autophagy (CMA), and macroautophagy. In microautophagy cytoplasm material is sequestered through direct invagination to the lysosomal membrane. Whereas in CMA proteins flagged with pentapeptide motif (KFERQ) were selectively degraded through direct translocation into lysosome. Macroautophagy involves the formation of subcellular double-membrane-bound structures called autophagosomes that contain degradable contents of cytoplasm materials and deliver them into lysosomes for breakdown by lysosomal enzymes. The molecular mechanism of autophagy involves several conserved Atg (autophagy-related) proteins. Systems produce modified complexes Atg8-PE and Atg5-Atg12-Atg16 as autophagy regulators. Autophagy is activated in response to diverse stress and physiological conditions. For example, food deprivation, hyperthermia, and hypoxia are mediated by factors like insulin/IGF-1, m-TOR signaling, FOXO transcription factors, and chaperones. The perturbance in autophagy may lead to several types of cancers, myopathies, and neuromuscular disorders. Several autophagy inducers and inhibitors like 3-methyladenine (3-MA), bafilomycin A1, LY294002 (LY), and Velcade have been used to treat disease is an intense field of study.

Kamal singh

Recently, the definition of cardiorenal syndrome (CRS), a condition with a complicated pathogenesis, has been revised. Logically, CRS syndrome should be classified according to the initial organ that is injured, resulting in damage to another organ. Hence, there are only three main categories of CRS. Category one includes acute and chronic CRS. Category two involves renal-cardiac syndrome (RCS), which can be classified as acute or chronic. The third category represents secondary CRS, referred to as cardio-reno-cardiac syndrome (CRCS), which can be subdivided into acute and chronic CRCS. In this part of our series, we will discuss the epidemiology, pathophysiology, diagnosis, treatment, and prevention of acute CRS. We retrieved articles published on acute CRS using different keywords and phrases between January 2019 and June 2025 to achieve these goals.

Karishma

The main purpose of the research is to develop modern tools for insurance management in the global economic crisis, to make an objective assessment based on a critical analysis of existing ones, to identify situations that could lead to international economic, social and natural threats. It is made some recommendations for the development of insurance calculations for the republic of Uzbekistan. Methods: Methods for reforming modern calculation of insurance tariff are recommended by means of theories of probabilities, statistical and mathematical analysis, and foreign advanced countries practical types of summarizing. Findings: While making an analysis, it has found that modern tools for the insurance management of Uzbekistan are needed. We proved this by the results of the modern calculation of insurance in tables (1-6). For the development of the insurance market of Uzbekistan, it should be analyzed by means of penetration and density of insurance premiums, making the deepest calculation of risks of the economy of Uzbekistan, and using the main principals and formulas of the theory of probability. Conclusions: In the end, we can take some results, and give some recommendations such as using the tools of theories of probabilities can help us find the main risks of economy, its powers of influences of the market economy, statistical and mathematical analysis also add some practical, objective results for making under control of any types of insurance risks.

Ikboljon odashev mashrabjonovich

Background: Idiopathic Parkinson's disease (PD) is a central nervous system degenerative disorder with an unknown etiology. PD is the second leading cause of neurological impairments. Exercise therapy treatment is commonly used for PD to improve health and decrease the functional limitations. Exercise therapy includes Strengthening, aerobic, agility etc.. Objective: To investigate the evidence on efcacy and limits of strength training in rehabilitation of Parkinson's disease Method: A comprehensive search on pubmed, clinical keys database using keywords Parkinson's disease, physical therapy, strength training ,resistance training. The studies including Randomized controlled trails and systematic reviews published since 2005 are reviewed. Results: 36 studies identied through database searching. 25 studies are excluded due to duplicates, irrelevance, based on titles, outcome diversity. 5 systemic reviews and Meta analysis, 6 RCT are included. Review and analysis of articles is going on Conclusion : The result of this review suggests that strength training program can be effective in people with mild and moderate parkinson's disease. It can improve functional independency with increased muscle strength, gait parameters, posture and balance, all of these positive role on participation and quality of life.

Nagarjuna narayanasetti

Adolescents’ scholastic and social life has become increasingly reliant on the internet and mobile technology in recent years. Problematic Internet Use (PIU) is a growing problem in Indian adolescents. However, in many cases, this use has become obsessive, causing them to neglect other elements of their lives. Adolescents account for over 35% of internet users in India. The purpose of this study was to evaluate the psychosomatic problems related to internet overuse among school going adolescent students. This cross-sectional survey was conducted among 348 students in selected schools of Aspur block in Dungarpur-district, Rajasthan, India in the month of February 2016. Problematic internet use (PIU) was assessed by Young’s twenty question internet addiction test. The Depression, Anxiety, Stress Scale (DASS-42) and self structured questionnaire check list was used to measure psychosomatic problems among adolescents. Approximately 5.17% adolescents showed Problematic internet use (PIU). Adolescents with PIU were associated with age between 14-16 year, males,10th class of study, using internet since more than 3 years, being at home, mobile as a source of internet use, purpose of internet use with online gaming. Compared with normal internet users, there were significant correlation between Problematic Internet Use and Somatic Complaints r=0.3660, p<0.05, Depression r=0.3982, p<0.05. Anxiety r=0.2512, p<0.05 and Stress r=0.2886, p<0.05. Problematic internet use (PIU) is an increasing problem among teenagers and it has been linked to psychosomatic issues. Timely Effective measures are needed to prevent the spread of this problem

Dr k c yadav