Background: Idiopathic Parkinson's disease (PD) is a central nervous system degenerative disorder with an unknown etiology. PD is the second leading cause of neurological impairments. Exercise therapy treatment is commonly used for PD to improve health and decrease the functional limitations. Exercise therapy includes Strengthening, aerobic, agility etc.. Objective: To investigate the evidence on efcacy and limits of strength training in rehabilitation of Parkinson's disease Method: A comprehensive search on pubmed, clinical keys database using keywords Parkinson's disease, physical therapy, strength training ,resistance training. The studies including Randomized controlled trails and systematic reviews published since 2005 are reviewed. Results: 36 studies identied through database searching. 25 studies are excluded due to duplicates, irrelevance, based on titles, outcome diversity. 5 systemic reviews and Meta analysis, 6 RCT are included. Review and analysis of articles is going on Conclusion : The result of this review suggests that strength training program can be effective in people with mild and moderate parkinson's disease. It can improve functional independency with increased muscle strength, gait parameters, posture and balance, all of these positive role on participation and quality of life.

Nagarjuna narayanasetti

his study explored the English Language Teaching appraisal of teachers in the trifocal Philippine education system in the Bicol Region as a basis for policy and advancement programs. This study used the descriptive-comparative-associational method using a content-validated and reliability-tested questionnaire. The frequency and percentage technique, weighted mean, Chi-Square, and Anova Test of Variance were used in the data treatment. Findings revealed that ELT teachers were predominantly females with 73.97%, CHED, 80.21%, DepEd, and 71.43% TESDA along age groups of early and mid-30s and 46 years above. They served the agencies for less than 10 years, mostly married. Professionally, these teachers were still pursuing post-graduate education and attending training. Along with appraisals on their professional and work responsibility, ELT Trifocal teachers very evidently performed their professional and work responsibilities; on the delivery system, respondents conveyed the mastery and application of theoretical and pedagogical knowledge; on their communicative competencies, they were classified as experts. Meanwhile, there was no significant difference among ELT teachers’ appraisal in the three systems (F–value 2.21< t-value 3.35; 5% level of significance). It follows that Philippine education has maintained an undeviating quality of ELT teachers regardless of which system of education they belong. The result showed no variations in ELT competencies despite differences in modalities, urgencies, and the attainment of quality education. Findings also unveiled that the ELT teachers’ appraisal and integration of ICT to language teaching are directly associated with their age, sex and civil status, and educational attainment. The higher the educational attainment, the higher the integration of ICT in language teaching. With these results, a policy development for the Professional Advancement Program in ELT was crafted.

Darrel ocampo

This paper examines India’s diplomatic stance towards Israeli settlements in the Palestinian territories, focusing on the complexities of the Israeli-Palestinian conflict and India’s historical relations with both sides. The issue of Israeli settlements has been an issue and a obstacle to peace in the region. As a prominent global player and staunch supporter of Palestinian rights, India finds itself in the delicate position of balancing its traditional support for the Palestinian cause with its growing strategic ties with Israel.The article delves into the evolving dynamics of India’s foreign policy and the factors influencing its stance on Israeli settlements. Analyses India’s historical suppor t for Palestinian self-determination and its voting record in international forums not supporting Israeli settlements. It also examines India’s growing economic and defence cooperation with Israel, which complicates its position on the issue of settlements.

Dr gedam kamalakar

Cancer is one of the most extreme medical conditions in both developing and developed countries around the world, causing millions of deaths each year. Chemotherapy and radiotherapy are critical treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer overall requires novel, efficacious treatment modalities. Natural medications offer feasible alternative options against malignancy in contrast to western medicines. Furanocoumarins’ defensive and restorative impacts have been observed in leukemia, glioma, breast, lung, renal, liver, colon, cervical, ovarian, and prostate malignancies. Experimental findings have shown that furanocoumarins activate multiple signalling pathways, leading to apoptosis, autophagy, antioxidant, antimetastatic, and cell cycle arrest in malignant cells. Additionally, furanocoumarins have been shown to have chemopreventive and chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Here, we address different pathways which are activated by furanocoumarins and their therapeutic efficacy in various tumors. Ideally, this review will trigger interest in furanocoumarins and their potential efficacy and safety as cancer-lessening agents.

Dr. salman ahmed

Nano technology refers to enhancing the function and delivering the upcoming smart solutions to products at the nanoscale level. It relates to organizing the molecules for altering in dimension and characteristic for improvement like smart fabric. These fabrics could assist producers with the added prominence on a standard of living, visual attraction, and system wanted technological produces. Nanosize particles can unveil unpredicted characteristics dissimilar from the bulk matter. The fundamental principle is that the features could radically be altered after the material is decreased to the nanometer scale. Nanotechnology has multipurpose functions in fabric manufacturing in producing the stain and wrinkles defiance, flame retardant, antimicrobial and antistatic properties, moisture control, ultraviolet protection, and release features. The nanomaterials inside the fabric could influence numerous qualities, comprising reduction, electrical conductivity, flammability, and strength. Nanotechnology has additionally created a significant impression on various application and implementation. Nano-doctored fabrics may advance numerous fabrications as the nano-science progresses further.

Munima haque

Menstruation is a normal physiological impact on each girl’s life. Menstruation is monthly uterine bleeding for 3-5 days after every 28 days from puberty till menopause. A change in mood, behaviour, appearance of some abnormal vague symptoms is often noticed in the second half of the cycle. Symptoms are severe enough to disturb the life cycle of a woman called premenstrual syndrome (PMS). The study aimed to assess the premenstrual symptoms and coping strategies among adolescent girls. The majority of the students suffered from premenstrual syndrome. Objective: to assess the premenstrual symptoms and coping strategies among adolescent girls. Methodology: A nonexperimental descriptive research design was adopted in this study. Non probability convenient sampling technique was used to select the sample size of 30 adolescent girls. The assessment of premenstrual symptoms and coping strategies was carried out using a self-reported Likert’s rating scale. Data was analyzed by using descriptive and inferential statistics. Result: Majority (93.3%) of the samples sometimes had physiological and psychological problems, 90% of them had behavioural symptoms. Majority (43.3%) of the samples always followed coping strategies and 16.7% of the samples sometimes followed coping strategies and 40% never followed any coping strategies. Conclusion: PMS was common among students at 18-24 years. The most common physical symptoms experienced by adolescent girls were headache, backache and lower abdominal pain. Adolescent girls used coping strategies as taking hot / cold drinks, do not express anger to others, and turn to study and forget things, hearing music and taking medications. Keywords: Premenstrual Symptoms, physiological, psychological & behavioural symptoms, Coping Strategies, Adolescent Girls.

Elsi queen

This study sets out to explore the Critical Success Factors (CSFs) necessary for Total Quality Management (TQM) implementation in hotels. It also aims to classify participating hotels into groups based on their TQM adoption by using cluster analysis. A quantitative survey method was applied. Data were collected from a sample of managers from four- and five-star hotels in Jordan, 170 questionnaires were distributed to managers and 104 usable questionnaires were returned. The findings revealed that TQM is existed and implemented in the hotel industry. The researcher then confirmed that four- and five-star hotels can be classified into two groups, namely, “high TQM adopters” and “low TQM adopters”.

Mukhles m. al-ababneh

Multimedia data encryption attempts to prevent unauthorized disclosure of confidential multimedia information in transit or storage. Security of multimedia files attracts more and more attention and many encryption methods have been proposed in literature. If we call a multimedia data stream (message) plaintext , the process of transforming the plaintext into unintelligible data stream is referred to as multimedia encryption (MME) where the encrypted message (data stream) is often named ciphertext. The process of transforming the ciphertext back into plaintext is termed decryption. We propose a new block cipher based on randomized key of size n × n where n is the block size and the block undergoes n 2 iterations with the plaintext. Every iteration generates the pseudo cipher text. The encryption process generate the ciphertext C with the help of the randomized key. The decryption apply the key in reverse order on the cipher text, to get back the plain text. This work deals with the problem of efficient multimedia data encryption.

S arul jothi

Object: The main purpose of the research is to develop modern tools for insurance management in the global economic crisis, to make an objective assessment based on a critical analysis of existing ones, to identify situations that could lead to international economic, social, and natural threats. It is made some recommendations for the development of insurance calculations for the republic of Uzbekistan. Methods: Methods for reforming modern calculation of insurance tariffication are recommended by means of theories of probabilities, statistical and mathematical analysis, and foreign advanced countries practical types of summarizing. Findings: While making an analysis, it has found that modern tools for the insurance management of Uzbekistan are needed. We proved this by the results of the modern calculation of insurance. For the development of the insurance market of Uzbekistan, it should be analyzed by means of penetration and density of insurance premiums, making the deepest calculation of risks of the economy of Uzbekistan, and using the main principles and formulas of the theory of probability. Conclusions: In the end, we can take some results, and give some recommendations such as using the tools of theories of probabilities can help us find the main risks of economy, it’s powers of influences of the market economy, statistical and mathematical analysis also add some practical, objective results for making under control of any types of insurance risks

Ikboljon odashev mashrabjonovich

There are several significant assays including bioavailability, Toxicity, high clearance, and further current therapies require higher and frequent dosing to gain desired therapeutic effects for Rheumatoid arthritis (RA). Nanoparticles have beenwidely investigated for rheumatoid arthritis (RA). Though, higher doses of Nanocarriers also increase the incidence of dreadful adverse effects. Wherever, nanocarrier properties are most populated by the use of different approaches like targeting ligands, to change the physicochemical properties including higher encapsulation, better penetrating ability in cells etc. The main advantage of the nanocarrier that they provide longer circulation which enhances drug localization at the inflamed site and selective targeting to enhance the therapeutic index of anti-arthritic drugs. However, the optimal properties of nanocarrier also depend on the route of administration and size of particles, thus larger size show more retention upon local injection and smaller sized ones are more optimal for passive targeting. The present article discusses the emergence of nano-carriers for antirheumatic drugs, which delivers drug molecule to the inflamed site by topical, intra-articular (i.a) and intra-venous (i.v) administration to take advantage of therapeutic efficacy by passive and active drug delivery. Advancements have been made extensively but still better investigations are needed to achieve the risk-benefit ratio for the development of safe, stable and effective targeting nanocarriers for the e treatment of rheumatoid arthritis (RA).

Dr. wahul umesh b

Evidence demonstrates that inappropriate drug disposal creates a significant risk to global environmental safety. Study participants' knowledge, attitude and practice regarding the disposal of unwanted and expired medications were assessed. The study was carried out at Sebha city, in southwestern Libya, from October 2021 to April 2022. A self-administered questionnaire designed explicitly to be completed by a respondent without an interviewer's assistance was used. Out of 650, only 500 completed questionnaires was returned. The majority of the respondents admitted they have at least one medication stored at home (71.6%). Keeping expired drugs were reported by 28.2% of the respondents compared with unused medications in their house (51.2%). Almost half of the respondents (47.4%) declared that their medication were taking from the private pharmacies. “I’ll need it in the future” (48.8%), "Medicines change" (37.2%) and "Symptoms improve and recover" (32.6%) were the top three explanations given by participants. The majority of drugs reported were antibiotics (41.0%). This is followed by antipyretic and analgesic drugs, which were used by 29.8% and 27.8% of respondents, respectively. 52.2% of the respondents agreed that disposing of medicines in the garbage is the most appropriate method. Concordantly, the majority of them indicated they discarded unused or expired medicines whether they were solid (82.6%), liquid (58.4%), or semisolid (79.6%). The majority of participants indicated they were aware of the negative impact of drug waste on the environment (80.6%). More than three quarters of the participants said they had never been given instructions on how to properly dispose of medications and 60.8% thought a medical team would be the best source of knowledge. Despite acknowledging being aware of the harmful effects on the environment, the majority of participants admitted to keeping unneeded pharmaceuticals in their homes and throwing them out in the trash. The government should support the pharmacists' role in educating the public about how to properly dispose of their medications and establish the Return Unwanted Medicines Project in order to raise awareness and create cost-effective medication waste management programs.

Mediterranean journal of pharmacy and pharmaceutical sciences

Hydatid disease or hydatidosis is a worldwide zoonosis disease caused by the tapeworm of Echinococcus granulosus and still widely endemic in Tunisia especially in rural areas where the sheep-dog cycle is dominant. It is an important public health problem in the pediatric age group causing significant morbidity and mortality. We report a case of primary hydatid cyst of the small intestine in a child and we want to highlight the difficulty that we meet in the diagnosis despite the contribution of imaging.

Sameh

Obsessive-compulsive disorder (OCD) is a mental disorder that causes repeated unwanted thoughts or sensations, or do something over and over again. It is affecting all ages in the world. It is unusual for symptoms to begin after the age of 35 and half of people develop problems before 20. This making university students a target of OCD. This study investigates the prevalence of symptoms of OCD and identifies possible risk factors among pharmacy students of University of Tripoli, Libya. 80 pharmacy students registered in the final academic year 2019/2020 were enrolled in this study. All the participants were females ranging of 22 to 24 years old of a same environmental background. This study is based on a validated questionnaire for screening of OCD as mentioned by the American Psychiatric Association without modification. A total of 63 students have returned the questionnaire (response rate, 78.8%). The study shows that OCD symptom is relatively common among pharmacy students. The most common symptoms are losing something of importance (71%) and checking things over and over or repeat actions many times to be sure they are done properly (63%). Among OCD symptoms, the most common associated trigger factors were stress and phobia which representing 62% of the participated students. This study indicates that pharmacy students are at risk of being susceptible to getting OCD. OCD affects academic performance and quality of student life, therefore, a psychological and health services for university students should be implanted.

Mediterranean journal of pharmacy and pharmaceutical sciences

The inclusion of hydroelectric power is crucial to Nigeria's overall energy mix, playing a significant role in electricity generation. However, the Shiroro hydro plant, one of the main facilities located on the Kaduna River, is currently facing operational obstacles due to deteriorating infrastructure and inadequate maintenance practices. To overcome these challenges and improve efficiency within Nigeria's hydroelectric power sector, a hybrid-optimization approach has been proposed. This study sought to enhance the efficiency of the Shiroro hydro plant by implementing this innovative method. To achieve our objectives and address pertinent research questions, a mixed research method combining primary and secondary data was employed. The analysis included hydropower modeling and hydro-turbine input-output modeling. Three optimizer models, namely the particle swarm optimizer (PSO), Ant colony optimizer (ACO), and Artificial bee colony optimizer (ABCO), were utilized to formulate objective functions and task representations. The study involved comparing the daily output and fitness response of the Shiroro hydro plant through swarm optimizer iterations. The findings revealed a clear correlation between the turbine's power output and the water flow rate and water column height, suggesting that altering these factors could significantly improve the plant's performance. The comparison of the PSO, ACO, and ABCO models demonstrated that PSO and ABCO generated optimal or near-optimal solutions, while ACO produced suboptimal results. Consequently, the study concluded that enhancing the Shiroro hydro plant's output was feasible by increasing the water flow rate and column height. Additionally, the utilization of PSO and ABCO models proved to be an effective means of accurately predicting the turbine's output. As a result, the study recommended the integration of hybrid optimization techniques to monitor and identify any deviations in the Shiroro hydro plant's daily power output. This approach would enable prompt maintenance to be carried out, preventing significant damage to the plant. Ultimately, this research contributes valuable insights into improving the efficiency and performance of Nigeria's Shiroro hydro plant.

Fxintegrity publishing

In the research described in this paper, we used computer simulations to analyze and compare different types of game strategies in the popular board game Don't Get Angry. Following a brief introduction, we summarized a few previous research papers examining similar board games' game strategies. Next, after a review of the Don't Get Angry game's official rules, we outlined four strategies that can be applied to increase the likelihood of winning. We simulated 50,000 games in which all four players made their moves randomly and 50,000 games where each used a different strategy. We tracked how frequently each player finished first, second, third, or last during the simulations. Furthermore, we recorded how many rounds were needed to complete the game for each player, how many times the players’ pawns were kicked out and returned to their houses by other players, and the number of players’ remaining steps during every gameplay. From the analysis of the recorded data, we could conclude that significant differences exist in the chances of winning the game for the examined strategies when all players use different strategies. The results improve the specific domain knowledge for the Don't Get Angry board game. It may help create more vigorous computer opponents and encourage further study to create a tool for evaluating students' strategic thinking while playing.

Ladislav végh

Globally, approximately 12% of the population is inflicted by various types of urolithiasis. Standard treatments are available to avert and treat urolithiasis, but with significant adverse side effects. Pentacyclic triterpenes represent a group of naturally occurring compounds with immense potential as treatments for kidney stones. This review aims to provide an integrative description of how pentacyclic triterpenes can effectively treat calcium oxalate urolithiasis through various antioxidant, anti-inflammatory, diuretic, and angiotensin-converting enzyme inhibition mechanisms. Some pentacylic triterpenes showing promising activities include lupeol, oleanolic acid, betulin, and taraxasterol. Moreover, future perspectives on developing pentacyclic triterpenes in formulations/drugs for urinary stone prevention are highlighted. It is anticipated that compiled information would serve as a scientific baseline to advocate further investigations on the potential of pentacyclic triterpenes in urolithiasis remediation.

Dr. salman ahmed

Araucaria columnaris is one of the ornamental plants of all over the world. It is commonly known as Christmas tree. In the present study tree exudates – resin from the bark of the Araucaria columnaris belonging to the family Araucariaceae were investigated for phytochemical and antibacterial activity. The resin was separately extracted with different solvents based on its polarity, water, methanol, ethyl acetate and benzene. The extracts were screened for phyto-chemical analysis, the result shows that methanolic extract involved in extraction of large number of phytochemicals when compared with other extracts and subjected to antibacterial assay against major human pathogens. Methanolic extract act as good inhibitory agent against major microorganisms. This finding revealed that methanolic resin extract of Araucaria columnaris had significant potential for the control of dreadful diseases causing human pathogens.

Dr. saranya devi k

This study was carried out to verify all the manual process involved in generating Students Examination Result and to seek a way of automating the system for effective operations. Computer and its appreciations have become vital tools in the economic, industrial and social development of advanced countries of the world. Most educational institutions in Nigeria, such as Universities, Polytechnics and Colleges of Education still operate on the manual method of record keeping and computation of students’ grade point averages (GPA) which is time-consuming and error-prone especially when the number of students is large. This paper examines the inadequacies involved in the manual method of calculating Students CGPA (cumulative grade point average) and proposes a solution by developing a software application to facilitate the automated processing of the results. The software was developed using the Microsoft Excel spreadsheet program. The developed software was tested and found to performed well and produced expected results on completion. With it, it was possible to compute Grade Point Average (GPA) and Cumulative Grade Point Average (CGPA) for each student based on examination scores entered. The new system has some qualities such as reduction in the cost of processing of information, reduction in time spent in computing GPA and generating transcripts, increase in accuracy and efficiency, and elimination of duplication of effort which makes it superior to the manual system of student record keeping. This new system is flexible and can be modified to suit any kind of student’s record-keeping and data processing.

Ogala justin onyarin

This study investigated workforce diversity and secondary school administration in Rivers state. The design for the study was the descriptive survey. Two research questions and two hypotheses were raised to guide the study. Mean and standard deviation statistics were used to answer the research questions while the hypotheses were tested at 0.05 level of significance using z-test statistics. A sample size of 667 respondents, representing 90% of the entire population of 741 principals and vice principals from all the 247 pubic senior secondary schools in Rivers state was drawn using the stratified random sampling technique. A researcher-designed instrument titled Workforce Diversity Management Questionnaire (WOFDIMQ) was used for data collection. The instrument was validated by experts in the area of measurement and evaluation at the University of Port Harcourt. The reliability index determined for the instrument using Cronbach Alpha was 0.82. The findings of the study revealed that secondary school administrators do have some administrative strategies put in place for the management of the diversities among teachers. It was therefore recommended among others, that the government should make some specific provisions that will guide school administrators in the management of diversities among teachers. Also, school administrators should develop operational plans and strategies that are based on their specific peculiarities that will help maximize the advantages of diversities among teachers, while at the same time, minimize the inherent disadvantages.

Fxintegrity publishing

The current study is carried out to evaluate the antiemetic activity of methanol extracts of five leguminous plants leaves viz., Cassia siamea Lamk., Cyamopsis tetragonoloba Taubert., Delonix regia Rafin., Samanea saman Merr. and Vigna trilobata Verdc. at a dose of 150 mg/kg body weight orally, using a chick emesis model. Emesis was induced in male chicks by the oral administration of copper sulphate (50 mg/Kg body weight). The antiemetic activity was determined by calculating the mean decrease in the number of retching as compare with the control. All the extracts showed antiemetic activity when compared with standard drug chlorpromazine (150 mg/kg body weight orally). Among all extracts, Delonix regia showed the highest (96.74%) and Cassia siamea lowest (18%) antiemetic activity.

Dr. salman ahmed